CA2678946C - Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors - Google Patents

Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors Download PDF

Info

Publication number
CA2678946C
CA2678946C CA2678946A CA2678946A CA2678946C CA 2678946 C CA2678946 C CA 2678946C CA 2678946 A CA2678946 A CA 2678946A CA 2678946 A CA2678946 A CA 2678946A CA 2678946 C CA2678946 C CA 2678946C
Authority
CA
Canada
Prior art keywords
dehydrogenase
coa
naturally occurring
bdo
microbial organism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2678946A
Other languages
English (en)
French (fr)
Other versions
CA2678946A1 (en
Inventor
Mark J. Burk
Stephen J. Van Dien
Anthony Burgard
Wei Niu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genomatica Inc
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of CA2678946A1 publication Critical patent/CA2678946A1/en
Application granted granted Critical
Publication of CA2678946C publication Critical patent/CA2678946C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/001—Processes specially adapted for distillation or rectification of fermented solutions
    • B01D3/002—Processes specially adapted for distillation or rectification of fermented solutions by continuous methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01061—4-Hydroxybutyrate dehydrogenase (1.1.1.61)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01016—Succinate-semialdehyde dehydrogenase [NAD(P)+] (1.2.1.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01076—Succinate-semialdehyde dehydrogenase (acetylating) (1.2.1.76)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01071—2-Oxoglutarate decarboxylase (4.1.1.71)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01004—Succinate-CoA ligase (GDP-forming) (6.2.1.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2678946A 2007-03-16 2008-03-14 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors Active CA2678946C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91846307P 2007-03-16 2007-03-16
US60/918,463 2007-03-16
PCT/US2008/057168 WO2008115840A2 (en) 2007-03-16 2008-03-14 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

Publications (2)

Publication Number Publication Date
CA2678946A1 CA2678946A1 (en) 2008-09-25
CA2678946C true CA2678946C (en) 2019-02-12

Family

ID=39766721

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2678946A Active CA2678946C (en) 2007-03-16 2008-03-14 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

Country Status (13)

Country Link
US (10) US8067214B2 (enExample)
EP (4) EP2821494B1 (enExample)
JP (6) JP5551448B2 (enExample)
CN (2) CN101668861A (enExample)
AU (1) AU2008229076B2 (enExample)
BR (2) BRPI0808988A2 (enExample)
CA (1) CA2678946C (enExample)
ES (2) ES2625439T3 (enExample)
HU (1) HUE032465T2 (enExample)
LT (1) LT2821494T (enExample)
PL (2) PL2137315T3 (enExample)
TW (2) TWI488964B (enExample)
WO (1) WO2008115840A2 (enExample)

Families Citing this family (108)

