JP5548983B2 - 組換えゼラチン - Google Patents

組換えゼラチン Download PDF

Info

Publication number
JP5548983B2
JP5548983B2 JP2009550597A JP2009550597A JP5548983B2 JP 5548983 B2 JP5548983 B2 JP 5548983B2 JP 2009550597 A JP2009550597 A JP 2009550597A JP 2009550597 A JP2009550597 A JP 2009550597A JP 5548983 B2 JP5548983 B2 JP 5548983B2
Authority
JP
Japan
Prior art keywords
gelatin
recombinant gelatin
cell
seq
recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009550597A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010519251A5 (enExample
JP2010519251A (ja
Inventor
デ・ボーア，アルジョ・リサンダー
ヴァン・ユルク，ヘンドリク
ヴァン・アステン，ペーター・フランシスクス・テレシウス・マリア
ボウストラ，ジャン・バスティアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07102839A external-priority patent/EP1961414A1/en
Priority claimed from EP07102838A external-priority patent/EP1961411A1/en
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of JP2010519251A publication Critical patent/JP2010519251A/ja
Publication of JP2010519251A5 publication Critical patent/JP2010519251A5/ja
Application granted granted Critical
Publication of JP5548983B2 publication Critical patent/JP5548983B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009550597A 2007-02-21 2008-02-21 組換えゼラチン Active JP5548983B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP07102838.5 2007-02-21
EP07102839A EP1961414A1 (en) 2007-02-21 2007-02-21 A controlled release composition comprising a recombinant gelatin
EP07102838A EP1961411A1 (en) 2007-02-21 2007-02-21 A controlled release composition
EP07102839.3 2007-02-21
EP07116189.7 2007-09-12
EP07116193 2007-09-12
EP07116189 2007-09-12
EP07116193.9 2007-09-12
EP08100556.3 2008-01-16
EP08100556 2008-01-16
PCT/NL2008/050098 WO2008103041A1 (en) 2007-02-21 2008-02-21 Recombinant gelatins

Publications (3)

Publication Number Publication Date
JP2010519251A JP2010519251A (ja) 2010-06-03
JP2010519251A5 JP2010519251A5 (enExample) 2011-02-03
JP5548983B2 true JP5548983B2 (ja) 2014-07-16

Family

ID=39503383

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009550597A Active JP5548983B2 (ja) 2007-02-21 2008-02-21 組換えゼラチン
JP2009550598A Active JP5349335B2 (ja) 2007-02-21 2008-02-21 高い安定性を有する組換えｘｒｇｄ富化ゼラチン
JP2009550599A Active JP5349336B2 (ja) 2007-02-21 2008-02-21 Ｒｇｄを含有する組換えゼラチン
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009550598A Active JP5349335B2 (ja) 2007-02-21 2008-02-21 高い安定性を有する組換えｘｒｇｄ富化ゼラチン
JP2009550599A Active JP5349336B2 (ja) 2007-02-21 2008-02-21 Ｒｇｄを含有する組換えゼラチン
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン

Country Status (5)

