JP6010617B2 - ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド - Google Patents
３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド Download PDFInfo
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- JP6010617B2 JP6010617B2 JP2014518934A JP2014518934A JP6010617B2 JP 6010617 B2 JP6010617 B2 JP 6010617B2 JP 2014518934 A JP2014518934 A JP 2014518934A JP 2014518934 A JP2014518934 A JP 2014518934A JP 6010617 B2 JP6010617 B2 JP 6010617B2
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- compound
- pharmaceutically acceptable
- acceptable salt
- hexyl
- phenyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
- C07D241/34—(Amino-pyrazine carbonamido) guanidines
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161501687P | 2011-06-27 | 2011-06-27 | |
| US61/501,687 | 2011-06-27 | ||
| US201261635745P | 2012-04-19 | 2012-04-19 | |
| US61/635,745 | 2012-04-19 | ||
| PCT/US2012/044272 WO2013003386A1 (en) | 2011-06-27 | 2012-06-26 | 3,5-diamino-6-chloro-n-(n-(4-(4-(2-(hexyl (2,3,4,5,6-pentahydroxyhexyl) amino) ethoxy) phenyl) butyl) carbamimidoyl) pyrazine-2-carboxamide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016061516A Division JP2016117773A (ja) | 2011-06-27 | 2016-03-25 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518268A JP2014518268A (ja) | 2014-07-28 |
| JP2014518268A5 JP2014518268A5 (cg-RX-API-DMAC7.html) | 2015-07-09 |
| JP6010617B2 true JP6010617B2 (ja) | 2016-10-19 |
Family
ID=46466941
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518934A Active JP6010617B2 (ja) | 2011-06-27 | 2012-06-26 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2016061516A Withdrawn JP2016117773A (ja) | 2011-06-27 | 2016-03-25 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2018039635A Withdrawn JP2018087252A (ja) | 2011-06-27 | 2018-03-06 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2019226645A Pending JP2020055865A (ja) | 2011-06-27 | 2019-12-16 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2021084641A Withdrawn JP2021120408A (ja) | 2011-06-27 | 2021-05-19 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2023041166A Pending JP2023072065A (ja) | 2011-06-27 | 2023-03-15 | ３，５－ジアミノ－６－クロロ－ｎ－（ｎ－（４－（４－（２－（ヘキシル（２，３，４，５，６－ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン－２－カルボキサミド |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016061516A Withdrawn JP2016117773A (ja) | 2011-06-27 | 2016-03-25 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2018039635A Withdrawn JP2018087252A (ja) | 2011-06-27 | 2018-03-06 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2019226645A Pending JP2020055865A (ja) | 2011-06-27 | 2019-12-16 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2021084641A Withdrawn JP2021120408A (ja) | 2011-06-27 | 2021-05-19 | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2023041166A Pending JP2023072065A (ja) | 2011-06-27 | 2023-03-15 | ３，５－ジアミノ－６－クロロ－ｎ－（ｎ－（４－（４－（２－（ヘキシル（２，３，４，５，６－ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン－２－カルボキサミド |
Country Status (37)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| BR122018075478B8 (pt) | 2004-06-24 | 2023-10-31 | Vertex Pharma | moduladores de transportadores de cassete de ligação de atp |
| HUE032813T2 (en) | 2005-12-28 | 2017-11-28 | Vertex Pharma | Solid forms of N- [2,4-bis (1,1-dimethyl ethyl) -5-hydroxyphenyl] -1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| HUE035160T2 (en) | 2009-03-20 | 2018-05-02 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| AR086745A1 (es) * | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| CA2839709C (en) | 2011-06-27 | 2020-01-14 | Parion Sciences, Inc. | A chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity |
| CN104024231A (zh) | 2011-11-02 | 2014-09-03 | 勃林格殷格翰国际有限公司 | 制备酰基胍和酰基硫脲化合物的新方法 |
| PL2773633T3 (pl) | 2011-11-02 | 2018-01-31 | Boehringer Ingelheim Int | Związki heterocykliczne, leki zawierające wymienione związki, ich zastosowanie i procesy ich wytwarzania |
| US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| CA2865519C (en) | 2012-02-27 | 2018-01-02 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis |
| EP2861577B1 (en) | 2012-05-25 | 2017-01-04 | Boehringer Ingelheim International GmbH | Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof |
| PT2855435T (pt) | 2012-05-29 | 2018-07-03 | Parion Sciences Inc | Aminoamidas do tipo dendrímeros possuindo atividade bloqueadora de canais de sódio para o tratamento do olho seco e outras doenças das mucosas |
| WO2014044849A1 (en) | 2012-09-24 | 2014-03-27 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| UA120343C2 (uk) * | 2012-12-17 | 2019-11-25 | Періон Сайєнсіз, Інк. | Похідні хлорпіразинкарбоксаміду, які мають активність блокування епітеліальних натрієвих каналів |
| CN108658876A (zh) * | 2012-12-17 | 2018-10-16 | 帕里昂科学公司 | 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物 |
| ES2674665T3 (es) * | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| HK1223561A1 (zh) | 2013-08-23 | 2017-08-04 | 帕里昂科学公司 | 二巯基化物类粘液溶解剂 |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| UY36034A (es) | 2014-03-18 | 2015-09-30 | Astrazeneca Ab | Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos |
| US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
| CN105588886B (zh) * | 2014-11-18 | 2020-01-31 | 重庆医药工业研究院有限责任公司 | 一种采用液相色谱法测定阿普斯特及其制剂中杂质的方法 |
| MX387071B (es) | 2015-01-30 | 2025-03-19 | Parion Sciences Inc | Agentes mucolíticos de monotiol novedosos |
| AU2016255851A1 (en) | 2015-04-30 | 2017-12-14 | Parion Sciences, Inc. | Novel prodrugs of dithiol mucolytic agents |
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) * | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| RS63124B1 (sr) | 2018-03-08 | 2022-05-31 | Incyte Corp | Aminopirazin diol jedinjenja kao pi3k-y inhibitori |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| BR112021016283A2 (pt) * | 2019-03-29 | 2021-10-13 | National University Corporation Kagawa University | Regulador da pressão osmótica contendo d-glicose, dialisado peritoneal, composição oftálmica ou infusão, métodos de regulagem da pressão osmótica e de diálise peritoneal, e, usos do regulador da pressão osmótica e de d-alose e/ou d-alulose |
| GB202406247D0 (en) | 2024-05-03 | 2024-06-19 | Enterprise Therapeutics Ltd | Compounds and pharmaceutical compositions |
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| JP6010617B2 (ja) | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド | |
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