FR1525670A - Procédé de fabrication de guanidines substituées - Google Patents

Procédé de fabrication de guanidines substituées

Info

Publication number
FR1525670A
FR1525670A FR109098A FR109098A FR1525670A FR 1525670 A FR1525670 A FR 1525670A FR 109098 A FR109098 A FR 109098A FR 109098 A FR109098 A FR 109098A FR 1525670 A FR1525670 A FR 1525670A
Authority
FR
France
Prior art keywords
substituted guanidines
manufacturing substituted
manufacturing
guanidines
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR109098A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to FR109098A priority Critical patent/FR1525670A/fr
Application granted granted Critical
Publication of FR1525670A publication Critical patent/FR1525670A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
FR109098A 1966-08-25 1967-06-05 Procédé de fabrication de guanidines substituées Expired FR1525670A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR109098A FR1525670A (fr) 1966-08-25 1967-06-05 Procédé de fabrication de guanidines substituées

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57492266A 1966-08-25 1966-08-25
FR109098A FR1525670A (fr) 1966-08-25 1967-06-05 Procédé de fabrication de guanidines substituées

Publications (1)

Publication Number Publication Date
FR1525670A true FR1525670A (fr) 1968-05-17

Family

ID=26177047

Family Applications (1)

Application Number Title Priority Date Filing Date
FR109098A Expired FR1525670A (fr) 1966-08-25 1967-06-05 Procédé de fabrication de guanidines substituées

Country Status (1)

Country Link
FR (1) FR1525670A (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2366285A1 (fr) * 1976-07-23 1978-04-28 Merck & Co Inc (3-amino-5-substitue-6-fluoropyrazinoyl ou pyrazamido) guanidines et leurs derives portant des substituants sur les atomes d'azote du noyau de guanidine, utiles comme medicaments
US7030117B2 (en) * 2003-02-19 2006-04-18 Parion Sciences, Inc. Sodium channel blockers
US7064129B2 (en) * 2003-08-18 2006-06-20 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US8669262B2 (en) 2011-06-27 2014-03-11 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
US9586911B2 (en) 2013-12-13 2017-03-07 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epthelial sodium channel blocking compounds
US9593084B2 (en) 2012-12-17 2017-03-14 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9695134B2 (en) 2012-12-17 2017-07-04 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(n-(4-phenylbutyl)carbamimidoyl)pyrazine-2-carboxamide compounds
US10167266B2 (en) 2002-02-19 2019-01-01 Parion Sciences, Inc. Sodium channel blockers

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2366285A1 (fr) * 1976-07-23 1978-04-28 Merck & Co Inc (3-amino-5-substitue-6-fluoropyrazinoyl ou pyrazamido) guanidines et leurs derives portant des substituants sur les atomes d'azote du noyau de guanidine, utiles comme medicaments
US10167266B2 (en) 2002-02-19 2019-01-01 Parion Sciences, Inc. Sodium channel blockers
US7030117B2 (en) * 2003-02-19 2006-04-18 Parion Sciences, Inc. Sodium channel blockers
US7368451B2 (en) 2003-08-18 2008-05-06 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7368447B2 (en) 2003-08-18 2008-05-06 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7410968B2 (en) 2003-08-18 2008-08-12 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7247637B2 (en) * 2003-08-18 2007-07-24 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7064129B2 (en) * 2003-08-18 2006-06-20 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US8669262B2 (en) 2011-06-27 2014-03-11 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
US9586910B2 (en) 2011-06-27 2017-03-07 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
US11578042B2 (en) 2011-06-27 2023-02-14 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
US10752597B2 (en) 2011-06-27 2020-08-25 Parion Sciences, Inc. 3,5-diamino-6-chloro-N—(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
US10246425B2 (en) 2012-12-17 2019-04-02 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
US9593084B2 (en) 2012-12-17 2017-03-14 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9695134B2 (en) 2012-12-17 2017-07-04 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(n-(4-phenylbutyl)carbamimidoyl)pyrazine-2-carboxamide compounds
US10071970B2 (en) 2012-12-17 2018-09-11 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9586911B2 (en) 2013-12-13 2017-03-07 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epthelial sodium channel blocking compounds
US10233158B2 (en) 2013-12-13 2019-03-19 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
US9957238B2 (en) 2013-12-13 2018-05-01 Parion Sciences, Inc. Arylalkyl-and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

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