JP6882172B2 - 神経変性疾患の治療に有用なtdp−43結合性ポリペプチド - Google Patents
神経変性疾患の治療に有用なtdp−43結合性ポリペプチド Download PDFInfo
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- JP6882172B2 JP6882172B2 JP2017529766A JP2017529766A JP6882172B2 JP 6882172 B2 JP6882172 B2 JP 6882172B2 JP 2017529766 A JP2017529766 A JP 2017529766A JP 2017529766 A JP2017529766 A JP 2017529766A JP 6882172 B2 JP6882172 B2 JP 6882172B2
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
- C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088012P | 2014-12-05 | 2014-12-05 | |
| CA2,874,083 | 2014-12-05 | ||
| CA2874083A CA2874083C (en) | 2014-12-05 | 2014-12-05 | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
| US62/088,012 | 2014-12-05 | ||
| PCT/CA2015/051280 WO2016086320A1 (en) | 2014-12-05 | 2015-12-07 | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502561A JP2018502561A (ja) | 2018-02-01 |
| JP2018502561A5 JP2018502561A5 (enExample) | 2019-01-24 |
| JP6882172B2 true JP6882172B2 (ja) | 2021-06-02 |
Family
ID=56090779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529766A Active JP6882172B2 (ja) | 2014-12-05 | 2015-12-07 | 神経変性疾患の治療に有用なtdp−43結合性ポリペプチド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10202443B2 (enExample) |
| EP (1) | EP3227330B1 (enExample) |
| JP (1) | JP6882172B2 (enExample) |
| AU (2) | AU2015358266A1 (enExample) |
| CA (1) | CA2874083C (enExample) |
| WO (1) | WO2016086320A1 (enExample) |
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| WO2010053655A2 (en) | 2008-11-07 | 2010-05-14 | University Of Kansas | Therapeutic methods with withaferin a and analogs |
| US20110287953A1 (en) | 2010-05-21 | 2011-11-24 | Chi-Ying Huang | Method for discovering potential drugs |
| WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
| US8598339B2 (en) | 2011-02-01 | 2013-12-03 | University Of Kansas | Withanolide isolated from Physalis longifolia and analogs and methods of use thereof |
| ES2679289T3 (es) | 2011-06-22 | 2018-08-23 | UNIVERSITé LAVAL | Procedimientos para el pronóstico y/o diagnóstico de una enfermedad neurodegenerativa, procedimientos para identificar compuestos candidatos y compuestos para tratar una enfermedad neurodegenerativa |
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2014
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2015
- 2015-12-07 US US15/532,909 patent/US10202443B2/en active Active
- 2015-12-07 EP EP15864525.9A patent/EP3227330B1/en active Active
- 2015-12-07 JP JP2017529766A patent/JP6882172B2/ja active Active
- 2015-12-07 WO PCT/CA2015/051280 patent/WO2016086320A1/en not_active Ceased
- 2015-12-07 AU AU2015358266A patent/AU2015358266A1/en not_active Abandoned
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|---|---|
| EP3227330C0 (en) | 2024-01-17 |
| CA2874083A1 (en) | 2016-06-05 |
| EP3227330A1 (en) | 2017-10-11 |
| CA2874083C (en) | 2024-01-02 |
| EP3227330B1 (en) | 2024-01-17 |
| US10202443B2 (en) | 2019-02-12 |
| AU2021250947A1 (en) | 2021-11-11 |
| EP3227330A4 (en) | 2018-10-31 |
| AU2015358266A1 (en) | 2017-06-29 |
| WO2016086320A1 (en) | 2016-06-09 |
| JP2018502561A (ja) | 2018-02-01 |
| US20170355756A1 (en) | 2017-12-14 |
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