JP5777519B2 - 改良されたアミノ脂質および核酸の送達方法 - Google Patents
改良されたアミノ脂質および核酸の送達方法Info
- Publication number
- JP5777519B2 JP5777519B2 JP2011531226A JP2011531226A JP5777519B2 JP 5777519 B2 JP5777519 B2 JP 5777519B2 JP 2011531226 A JP2011531226 A JP 2011531226A JP 2011531226 A JP2011531226 A JP 2011531226A JP 5777519 B2 JP5777519 B2 JP 5777519B2
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- sirna
- nucleic acid
- dma
- dlin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
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| EP2350043A4 (en) | 2012-06-13 |
| CA2740000A1 (en) | 2010-04-15 |
| CN102245590B (zh) | 2014-03-19 |
| JP2016196508A (ja) | 2016-11-24 |
| US9139554B2 (en) | 2015-09-22 |
| JP2012505250A (ja) | 2012-03-01 |
| WO2010042877A1 (en) | 2010-04-15 |
| JP2015028054A (ja) | 2015-02-12 |
| CN104119242A (zh) | 2014-10-29 |
| EP2350043B9 (en) | 2014-08-20 |
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| EP2743265A1 (en) | 2014-06-18 |
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| EP2743265B1 (en) | 2017-03-15 |
| AU2009303345A1 (en) | 2010-04-15 |
| CA2984026A1 (en) | 2010-04-15 |
| EP2350043B1 (en) | 2014-03-26 |
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