Country Link
US (5) US8158756B2 (enExample)
EP (4) EP2121749B1 (enExample)
JP (4) JP5548983B2 (enExample)
AT (2) ATE551364T1 (enExample)
WO (4) WO2008103041A1 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2121749B1 (en) * 2007-02-21 2013-07-03 FUJIFILM Manufacturing Europe B.V. Recombinant gelatins
US20100273215A1 (en) * 2007-12-21 2010-10-28 Anna Cornelia Hendrika Van Hautum Secretion Yield of a Protein of Interest by in vivo Proteolytic Processing of a Multimeric Precursor
JP2011518782A (ja) * 2008-04-10 2011-06-30 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ ヘパリン結合部位および／またはヘパラン硫酸結合部位を富化した組換えタンパク質
EP2310060B1 (en) * 2008-07-04 2013-02-27 Fujifilm Manufacturing Europe BV Coating method for medical devices
EP2344593A2 (en) * 2008-10-02 2011-07-20 Fujifilm Manufacturing Europe BV Antimicrobial coating
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
EP2428215B1 (en) 2009-05-07 2017-10-18 FUJIFILM Corporation Recombinant gelatin for use in the treatment of ischemic and heart disease and others
WO2010143708A1 (ja) * 2009-06-12 2010-12-16 富士フイルム株式会社 新生血管に対する標的化剤
WO2010147109A1 (ja) * 2009-06-15 2010-12-23 富士フイルム株式会社 遺伝子組み換えゼラチン及び塩基性線維芽細胞増殖因子を含む血管新生誘導剤
US20120196807A1 (en) * 2009-07-30 2012-08-02 Fujifilm Corporation Kidney-targeting drug delivery agent comprising recombinant gelatin
US9259485B2 (en) 2009-07-30 2016-02-16 Fujifilm Corporation Kidney-imaging agent comprising recombinant gelatin
CN102625717B (zh) * 2009-09-04 2016-03-16 富士胶片株式会社 包含明胶的骨再生剂
WO2011060583A1 (zh) * 2009-11-19 2011-05-26 浙江大学 非天然的胶原样蛋白及其应用
GB0921460D0 (en) 2009-12-08 2010-01-20 Fujifilm Mfg Europe Bv Anti-fibrotic hydrogel compositions
EP2522366B1 (en) * 2010-01-08 2018-10-31 FUJIFILM Corporation Targeting agent for tumor site
CN102858381B (zh) 2010-03-01 2015-09-30 富士胶片株式会社 包括具有生物相容性的聚合物块和细胞的细胞构建体
US9101686B2 (en) 2010-03-02 2015-08-11 Fujifilm Corporation Cell support and bone regeneration material
GB201008404D0 (en) 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
GB201014388D0 (en) 2010-08-31 2010-10-13 Fujifilm Mfg Europe Bv Biocompatible compositions for tissue augmentation
GB201018044D0 (en) 2010-10-26 2010-12-08 Fujifilm Mfg Europe Bv Non-natural gelatin-like proteins with enhanced functionality
JP5847418B2 (ja) * 2011-03-30 2016-01-20 富士フイルム株式会社 細胞接着性タンパク質
US20120263681A1 (en) * 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
JP2012244909A (ja) * 2011-05-25 2012-12-13 Nagoya City Univ 組み換え蛋白質の製造方法及び蛋白質の導入方法
JP5990298B2 (ja) * 2011-08-31 2016-09-14 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5876787B2 (ja) 2011-08-31 2016-03-02 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5808631B2 (ja) 2011-09-29 2015-11-10 富士フイルム株式会社 血管新生用足場、及び再生医療用の血管の製造方法
GB201119173D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
GB201119182D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
JP5902112B2 (ja) 2012-03-12 2016-04-13 富士フイルム株式会社 骨組織修復材の製造方法
CN104662040B (zh) 2012-09-26 2018-01-30 富士胶片株式会社 多肽、支架组合物、软骨组织修复用组合物、软骨细胞培养用组合物及糖胺聚糖产生促进用组合物
JPWO2014115732A1 (ja) * 2013-01-25 2017-01-26 富士フイルム株式会社 移植用人工真皮およびその製造方法
WO2014133081A1 (ja) 2013-02-27 2014-09-04 富士フイルム株式会社 細胞移植用細胞構造体、生体親和性高分子ブロック及びそれらの製造方法
ES2711672T3 (es) 2013-03-12 2019-05-06 Fujifilm Corp Material para reparación de tejidos
GB201304947D0 (en) * 2013-03-18 2013-05-01 Cass Anthony E G Biomimetic collagen
EP3050580B1 (en) 2013-09-25 2020-02-19 FUJIFILM Corporation Method for producing biocompatible macromolecular porous body, biocompatible macromolecular porous body, biocompatible macromolecular block and cell structure
JP6330042B2 (ja) 2014-06-16 2018-05-23 富士フイルム株式会社 脳損傷治療用細胞構造体、その製造方法、及び脳損傷治療剤
CN107735405B (zh) 2015-06-25 2022-04-08 克拉根制药株式会社 具有胶原模拟肽结构的聚合肽和凝胶
EP3348384B1 (en) 2015-09-11 2023-06-28 FUJIFILM Corporation Method for producing gelatin structure, and gelatin structure production system
EP3397753B1 (en) 2015-12-30 2021-10-27 FUJIFILM Cellular Dynamics, Inc. Microtissue formation using stem cell-derived human hepatocytes
WO2017170487A1 (ja) * 2016-03-28 2017-10-05 富士フイルム株式会社 製剤、製剤用部材およびそれらの製造方法
WO2017170342A1 (ja) * 2016-03-29 2017-10-05 富士フイルム株式会社 細胞シート包埋剤、細胞シート含有組成物およびキット
EP3438246B1 (en) * 2016-03-29 2020-08-26 FUJIFILM Corporation Laminate containing cell sheet, agent for treating cardiac diseases, and film for being laminated on cell sheet
JPWO2017200039A1 (ja) * 2016-05-19 2019-03-22 富士フイルム株式会社 細胞培養方法、培地及び培地キット
JP6728350B2 (ja) 2016-05-30 2020-07-22 富士フイルム株式会社 リン酸カルシウム成形体の製造方法、リン酸カルシウム成形体及び移植用材料
WO2017213170A1 (ja) 2016-06-08 2017-12-14 富士フイルム株式会社 ゼラチン成形体の製造方法及びゼラチン成形体
WO2018159797A1 (ja) * 2017-03-02 2018-09-07 富士フイルム株式会社 細胞塊または細胞構造体の包埋剤、細胞塊または細胞構造体含有組成物およびキット
WO2018169061A1 (ja) 2017-03-16 2018-09-20 富士フイルム株式会社 巨核球と血小板とを分離する方法および巨核球と血小板とを分離するための器具
WO2018169065A1 (ja) 2017-03-17 2018-09-20 富士フイルム株式会社 細胞構造体の製造方法
WO2018207923A1 (ja) 2017-05-12 2018-11-15 富士フイルム株式会社 間葉系幹細胞の製造方法、およびその応用
WO2019004446A1 (ja) 2017-06-30 2019-01-03 富士フイルム株式会社 ライソゾーム病処置剤
CN111050815B (zh) 2017-08-30 2022-06-10 富士胶片株式会社 血管新生剂及其制造方法
EP3677287B1 (en) 2017-08-30 2024-05-29 FUJIFILM Corporation Cell transplantation device and method for manufacturing same
KR102476632B1 (ko) * 2017-11-06 2022-12-09 후지필름 가부시키가이샤 진주 양식용 재료 및 코팅용 조성물
WO2019093468A1 (ja) 2017-11-10 2019-05-16 富士フイルム株式会社 間葉系幹細胞からインスリン産生細胞を製造する方法、インスリン産生細胞、細胞構造体および医薬組成物
WO2019151205A1 (ja) * 2018-01-30 2019-08-08 富士フイルム株式会社 フィブリン組成物、再生医療用基材、フィブリン組成物の製造方法およびキット
WO2020050205A1 (ja) 2018-09-03 2020-03-12 富士フイルム株式会社 ゲル形成キット、ゲルおよびゲルの製造方法
JP6906713B2 (ja) * 2018-10-12 2021-07-21 富士フイルム株式会社 真珠養殖用材料、挿核方法及び真珠養殖用材料組成物
EP4005597A4 (en) 2019-07-26 2022-11-30 FUJIFILM Corporation BIOGRAFT MATERIAL
WO2021039610A1 (ja) 2019-08-23 2021-03-04 富士フイルム株式会社 ミクロカプセルと細胞構造体とを含む組成物
WO2021241409A1 (ja) 2020-05-25 2021-12-02 富士フイルム株式会社 組成物、シート状成形体、人工皮革およびシート状成形体の製造方法
GB2596525A (en) * 2020-06-26 2022-01-05 Fujifilm Corp Modified gelatins
JPWO2022202632A1 (enExample) 2021-03-24 2022-09-29
CN117043535A (zh) 2021-03-26 2023-11-10 富士胶片株式会社 冷冻干燥用容器
JPWO2022202633A1 (enExample) 2021-03-26 2022-09-29
WO2022210204A1 (ja) 2021-03-31 2022-10-06 富士フイルム株式会社 粉砕方法、高分子ブロック製造方法及び粉砕装置
US20250163389A1 (en) 2021-08-02 2025-05-22 Rainbow Inc. Method for storing or transporting stem cells in unfrozen state
WO2023053710A1 (ja) 2021-09-30 2023-04-06 富士フイルム株式会社 組織修復材キット及び組織修復方法
JPWO2023188492A1 (enExample) 2022-03-30 2023-10-05
CN121263531A (zh) 2023-06-06 2026-01-02 富士胶片株式会社 基因重组酵母、目标蛋白质的制造方法、试剂盒及基因重组酵母的制造方法
WO2025122874A1 (en) * 2023-12-08 2025-06-12 Bolt Threads, Inc. Recombinant silk polypeptides and compositions made thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US58703A (en) * 1866-10-09 Improved mop-head
US196496A (en) * 1877-10-23 Improvement in elevator-cups
US143568A (en) * 1873-10-14 Improvement in stays for ships sails
US237663A (en) * 1881-02-08 Hydrocarbon-gas generator
US204551A (en) * 1878-06-04 Improvement in bee-hives
US28243A (en) * 1860-05-08 williams
US229264A (en) * 1880-06-29 Recovering soda from spent liquors after treating vegetable fiber
US24361A (en) * 1859-06-07 Jacob j
US68013A (en) * 1867-08-20 Es ait t aeeaft
US274957A (en) * 1883-04-03 Punch for nut-machines
US31501A (en) * 1861-02-19 Fracture apparatus
US121609A (en) * 1871-12-05 Improvement in tremolos for reed organs
US177492A (en) * 1876-05-16 Improvement in anchors
US147690A (en) * 1874-02-17 Improvement in belt-fastenings
US7991A (en) * 1851-03-18 Of beehives
US251719A (en) * 1882-01-03 Crucible
US106410A (en) * 1870-08-16 William f
US64074A (en) * 1867-04-23 Thesraphic oo
US114078A (en) * 1871-04-25 Improvement in valves and steam-chests for engines
US9580A (en) * 1853-02-08 Improvement in gas-meters
US24346A (en) * 1859-06-07 Lock attachment
US4034A (en) * 1845-05-07 Improvement in machines for breaking and cleaning hemp
US107666A (en) * 1870-09-27 Improvement in rollers for sewing-machines
US167446A (en) * 1875-09-07 Improvement in refrigerators
US190153A (en) * 1877-05-01 Improvement in processes of making shoes
US241032A (en) * 1881-05-03 Machine for making curved lead pipe
US147501A (en) * 1874-02-17 Improvement in eooklnq-stoves
US113910A (en) * 1871-04-18 Improvement in door-locks
US208141A (en) * 1878-09-17 Improvement in harvester guard-fingers
US119170A (en) * 1871-09-19 Improvement in harvester-cutters
US4855134A (en) * 1983-10-14 1989-08-08 Sumitomo Pharmaceuticals Company, Limited Sustained-release preparation
IL78826A (en) 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US5002769A (en) * 1987-03-13 1991-03-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for the sustained-release of chlorhexidine
US4994388A (en) 1988-04-15 1991-02-19 Solohill Engineering, Inc. Collagen-coated polystyrene microcarrier beads
EP0406357B1 (en) * 1988-11-09 1998-01-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
IL95500A (en) * 1989-09-11 1997-03-18 Matrix Pharma ANTI-PROLIFERATIVE COMPOSITIONS CONTAINING TGF-b PROTEIN IN A VISCOUS MATRIX AND THEIR USE
EP0670848B1 (en) * 1991-11-12 2004-02-04 Protein Polymer Technologies, Inc. High molecular weight collagen-like protein polymers
DE4140192C2 (de) * 1991-12-05 1996-02-29 Alfatec Pharma Gmbh Sol-gesteuerte Thermokolloidmatrix auf Gelatinebasis für perorale Retardformen
DE4210334A1 (de) * 1992-03-30 1993-10-07 Stoess & Co Gelatine Biologisch abbaubares, wasserresistentes Polymer-Material
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
US5512474A (en) 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
ATE203913T1 (de) 1993-05-31 2001-08-15 Kaken Pharma Co Ltd Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
IL109539A0 (en) * 1994-05-03 1994-08-26 Yissum Res Dev Co Substained-release pharmaceutical system for the delivery of antioxidants
PT986408E (pt) 1997-06-03 2005-09-30 Innogenetics Nv Novos medicamentos baseados em polimeros compostos por gelatina modificada com metacrilamida
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
NL1007908C2 (nl) * 1997-12-24 1999-06-25 Fuji Photo Film Bv Zilverhalide-emulsies met recombinant collageen die geschikt zijn voor fotografische toediening alsmede de bereiding daarvan.
US6150081A (en) * 1997-12-24 2000-11-21 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US20050147690A1 (en) 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
DE69940802D1 (de) 1998-12-23 2009-06-10 Fujifilm Mfg Europe Bv Silberhalogenidemulsionen, die rekombinante gelatineartige Proteine enthalten
CA2388477C (en) 1999-11-12 2014-01-21 Fibrogen, Inc. Recombinant gelatins with uniform molecular weight
US6992172B1 (en) 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
US20030118598A1 (en) 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
EP1238675A1 (en) 2001-03-06 2002-09-11 Fuji Photo Film B.V. Recombinant gelatin-like proteins for use as plasma expanders
US20060024346A1 (en) 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
US7067150B2 (en) * 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
US20070196496A1 (en) 2002-04-16 2007-08-23 Michael Farber Delivery systems for functional ingredients
JP4723862B2 (ja) 2002-12-23 2011-07-13 フジフィルム マニュファクチャリング ユーロプ ビー．ブイ． 細胞培養支持体を被覆する方法
US20060147501A1 (en) * 2003-02-28 2006-07-06 Hillas Patrick J Collagen compositions and biomaterials
JP4459543B2 (ja) 2003-03-17 2010-04-28 株式会社メドジェル 徐放性ハイドロゲル製剤
ATE452649T1 (de) * 2003-03-28 2010-01-15 Fuji Film Mfg Europ B V Rgd-angereicherte, gelatine-ähnliche proteine zur verhinderung der zelladhäsion
US20050058703A1 (en) * 2003-08-01 2005-03-17 Chang Robert C. Gelatin capsules
WO2005011740A1 (en) 2003-08-05 2005-02-10 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions
WO2005011739A1 (en) * 2003-08-05 2005-02-10 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin as a stabiliser in vaccines
WO2005072223A2 (en) * 2004-01-23 2005-08-11 California Institute Of Technology Engineered proteins, and methods of making and using
JP2005211477A (ja) 2004-01-30 2005-08-11 Gunze Ltd 再生医療用支持体
WO2005079879A1 (ja) 2004-02-25 2005-09-01 Ihara & Company Ltd. コラーゲンゲルおよびその製造方法
US20070190153A1 (en) * 2004-03-05 2007-08-16 Jonathan Farber Delivery systems for non-steroidal anti-inflammatory drugs (nsaids)
JP2008504912A (ja) 2004-06-30 2008-02-21 コヴァロン テクノロジーズ リミテッド 非接着性ヒドロゲル
US20060024361A1 (en) 2004-07-28 2006-02-02 Isa Odidi Disintegrant assisted controlled release technology
CA2581328A1 (en) 2004-09-21 2006-03-30 Massachusetts Institute Of Technology Gradient scaffolding and methods of producing the same
UA88321C2 (ru) * 2004-09-30 2009-10-12 Ковалон Текнолоджиз Инк. Неадгезивные эластичные желатиновые матрицы
DE602006015289D1 (de) 2005-02-23 2010-08-19 Fujifilm Mfg Europe Bv Nicht-glycosylierte rekombinante collagen-ähnliche polypeptide
US8435542B2 (en) * 2005-03-03 2013-05-07 Takasago International Corp. (Usa) Synergistic salivation agents
EP1801122A1 (en) 2005-12-23 2007-06-27 FUJIFILM Manufacturing Europe B.V. Recombinant gelatin particles for cell adhesion
EP2121749B1 (en) * 2007-02-21 2013-07-03 FUJIFILM Manufacturing Europe B.V. Recombinant gelatins

Also Published As

Publication number Publication date
EP2121749B1 (en) 2013-07-03
US20100119574A1 (en) 2010-05-13
JP2010518833A (ja) 2010-06-03
WO2008103043A8 (en) 2009-07-23
WO2008103041A1 (en) 2008-08-28
JP5548984B2 (ja) 2014-07-16
JP5349336B2 (ja) 2013-11-20
JP2010519252A (ja) 2010-06-03
EP2112997B1 (en) 2012-08-01
WO2008103042A1 (en) 2008-08-28
US8173776B1 (en) 2012-05-08
US8158756B2 (en) 2012-04-17
US20100075902A1 (en) 2010-03-25
WO2008103044A8 (en) 2010-03-04
JP5349335B2 (ja) 2013-11-20
EP2112998A1 (en) 2009-11-04
WO2008103041A8 (en) 2009-07-23
ATE554103T1 (de) 2012-05-15
EP2112998B1 (en) 2012-04-18
ATE551364T1 (de) 2012-04-15
JP2010519251A (ja) 2010-06-03
EP2112999A1 (en) 2009-11-04
JP2010519293A (ja) 2010-06-03
EP2112999B1 (en) 2012-03-28
EP2121749A1 (en) 2009-11-25
US8349588B2 (en) 2013-01-08
WO2008103044A1 (en) 2008-08-28
US8198047B2 (en) 2012-06-12
US20100105618A1 (en) 2010-04-29
US20100062531A1 (en) 2010-03-11
US8349589B2 (en) 2013-01-08
US20120107372A1 (en) 2012-05-03
WO2008103043A1 (en) 2008-08-28
WO2008103042A8 (en) 2009-07-23
EP2112997A1 (en) 2009-11-04

Similar Documents

Publication Publication Date Title
JP5548983B2 (ja) 組換えゼラチン
US7598347B2 (en) RGD-enriched gelatines
US7803771B2 (en) Recombinant gelatin particles for cell adhesion

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101203

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101203

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121217

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130312

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130722

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131017

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140402

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20140404

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140430

R150 Certificate of patent or registration of utility model

Ref document number: 5548983

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250