JP7275111B2 - 脂質ナノ粒子の生成方法 - Google Patents
脂質ナノ粒子の生成方法 Download PDFInfo
- Publication number
- JP7275111B2 JP7275111B2 JP2020512372A JP2020512372A JP7275111B2 JP 7275111 B2 JP7275111 B2 JP 7275111B2 JP 2020512372 A JP2020512372 A JP 2020512372A JP 2020512372 A JP2020512372 A JP 2020512372A JP 7275111 B2 JP7275111 B2 JP 7275111B2
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- Prior art keywords
- lipid
- mir
- optionally substituted
- peg
- glycero
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023076121A JP2023093756A (ja) | 2017-08-31 | 2023-05-02 | 脂質ナノ粒子の生成方法 |
| JP2025072087A JP2025108727A (ja) | 2017-08-31 | 2025-04-24 | 脂質ナノ粒子の生成方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553088P | 2017-08-31 | 2017-08-31 | |
| US201762553085P | 2017-08-31 | 2017-08-31 | |
| US62/553,085 | 2017-08-31 | ||
| US62/553,088 | 2017-08-31 | ||
| US201762590193P | 2017-11-22 | 2017-11-22 | |
| US62/590,193 | 2017-11-22 | ||
| PCT/US2018/049251 WO2019046809A1 (en) | 2017-08-31 | 2018-08-31 | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076121A Division JP2023093756A (ja) | 2017-08-31 | 2023-05-02 | 脂質ナノ粒子の生成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532528A JP2020532528A (ja) | 2020-11-12 |
| JP2020532528A5 JP2020532528A5 (https=) | 2021-10-07 |
| JP7275111B2 true JP7275111B2 (ja) | 2023-05-17 |
Family
ID=63684527
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512372A Active JP7275111B2 (ja) | 2017-08-31 | 2018-08-31 | 脂質ナノ粒子の生成方法 |
| JP2023076121A Pending JP2023093756A (ja) | 2017-08-31 | 2023-05-02 | 脂質ナノ粒子の生成方法 |
| JP2025072087A Pending JP2025108727A (ja) | 2017-08-31 | 2025-04-24 | 脂質ナノ粒子の生成方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076121A Pending JP2023093756A (ja) | 2017-08-31 | 2023-05-02 | 脂質ナノ粒子の生成方法 |
| JP2025072087A Pending JP2025108727A (ja) | 2017-08-31 | 2025-04-24 | 脂質ナノ粒子の生成方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11744801B2 (https=) |
| EP (1) | EP3675817A1 (https=) |
| JP (3) | JP7275111B2 (https=) |
| CN (1) | CN111315359A (https=) |
| AU (1) | AU2018326799A1 (https=) |
| CA (1) | CA3073211A1 (https=) |
| MX (1) | MX2020002348A (https=) |
| WO (1) | WO2019046809A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023093756A (ja) * | 2017-08-31 | 2023-07-04 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子の生成方法 |
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| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
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| AU2018326799A1 (en) | 2020-02-27 |
| US20200306191A1 (en) | 2020-10-01 |
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