BR112016003736A2 - síntese de bifenilalaninol via novos intermed!ários - Google Patents
síntese de bifenilalaninol via novos intermed!áriosInfo
- Publication number
- BR112016003736A2 BR112016003736A2 BR112016003736A BR112016003736A BR112016003736A2 BR 112016003736 A2 BR112016003736 A2 BR 112016003736A2 BR 112016003736 A BR112016003736 A BR 112016003736A BR 112016003736 A BR112016003736 A BR 112016003736A BR 112016003736 A2 BR112016003736 A2 BR 112016003736A2
- Authority
- BR
- Brazil
- Prior art keywords
- biphenylalaninol
- synthesis via
- new intermediates
- via new
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13181136 | 2013-08-21 | ||
PCT/EP2014/067804 WO2015024991A1 (en) | 2013-08-21 | 2014-08-21 | Synthesis of biphenylalaninol via novel intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016003736A2 true BR112016003736A2 (pt) | 2018-12-04 |
Family
ID=48998540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016003736A BR112016003736A2 (pt) | 2013-08-21 | 2014-08-21 | síntese de bifenilalaninol via novos intermed!ários |
Country Status (8)
Country | Link |
---|---|
US (1) | US20160200665A1 (pt) |
EP (1) | EP3119742A1 (pt) |
JP (1) | JP2016528271A (pt) |
CN (1) | CN105473546A (pt) |
AU (1) | AU2014310569A1 (pt) |
BR (1) | BR112016003736A2 (pt) |
CA (1) | CA2919317A1 (pt) |
WO (1) | WO2015024991A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2015037460A1 (ja) * | 2013-09-10 | 2017-03-02 | 住友化学株式会社 | 光学活性な3−(ビフェニル−4−イル)−2−〔(t−ブトキシカルボニル)アミノ〕プロパン−1−オールの製造方法 |
CN105017082B (zh) * | 2015-07-31 | 2017-09-19 | 上海皓元医药股份有限公司 | 一种心衰药Entresto 关键中间体(R)‑叔丁基 (1‑([1,1`‑联苯]‑4‑基)‑3‑羟基丙烷‑2‑基)氨基甲酸酯的制备方法 |
CN105330569A (zh) * | 2015-09-11 | 2016-02-17 | 天台宜生生化科技有限公司 | 一种(r)-2-(n-叔丁氧羰基氨基)联苯丙醇的制备方法 |
CN105198775B (zh) * | 2015-10-10 | 2017-11-14 | 凯瑞斯德生化(苏州)有限公司 | 一种手性N‑Boc联苯丙氨醇的制备方法 |
CN105820064A (zh) * | 2016-04-18 | 2016-08-03 | 浙江天宇药业股份有限公司 | 一种联苯基丙氨醇衍生物的合成方法及中间体 |
WO2018007919A1 (en) | 2016-07-05 | 2018-01-11 | Novartis Ag | New process for early sacubitril intermediates |
JP6945619B2 (ja) | 2016-08-17 | 2021-10-06 | ノバルティス アーゲー | Nep阻害剤合成のための新規な方法および中間体 |
WO2018116203A1 (en) | 2016-12-23 | 2018-06-28 | Novartis Ag | New process for early sacubitril intermediates |
CN117384029B (zh) * | 2023-12-12 | 2024-02-20 | 山东国邦药业有限公司 | 一种2,4,5-三氟苯乙酸的合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3278600A (en) * | 1963-08-30 | 1966-10-11 | Parke Davis & Co | alpha-amine-p-methoxyisobutyrophenone and salts thereof |
US4774256A (en) * | 1983-10-03 | 1988-09-27 | E. R. Squibb & Sons, Inc. | Use of enkephalinase inhibitors as analgesic agents |
FR2864079B1 (fr) * | 2003-12-17 | 2006-04-07 | Prod Chim Auxiliaires Et De Sy | Nouveaux intermediaires de syntheses de la (r)-tamsulosine et de ses sels pharmaceutiquement acceptables et procede pour leur preparation |
EP1903027A1 (en) * | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
CN101362708B (zh) * | 2008-09-05 | 2012-05-16 | 浙江工业大学 | 叔丁基-[2-(联苯-4-基)-1-(羟甲基)乙基]氨基甲酸酯的合成方法 |
WO2013026773A1 (en) * | 2011-08-19 | 2013-02-28 | Dsm Ip Assets B.V. | Synthesis of r-biphenylalaninol |
-
2014
- 2014-08-21 EP EP14755356.4A patent/EP3119742A1/en not_active Withdrawn
- 2014-08-21 US US14/912,313 patent/US20160200665A1/en not_active Abandoned
- 2014-08-21 CA CA2919317A patent/CA2919317A1/en not_active Abandoned
- 2014-08-21 BR BR112016003736A patent/BR112016003736A2/pt not_active Application Discontinuation
- 2014-08-21 CN CN201480046246.0A patent/CN105473546A/zh active Pending
- 2014-08-21 AU AU2014310569A patent/AU2014310569A1/en not_active Abandoned
- 2014-08-21 JP JP2016535476A patent/JP2016528271A/ja active Pending
- 2014-08-21 WO PCT/EP2014/067804 patent/WO2015024991A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CA2919317A1 (en) | 2015-02-26 |
WO2015024991A1 (en) | 2015-02-26 |
US20160200665A1 (en) | 2016-07-14 |
AU2014310569A1 (en) | 2016-02-18 |
JP2016528271A (ja) | 2016-09-15 |
CN105473546A (zh) | 2016-04-06 |
EP3119742A1 (en) | 2017-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |