JP5551448B2 - 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法 - Google Patents

1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法 Download PDF

Info

Publication number
JP5551448B2
JP5551448B2 JP2009553836A JP2009553836A JP5551448B2 JP 5551448 B2 JP5551448 B2 JP 5551448B2 JP 2009553836 A JP2009553836 A JP 2009553836A JP 2009553836 A JP2009553836 A JP 2009553836A JP 5551448 B2 JP5551448 B2 JP 5551448B2
Authority
JP
Japan
Prior art keywords
coa
bdo
dehydrogenase
microorganism
naturally occurring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009553836A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010521182A (ja
JP2010521182A5 (enExample
Inventor
マーク ジェイ. バーク,
ディーン, スティーブン ジェイ. バン
アンソニー バーガード,
ウェイ ニュー,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genomatica Inc
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of JP2010521182A publication Critical patent/JP2010521182A/ja
Publication of JP2010521182A5 publication Critical patent/JP2010521182A5/ja
Application granted granted Critical
Publication of JP5551448B2 publication Critical patent/JP5551448B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/001—Processes specially adapted for distillation or rectification of fermented solutions
    • B01D3/002—Processes specially adapted for distillation or rectification of fermented solutions by continuous methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01061—4-Hydroxybutyrate dehydrogenase (1.1.1.61)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01016—Succinate-semialdehyde dehydrogenase [NAD(P)+] (1.2.1.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01076—Succinate-semialdehyde dehydrogenase (acetylating) (1.2.1.76)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01071—2-Oxoglutarate decarboxylase (4.1.1.71)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01004—Succinate-CoA ligase (GDP-forming) (6.2.1.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009553836A 2007-03-16 2008-03-14 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法 Active JP5551448B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91846307P 2007-03-16 2007-03-16
US60/918,463 2007-03-16
PCT/US2008/057168 WO2008115840A2 (en) 2007-03-16 2008-03-14 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013186002A Division JP2013240359A (ja) 2007-03-16 2013-09-09 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法

Publications (3)

Publication Number Publication Date
JP2010521182A JP2010521182A (ja) 2010-06-24
JP2010521182A5 JP2010521182A5 (enExample) 2011-05-06
JP5551448B2 true JP5551448B2 (ja) 2014-07-16

Family

ID=39766721

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2009553836A Active JP5551448B2 (ja) 2007-03-16 2008-03-14 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2013186002A Withdrawn JP2013240359A (ja) 2007-03-16 2013-09-09 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2016017686A Withdrawn JP2016093191A (ja) 2007-03-16 2016-02-02 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2017254172A Withdrawn JP2018046861A (ja) 2007-03-16 2017-12-28 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2019188459A Withdrawn JP2020072661A (ja) 2007-03-16 2019-10-15 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2021173856A Pending JP2022023169A (ja) 2007-03-16 2021-10-25 1,4-ブタンジオールおよびその前駆体の生合成のための組成物および方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2013186002A Withdrawn JP2013240359A (ja) 2007-03-16 2013-09-09 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2016017686A Withdrawn JP2016093191A (ja) 2007-03-16 2016-02-02 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2017254172A Withdrawn JP2018046861A (ja) 2007-03-16 2017-12-28 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2019188459A Withdrawn JP2020072661A (ja) 2007-03-16 2019-10-15 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
JP2021173856A Pending JP2022023169A (ja) 2007-03-16 2021-10-25 1,4-ブタンジオールおよびその前駆体の生合成のための組成物および方法

Country Status (13)

