SI2961844T1 - Spremenjeni polipeptidi transaminaze za industrijsko biokatalizo - Google Patents
Spremenjeni polipeptidi transaminaze za industrijsko biokatalizoInfo
- Publication number
- SI2961844T1 SI2961844T1 SI201430901T SI201430901T SI2961844T1 SI 2961844 T1 SI2961844 T1 SI 2961844T1 SI 201430901 T SI201430901 T SI 201430901T SI 201430901 T SI201430901 T SI 201430901T SI 2961844 T1 SI2961844 T1 SI 2961844T1
- Authority
- SI
- Slovenia
- Prior art keywords
- engineered transaminase
- transaminase polypeptides
- industrial biocatalysis
- biocatalysis
- industrial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361770814P | 2013-02-28 | 2013-02-28 | |
PCT/US2014/018005 WO2014133960A1 (en) | 2013-02-28 | 2014-02-24 | Engineered transaminase polypeptides for industrial biocatalysis |
EP14757245.7A EP2961844B1 (en) | 2013-02-28 | 2014-02-24 | Engineered transaminase polypeptides for industrial biocatalysis |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2961844T1 true SI2961844T1 (sl) | 2018-11-30 |
Family
ID=51428721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201430901T SI2961844T1 (sl) | 2013-02-28 | 2014-02-24 | Spremenjeni polipeptidi transaminaze za industrijsko biokatalizo |
Country Status (12)
Country | Link |
---|---|
US (5) | US9617573B2 (sl) |
EP (1) | EP2961844B1 (sl) |
JP (2) | JP6436541B2 (sl) |
CN (2) | CN115927231A (sl) |
CA (1) | CA2902824C (sl) |
DK (1) | DK2961844T3 (sl) |
ES (1) | ES2694327T3 (sl) |
HU (1) | HUE042206T2 (sl) |
IL (1) | IL240565B (sl) |
SG (1) | SG11201506748WA (sl) |
SI (1) | SI2961844T1 (sl) |
WO (1) | WO2014133960A1 (sl) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8921079B2 (en) * | 2009-06-22 | 2014-12-30 | Codexis, Inc. | Transaminase reactions |
EP2961844B1 (en) | 2013-02-28 | 2018-09-26 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
US9523107B2 (en) * | 2013-02-28 | 2016-12-20 | Merck Sharp & Dohme Corp. | Immobilized transaminases and process for making and using immobilized transaminase |
WO2018116203A1 (en) * | 2016-12-23 | 2018-06-28 | Novartis Ag | New process for early sacubitril intermediates |
EP3415630A1 (en) | 2017-06-14 | 2018-12-19 | EntreChem, S.L. | Method for one-pot production of a primary amine from an alcohol |
US11359183B2 (en) | 2017-06-14 | 2022-06-14 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
CN109251925A (zh) * | 2017-07-14 | 2019-01-22 | 上海蓝木化工有限公司 | 一种离子交换树脂固定化转氨酶的制备及其应用 |
WO2019207443A1 (en) * | 2018-04-24 | 2019-10-31 | Unichem Laboratories Ltd | An enzymatic process for the preparation of (r)-sitagliptin |
JP2022518212A (ja) * | 2019-01-15 | 2022-03-14 | コデクシス, インコーポレイテッド | 操作されたトランスアミナーゼポリペプチド |
CN109777813B (zh) * | 2019-01-25 | 2021-05-07 | 浙江工业大学 | 一种转氨酶-plp共固定化酶及其制备与应用 |
CN110106130B (zh) * | 2019-05-23 | 2021-05-04 | 浙江工业大学 | 一种转氨酶-辅酶共固定化工程菌细胞及应用 |
US20220220519A1 (en) * | 2019-05-30 | 2022-07-14 | Asymchem Life Science (Tianjin) Co., Ltd. | Transaminase mutant and use thereof |
CN110747181B (zh) * | 2019-11-27 | 2021-05-28 | 江南大学 | 一种ω-转氨酶突变体及其在生产手性芳香胺中的应用 |
CN113061594B (zh) * | 2019-12-31 | 2023-11-24 | 弈柯莱生物科技(集团)股份有限公司 | 转氨酶突变体、固定化转氨酶及用于制备西他列汀的用途 |
CN111189813B (zh) * | 2020-01-14 | 2022-05-17 | 重庆师范大学 | 一种以戊二醛-壳聚糖非共轭荧光聚合物为荧光探针检测gsh的方法 |
CN112094856B (zh) * | 2020-09-23 | 2023-06-27 | 国药集团威奇达药业有限公司 | 一种转氨酶突变体及其在西格列汀合成中的应用 |
CN113789310B (zh) * | 2021-01-25 | 2023-11-10 | 上海予君生物科技发展有限公司 | 一种转氨酶及其在制备莫西沙星或其中间体中的应用 |
CN115466756A (zh) * | 2021-06-11 | 2022-12-13 | 弈柯莱生物科技(上海)股份有限公司 | 转氨酶、固定化转氨酶及用于制备西他列汀的用途 |
CN113481254B (zh) * | 2021-06-29 | 2023-05-26 | 台州酶易生物技术有限公司 | 西他列汀中间体的制备方法 |
Family Cites Families (39)
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US4600692A (en) | 1983-02-10 | 1986-07-15 | Purification Engineering, Inc. | Immobilized cells for preparing phenylalanine |
US4518692A (en) | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
US4826766A (en) | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
US5316943A (en) | 1988-06-14 | 1994-05-31 | Kidman Gene E | Racemic conversion of using a transaminase |
US5169780A (en) | 1989-06-22 | 1992-12-08 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
US4950606A (en) | 1989-06-22 | 1990-08-21 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
US5300437A (en) | 1989-06-22 | 1994-04-05 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
DK0765394T3 (da) | 1994-06-03 | 2001-12-10 | Novozymes As | Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse |
AU2705895A (en) | 1994-06-30 | 1996-01-25 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
JP4213771B2 (ja) * | 1997-04-23 | 2009-01-21 | 株式会社カネカ | 光学活性アミノ化合物の製造方法 |
US6197558B1 (en) | 1997-05-19 | 2001-03-06 | Nsc Technologies | Transaminase biotransformation process |
US6537746B2 (en) | 1997-12-08 | 2003-03-25 | Maxygen, Inc. | Method for creating polynucleotide and polypeptide sequences |
JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
WO2001075767A2 (en) | 2000-03-30 | 2001-10-11 | Maxygen, Inc. | In silico cross-over site selection |
US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
JO2625B1 (en) | 2003-06-24 | 2011-11-01 | ميرك شارب اند دوم كوربوريشن | Phosphoric acid salts of dipeptidyl betidase inhibitor 4 |
US20050009151A1 (en) | 2003-07-10 | 2005-01-13 | Pharmacia Corporation | Methods for the stereospecific and enantiomeric enrichment of beta-amino acids |
WO2005017135A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
US7618799B2 (en) | 2007-01-31 | 2009-11-17 | Dow Global Technologies Inc | Bacterial leader sequences for increased expression |
WO2009008908A2 (en) | 2007-02-12 | 2009-01-15 | Codexis, Inc. | Structure-activity relationships |
WO2008108998A2 (en) | 2007-03-02 | 2008-09-12 | Richmond Chemical Corporation | Method to increase the yield and improve purification of products from transaminase reactions |
WO2008127646A2 (en) | 2007-04-11 | 2008-10-23 | Dsm Ip Assets B.V. | Transaminase-based processes for preparation of pregabalin |
CA2726928A1 (en) * | 2008-01-03 | 2009-07-16 | Cargill, Incorporated | Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using |
US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
ES2448816T3 (es) * | 2009-02-26 | 2014-03-17 | Codexis, Inc. | Biocatalizadores de transaminasa |
