JP5875083B2 - 増殖性疾患治療用ピロロベンゾジアゼピン - Google Patents

増殖性疾患治療用ピロロベンゾジアゼピン Download PDF

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JP5875083B2
JP5875083B2 JP2013505172A JP2013505172A JP5875083B2 JP 5875083 B2 JP5875083 B2 JP 5875083B2 JP 2013505172 A JP2013505172 A JP 2013505172A JP 2013505172 A JP2013505172 A JP 2013505172A JP 5875083 B2 JP5875083 B2 JP 5875083B2
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JP2013523897A (ja
JP2013523897A5 (OSRAM
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ハワード，フィリップ，ウィルソン
マスターソン，ルーク
ティベルギーン，アルノー
ジェフリー，スコット
バーク，パトリック
センター，ピーター
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MedImmune Ltd
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
JP2013505172A 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン Active JP5875083B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32445310P 2010-04-15 2010-04-15
US61/324,453 2010-04-15
PCT/US2011/032668 WO2011130616A1 (en) 2010-04-15 2011-04-15 Pyrrolobenzodiazepines used to treat proliferative diseases

Publications (3)

Publication Number Publication Date
JP2013523897A JP2013523897A (ja) 2013-06-17
JP2013523897A5 JP2013523897A5 (OSRAM) 2014-05-29
JP5875083B2 true JP5875083B2 (ja) 2016-03-02

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JP2013505172A Active JP5875083B2 (ja) 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン

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Country Link
US (2) US8697688B2 (OSRAM)
EP (2) EP2789622B1 (OSRAM)
JP (1) JP5875083B2 (OSRAM)
KR (1) KR101687054B1 (OSRAM)
CN (1) CN102971329B (OSRAM)
AU (1) AU2011239525B2 (OSRAM)
BR (1) BR112012026410B8 (OSRAM)
CA (1) CA2795353C (OSRAM)
ES (1) ES2623057T3 (OSRAM)
MX (2) MX368648B (OSRAM)
NZ (1) NZ602933A (OSRAM)
WO (1) WO2011130616A1 (OSRAM)
ZA (1) ZA201207357B (OSRAM)

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NZ602932A (en) 2010-04-15 2014-08-29 Seattle Genetics Inc Targeted pyrrolobenzodiazapine conjugates
EP2675479B1 (en) 2011-02-15 2016-01-13 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
MX341524B (es) * 2011-09-20 2016-08-24 Medimmune Ltd Pirrolobenzodiazepinas como compuestos pbd dimericos asimetricos para inclusion en conjugados dirigidos.
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
KR101891859B1 (ko) 2011-10-14 2018-08-24 메디뮨 리미티드 피롤로벤조디아제핀
EP2751110B1 (en) * 2011-10-14 2017-04-19 MedImmune Limited Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative and autoimmune diseases
AU2012322613B2 (en) 2011-10-14 2016-04-21 Medimmune Limited Pyrrolobenzodiazepines and targeted conjugates
EP2793949B1 (en) 2011-12-23 2018-08-22 Innate Pharma Enzymatic conjugation of antibodies
ES2812849T3 (es) 2012-02-24 2021-03-18 Abbvie Stemcentrx Llc Anticuerpos anti-DLL3 y procedimientos de utilización de los mismos
PE20150091A1 (es) 2012-02-24 2015-02-16 Stem Centrx Inc Anticuerpos anti-sez6 y metodos de empleo
CA2873793C (en) 2012-05-18 2022-02-22 Medical Research Council Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase
EP2872894B1 (en) 2012-07-13 2019-04-17 Innate Pharma Screening of conjugated antibodies
WO2014057074A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
PT2906298T (pt) 2012-10-12 2018-12-28 Medimmune Ltd Conjugados de pirrolobenzodiazepina-anticorpos
HRP20171264T1 (hr) * 2012-10-12 2017-10-20 Adc Therapeutics Sa Konjugati protutijela anti-her2-pirolobenzodiazepina
WO2014057118A1 (en) * 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
WO2014057122A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
ES2713164T3 (es) 2012-10-12 2019-05-20 Medimmune Ltd Pirrolobenzodiazepinas y conjugados de las mismas
EP2906250B1 (en) 2012-10-12 2018-05-30 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-psma antibody conjugates
SI2906253T1 (sl) * 2012-10-12 2018-11-30 Adc Therapeutics Sa Konjugati pirolobenzodiazepin-protitelo proti PSMA
EP2906249B1 (en) 2012-10-12 2018-06-27 MedImmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
SMT201800346T1 (it) * 2012-10-12 2018-09-13 Medimmune Ltd Coniugati pirrolobenzodiazepina-anticorpo
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