Country Link
US (10) US8067214B2 (enExample)
EP (4) EP2821494B1 (enExample)
JP (6) JP5551448B2 (enExample)
CN (2) CN101668861A (enExample)
AU (1) AU2008229076B2 (enExample)
BR (2) BRPI0808988A2 (enExample)
CA (1) CA2678946C (enExample)
ES (2) ES2527867T3 (enExample)
HU (1) HUE032465T2 (enExample)
LT (1) LT2821494T (enExample)
PL (2) PL2821494T3 (enExample)
TW (2) TWI568847B (enExample)
WO (1) WO2008115840A2 (enExample)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673601B2 (en) * 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於1,4-丁二醇及其前驅物之生物合成的組合物及方法
TWI525195B (zh) * 2007-08-10 2016-03-11 奇諾麥提卡公司 合成烯酸及其衍生物之方法
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
US7803589B2 (en) 2008-01-22 2010-09-28 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
SI2262901T1 (sl) 2008-03-05 2019-02-28 Genomatica, Inc. Primarni alkohol producirajoči organizmi
EP3351619A1 (en) * 2008-03-27 2018-07-25 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
EP2285973A4 (en) 2008-05-01 2012-04-25 Genomatica Inc PROCESS FOR PREPARING METHACRYLIC ACID
EP2304039B1 (en) 2008-06-17 2019-08-21 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
US20110190513A1 (en) * 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
CA2735883C (en) * 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
WO2010057022A1 (en) * 2008-11-14 2010-05-20 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
EP2379730B1 (en) 2008-12-31 2015-07-22 Metabolic Explorer Method for the preparation of diols
AU2013202629B2 (en) * 2009-04-30 2016-03-10 Genomatica, Inc. Organisms for the production of 1,3-butanediol
KR102115497B1 (ko) 2009-04-30 2020-05-26 게노마티카 인코포레이티드 1,3-부탄다이올 생산 유기체
AU2010242849A1 (en) 2009-04-30 2011-11-24 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
KR20200038334A (ko) 2009-05-07 2020-04-10 게노마티카 인코포레이티드 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법
EP2429587A4 (en) * 2009-05-15 2014-10-08 Genomatica Inc ORGANISMS FOR THE PREPARATION OF CYCLOHEXANONE
AU2013203177B2 (en) * 2009-06-04 2016-02-11 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
US8129169B2 (en) * 2009-06-04 2012-03-06 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
KR20180042467A (ko) * 2009-06-04 2018-04-25 게노마티카 인코포레이티드 발효액 성분들의 분리 방법
JP2012529889A (ja) * 2009-06-10 2012-11-29 ゲノマチカ, インク. Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法
WO2011017560A1 (en) 2009-08-05 2011-02-10 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
WO2011022511A2 (en) * 2009-08-19 2011-02-24 Strategic Enzyme Applications, Inc. Methods of reducing lignin and products thereof
EP2475775A4 (en) * 2009-09-09 2013-03-20 Genomatica Inc MICROORGANISMS AND METHOD FOR THE SIMULTANEOUS PREPARATION OF ISOPROPANOL AND PRIMARY ALCOHOLS, DIOLES AND ACIDS
WO2011047101A1 (en) * 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
KR20120088753A (ko) 2009-10-23 2012-08-08 게노마티카 인코포레이티드 아닐린의 제조를 위한 미생물
US9090919B2 (en) * 2009-10-29 2015-07-28 Korea Research Institute Of Bioscience And Biotechnology Method of producing 3-hydroxypropionic acid from glycerol
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
CA2783096A1 (en) 2009-12-10 2011-06-16 Genomatica, Inc. Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
BR112012018620A2 (pt) * 2010-01-29 2015-09-15 Genomatica Inc organismo microbiano de ocorrência não-natural, método para produzir (2-hidroxi-3-metil-4-oxobutoxi) fosfonato, método para produção de p-toluato, método para produzir tereftalato
CN102781901B (zh) 2010-02-11 2016-08-03 梅塔玻利克斯公司 用于从经遗传修饰的聚羟基链烷酸酯生物质制备单体组分的方法
US8445244B2 (en) * 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
JP5911847B2 (ja) 2010-05-05 2016-04-27 ジェノマティカ, インコーポレイテッド ブタジエンの生合成のための微生物および方法
US8911978B2 (en) * 2010-07-02 2014-12-16 Metabolic Explorer Method for the preparation of hydroxy acids
SG187174A1 (en) 2010-07-26 2013-02-28 Genomatica Inc Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
EP2633038B1 (en) * 2010-10-28 2017-04-05 Adisseo France S.A.S. A method of production of 2,4-dihydrobutyric acid
JP5907072B2 (ja) 2010-12-17 2016-04-20 三菱化学株式会社 合成経路作成装置、合成経路作成方法及び合成経路作成プログラム
WO2012089613A1 (en) * 2010-12-28 2012-07-05 Dsm Ip Assets B.V. Process to increase the production of a succinyl-coa derived compound
WO2012106516A1 (en) 2011-02-02 2012-08-09 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
EP2511377A1 (en) 2011-04-14 2012-10-17 B.R.A.I.N. Biotechnology Research And Information Network AG Means and methods for producing crotonic acid
US9169486B2 (en) 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
WO2012177619A2 (en) * 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing 1,3-butanediol and methods related thereto
WO2012177943A1 (en) 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing 1,4-butanediol and methods related thereto
WO2012177983A2 (en) * 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing ethylene glycol and methods related thereto
US20130072714A1 (en) * 2011-09-16 2013-03-21 BioAmber International S.à.r.l. Biobased compositions of diammonium succinate, monoammonium succinate and/or succinic acid and derivatives thereof
KR20130094115A (ko) * 2012-02-15 2013-08-23 삼성전자주식회사 1,4-부탄디올의 생산을 위한 변형 미생물
ITNO20120002A1 (it) 2012-03-20 2013-09-21 Novamont Spa Processo per la produzione di composti organici a partire da specie vegetali
EP2850180A1 (en) 2012-05-18 2015-03-25 Novozymes A/S Bacterial mutants with improved transformation efficiency
SI2855687T1 (sl) 2012-06-04 2020-09-30 Genomatica, Inc. Mikroorganizmi in metode za proizvodnjo 4-hidroksibutirat, 1,4-butandiola in sorodne spojine
KR102086324B1 (ko) 2012-06-05 2020-03-09 미쯔비시 케미컬 주식회사 폴리부틸렌테레프탈레이트의 제조 방법
EP2857377B1 (en) 2012-06-05 2019-05-08 Mitsubishi Chemical Corporation Production method for 1, 4-butanediol
CN107602824B (zh) 2012-06-05 2020-11-13 基因组股份公司 聚酯和聚氨基甲酸酯的制造方法
BR112014030203B1 (pt) 2012-06-08 2021-10-13 Cj Cheiljedang Corporation Processo para produção de produtos de ácido acrílico de base biológica
WO2014004625A1 (en) * 2012-06-26 2014-01-03 Genomatica, Inc. Microorganisms for producing ethylene glycol using synthesis gas
KR102023618B1 (ko) 2012-07-27 2019-09-20 삼성전자주식회사 1,4-bdo 생성능이 개선된 변이 미생물 및 이를 이용한 1,4-bdo의 제조방법
KR102145000B1 (ko) * 2013-10-01 2020-08-14 삼성전자주식회사 대장균 내에서 1,4-부탄디올의 생합성에 사용되는 효소, 이의 변이체 및 이를 이용한 1,4-부탄디올 생산방법
US9657316B2 (en) 2012-08-27 2017-05-23 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
US20150232830A1 (en) 2012-09-24 2015-08-20 Showa Denko K.K. Gene, microbe, conversion method, and manufacturing method
WO2014052630A1 (en) 2012-09-27 2014-04-03 Novozymes, Inc. Bacterial mutants with improved transformation efficiency
US9932611B2 (en) * 2012-10-22 2018-04-03 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
US9909150B2 (en) 2012-11-05 2018-03-06 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,2-propanediol, n-propanol, 1,3-propanediol, or glycerol related thereto
ES2774932T3 (es) 2012-11-14 2020-07-23 Cj Cheiljedang Corp Producción de sales de 4-hidroxibutirato utilizando materias primas de base biológica
EP2924122B1 (en) 2012-11-26 2017-08-23 Showa Denko K.K. 1,4-butanediol manufacturing method and microorganism
WO2014087921A1 (ja) 2012-12-05 2014-06-12 昭和電工株式会社 1,4-ブタンジオールの製造方法、微生物及び遺伝子
JP6342337B2 (ja) * 2013-01-21 2018-06-13 積水化学工業株式会社 組換え細胞、並びに、1,4−ブタンジオールの生産方法
CN105209414B (zh) 2013-03-15 2018-04-17 基因组股份公司 用于从发酵肉汤中获得1,4‑丁二醇的方法和系统
EP2984064B1 (en) 2013-04-12 2019-03-06 Toray Industries, Inc. Process of producing 1,4-butanediol
MY187966A (en) * 2013-04-26 2021-11-02 Genomatica Inc Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
US9718752B2 (en) 2013-05-31 2017-08-01 Shell Oil Company Process for the separation of an alkylene glycol
BR112015021060A2 (pt) 2013-05-31 2017-07-18 Shell Int Research processo para a recuperação de 1,4-butanodiol e pelo menos um coproduto selecionado
AU2014274278B2 (en) 2013-05-31 2017-05-04 Shell Internationale Research Maatschappij B.V. Glycol recovery with solvent extraction
KR20150013092A (ko) * 2013-07-26 2015-02-04 삼성전자주식회사 숙신산 생산능이 향상된 박테리아 세포 및 이를 이용하여 숙신산을 생산하는 방법
KR102113254B1 (ko) 2013-08-23 2020-05-21 삼성전자주식회사 1,4―bdo 생산을 위한 유전자 스크리닝 방법
KR102097065B1 (ko) 2013-08-23 2020-04-03 삼성전자주식회사 4-히드록시부티레이트 생산 균주 및 이를 이용한 4-히드록시부티레이트의 혐기적 생산 방법
US10035749B2 (en) 2013-09-03 2018-07-31 Myriant Corporation Process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
CA2925699A1 (en) 2013-10-04 2015-04-09 Genomatica, Inc. Alchohol dehydrogenase variants having increased substrate conversion
WO2015084633A1 (en) 2013-12-03 2015-06-11 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
CN118879602A (zh) 2013-12-27 2024-11-01 基因组股份公司 具有增加的碳通量效率的方法和生物
JP6309304B2 (ja) * 2014-02-24 2018-04-11 積水化学工業株式会社 組換え細胞、並びに、1,4−ブタンジオールの生産方法
US10227616B2 (en) 2014-04-16 2019-03-12 Novamont S.P.A. Process for the production of 1,4-butanediol
WO2015167043A1 (ko) * 2014-04-30 2015-11-05 삼성전자 주식회사 증가된 알파-케토글루타레이트 데카르복실라제 활성을 갖는 미생물 및 이를 이용한 1,4-부탄디올 생산방법
TWI751100B (zh) * 2014-05-05 2022-01-01 盧森堡商英威達技術有限公司 生物衍生之聚胺基甲酸酯纖維
BR112017005665A2 (pt) 2014-09-18 2017-12-12 Genomatica Inc organismos microbianos não naturais com eficiência energética melhorada
CN108026214B (zh) 2015-05-30 2021-03-02 基因组股份公司 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用
WO2017037897A1 (ja) * 2015-09-02 2017-03-09 積水化学工業株式会社 組換え細胞、組換え細胞の製造方法、並びに、1,4-ブタンジオールの生産方法
SG11201803164SA (en) 2015-10-30 2018-05-30 Genomatica Inc Methanol dehydrogenase fusion proteins
WO2018064599A1 (en) 2016-09-30 2018-04-05 Abdelrahman Omar A Forming dienes from cyclic ethers and diols, including tetrahydrofuran and 2-methyl-1,4-butanediol
KR102645531B1 (ko) 2017-03-31 2024-03-11 게노마티카 인코포레이티드 알데하이드 데하이드로게나제 변이체 및 사용 방법
EP3717091A1 (en) 2017-11-27 2020-10-07 Novamont S.p.A. Process for the production of 1,4-butanediol from renewable sources and polyesters obtained therefrom
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
CN113166784A (zh) 2018-06-26 2021-07-23 基因组股份公司 包括具有合成或增强的甲基营养的那些工程微生物的、具有g3p→3pg酶和/或果糖-1,6-二磷酸酶的工程微生物
WO2020068900A1 (en) 2018-09-26 2020-04-02 Genomatica, Inc. Aldehyde dehydrogenase variants and methods of using same
WO2021231271A1 (en) 2020-05-12 2021-11-18 Genomatica, Inc. Process of synthesizing and purifying (3r)-hydroxybutyl (3r)-hydroxybutanoate
IT202000013243A1 (it) 2020-06-04 2021-12-04 Novamont Spa Processo per la purificazione di una miscela di dioli
CN113956130B (zh) * 2021-11-23 2023-12-19 东莞理工学院 一种r-(-)-1,3-丁二醇的合成方法
IT202100030572A1 (it) 2021-12-02 2023-06-02 Novamont Spa 1,3-butandiolo purificato da una miscela di dioli
CN114350583B (zh) * 2021-12-17 2023-07-25 清华大学 一种发酵生产1,2-丁二醇的方法、重组微生物及其应用
CN116083329A (zh) * 2022-09-26 2023-05-09 北京绿色康成生物技术有限公司 发酵生产γ-丁内酯或1,4-丁二醇的方法
EP4293079B1 (en) 2022-10-27 2025-04-16 Basf Se Biodegradable polymer composition
CN116254241B (zh) * 2022-12-16 2025-05-16 浙江大学杭州国际科创中心 一种2,3-丁二醇脱氢酶突变体及其应用
EP4438680A1 (en) 2023-03-27 2024-10-02 Basf Se Polyesterblend for home compostable applications
CN116445390A (zh) * 2023-05-26 2023-07-18 江南大学 一种全细胞催化生产1,4-丁二醇的方法及其应用
IT202300019440A1 (it) 2023-09-21 2025-03-21 Novamont Spa Idrolizzato proteico di cellule di escherichia coli residue da un processo di fermentazione
CN117736950A (zh) * 2023-11-06 2024-03-22 清华大学 生产4-羟基丁酸或1,4-丁二醇的重组微生物及其构建方法与应用
EP4624529A1 (en) 2024-03-28 2025-10-01 Basf Se Biodegradable polymer composition for injection molding and thermoforming
WO2026068739A1 (en) 2024-09-27 2026-04-02 Basf Se Foamed pellets comprising polyesters
WO2026073906A1 (en) 2024-10-01 2026-04-09 Basf Se Home compostable stretched polymer film
WO2026073902A1 (en) 2024-10-01 2026-04-09 Basf Se Home compostable non-woven and multilayer structures
WO2026073908A1 (en) 2024-10-01 2026-04-09 Basf Se Home compostable polymer film with inorganic layer
WO2026109456A1 (en) 2024-11-19 2026-05-28 Basf Se Non-particle foamed articles

