JP7138106B2 - 初期サクビトリル中間体のための新規な方法 - Google Patents

初期サクビトリル中間体のための新規な方法 Download PDF

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JP7138106B2
JP7138106B2 JP2019534372A JP2019534372A JP7138106B2 JP 7138106 B2 JP7138106 B2 JP 7138106B2 JP 2019534372 A JP2019534372 A JP 2019534372A JP 2019534372 A JP2019534372 A JP 2019534372A JP 7138106 B2 JP7138106 B2 JP 7138106B2
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formula
compound
alkyl
salt
aryl
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JP2020502244A (ja
JP2020502244A5 (enExample
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カール クラインベック－リニカー，フロリアン
カプフェラー，トビアス
ラウメン，クルト
ルッホ，トーマス
シュラマ，ティエリ
ク，ジエ
リ，ユンジョン
ペン，ウェイ
ヤン，ヤオ
キム，ホンヤン
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019534372A 2016-12-23 2017-12-20 初期サクビトリル中間体のための新規な方法 Active JP7138106B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016111674 2016-12-23
CNPCT/CN2016/111674 2016-12-23
PCT/IB2017/058203 WO2018116203A1 (en) 2016-12-23 2017-12-20 New process for early sacubitril intermediates

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JP2020502244A JP2020502244A (ja) 2020-01-23
JP2020502244A5 JP2020502244A5 (enExample) 2021-02-04
JP7138106B2 true JP7138106B2 (ja) 2022-09-15

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US (1) US10774036B2 (enExample)
EP (1) EP3558930B1 (enExample)
JP (1) JP7138106B2 (enExample)
CN (1) CN110088079A (enExample)
ES (1) ES2883363T3 (enExample)
WO (1) WO2018116203A1 (enExample)

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CN110964759B (zh) * 2018-09-28 2021-04-09 北京瑞莱博基医药科技有限公司 一种抗心衰药物中间体的新合成工艺
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN111205204A (zh) * 2020-01-16 2020-05-29 南京红杉生物科技有限公司 沙库必曲中间体及其合成方法、应用
CN114524741A (zh) * 2022-02-15 2022-05-24 上海龙翔生物医药开发有限公司 一种抗肿瘤药物美法仑的合成工艺
EP4630568A1 (en) * 2022-12-09 2025-10-15 KRKA, D.D., Novo Mesto Process for the preparation of sitagliptin
CN116606224A (zh) * 2023-04-18 2023-08-18 重庆普佑生物医药有限公司 一种沙库比曲中间体的酶催化制备方法
CN118931983A (zh) * 2024-07-24 2024-11-12 苏州弗莱明生物技术有限公司 一种沙库巴曲中间体及其制备方法

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Also Published As

Publication number Publication date
ES2883363T3 (es) 2021-12-07
CN110088079A (zh) 2019-08-02
WO2018116203A1 (en) 2018-06-28
JP2020502244A (ja) 2020-01-23
EP3558930B1 (en) 2021-05-26
US20190359554A1 (en) 2019-11-28
US10774036B2 (en) 2020-09-15
EP3558930A1 (en) 2019-10-30

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