* Cited by examiner, โ€  Cited by third party
Publication number Priority date Publication date Assignee Title
US8673601B2 (en) * 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
CA2678946C (en) 2007-03-16 2019-02-12 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
CA2696018A1 (en) * 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of olefins and derivatives
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
JP5755884B2 (ja) * 2008-03-05 2015-07-29 ใ‚ธใ‚งใƒŽใƒžใƒ†ใ‚ฃใ‚ซ๏ผŒ ใ‚คใƒณใ‚ณใƒผใƒใƒฌใ‚คใƒ†ใƒƒใƒ‰ ็ฌฌไธ€็ดšใ‚ขใƒซใ‚ณใƒผใƒซใ‚’็”ฃ็”Ÿใ™ใ‚‹็”Ÿ็‰ฉ
SI2265709T1 (en) 2008-03-27 2018-03-30 Genomatica, Inc. MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS
JP2011519561A (ja) 2008-05-01 2011-07-14 ใ‚ธใ‚งใƒŽใƒžใƒ†ใ‚ฃใ‚ซ๏ผŒ ใ‚คใƒณใ‚ณใƒผใƒใƒฌใ‚คใƒ†ใƒƒใƒ‰ ใƒกใ‚ฟใ‚ฏใƒชใƒซ้…ธใฎ็”ฃ็”ŸใฎใŸใ‚ใฎๅพฎ็”Ÿ็‰ฉ
US8129154B2 (en) * 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
EP2313491A4 (en) * 2008-07-08 2011-12-07 Opx Biotechnologies Inc METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
CA2735883C (en) * 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
US20100184173A1 (en) * 2008-11-14 2010-07-22 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
KR20110097951A (ko) * 2008-12-16 2011-08-31 ๊ฒŒ๋…ธ๋งˆํ‹ฐ์นด ์ธ์ฝ”ํฌ๋ ˆ์ดํ‹ฐ๋“œ ํ•ฉ์„ฑ๊ฐ€์Šค์™€ ๋‹ค๋ฅธ ํƒ„์†Œ์›์„ ์œ ์šฉ ์ œํ’ˆ์œผ๋กœ ์ „ํ™˜์‹œํ‚ค๊ธฐ ์œ„ํ•œ ๋ฏธ์ƒ๋ฌผ ๋ฐ ๋ฐฉ๋ฒ•
MX2011007039A (es) 2008-12-31 2011-07-20 Metabolic Explorer Sa Metodo para la preparacion de dioles.
BRPI1013426A2 (pt) 2009-04-30 2016-11-08 Genomatica Inc organismos para produรงรฃo de 1,3-butanodiol
AU2013202629B2 (en) * 2009-04-30 2016-03-10 Genomatica, Inc. Organisms for the production of 1,3-butanediol
US8993285B2 (en) 2009-04-30 2015-03-31 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
ES2749423T3 (es) 2009-05-07 2020-03-20 Genomatica Inc Microorganismos y mรฉtodos para la biosรญntesis de adipato, hexametilendiamina y รกcido 6-aminocaproico
EP2429587A4 (en) * 2009-05-15 2014-10-08 Genomatica Inc ORGANISMS FOR THE PREPARATION OF CYCLOHEXANONE
LT2438036T (lt) * 2009-06-04 2017-06-26 Genomatica, Inc. Fermentacijos sultinio komponentลณ iลกskyrimo bลซdas
AU2013203177B2 (en) * 2009-06-04 2016-02-11 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
SI3392340T1 (sl) * 2009-06-04 2022-05-31 Genomatica, Inc. Mikroorganizmi za proizvodnjo 1,4-BUTANDIOLA in pripadajoฤi postopki
JP2012529889A (ja) 2009-06-10 2012-11-29 ใ‚ฒใƒŽใƒžใƒใ‚ซ๏ผŒ ใ‚คใƒณใ‚ฏ๏ผŽ ๏ผญ๏ฝ…๏ฝ‹ๅŠใณ๏ผ’โˆ’ใƒ–ใ‚ฟใƒŽใƒผใƒซใฎ็‚ญ็ด ๅŠน็Ž‡ใฎใ‚ˆใ„็”ŸๅˆๆˆใฎใŸใ‚ใฎๅพฎ็”Ÿ็‰ฉๅŠใณๆ–นๆณ•
EP2462221B1 (en) 2009-08-05 2017-02-22 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
WO2011022511A2 (en) * 2009-08-19 2011-02-24 Strategic Enzyme Applications, Inc. Methods of reducing lignin and products thereof
BR112012005296A2 (pt) * 2009-09-09 2019-01-15 Genomatica Inc microorganismos e mรฉtodos para a coproduรงรฃo de isopropanol com alcoรณis primรกrios, diรณs e รกcidos.
AU2010306785B2 (en) * 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
KR20180014240A (ko) 2009-10-23 2018-02-07 ๊ฒŒ๋…ธ๋งˆํ‹ฐ์นด ์ธ์ฝ”ํฌ๋ ˆ์ดํ‹ฐ๋“œ ์•„๋‹๋ฆฐ์˜ ์ œ์กฐ๋ฅผ ์œ„ํ•œ ๋ฏธ์ƒ๋ฌผ
EP2495328B1 (en) * 2009-10-29 2016-03-30 Korea Research Institute of Bioscience and Biotechnology Novel method for producing 3-hydroxypropionic acid from glycerol
US8530210B2 (en) * 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
CN109136161A (zh) * 2009-12-10 2019-01-04 ๅŸบๅ› ็ป„่‚กไปฝๅ…ฌๅธ ๅˆๆˆๆฐ”ๆˆ–ๅ…ถไป–ๆฐ”ๆ€็ขณๆบๅ’Œ็”ฒ้†‡่ฝฌๅŒ–ไธบ1,3-ไธไบŒ้†‡็š„ๆ–นๆณ•ๅ’Œๆœ‰ๆœบไฝ“
CA2787314A1 (en) 2010-01-29 2011-08-04 Genomatica, Inc. Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
RU2012132908A (ru) 2010-02-11 2014-03-20 ะœะตั‚ะฐะฑะพะปะธะบั, ะ˜ะฝะบ. ะกะฟะพัะพะฑ ะฟะพะปัƒั‡ะตะฝะธั ะฟั€ะพะธะทะฒะพะดะฝั‹ั… ั…ะธะผะธั‡ะตัะบะธั… ัะพะตะดะธะฝะตะฝะธะน
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) * 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
MX336229B (es) 2010-05-05 2016-01-08 Genomatica Inc Microorganismos y metodos para la biosintesis de butadieno.
EP2588598B1 (en) 2010-07-02 2016-03-09 Metabolic Explorer Method for the preparation of hydroxy acids
JP2013535203A (ja) 2010-07-26 2013-09-12 ใ‚ธใ‚งใƒŽใƒžใƒ†ใ‚ฃใ‚ซใƒปใ‚คใƒณใ‚ณใƒผใƒใƒฌใ‚คใƒ†ใƒƒใƒ‰ ่Šณ้ฆ™ๆ—ใ€๏ผ’๏ผŒ๏ผ”โˆ’ใƒšใƒณใ‚ฟใ‚ธใ‚จใƒŽใ‚จใƒผใƒˆใŠใ‚ˆใณ๏ผ‘๏ผŒ๏ผ“โˆ’ใƒ–ใ‚ฟใ‚ธใ‚จใƒณใ‚’็”Ÿๅˆๆˆใ™ใ‚‹ใŸใ‚ใฎๅพฎ็”Ÿ็‰ฉใŠใ‚ˆใณๆ–นๆณ•
CN105505892B (zh) * 2010-10-28 2019-03-26 ๅฎ‰่ฟช่‹ๆณ•ๅ›ฝ่”ๅˆ่‚กไปฝๆœ‰้™ๅ…ฌๅธ 2,4-ไบŒ็พŸๅŸบไธ้…ธ็š„็”Ÿไบงๆ–นๆณ•
WO2012081723A1 (ja) 2010-12-17 2012-06-21 ไธ‰่ฑๅŒ–ๅญฆๆ ชๅผไผš็คพ ๅˆๆˆ็ตŒ่ทฏไฝœๆˆ่ฃ…็ฝฎใ€ๅˆๆˆ็ตŒ่ทฏไฝœๆˆๆ–นๆณ•ๅŠใณๅˆๆˆ็ตŒ่ทฏไฝœๆˆใƒ—ใƒญใ‚ฐใƒฉใƒ ใชใ‚‰ใณใซ๏ผ“๏ผใƒ’ใƒ‰ใƒญใ‚ญใ‚ทใƒ—ใƒญใƒ”ใ‚ชใƒณ้…ธใ€ใ‚ฏใƒญใƒˆใƒ‹ใƒซใ‚ขใƒซใ‚ณใƒผใƒซใŠใ‚ˆใณใƒ–ใ‚ฟใ‚ธใ‚จใƒณใฎ่ฃฝ้€ ๆ–นๆณ•
WO2012089613A1 (en) * 2010-12-28 2012-07-05 Dsm Ip Assets B.V. Process to increase the production of a succinyl-coa derived compound
MX348334B (es) 2011-02-02 2017-06-07 Genomatica Inc Microorganismo y metodos para la biosintesis de butadieno.
EP2511377A1 (en) 2011-04-14 2012-10-17 B.R.A.I.N. Biotechnology Research And Information Network AG Means and methods for producing crotonic acid
US9169486B2 (en) 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
WO2012177619A2 (en) * 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing 1,3-butanediol and methods related thereto
US20130034884A1 (en) 2011-06-22 2013-02-07 Genomatica, Inc. Microorganisms for producing 1,4-butanediol and methods related thereto
WO2012177983A2 (en) * 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing ethylene glycol and methods related thereto
US20130072714A1 (en) * 2011-09-16 2013-03-21 BioAmber International S.ร .r.l. Biobased compositions of diammonium succinate, monoammonium succinate and/or succinic acid and derivatives thereof
KR20130094115A (ko) * 2012-02-15 2013-08-23 ์‚ผ์„ฑ์ „์ž์ฃผ์‹ํšŒ์‚ฌ 1,4-๋ถ€ํƒ„๋””์˜ฌ์˜ ์ƒ์‚ฐ์„ ์œ„ํ•œ ๋ณ€ํ˜• ๋ฏธ์ƒ๋ฌผ
ITNO20120002A1 (it) 2012-03-20 2013-09-21 Novamont Spa Processo per la produzione di composti organici a partire da specie vegetali
US9803209B2 (en) 2012-05-18 2017-10-31 Novozymes A/S Bacterial mutants with improved transformation efficiency
EP3831951A3 (en) * 2012-06-04 2021-09-15 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
BR112014030247B1 (pt) 2012-06-05 2021-07-13 Mitsubishi Chemical Corporation Mรฉtodo de produรงรฃo de 1,4-butanodiol e uso de 1,4-butanodiol derivado de biomassa obtenรญvel pelo mesmo
WO2013183593A1 (ja) 2012-06-05 2013-12-12 ไธ‰่ฑๅŒ–ๅญฆๆ ชๅผไผš็คพ ใƒใƒชใ‚จใ‚นใƒ†ใƒซๅŠใณใƒใƒชใ‚ฆใƒฌใ‚ฟใƒณใฎ่ฃฝ้€ ๆ–นๆณ•
CN104540873B (zh) * 2012-06-05 2017-09-01 ไธ‰่ฑๅŒ–ๅญฆๆ ชๅผไผš็คพ ่šๅฏน่‹ฏไบŒ็”ฒ้…ธไธไบŒ้…ฏ็š„ๅˆถ้€ ๆ–นๆณ•
BR112014030203B1 (pt) 2012-06-08 2021-10-13 Cj Cheiljedang Corporation Processo para produรงรฃo de produtos de รกcido acrรญlico de base biolรณgica
WO2014004625A1 (en) * 2012-06-26 2014-01-03 Genomatica, Inc. Microorganisms for producing ethylene glycol using synthesis gas
KR102023618B1 (ko) 2012-07-27 2019-09-20 ์‚ผ์„ฑ์ „์ž์ฃผ์‹ํšŒ์‚ฌ 1,4-๏ฝ‚๏ฝ„๏ฝ ์ƒ์„ฑ๋Šฅ์ด ๊ฐœ์„ ๋œ ๋ณ€์ด ๋ฏธ์ƒ๋ฌผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ 1,4-๏ฝ‚๏ฝ„๏ฝ์˜ ์ œ์กฐ๋ฐฉ๋ฒ•
KR102145000B1 (ko) * 2013-10-01 2020-08-14 ์‚ผ์„ฑ์ „์ž์ฃผ์‹ํšŒ์‚ฌ ๋Œ€์žฅ๊ท  ๋‚ด์—์„œ 1,4-๋ถ€ํƒ„๋””์˜ฌ์˜ ์ƒํ•ฉ์„ฑ์— ์‚ฌ์šฉ๋˜๋Š” ํšจ์†Œ, ์ด์˜ ๋ณ€์ด์ฒด ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ 1,4-๋ถ€ํƒ„๋””์˜ฌ ์ƒ์‚ฐ๋ฐฉ๋ฒ•
US9657316B2 (en) 2012-08-27 2017-05-23 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
WO2014046178A1 (ja) 2012-09-24 2014-03-27 ๆ˜ญๅ’Œ้›ปๅทฅๆ ชๅผไผš็คพ ้บไผๅญใ€ๅพฎ็”Ÿ็‰ฉใ€ๅค‰ๆ›ๆ–นๆณ•ๅŠใณ่ฃฝ้€ ๆ–นๆณ•
WO2014052630A1 (en) 2012-09-27 2014-04-03 Novozymes, Inc. Bacterial mutants with improved transformation efficiency
US11535874B2 (en) 2012-10-22 2022-12-27 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
WO2014071286A1 (en) 2012-11-05 2014-05-08 Genomatica, Inc. Microorganisms for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,2-propanediol
US20160068463A1 (en) 2012-11-14 2016-03-10 Metabolix, Inc. Production of salts of 4-hydroxybutyrate using biobased raw materials
JPWO2014080683A1 (ja) 2012-11-26 2017-01-05 ๆ˜ญๅ’Œ้›ปๅทฅๆ ชๅผไผš็คพ ๏ผ‘๏ผŒ๏ผ”โˆ’ใƒ–ใ‚ฟใƒณใ‚ธใ‚ชใƒผใƒซใฎ่ฃฝ้€ ๆ–นๆณ•ๅŠใณๅพฎ็”Ÿ็‰ฉ
EP2930239A4 (en) 2012-12-05 2016-06-29 Showa Denko Kk 1,4-butanediol production method, microorganism, and gene
EP2947143B1 (en) * 2013-01-21 2018-07-11 Sekisui Chemical Co., Ltd. Recombinant cell, and method for producing 1,4-butanediol
CA2900536A1 (en) 2013-03-15 2014-09-25 Genomatica, Inc. Process and systems for obtaining 1,4-butanediol from fermentation broths
EP2984064B1 (en) 2013-04-12 2019-03-06 Toray Industries, Inc. Process of producing 1,4-butanediol
WO2014176514A2 (en) 2013-04-26 2014-10-30 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
WO2014193889A1 (en) 2013-05-31 2014-12-04 Shell Oil Company Glycol recovery with solvent extraction
US9718752B2 (en) 2013-05-31 2017-08-01 Shell Oil Company Process for the separation of an alkylene glycol
WO2014191504A1 (en) 2013-05-31 2014-12-04 Shell Internationale Research Maatschappij B.V. Process for the separation of 1,4-butanediol and co-products
US20150031101A1 (en) * 2013-07-26 2015-01-29 Samsung Electronics Co., Ltd. Bacterial cell having enhanced succinic acid production and a method for producing the succinic acid using the same
KR102113254B1 (ko) 2013-08-23 2020-05-21 ์‚ผ์„ฑ์ „์ž์ฃผ์‹ํšŒ์‚ฌ 1,4โ€•๏ฝ‚๏ฝ„๏ฝ ์ƒ์‚ฐ์„ ์œ„ํ•œ ์œ ์ „์ž ์Šคํฌ๋ฆฌ๋‹ ๋ฐฉ๋ฒ•
KR102097065B1 (ko) 2013-08-23 2020-04-03 ์‚ผ์„ฑ์ „์ž์ฃผ์‹ํšŒ์‚ฌ 4-ํžˆ๋“œ๋ก์‹œ๋ถ€ํ‹ฐ๋ ˆ์ดํŠธ ์ƒ์‚ฐ ๊ท ์ฃผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ 4-ํžˆ๋“œ๋ก์‹œ๋ถ€ํ‹ฐ๋ ˆ์ดํŠธ์˜ ํ˜๊ธฐ์  ์ƒ์‚ฐ ๋ฐฉ๋ฒ•
KR102266181B1 (ko) 2013-09-03 2021-06-17 ํ”ผํ‹ฐํ‹ฐ ๊ธ€๋กœ๋ฒŒ ์ผ€๋ฏธ์ปฌ ํผ๋ธ”๋ฆญ ์ปดํผ๋‹ˆ ๋ฆฌ๋ฏธํ‹ฐ๋“œ 1,3-ํ”„๋กœํŒ๋””์˜ฌ๋กœ๋ถ€ํ„ฐ ์•„ํฌ๋ฆด์‚ฐ, ์•„ํฌ๋ฆด๋กœ๋‹ˆํŠธ๋ฆด ๋ฐ 1,4-๋ถ€ํƒ„๋””์˜ฌ์˜ ์ œ์กฐ๋ฐฉ๋ฒ•
WO2015051298A2 (en) 2013-10-04 2015-04-09 Genomatica, Inc. Alcohol dehydrogenase variants
PL3077501T3 (pl) 2013-12-03 2022-01-31 Genomatica, Inc. Mikroorganizmy i sposoby poprawy wydajnoล›ci produktu na metanolu z uลผyciem syntezy acetylo-coa
WO2015100338A2 (en) 2013-12-27 2015-07-02 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
JP6309304B2 (ja) * 2014-02-24 2018-04-11 ็ฉๆฐดๅŒ–ๅญฆๅทฅๆฅญๆ ชๅผไผš็คพ ็ต„ๆ›ใˆ็ดฐ่ƒžใ€ไธฆใณใซใ€๏ผ‘๏ผŒ๏ผ”โˆ’ใƒ–ใ‚ฟใƒณใ‚ธใ‚ชใƒผใƒซใฎ็”Ÿ็”ฃๆ–นๆณ•
EP3132046B1 (en) 2014-04-16 2019-07-24 Novamont S.p.A. Process for the production of 1,4-butanediol
WO2015167043A1 (ko) * 2014-04-30 2015-11-05 ์‚ผ์„ฑ์ „์ž ์ฃผ์‹ํšŒ์‚ฌ ์ฆ๊ฐ€๋œ ์•ŒํŒŒ-์ผ€ํ† ๊ธ€๋ฃจํƒ€๋ ˆ์ดํŠธ ๋ฐ์นด๋ฅด๋ณต์‹ค๋ผ์ œ ํ™œ์„ฑ์„ ๊ฐ–๋Š” ๋ฏธ์ƒ๋ฌผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ 1,4-๋ถ€ํƒ„๋””์˜ฌ ์ƒ์‚ฐ๋ฐฉ๋ฒ•
TWI751100B (zh) 2014-05-05 2022-01-01 ็›งๆฃฎๅ กๅ•†่‹ฑๅจ้”ๆŠ€่ก“ๆœ‰้™ๅ…ฌๅธ ็”Ÿ็‰ฉ่ก็”Ÿไน‹่š่ƒบๅŸบ็”ฒ้…ธ้…ฏ็บ–็ถญ
EP3741865B1 (en) 2014-09-18 2024-03-13 Genomatica, Inc. Non-natural microbial organisms with improved energetic efficiency
CN108026214B (zh) 2015-05-30 2021-03-02 ๅŸบๅ› ็ป„่‚กไปฝๅ…ฌๅธ ไน™็ƒฏๅŸบๅผ‚ๆž„้…ถ-่„ฑๆฐด้…ถใ€็ƒฏ้†‡่„ฑๆฐด้…ถใ€่ŠณๆจŸ้†‡่„ฑๆฐด้…ถๅ’Œ/ๆˆ–ๅทด่ฑ†้†‡่„ฑๆฐด้…ถๅŠๅ…ถๅˆถๅค‡ๅ’Œไฝฟ็”จ
WO2017037897A1 (ja) * 2015-09-02 2017-03-09 ็ฉๆฐดๅŒ–ๅญฆๅทฅๆฅญๆ ชๅผไผš็คพ ็ต„ๆ›ใˆ็ดฐ่ƒžใ€็ต„ๆ›ใˆ็ดฐ่ƒžใฎ่ฃฝ้€ ๆ–นๆณ•ใ€ไธฆใณใซใ€๏ผ‘๏ผŒ๏ผ”๏ผใƒ–ใ‚ฟใƒณใ‚ธใ‚ชใƒผใƒซใฎ็”Ÿ็”ฃๆ–นๆณ•
SG11201803164SA (en) 2015-10-30 2018-05-30 Genomatica Inc Methanol dehydrogenase fusion proteins
US10919030B2 (en) 2016-09-30 2021-02-16 Regents Of The University Of Minnesota Forming dienes from cyclic ethers and diols, including tetrahydrofuran and 2-methyl-1,4-butanediol
BR112019020461A2 (pt) 2017-03-31 2020-06-09 Genomatica Inc variantes de aldeรญdo desidrogenase e mรฉtodos de uso
US11377409B2 (en) 2017-11-27 2022-07-05 Novamont Spa Process for the production of 1,4-butanediol from renewable sources and polyesters obtained therefrom
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
EP3814515A2 (en) 2018-06-26 2021-05-05 Genomatica, Inc. Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy
KR20210068489A (ko) 2018-09-26 2021-06-09 ๊ฒŒ๋…ธ๋งˆํ‹ฐ์นด ์ธ์ฝ”ํฌ๋ ˆ์ดํ‹ฐ๋“œ ์•Œ๋ฐํ•˜์ด๋“œ ๋ฐํ•˜์ด๋“œ๋กœ๊ฒŒ๋‚˜์ œ ๋ณ€์ด์ฒด ๋ฐ ์ด์˜ ์ด์šฉ ๋ฐฉ๋ฒ•
EP4149918A1 (en) 2020-05-12 2023-03-22 Genomatica, Inc. Process of synthesizing and purifying (3r)-hydroxybutyl (3r)-hydroxybutanoate
IT202000013243A1 (it) 2020-06-04 2021-12-04 Novamont Spa Processo per la purificazione di una miscela di dioli
CN113956130B (zh) * 2021-11-23 2023-12-19 ไธœ่Žž็†ๅทฅๅญฆ้™ข ไธ€็งr-(-)-1,3-ไธไบŒ้†‡็š„ๅˆๆˆๆ–นๆณ•
IT202100030572A1 (it) 2021-12-02 2023-06-02 Novamont Spa 1,3-butandiolo purificato da una miscela di dioli
CN114350583B (zh) * 2021-12-17 2023-07-25 ๆธ…ๅŽๅคงๅญฆ ไธ€็งๅ‘้…ต็”Ÿไบง1,2-ไธไบŒ้†‡็š„ๆ–นๆณ•ใ€้‡็ป„ๅพฎ็”Ÿ็‰ฉๅŠๅ…ถๅบ”็”จ
CN116083329A (zh) * 2022-09-26 2023-05-09 ๅŒ—ไบฌ็ปฟ่‰ฒๅบทๆˆ็”Ÿ็‰ฉๆŠ€ๆœฏๆœ‰้™ๅ…ฌๅธ ๅ‘้…ต็”Ÿไบงฮณ-ไธๅ†…้…ฏๆˆ–1,4-ไธไบŒ้†‡็š„ๆ–นๆณ•
HRP20250823T1 (hr) 2022-10-27 2025-09-12 Basf Se Biorazgradivi polimerni pripravak
CN116254241B (zh) * 2022-12-16 2025-05-16 ๆต™ๆฑŸๅคงๅญฆๆญๅทžๅ›ฝ้™…็ง‘ๅˆ›ไธญๅฟƒ ไธ€็ง2,3-ไธไบŒ้†‡่„ฑๆฐข้…ถ็ชๅ˜ไฝ“ๅŠๅ…ถๅบ”็”จ
EP4438680A1 (en) 2023-03-27 2024-10-02 Basf Se Polyesterblend for home compostable applications
IT202300019440A1 (it) 2023-09-21 2025-03-21 Novamont Spa Idrolizzato proteico di cellule di escherichia coli residue da un processo di fermentazione
EP4624529A1 (en) 2024-03-28 2025-10-01 Basf Se Biodegradable polymer composition for injection molding and thermoforming

Family Cites Families (152)

* Cited by examiner, โ€  Cited by third party
Publication number Priority date Publication date Assignee Title
GB1230276A (enExample) 1968-12-09 1971-04-28
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
DE2455617C3 (de) 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran รผber die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
GB1583517A (en) 1977-05-04 1981-01-28 Jackson J F Solid bowl decanter centrifuges of the scroll discharge type
DE2842575A1 (de) 1977-10-04 1979-04-12 Broadbent & Sons Ltd Thomas Vollmantel-abklaerzentrifuge
US4344002A (en) 1978-02-22 1982-08-10 Supertex, Inc. Detection circuit and structure therefor
JPS575693A (en) 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
IT1190783B (it) 1981-04-29 1988-02-24 Davy Mckee Oil & Chem Processo per l'idrogenolisi di esteri di acidi carbossilici
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
JPS62285779A (ja) 1986-06-04 1987-12-11 Chiyoda Chem Eng & Constr Co Ltd ๏ผ‘๏ผŒ๏ผ”โˆ’ใƒ–ใ‚ฟใƒณใ‚ธใ‚ชโˆ’ใƒซ็”ฃ็”Ÿใƒใƒใƒซใ‚นๅฑž็ดฐ่ŒๅŠใณใใ‚Œใ‚’็”จใ„ใ‚‹๏ผ‘๏ผŒ๏ผ”โˆ’ใƒ–ใ‚ฟใƒณใ‚ธใ‚ชโˆ’ใƒซใฎ่ฃฝ้€ ๆ–นๆณ•
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US4876331A (en) 1987-08-18 1989-10-24 Mitsubishi Kasei Corporation Copolyester and process for producing the same
US5219757A (en) 1988-04-27 1993-06-15 Daicel Chemical Industries, Ltd. Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone
EP0373230B1 (en) 1988-12-12 1993-02-17 Unilever N.V. Process for the microbiological preparation of 1,3-propane-diol from glycerol
US5371002A (en) 1989-06-07 1994-12-06 James Madison University Method of production of poly-beta-hydroxyalkanoate copolymers
ES2131489T3 (es) 1989-07-10 2003-05-16 Massachusetts Inst Technology Una planta o una celula vegetal recombinante capaz de producir polihidroxibutirato u otro polihidroxialcanoato.
IE893328A1 (en) 1989-10-16 1991-04-24 Mcdaid Denis Telephone lock
GB9011777D0 (en) 1990-05-25 1990-07-18 Ici Plc Hv/hb copolymer production
US5475086A (en) 1990-09-21 1995-12-12 The Regents Of The University Of California Cloned glutamic acid decarboxylase peptides
US6682906B1 (en) 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
US5998366A (en) 1990-09-21 1999-12-07 The Regents Of The University Of California Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders
US5674978A (en) 1990-09-21 1997-10-07 The Regents Of The University Of California Peptides derived from glutamic acid decarboxylase
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
US5286842A (en) 1991-07-01 1994-02-15 Mitsubishi Kasei Corporation Process for producing a biodegradable polymer
GB9115245D0 (en) 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
CA2113412C (en) 1991-07-19 2000-01-25 Christopher R. Somerville Transgenic plants producing polyhydroxyalkanoates
US5610041A (en) 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
PH30131A (en) 1991-08-07 1997-01-21 Ajinomoto Kk Process for producing l-glutamic acid by fermentation
JP2777757B2 (ja) 1991-09-17 1998-07-23 ้˜ๆทตๅŒ–ๅญฆๅทฅๆฅญๆ ชๅผไผš็คพ ๅ…ฑ้‡ๅˆไฝ“ใŠใ‚ˆใณใใฎ่ฃฝ้€ ๆ–นๆณ•
DE4220759A1 (de) 1992-06-24 1994-01-05 Inst Genbiologische Forschung DNA-Sequenzen fรผr Oligosaccharid-Transporter, Plasmide, Bakterien und Pflanzen enthaltend einen Transporter sowie Verfahren zur Herstellung und Transformation von Hefestรคmmen zur Identifikation des Transporteers
GB9223332D0 (en) 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
WO1994012014A1 (en) 1992-11-20 1994-06-09 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
JP3263710B2 (ja) 1992-12-11 2002-03-11 ้ซ˜็ ‚้ฆ™ๆ–™ๅทฅๆฅญๆ ชๅผไผš็คพ ็”Ÿๅˆ†่งฃๆ€งๅ…‰ๅญฆๆดปๆ€งใƒใƒชใƒžใƒผๅŠใณใใฎ่ฃฝ้€ ๆ–นๆณ•
JP3241505B2 (ja) 1993-08-11 2001-12-25 ้ซ˜็ ‚้ฆ™ๆ–™ๅทฅๆฅญๆ ชๅผไผš็คพ ็”Ÿๅˆ†่งฃๆ€งๅ…‰ๅญฆๆดปๆ€งใ‚ณใƒใƒชใƒžใƒผๅŠใณใใฎ่ฃฝ้€ ๆ–นๆณ•
DK0733712T3 (da) 1993-10-28 2002-03-18 Ajinomoto Kk Fremgangsmรฅde til fremstilling af et stof
GB9414506D0 (en) 1994-07-18 1994-09-07 Zeneca Ltd Improved production of polyhydroxyalkanoate
DE4433134A1 (de) 1994-09-16 1996-03-21 Buck Chem Tech Werke Verfahren zur Herstellung von Polyhydroxyfettsรคuren sowie rekombinanter Bakterienstรคmme zur Durchfรผhrung des Verfahrens
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5747311A (en) 1995-08-22 1998-05-05 Microgen Corporation Process for chemical modification of reactants by microbes
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
DE19543635A1 (de) 1995-11-23 1997-05-28 Hp Chemie Pelzer Res & Dev Verbundwerkstoffe aus Polyhydroxyfettsรคuren und Fasermaterialien
US5849894A (en) 1995-11-29 1998-12-15 Monsanto Company Rhodospirillum rubrum poly-ฮฒ-hydroxyalkanoate synthase
JP2000506012A (ja) 1996-02-27 2000-05-23 ใƒŸใ‚ทใ‚ฌใƒณ ใ‚นใƒ†ใ‚คใƒˆ ใƒฆใƒ‹ใƒดใ‚กใƒผใ‚ทใƒ†ใ‚ฃใƒผ ใ‚ตใƒผใƒขใ‚ขใƒณใ‚จใ‚ขใƒญใƒใ‚ฏใ‚ฟใƒผใƒปใ‚จใ‚ฟใƒŽใƒชใ‚ซใ‚น๏ผ“๏ผ™๏ฝ…ใฎ็ฌฌไบŒ็ดšใ‚ขใƒซใ‚ณใƒผใƒซใƒ‡ใƒ’ใƒ‰ใƒญใ‚ฒใƒŠใƒผใ‚ผใ‚’ใ‚ณใƒผใƒ‰ใ™ใ‚‹้บไผๅญใฎใ‚ฏใƒญใƒผใƒ‹ใƒณใ‚ฐๅŠใณ็™บ็พไธฆใณใซ้…ต็ด ใฎ็”ŸๅŒ–ๅญฆ็š„็‰นๅพดไป˜ใ‘
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-ฮฒ-hydroxybutyrate-co-poly-ฮฒ-hydroxyvalerate in bacteria and plants
US5959179A (en) 1996-03-13 1999-09-28 Monsanto Company Method for transforming soybeans
US6091002A (en) 1996-03-13 2000-07-18 Monsanto Company Polyhydroxyalkanoates of narrow molecular weight distribution prepared in transgenic plants
US5750848A (en) 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
US6730503B1 (en) 1996-09-19 2004-05-04 Roche Vitamins Inc. Alcohol/aldehyde dehydrogenase
JPH10166664A (ja) 1996-12-12 1998-06-23 Casio Electron Mfg Co Ltd ใ‚ซใƒฉใƒผๅฐๅˆท่ฃ…็ฝฎ
US6117658A (en) * 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6759219B2 (en) 1997-03-03 2004-07-06 Metabolix, Inc. Methods for the biosynthesis of polyesters
US6156852A (en) 1997-04-21 2000-12-05 Monsanto Company Hydroxy-terminated polyhydroxyalkanoates
EP0977882B1 (en) 1997-04-21 2007-06-13 Metabolix, Inc. Hydroxy-terminated polyhydroxyalkanoates
KR19990013007A (ko) 1997-07-31 1999-02-25 ๋ฐ•์›ํ›ˆ ํ˜•์งˆ์ „ํ™˜๋œ ๋Œ€์žฅ๊ท  ๏ฝ“๏ฝ“373(๏ฝ‹๏ฝƒ๏ฝ”๏ฝƒ 8818๏ฝ)๊ณผ ์ด๋ฅผ ์ด์šฉํ•œ์ˆ™์‹ ์‚ฐ์˜ ์ƒ์‚ฐ๋ฐฉ๋ฒ•
EP1710302B1 (en) * 1997-09-19 2007-11-21 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
ATE323152T1 (de) 1997-09-19 2006-04-15 Metabolix Inc Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysรคure enthalten
US6228579B1 (en) 1997-11-14 2001-05-08 San Diego State University Foundation Method for identifying microbial proliferation genes
US6280986B1 (en) 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
DE69938105T2 (de) 1998-08-04 2009-01-29 Metabolix, Inc., Cambridge Herstellung von polyhydroxyalkanoaten aus polyolen
DE69930276T2 (de) 1998-08-18 2006-10-05 Metabolix, Inc., Cambridge Transgene polyhydroxyalkanoat produzierende mikroben
US6835820B2 (en) 1999-01-07 2004-12-28 The University Of Massachusetts Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium
WO2000046405A2 (en) 1999-02-02 2000-08-10 Bernhard Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6448473B1 (en) 1999-03-05 2002-09-10 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
AU3798900A (en) * 1999-04-09 2000-11-14 University Of Guelph Novel proteins related to gaba metabolism
KR100329019B1 (ko) 1999-04-13 2002-03-18 ์œค๋•์šฉ ์œ ๊ธฐ์‚ฐ์˜ ๊ณ ํšจ์œจ ์ƒ์‚ฐ๋ฐฉ๋ฒ•
CA2380616C (en) 1999-08-18 2011-05-24 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high titer
US6361983B1 (en) 1999-09-30 2002-03-26 E. I. Du Pont De Nemours And Company Process for the isolation of 1,3-propanediol from fermentation broth
DE19956686A1 (de) 1999-11-25 2001-05-31 Degussa Neue fรผr die Gene sucC und sucD codierende Nukleotidsequenzen
US6897055B2 (en) 1999-11-25 2005-05-24 Degussa Ag Nucleotide sequences coding for the genes sucC and sucD
WO2001068803A2 (en) * 2000-03-02 2001-09-20 Maxygen, Inc. Enzymes, pathways and organisms for making a polymerizable monomer by whole cell bioprocess
US20020164729A1 (en) 2000-07-21 2002-11-07 Skraly Frank A. Production of polyhydroxyalkanoates from polyols
AU2001285041A1 (en) 2000-08-18 2002-03-04 Metabolix, Inc. Sulfur containing polyhydroxyalkanoate compositions and method of production
US6916637B2 (en) 2000-09-30 2005-07-12 Degussa Ag Fermentation process for the preparation of L-amino acids using strains of the family Enterobacteriaceae
JP4490628B2 (ja) 2000-11-20 2010-06-30 ใ‚ซใƒผใ‚ฎใƒซ ใ‚คใƒณใ‚ณใƒผใƒใƒฌใ‚คใƒ†ใƒƒใƒ‰ ๏ผ“โˆ’ใƒ’ใƒ‰ใƒญใ‚ญใ‚ทใƒ—ใƒญใƒ”ใ‚ชใƒณ้…ธใŠใ‚ˆใณไป–ใฎๆœ‰ๆฉŸๅŒ–ๅˆ็‰ฉ
US7501268B2 (en) 2000-12-28 2009-03-10 Toyota Jidosha Kabushiki Kaisha Methods of producing prenyl alcohols
CA2434224C (en) 2001-01-10 2013-04-02 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
US20030059792A1 (en) 2001-03-01 2003-03-27 Palsson Bernhard O. Models and methods for determining systemic properties of regulated reaction networks
US7052883B2 (en) 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
EP1407021B1 (en) 2001-07-18 2008-02-27 Evonik Degussa GmbH Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an attenuated ugpb gene
US20090158452A1 (en) 2001-12-04 2009-06-18 Johnson Richard G Transgenic plants with enhanced agronomic traits
US20090100536A1 (en) 2001-12-04 2009-04-16 Monsanto Company Transgenic plants with enhanced agronomic traits
CN1217001C (zh) 2002-01-04 2005-08-31 ๆธ…ๅŽๅคงๅญฆ ไธ€็ง็”Ÿไบงd๏ผ(๏ผ)๏ผ3๏ผ็พŸๅŸบไธ้…ธ็š„ๆ–นๆณ•
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
CA2480216A1 (en) 2002-03-29 2003-10-09 Genomatica, Inc. Human metabolic models and methods
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US20050287655A1 (en) 2002-05-10 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
EP1532516A4 (en) 2002-07-10 2007-05-23 Penn State Res Found Method for determining gene knockout strategies
WO2004007688A2 (en) 2002-07-15 2004-01-22 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
WO2004015132A2 (en) 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
EP2365088B1 (en) 2002-09-12 2015-05-27 Metabolix, Inc. Polyhydroxyalkanoate production by coenzyme a-dependent aldehyde dehydrogenase pathways
DE60322921D1 (de) 2002-09-27 2008-09-25 Dsm Ip Assets Bv Aldehyddehyrdrogenase-gen
AU2003222214B2 (en) 2002-10-15 2010-08-12 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
AU2003287625A1 (en) 2002-11-06 2004-06-03 University Of Florida Materials and methods for the efficient production of acetate and other products
RU2005125072A (ru) 2003-01-09 2006-06-10 ะ‘ะะกะค ะะบั†ะธะตะฝะณะตะทะตะปัŒัˆะฐั„ั‚ (DE) ะกะฟะพัะพะฑ ะฟะพะปัƒั‡ะตะฝะธั ะบะฐั€ะพั‚ะธะฝะพะธะดะพะฒ ะธะปะธ ะธั… ะฟั€ะตะดัˆะตัั‚ะฒะตะฝะฝะธะบะพะฒ ั ะฟะพะผะพั‰ัŒัŽ ะณะตะฝะฝะพ-ะธะฝะถะตะฝะตั€ะฝะพ ะฒะธะดะพะธะทะผะตะฝะตะฝะฝั‹ั… ะผะธะบั€ะพะพั€ะณะฐะฝะธะทะผะพะฒ ัะตะผะตะนัั‚ะฒะฐ blakeslea, ะฟะพะปัƒั‡ะตะฝะฝั‹ะต ัƒะบะฐะทะฐะฝะฝั‹ะผ ัะฟะพัะพะฑะพะผ ะบะฐั€ะพั‚ะธะฝะพะธะดั‹ ะธะปะธ ะธั… ะฟั€ะตะดัˆะตัั‚ะฒะตะฝะฝะธะบะธ ะธ ะธั… ะฟั€ะธะผะตะฝะตะฝะธะต
US6997524B2 (en) * 2003-02-26 2006-02-14 Ford Global Technologies Llc System and method for controlling a hydraulic system
AU2004266100A1 (en) 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
US7927859B2 (en) 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005026338A1 (en) 2003-09-18 2005-03-24 Ciba Specialty Chemicals Holding Inc. Alcohol dehydrogenases with increased solvent and temperature stability
ATE498691T1 (de) 2003-10-21 2011-03-15 Cargill Inc Herstellung von monatin und monatinvorstufen
EP1692271B2 (en) 2003-11-27 2022-08-03 Korea Advanced Institute of Science and Technology Novel rumen bacteria variants and process for preparing succinic acid employing the same
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
DE102004031177A1 (de) 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
KR100656590B1 (ko) 2004-07-30 2006-12-11 ํ•œ๊ตญ๊ณผํ•™๊ธฐ์ˆ ์› ๋ฐ•ํ…Œ๋ฆฌ์•„ ๋ณ€์ด๊ท ์ฃผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์ˆ™์‹ ์‚ฐ ๋ฐ ์•„๋ฏธ๋…ธ์‚ฐ์˜์ œ์กฐ๋ฐฉ๋ฒ•
US7601858B2 (en) 2004-08-17 2009-10-13 Gs Cleantech Corporation Method of processing ethanol byproducts and related subsystems
CN101044245B (zh) 2004-08-27 2012-05-02 ่Žฑๆ–ฏๅคงๅญฆ ๅ…ทๆœ‰ๅขžๅŠ ็š„็ฅ็€้…ธไบง้‡็š„็ชๅ˜ๅคง่‚ ๆ†่Œ่Œๆ ช
GB0419424D0 (en) * 2004-09-02 2004-10-06 Viragen Scotland Ltd Transgene optimisation
EP2434015B1 (en) 2004-09-09 2013-11-20 Research Institute Of Innovative Technology For The Earth DNA fragment having promoter function
US7569380B2 (en) 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
KR100676160B1 (ko) 2005-08-19 2007-02-01 ํ•œ๊ตญ๊ณผํ•™๊ธฐ์ˆ ์› ๋ง๋ฆญํšจ์†Œ๋ฅผ ์ฝ”๋”ฉํ•˜๋Š” ์œ ์ „์ž๋กœ ํ˜•์งˆ์ „ํ™˜๋œ ์žฌ์กฐํ•ฉ ๋ฏธ์ƒ๋ฌผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์ˆ™์‹ ์‚ฐ์˜ ์ œ์กฐ๋ฐฉ๋ฒ•
KR100679638B1 (ko) 2005-08-19 2007-02-06 ํ•œ๊ตญ๊ณผํ•™๊ธฐ์ˆ ์› ํฌ๋ฉ”์ดํŠธ ๋””ํ•˜์ด๋“œ๋กœ๊ฒŒ๋‚˜์ œ ๏ฝ„ ๋˜๋Š” ๏ฝ…๋ฅผ ์ฝ”๋”ฉํ•˜๋Š” ์œ ์ „์ž๋กœ ํ˜•์งˆ์ „ํ™˜๋œ ๋ฏธ์ƒ๋ฌผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์ˆ™์‹ ์‚ฐ์˜ ์ œ์กฐ๋ฐฉ๋ฒ•
KR100727054B1 (ko) 2005-08-19 2007-06-12 ํ•œ๊ตญ๊ณผํ•™๊ธฐ์ˆ ์› ํ‘ธ๋งˆ๋ ˆ์ดํŠธ ํ•˜์ด๋“œ๋ผํƒ€์ œ ๏ฝƒ๋ฅผ ์ฝ”๋”ฉํ•˜๋Š” ์œ ์ „์ž๋กœ ํ˜•์งˆ์ „ํ™˜๋œ ์žฌ์กฐํ•ฉ ๋ฏธ์ƒ๋ฌผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์ˆ™์‹ ์‚ฐ์˜ ์ œ์กฐ๋ฐฉ๋ฒ•
AU2006287257A1 (en) * 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
KR20070096348A (ko) * 2006-03-23 2007-10-02 ์ฃผ์‹ํšŒ์‚ฌ ์—˜์ง€ํ™”ํ•™ 1,4โ€•๏ฝ‚๏ฝ•๏ฝ”๏ฝ๏ฝŽ๏ฝ…๏ฝ„๏ฝ‰๏ฝ๏ฝŒใ€”๏ผ‘๏ผŒ๏ผ”โ€•๏ผข๏ผค๏ผฏใ€•์ƒ์„ฑ๋Šฅ์„๊ฐ€์ง€๋Š” ๋ณ€์ด์ฒด ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ๏ผ‘๏ผŒ๏ผ”โ€•๏ผข๏ผค๏ผฏ์˜ ์ œ์กฐ๋ฐฉ๋ฒ•
MY157798A (en) 2006-05-01 2016-07-29 Univ Florida Ethanol production in non-recombination hosts
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
BRPI0716212A2 (pt) 2006-08-30 2013-10-15 Cargill Inc Beta-alanina/alfa-cetoglutarato aminotransferase para produรงรฃo de รกcido 3-hidroxipropiรดnico
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
CA2678261A1 (en) * 2007-02-09 2008-08-14 The Regents Of The University Of California Biofuel production by recombinant microorganisms
CA2678946C (en) 2007-03-16 2019-02-12 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
EP2121915B1 (en) 2007-03-20 2012-08-08 University of Florida Research Foundation, Inc. Materials and methods for efficient succinate and malate production
WO2008124523A1 (en) * 2007-04-04 2008-10-16 The Regents Of The University Of California Butanol production by recombinant microorganisms
KR101573775B1 (ko) 2007-04-18 2015-12-04 ๋ถ€ํƒ€๋งฅ์Šค ์–ด๋“œ๋ฐด์Šค๋“œ ๋ฐ”์ด์˜คํ“จ์–ผ์Šค ์—˜์—˜์”จ ๊ณ ๋„ ํ™œ์„ฑ ์ผ€ํ†จ-์‚ฐ ๋ฆฌ๋•ํ† ์•„์ด์†Œ๋จธ๋ผ์•„์ œ ํšจ์†Œ๋ฅผ ์ด์šฉํ•œ ์•„์ด์†Œ๋ถ€ํƒ„์˜ฌ์˜ ๋ฐœํšจ ์ƒ์‚ฐ
EP2147111A4 (en) 2007-04-18 2010-06-23 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL
US8426173B2 (en) 2007-05-02 2013-04-23 Butamax (Tm) Advanced Biofuels Llc Method for the production of 1-butanol
US8426174B2 (en) 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
EP2158323A4 (en) 2007-05-18 2011-06-22 Microbia Prec Engineering Inc PRODUCTION OF ORGANIC ACID BY PILZ CELLS
US20110045559A1 (en) 2007-05-18 2011-02-24 Aaron Adriaan Winkler Malic acid production in recombinant yeast
US20090023182A1 (en) 2007-07-18 2009-01-22 Schilling Christophe H Complementary metabolizing organisms and methods of making same
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
KR101042242B1 (ko) 2007-09-07 2011-06-17 ํ•œ๊ตญ๊ณผํ•™๊ธฐ์ˆ ์› 1,4-๋ถ€ํƒ„๋””์˜ฌ ์ƒ์„ฑ๋Šฅ์„ ๊ฐ€์ง€๋Š” ๋ณ€์ด์ฒด ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ1,4-๋ถ€ํƒ„๋””์˜ฌ์˜ ์ œ์กฐ๋ฐฉ๋ฒ•
AU2008310573A1 (en) 2007-10-12 2009-04-16 The Regents Of The University Of California Microorganism engineered to produce isopropanol
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009103026A1 (en) 2008-02-15 2009-08-20 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20090246842A1 (en) 2008-02-15 2009-10-01 Gevo, Inc. Engineered microorganisms for producing propanol
CN102015995B (zh) 2008-03-03 2014-10-22 ็„ฆ่€ณๆ— ้™็ง‘ๆŠ€ๅ…ฌๅธ ไบง็”Ÿ็ขณๅŸบ็›ฎ็š„ไบง็‰ฉ็š„ไบŒๆฐงๅŒ–็ขณๅ›บๅฎšๅทฅ็จ‹ๅพฎ็”Ÿ็‰ฉ
CA2735883C (en) * 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
US8357826B2 (en) 2008-10-16 2013-01-22 Karl Kharas Methods and apparatus for synthesis of alcohols from syngas

Also Published As

Publication number Publication date
EP2137315A4 (en) 2010-06-02
JP2016093191A (ja) 2016-05-26
EP2137315B1 (en) 2014-09-03
EP2821494A1 (en) 2015-01-07
EP3800262A1 (en) 2021-04-07
WO2008115840A3 (en) 2009-01-29
US20230134936A1 (en) 2023-05-04
US20150368676A1 (en) 2015-12-24
US8357520B2 (en) 2013-01-22
US20170022524A1 (en) 2017-01-26
PL2137315T3 (pl) 2015-02-27
US20090075351A1 (en) 2009-03-19
CN105936887A (zh) 2016-09-14
US20120094345A1 (en) 2012-04-19
EP2137315A2 (en) 2009-12-30
EP2821494B1 (en) 2017-03-08
EP3214179A1 (en) 2017-09-06
PL2821494T3 (pl) 2017-07-31
TWI488964B (zh) 2015-06-21
US20150267229A1 (en) 2015-09-24
TW200911985A (en) 2009-03-16
AU2008229076B2 (en) 2014-05-15
US20190062758A1 (en) 2019-02-28
JP2010521182A (ja) 2010-06-24
EP3214179B1 (en) 2021-03-03
US11371046B2 (en) 2022-06-28
WO2008115840A2 (en) 2008-09-25
ES2625439T3 (es) 2017-07-19
JP2013240359A (ja) 2013-12-05
BRPI0808988A2 (pt) 2011-11-08
US20130196397A1 (en) 2013-08-01
CA2678946A1 (en) 2008-09-25
US20170088840A1 (en) 2017-03-30
ES2527867T3 (es) 2015-01-30
BRPI0823327A2 (pt) 2013-10-22
JP2018046861A (ja) 2018-03-29
US9487803B2 (en) 2016-11-08
US20120122171A1 (en) 2012-05-17
US8969054B2 (en) 2015-03-03
CN101668861A (zh) 2010-03-10
TWI568847B (zh) 2017-02-01
TW201527529A (zh) 2015-07-16
AU2008229076A1 (en) 2008-09-25
JP5551448B2 (ja) 2014-07-16
JP2022023169A (ja) 2022-02-07
HUE032465T2 (en) 2017-09-28
US8889399B2 (en) 2014-11-18
LT2821494T (lt) 2017-04-25
JP2020072661A (ja) 2020-05-14
US8067214B2 (en) 2011-11-29

Similar Documents

Publication Publication Date Title
US20230134936A1 (en) Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
EP2679676B1 (en) Methods and organisms for the growth-coupled production of 1,4-butanediol
JP2010521182A5 (enExample)
AU2013204038B2 (en) Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130313