JP6997197B2 - カリウムチャネルモジュレーター - Google Patents

カリウムチャネルモジュレーター Download PDF

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JP6997197B2
JP6997197B2 JP2019539923A JP2019539923A JP6997197B2 JP 6997197 B2 JP6997197 B2 JP 6997197B2 JP 2019539923 A JP2019539923 A JP 2019539923A JP 2019539923 A JP2019539923 A JP 2019539923A JP 6997197 B2 JP6997197 B2 JP 6997197B2
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pharmaceutically acceptable
mmol
disease
compounds
pharmaceutical composition
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JP2020504165A5 (enExample
JP2020504165A (ja
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アムルトカー，ディパック・バサントラオ
フォスター，ケリー
ヤコプスン，トマス・アモス
ジェフソン，マーティン・アール
キーニー，グレッグ・エフ
ラースン，イェーヌス・スライバ
ニルスン，カーリン・サンエーヤ
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カデント セラピューティクス，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
JP2019539923A 2017-01-23 2018-01-23 カリウムチャネルモジュレーター Active JP6997197B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449270P 2017-01-23 2017-01-23
US62/449,270 2017-01-23
PCT/US2018/014792 WO2018136917A1 (en) 2017-01-23 2018-01-23 Potassium channel modulators

Publications (3)

Publication Number Publication Date
JP2020504165A JP2020504165A (ja) 2020-02-06
JP2020504165A5 JP2020504165A5 (enExample) 2021-02-25
JP6997197B2 true JP6997197B2 (ja) 2022-01-17

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JP2019539923A Active JP6997197B2 (ja) 2017-01-23 2018-01-23 カリウムチャネルモジュレーター

Country Status (30)

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US (4) US9975886B1 (enExample)
EP (1) EP3571193B1 (enExample)
JP (1) JP6997197B2 (enExample)
KR (1) KR102664772B1 (enExample)
CN (1) CN110198935B (enExample)
AR (1) AR110770A1 (enExample)
BR (1) BR112019014814B1 (enExample)
CL (1) CL2019002031A1 (enExample)
CO (1) CO2019009060A2 (enExample)
CU (1) CU24560B1 (enExample)
CY (1) CY1125463T1 (enExample)
DK (1) DK3571193T3 (enExample)
EA (1) EA036668B1 (enExample)
ES (1) ES2906078T3 (enExample)
HR (1) HRP20220079T1 (enExample)
HU (1) HUE057710T2 (enExample)
IL (1) IL267954B (enExample)
LT (1) LT3571193T (enExample)
MX (1) MX376080B (enExample)
MY (1) MY195123A (enExample)
PH (1) PH12019501678A1 (enExample)
PL (1) PL3571193T3 (enExample)
PT (1) PT3571193T (enExample)
RS (1) RS62899B1 (enExample)
SG (1) SG11201905893WA (enExample)
SI (1) SI3571193T1 (enExample)
TW (1) TWI751271B (enExample)
UA (1) UA123810C2 (enExample)
WO (1) WO2018136917A1 (enExample)
ZA (1) ZA201904458B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10774064B2 (en) * 2016-06-02 2020-09-15 Cadent Therapeutics, Inc. Potassium channel modulators
JP6997197B2 (ja) * 2017-01-23 2022-01-17 カデント セラピューティクス，インコーポレーテッド カリウムチャネルモジュレーター
MX2021004647A (es) * 2018-10-22 2021-08-16 Novartis Ag Formas cristalinas de moduladores de los canales de potasio.
CN118985622B (zh) * 2024-07-05 2025-12-02 云南大学 一种吡唑类化合物在防治植物根结线虫中的应用

Citations (3)

* Cited by examiner, † Cited by third party
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JP2008534472A (ja) 2005-03-22 2008-08-28 ノイロサーチ アクティーゼルスカブ カリウムチャンネル調節剤としてのピラゾリル−ピリミジン及びその医学的使用
JP2012501308A (ja) 2008-09-02 2012-01-19 ノイロサーチ アクティーゼルスカブ ピラゾリルピリミジン誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用
JP2016526561A (ja) 2013-07-11 2016-09-05 アジオス ファーマシューティカルズ， インコーポレイテッド 治療活性化合物およびそれらの使用方法

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