Family Cites Families (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1230276A (enExample) 1968-12-09 1971-04-28
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
DE2455617C3 (de) 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
GB1583517A (en) * 1977-05-04 1981-01-28 Jackson J F Solid bowl decanter centrifuges of the scroll discharge type
DE2842575A1 (de) * 1977-10-04 1979-04-12 Broadbent & Sons Ltd Thomas Vollmantel-abklaerzentrifuge
US4344002A (en) 1978-02-22 1982-08-10 Supertex, Inc. Detection circuit and structure therefor
JPS575693A (en) * 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
IT1190783B (it) 1981-04-29 1988-02-24 Davy Mckee Oil & Chem Processo per l'idrogenolisi di esteri di acidi carbossilici
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
JPS62285779A (ja) 1986-06-04 1987-12-11 Chiyoda Chem Eng & Constr Co Ltd 1,4−ブタンジオ−ル産生バチルス属細菌及びそれを用いる1,4−ブタンジオ−ルの製造方法
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) * 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US4876331A (en) * 1987-08-18 1989-10-24 Mitsubishi Kasei Corporation Copolyester and process for producing the same
EP0633319B1 (en) * 1988-04-27 1999-03-17 Daicel Chemical Industries, Ltd. Process for producing optically active 1,3-butanediol
DE3878564T2 (de) * 1988-12-12 1993-08-19 Unilever Nv Verfahren zur mikrobiologischen herstellung von 1,3-propandiol aus glycerin.
US5371002A (en) 1989-06-07 1994-12-06 James Madison University Method of production of poly-beta-hydroxyalkanoate copolymers
ATE227340T1 (de) 1989-07-10 2002-11-15 Massachusetts Inst Technology Eine zur herstellung von polyhydroxybutyrat oder einem anderen polyhydroxyalkanoat geeignete pflanze oder pflanzliche zelle
IE893328A1 (en) 1989-10-16 1991-04-24 Mcdaid Denis Telephone lock
GB9011777D0 (en) 1990-05-25 1990-07-18 Ici Plc Hv/hb copolymer production
US5674978A (en) 1990-09-21 1997-10-07 The Regents Of The University Of California Peptides derived from glutamic acid decarboxylase
US6682906B1 (en) 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
US5475086A (en) 1990-09-21 1995-12-12 The Regents Of The University Of California Cloned glutamic acid decarboxylase peptides
US5998366A (en) 1990-09-21 1999-12-07 The Regents Of The University Of California Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
US5286842A (en) * 1991-07-01 1994-02-15 Mitsubishi Kasei Corporation Process for producing a biodegradable polymer
GB9115245D0 (en) 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
US5610041A (en) 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
JP3696233B2 (ja) 1991-07-19 2005-09-14 ミシガン、ステート、ユニバーシティー ポリヒドロキシアルカノエートを生産するトランスジェニック植物
BR9203053A (pt) * 1991-08-07 1993-03-30 Ajinomoto Kk Processo para produzir acido l-glutamico pro fermentacao
JP2777757B2 (ja) * 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
DE4220759A1 (de) 1992-06-24 1994-01-05 Inst Genbiologische Forschung DNA-Sequenzen für Oligosaccharid-Transporter, Plasmide, Bakterien und Pflanzen enthaltend einen Transporter sowie Verfahren zur Herstellung und Transformation von Hefestämmen zur Identifikation des Transporteers
GB9223332D0 (en) 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
AU5676394A (en) 1992-11-20 1994-06-22 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
JP3263710B2 (ja) 1992-12-11 2002-03-11 高砂香料工業株式会社 生分解性光学活性ポリマー及びその製造方法
JP3241505B2 (ja) * 1993-08-11 2001-12-25 高砂香料工業株式会社 生分解性光学活性コポリマー及びその製造方法
WO1995011985A1 (en) 1993-10-28 1995-05-04 Ajinomoto Co., Inc. Process for producing substance
GB9414506D0 (en) 1994-07-18 1994-09-07 Zeneca Ltd Improved production of polyhydroxyalkanoate
DE4433134A1 (de) 1994-09-16 1996-03-21 Buck Chem Tech Werke Verfahren zur Herstellung von Polyhydroxyfettsäuren sowie rekombinanter Bakterienstämme zur Durchführung des Verfahrens
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5747311A (en) 1995-08-22 1998-05-05 Microgen Corporation Process for chemical modification of reactants by microbes
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
DE19543635A1 (de) 1995-11-23 1997-05-28 Hp Chemie Pelzer Res & Dev Verbundwerkstoffe aus Polyhydroxyfettsäuren und Fasermaterialien
US5849894A (en) 1995-11-29 1998-12-15 Monsanto Company Rhodospirillum rubrum poly-β-hydroxyalkanoate synthase
CA2247038A1 (en) * 1996-02-27 1997-09-04 Michigan State University Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
US5959179A (en) 1996-03-13 1999-09-28 Monsanto Company Method for transforming soybeans
US6091002A (en) 1996-03-13 2000-07-18 Monsanto Company Polyhydroxyalkanoates of narrow molecular weight distribution prepared in transgenic plants
US5750848A (en) 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
US6730503B1 (en) 1996-09-19 2004-05-04 Roche Vitamins Inc. Alcohol/aldehyde dehydrogenase
JPH10166664A (ja) * 1996-12-12 1998-06-23 Casio Electron Mfg Co Ltd カラー印刷装置
EP0977865A1 (en) * 1997-02-13 2000-02-09 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6759219B2 (en) 1997-03-03 2004-07-06 Metabolix, Inc. Methods for the biosynthesis of polyesters
US6156852A (en) 1997-04-21 2000-12-05 Monsanto Company Hydroxy-terminated polyhydroxyalkanoates
AU7140598A (en) 1997-04-21 1998-11-13 Monsanto Company Hydroxy-terminated polyhydroxyalkanoates
KR19990013007A (ko) 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ss373(kctc 8818p)과 이를 이용한숙신산의 생산방법
US6316262B1 (en) 1997-09-19 2001-11-13 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
EP1710302B1 (en) * 1997-09-19 2007-11-21 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
US6228579B1 (en) 1997-11-14 2001-05-08 San Diego State University Foundation Method for identifying microbial proliferation genes
US6280986B1 (en) 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
EP1105514B1 (en) 1998-08-04 2008-02-06 Metabolix, Inc. Polyhydroxyalkanoate production from polyols
WO2000011188A1 (en) 1998-08-18 2000-03-02 Metabolix, Inc. Transgenic microbial polyhydroxyalkanoate producers
US6835820B2 (en) 1999-01-07 2004-12-28 The University Of Massachusetts Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium
EP1147229A2 (en) 1999-02-02 2001-10-24 Bernhard O. Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
EP1159435A1 (en) 1999-03-05 2001-12-05 Monsanto Technology LLC Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
AU3798900A (en) * 1999-04-09 2000-11-14 University Of Guelph Novel proteins related to gaba metabolism
KR100329019B1 (ko) * 1999-04-13 2002-03-18 윤덕용 유기산의 고효율 생산방법
PT1204755E (pt) 1999-08-18 2006-11-30 Du Pont Processo para a produção biológica de 1, 3-propanodiol
US6361983B1 (en) 1999-09-30 2002-03-26 E. I. Du Pont De Nemours And Company Process for the isolation of 1,3-propanediol from fermentation broth
DE19956686A1 (de) 1999-11-25 2001-05-31 Degussa Neue für die Gene sucC und sucD codierende Nukleotidsequenzen
US6897055B2 (en) 1999-11-25 2005-05-24 Degussa Ag Nucleotide sequences coding for the genes sucC and sucD
AU2001269676A1 (en) * 2000-03-02 2001-09-24 Maxygen, Inc. Enzymes, pathways and organisms for making a polymerizable monomer by whole cellbioprocess
KR20040014389A (ko) 2000-07-21 2004-02-14 메타볼릭스 인코포레이티드 폴리올로부터 폴리하이드록시알칸노에이트를 제조하는 방법
US6495152B2 (en) 2000-08-18 2002-12-17 Tepha, Inc. Sulfur containing polyhydroxyalkanoate compositions and method of production
US6916637B2 (en) 2000-09-30 2005-07-12 Degussa Ag Fermentation process for the preparation of L-amino acids using strains of the family Enterobacteriaceae
AU2002219818B2 (en) 2000-11-20 2007-08-16 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
WO2002053746A1 (fr) * 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Procédé de production d'alcool prényle
US7711490B2 (en) 2001-01-10 2010-05-04 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) * 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
EP1381860A4 (en) 2001-03-01 2008-10-15 Univ California MODELS AND METHOD FOR DETERMINING SYSTEMIC PROPERTIES OF REGULATED RESPONSE NETWORKS
US7052883B2 (en) 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
US7256021B2 (en) 2001-07-18 2007-08-14 Degussa Ag Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids
US20090100536A1 (en) 2001-12-04 2009-04-16 Monsanto Company Transgenic plants with enhanced agronomic traits
US20090158452A1 (en) 2001-12-04 2009-06-18 Johnson Richard G Transgenic plants with enhanced agronomic traits
CN1217001C (zh) 2002-01-04 2005-08-31 清华大学 一种生产d-(-)-3-羟基丁酸的方法
US7309597B2 (en) * 2002-01-18 2007-12-18 Cargill, Incorporated Alanine 2,3-Aminomutase
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
JP2005521929A (ja) 2002-03-29 2005-07-21 ジェノマティカ・インコーポレイテッド ヒト代謝モデルおよび方法
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US20050287655A1 (en) * 2002-05-10 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
JP4418793B2 (ja) 2002-07-10 2010-02-24 ザ ペン ステート リサーチ ファウンデーション 遺伝子ノックアウト戦略を決定する方法
AU2003253949A1 (en) * 2002-07-15 2004-02-02 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
AU2003258187A1 (en) 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
ATE505559T1 (de) 2002-09-12 2011-04-15 Metabolix Inc Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege
EP1543114B1 (en) 2002-09-27 2008-08-13 DSM IP Assets B.V. Aldehyde dehydrogenase gene
JP5064656B2 (ja) 2002-10-15 2012-10-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 実施反応経路を同定するための方法およびシステム
AU2003287625A1 (en) * 2002-11-06 2004-06-03 University Of Florida Materials and methods for the efficient production of acetate and other products
