CN110198935B - 钾通道调节剂 - Google Patents

钾通道调节剂 Download PDF

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Publication number
CN110198935B
CN110198935B CN201880007979.1A CN201880007979A CN110198935B CN 110198935 B CN110198935 B CN 110198935B CN 201880007979 A CN201880007979 A CN 201880007979A CN 110198935 B CN110198935 B CN 110198935B
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compound
disease
pharmaceutically acceptable
mmol
acceptable salt
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CN110198935A (zh
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D·V·阿姆鲁特卡尔
K·福斯特
T·A·雅各布森
M·R·杰弗森
G·F·基尼
J·S·拉森
K·S·尼尔森
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Novartis AG
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Cadent Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
CN201880007979.1A 2017-01-23 2018-01-23 钾通道调节剂 Active CN110198935B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449270P 2017-01-23 2017-01-23
US62/449,270 2017-01-23
PCT/US2018/014792 WO2018136917A1 (en) 2017-01-23 2018-01-23 Potassium channel modulators

Publications (2)

Publication Number Publication Date
CN110198935A CN110198935A (zh) 2019-09-03
CN110198935B true CN110198935B (zh) 2022-05-31

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US (4) US9975886B1 (enExample)
EP (1) EP3571193B1 (enExample)
JP (1) JP6997197B2 (enExample)
KR (1) KR102664772B1 (enExample)
CN (1) CN110198935B (enExample)
AR (1) AR110770A1 (enExample)
BR (1) BR112019014814B1 (enExample)
CL (1) CL2019002031A1 (enExample)
CO (1) CO2019009060A2 (enExample)
CU (1) CU24560B1 (enExample)
CY (1) CY1125463T1 (enExample)
DK (1) DK3571193T3 (enExample)
EA (1) EA036668B1 (enExample)
ES (1) ES2906078T3 (enExample)
HR (1) HRP20220079T1 (enExample)
HU (1) HUE057710T2 (enExample)
IL (1) IL267954B (enExample)
LT (1) LT3571193T (enExample)
MX (1) MX376080B (enExample)
MY (1) MY195123A (enExample)
PH (1) PH12019501678A1 (enExample)
PL (1) PL3571193T3 (enExample)
PT (1) PT3571193T (enExample)
RS (1) RS62899B1 (enExample)
SG (1) SG11201905893WA (enExample)
SI (1) SI3571193T1 (enExample)
TW (1) TWI751271B (enExample)
UA (1) UA123810C2 (enExample)
WO (1) WO2018136917A1 (enExample)
ZA (1) ZA201904458B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10774064B2 (en) * 2016-06-02 2020-09-15 Cadent Therapeutics, Inc. Potassium channel modulators
JP6997197B2 (ja) * 2017-01-23 2022-01-17 カデント セラピューティクス，インコーポレーテッド カリウムチャネルモジュレーター
MX2021004647A (es) * 2018-10-22 2021-08-16 Novartis Ag Formas cristalinas de moduladores de los canales de potasio.
CN118985622B (zh) * 2024-07-05 2025-12-02 云南大学 一种吡唑类化合物在防治植物根结线虫中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006100212A1 (en) * 2005-03-22 2006-09-28 Neurosearch A/S Pyrazolyl-pyrimidines as potassium channel modulating agents and their medical use
CN101115736A (zh) * 2005-03-14 2008-01-30 神经研究公司 钾通道调节剂和它们的医药用途
CN102177154A (zh) * 2008-09-02 2011-09-07 神经研究公司 吡唑基-嘧啶衍生物及其作为钾通道调节剂的应用

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