US8921079B2 (en) | 2009-06-22 | 2014-12-30 | Codexis, Inc. | Transaminase reactions |
CA2769795C (en) | 2009-08-05 | 2020-01-07 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
HUE038434T2 (hu) | 2010-06-17 | 2018-10-29 | Codexis Inc | Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez |
US8932836B2 (en) | 2010-08-16 | 2015-01-13 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
WO2012024100A2 (en) * | 2010-08-16 | 2012-02-23 | Merck Sharp & Dohme Corp. | Process for preparing aminocyclohexyl ether compounds |
US9587229B2 (en) * | 2011-06-24 | 2017-03-07 | Merck Sharp & Dohme Corp. | Immobilized transaminases and process for making and using immobilized transaminase |
WO2013036861A1 (en) | 2011-09-08 | 2013-03-14 | Codexis, Inc | Biocatalysts and methods for the synthesis of substituted lactams |
EP2961844B1 (en) | 2013-02-28 | 2018-09-26 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
-
2014
- 2014-02-24 EP EP14757245.7A patent/EP2961844B1/en active Active
- 2014-02-24 CN CN202210813494.XA patent/CN115927231A/zh active Pending
- 2014-02-24 SG SG11201506748WA patent/SG11201506748WA/en unknown
- 2014-02-24 CN CN201480024103.XA patent/CN105164263B/zh active Active
- 2014-02-24 CA CA2902824A patent/CA2902824C/en active Active
- 2014-02-24 SI SI201430901T patent/SI2961844T1/sl unknown
- 2014-02-24 ES ES14757245.7T patent/ES2694327T3/es active Active
- 2014-02-24 WO PCT/US2014/018005 patent/WO2014133960A1/en active Application Filing
- 2014-02-24 HU HUE14757245A patent/HUE042206T2/hu unknown
- 2014-02-24 US US14/768,408 patent/US9617573B2/en active Active
- 2014-02-24 JP JP2015560237A patent/JP6436541B2/ja active Active
- 2014-02-24 DK DK14757245.7T patent/DK2961844T3/da active
-
2015
- 2015-08-13 IL IL24056515A patent/IL240565B/en active IP Right Grant
-
2017
- 2017-02-27 US US15/443,792 patent/US9963685B2/en active Active
- 2017-11-09 JP JP2017216318A patent/JP2018019723A/ja not_active Withdrawn
-
2018
- 2018-04-04 US US15/945,549 patent/US10604744B2/en active Active
-
2020
- 2020-02-13 US US16/790,534 patent/US11098292B2/en active Active
-
2021
- 2021-07-19 US US17/379,563 patent/US20210348138A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2016509841A (ja) | 2016-04-04 |
US10604744B2 (en) | 2020-03-31 |
US20180223265A1 (en) | 2018-08-09 |
US20160002688A1 (en) | 2016-01-07 |
WO2014133960A1 (en) | 2014-09-04 |
JP2018019723A (ja) | 2018-02-08 |
EP2961844A1 (en) | 2016-01-06 |
US20210348138A1 (en) | 2021-11-11 |
IL240565A0 (en) | 2015-09-24 |
CN105164263A (zh) | 2015-12-16 |
CN105164263B (zh) | 2022-07-01 |
SG11201506748WA (en) | 2015-09-29 |
ES2694327T3 (es) | 2018-12-19 |
US20170175090A1 (en) | 2017-06-22 |
US9617573B2 (en) | 2017-04-11 |
US9963685B2 (en) | 2018-05-08 |
CA2902824C (en) | 2021-06-22 |
EP2961844B1 (en) | 2018-09-26 |
JP6436541B2 (ja) | 2018-12-12 |
DK2961844T3 (da) | 2019-01-02 |
US20200172882A1 (en) | 2020-06-04 |
CA2902824A1 (en) | 2014-09-04 |
EP2961844A4 (en) | 2016-10-19 |
CN115927231A (zh) | 2023-04-07 |
US11098292B2 (en) | 2021-08-24 |
HUE042206T2 (hu) | 2019-06-28 |
IL240565B (en) | 2019-10-31 |
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