JP2006515516A (ja) 2003-01-09 2006-06-01 ビーエーエスエフ アクチェンゲゼルシャフト 遺伝子改変されたBlakeslea属の生物を使用する、カロチノイドまたはそれらの前駆体を製造するための方法、上記方法によって製造されたカロチノイドまたはそれらの前駆体、ならびにそれらの使用
US6997524B2 (en) * 2003-02-26 2006-02-14 Ford Global Technologies Llc System and method for controlling a hydraulic system
WO2005018579A2 (en) 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
US7927859B2 (en) 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
EP1664286A1 (en) 2003-09-18 2006-06-07 Ciba SC Holding AG Alcohol dehydrogenases with increased solvent and temperature stability
US8206955B2 (en) 2003-10-21 2012-06-26 Cargill, Incorporated Production of monatin and monatin precursors
WO2005052135A1 (en) 2003-11-27 2005-06-09 Korea Advanced Institute Of Science And Technology Novel rumen bacteria variants and process for preparing succinic acid employing the same
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
DE102004031177A1 (de) * 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
KR100656590B1 (ko) 2004-07-30 2006-12-11 한국과학기술원 박테리아 변이균주 및 이를 이용한 숙신산 및 아미노산의제조방법
US7601858B2 (en) 2004-08-17 2009-10-13 Gs Cleantech Corporation Method of processing ethanol byproducts and related subsystems
EP3130676A1 (en) 2004-08-27 2017-02-15 Rice University Mutant e. coli strain with increased succinic acid production
GB0419424D0 (en) * 2004-09-02 2004-10-06 Viragen Scotland Ltd Transgene optimisation
WO2006028063A1 (ja) * 2004-09-09 2006-03-16 Research Institute Of Innovative Technology For The Earth プロモーター機能を有するdna断片
US7569380B2 (en) 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
KR100727054B1 (ko) 2005-08-19 2007-06-12 한국과학기술원 푸마레이트 하이드라타제 c를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
KR100676160B1 (ko) 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
KR100679638B1 (ko) 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 d 또는 e를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
CN101300356A (zh) * 2005-09-09 2008-11-05 基因组股份公司 用于琥珀酸盐之生长关联性生产的方法和生物
US9297028B2 (en) * 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
KR20070096348A (ko) * 2006-03-23 2007-10-02 주식회사 엘지화학 1,4―butanediol〔1,4―BDO〕생성능을가지는 변이체 및 이를 이용한 1,4―BDO의 제조방법
CA2650505A1 (en) 2006-05-01 2008-02-14 University Of Florida Research Foundation, Inc. Ethanol production in non-recombinant hosts
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
WO2008027742A1 (en) 2006-08-30 2008-03-06 Cargill, Incorporated Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
US8017364B2 (en) * 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
EP2118266A4 (en) * 2007-02-09 2010-05-19 Univ California BIOFUEL PRODUCTION BY RECOMBINANT MICROORGANISMS
TWI568847B (zh) * 2007-03-16 2017-02-01 奇諾麥提卡公司 用於1,4-丁二醇及其前驅物之生物合成的組合物及方法
US8691539B2 (en) 2007-03-20 2014-04-08 University Of Florida Research Foundation, Inc. Materials and methods for efficient succinate and malate production
WO2008124523A1 (en) * 2007-04-04 2008-10-16 The Regents Of The University Of California Butanol production by recombinant microorganisms
NZ579780A (en) 2007-04-18 2012-07-27 Butamax Advanced Biofuels Llc Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
EP2147111A4 (en) * 2007-04-18 2010-06-23 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL
US8426174B2 (en) 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
US8426173B2 (en) 2007-05-02 2013-04-23 Butamax (Tm) Advanced Biofuels Llc Method for the production of 1-butanol
US20110039327A1 (en) 2007-05-18 2011-02-17 Aaron Adriaan Winkler Organic acid production by fungal cells
EP2155885A4 (en) 2007-05-18 2010-12-01 Microbia Prec Engineering Inc ACIDIC ACID PRODUCTION IN RECOMBINANT YEAST
US20090023182A1 (en) 2007-07-18 2009-01-22 Schilling Christophe H Complementary metabolizing organisms and methods of making same
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
KR101042242B1 (ko) * 2007-09-07 2011-06-17 한국과학기술원 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법
JP2011500031A (ja) 2007-10-12 2011-01-06 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア イソプロパノールを生産するように操作された微生物
US7803589B2 (en) 2008-01-22 2010-09-28 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009103026A1 (en) 2008-02-15 2009-08-20 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20090246842A1 (en) 2008-02-15 2009-10-01 Gevo, Inc. Engineered microorganisms for producing propanol
US7981647B2 (en) 2008-03-03 2011-07-19 Joule Unlimited, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
CA2735883C (en) * 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
US8354563B2 (en) * 2008-10-16 2013-01-15 Maverick Biofuels, Inc. Methods and apparatus for synthesis of alcohols from syngas

Also Published As

Publication number Publication date
WO2008115840A2 (en) 2008-09-25
JP2018046861A (ja) 2018-03-29
JP2016093191A (ja) 2016-05-26
US20130196397A1 (en) 2013-08-01
US20090075351A1 (en) 2009-03-19
TWI488964B (zh) 2015-06-21
EP2137315B1 (en) 2014-09-03
JP2010521182A (ja) 2010-06-24
US8889399B2 (en) 2014-11-18
HUE032465T2 (en) 2017-09-28
LT2821494T (lt) 2017-04-25
JP2020072661A (ja) 2020-05-14
PL2137315T3 (pl) 2015-02-27
EP3214179A1 (en) 2017-09-06
US8067214B2 (en) 2011-11-29
EP3800262A1 (en) 2021-04-07
US20170022524A1 (en) 2017-01-26
US20190062758A1 (en) 2019-02-28
US8357520B2 (en) 2013-01-22
US20230134936A1 (en) 2023-05-04
PL2821494T3 (pl) 2017-07-31
ES2527867T3 (es) 2015-01-30
JP2013240359A (ja) 2013-12-05
TWI568847B (zh) 2017-02-01
EP2821494A1 (en) 2015-01-07
US9487803B2 (en) 2016-11-08
EP3214179B1 (en) 2021-03-03
US11371046B2 (en) 2022-06-28
TW200911985A (en) 2009-03-16
JP2022023169A (ja) 2022-02-07
TW201527529A (zh) 2015-07-16
US20120094345A1 (en) 2012-04-19
CN101668861A (zh) 2010-03-10
ES2625439T3 (es) 2017-07-19
AU2008229076A1 (en) 2008-09-25
US20170088840A1 (en) 2017-03-30
US8969054B2 (en) 2015-03-03
CA2678946C (en) 2019-02-12
WO2008115840A3 (en) 2009-01-29
AU2008229076B2 (en) 2014-05-15
EP2137315A4 (en) 2010-06-02
BRPI0808988A2 (pt) 2011-11-08
EP2821494B1 (en) 2017-03-08
CA2678946A1 (en) 2008-09-25
BRPI0823327A2 (pt) 2013-10-22
US20120122171A1 (en) 2012-05-17
EP2137315A2 (en) 2009-12-30
US20150267229A1 (en) 2015-09-24
US20150368676A1 (en) 2015-12-24
CN105936887A (zh) 2016-09-14

Similar Documents

Publication Publication Date Title
US20230134936A1 (en) Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
JP2010521182A5 (enExample)
CN113528417A (zh) 生产1,4-丁二醇的微生物和相关方法
AU2013204038B2 (en) Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20110309

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110309

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120227

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130308

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130613

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130909

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131003

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140317

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20140409

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140428

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140522

R150 Certificate of patent or registration of utility model

Ref document number: 5551448

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250