ATE203913T1 - Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält - Google Patents

Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält

Info

Publication number
ATE203913T1
ATE203913T1 AT94916430T AT94916430T ATE203913T1 AT E203913 T1 ATE203913 T1 AT E203913T1 AT 94916430 T AT94916430 T AT 94916430T AT 94916430 T AT94916430 T AT 94916430T AT E203913 T1 ATE203913 T1 AT E203913T1
Authority
AT
Austria
Prior art keywords
cross
growth factor
linked gelatin
fibroblasts
gel preparation
Prior art date
Application number
AT94916430T
Other languages
English (en)
Inventor
Yoshito Ikada
Yasuhiko Tabata
Shigeki Hijikata
Makoto Tamura
Original Assignee
Kaken Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharma Co Ltd filed Critical Kaken Pharma Co Ltd
Application granted granted Critical
Publication of ATE203913T1 publication Critical patent/ATE203913T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1658Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2063Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT94916430T 1993-05-31 1994-05-31 Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält ATE203913T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15274993 1993-05-31
PCT/JP1994/000876 WO1994027630A1 (fr) 1993-05-31 1994-05-31 Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base

Publications (1)

Publication Number Publication Date
ATE203913T1 true ATE203913T1 (de) 2001-08-15

Family

ID=15547330

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94916430T ATE203913T1 (de) 1993-05-31 1994-05-31 Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält

Country Status (6)

Country Link
US (1) US6831058B1 (de)
EP (1) EP0702959B1 (de)
JP (1) JP3639593B2 (de)
AT (1) ATE203913T1 (de)
DE (1) DE69427908T2 (de)
WO (1) WO1994027630A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
JP2011046749A (ja) * 1996-08-27 2011-03-10 Baxter Internatl Inc 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
AU736784B2 (en) * 1997-06-03 2001-08-02 Celltran Limited New medicaments based on polymers composed of methacrylamide-modified gelatin
AU7449500A (en) 1999-09-30 2001-04-30 Kaken Pharmaceutical Co., Ltd. Method to enhance healing of sternum after sternotomy
CA2389056C (en) * 1999-10-26 2011-08-16 Kaken Pharmaceutical Co., Ltd. Vessel embolic material comprising hydrogel and method of treatment using the same
WO2002019887A2 (en) * 2000-09-05 2002-03-14 Technion Research And Development Foundation Ltd. Methods of repairing longitudinal bone defects
JP2003238439A (ja) * 2002-02-13 2003-08-27 Yasuhiko Tabata 虚血治療剤
CA2481214A1 (en) * 2002-04-01 2003-10-09 Kaken Pharmaceutical Co., Ltd. Viscous preparation for dental use containing basic fibroblast growth factor
JP2004115413A (ja) * 2002-09-25 2004-04-15 Yasuhiko Tabata 冠状動脈狭窄または閉塞治療用徐放性製剤
JP2004123576A (ja) * 2002-09-30 2004-04-22 Medgel Corp 多血小板血漿を含有する徐放性製剤
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
JP4578067B2 (ja) * 2003-06-06 2010-11-10 宏 清水 局所医薬組成物
CN1809563A (zh) * 2003-06-20 2006-07-26 希龙公司 吡啶并[1,2-a]嘧啶-4-酮化合物用作抗癌药
US7927626B2 (en) 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
JP4532092B2 (ja) * 2003-09-30 2010-08-25 泰彦 田畑 血管新生剤
CA2542041C (en) * 2003-10-10 2014-12-09 Cellular Bioengineering, Inc. Methods and compositions for growing corneal endothelial and related cells on biopolymers and creation of artifical corneal transplants
JP2005218780A (ja) * 2004-02-09 2005-08-18 Menicon Co Ltd 薬物放出速度を制御し得る薬物徐放可能なヒドロゲル材料の製造方法
WO2005087257A1 (ja) * 2004-03-16 2005-09-22 Kaken Pharmaceutical Co., Ltd. 架橋ゼラチンゲルを担体とする軟骨組織修復治療剤
JPWO2005097166A1 (ja) * 2004-04-09 2008-02-28 二郎 中村 ゼラチンゲルを担体とする糖尿病性神経障害治療剤
JP2005325075A (ja) * 2004-05-14 2005-11-24 Yasuhiko Tabata 架橋ゼラチンゲルを担体とする半月板損傷治療剤
JP4685090B2 (ja) * 2005-02-14 2011-05-18 株式会社メドジェル 医療用ハイドロゲル
EP1952821B1 (de) * 2005-10-19 2013-02-20 Osaka University Therapeutisches mittel zur regeneration des dentin-pulpa-komplexes
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
AU2007267338B2 (en) 2006-05-31 2013-04-04 Baxter Healthcare S.A. Method for directed cell in-growth and controlled tissue regeneration in spinal surgery
EP2052740A4 (de) * 2006-08-01 2009-11-11 Nichiban Kk Vernetzte mehrschichtige gelatinegelstruktur, träger für einen bioaktiven faktor, zubereitung zur freisetzung des bioaktiven faktors und herstellungsverfahren dafür
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
WO2008047904A1 (fr) * 2006-10-20 2008-04-24 National University Corporation Nagoya University Agent thérapeutique pour vasculopathie périphérique oblitérante et utilisation
JPWO2008072379A1 (ja) * 2006-12-13 2010-03-25 富士フイルム株式会社 修飾された生体高分子の製造方法及び生体高分子の架橋方法
JP5047603B2 (ja) * 2006-12-15 2012-10-10 エア・ウォーター株式会社 ゼラチン成形物およびその製造方法
EP1961414A1 (de) * 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. Rekombinante Gelatine enthaltende Zusammensetzung mit gesteuerter Freisetzung
EP1961411A1 (de) * 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. Zusammensetzung mit gesteuerter Freisetzung
EP2121749B1 (de) 2007-02-21 2013-07-03 FUJIFILM Manufacturing Europe B.V. Rekombinante gelatinen
DE102007051059B4 (de) * 2007-10-18 2014-04-03 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen
US8790698B2 (en) 2007-10-30 2014-07-29 Baxter International Inc. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
EP2218459B1 (de) 2007-11-07 2012-02-01 Ono Pharmaceutical Co., Ltd. Sdf-1 enthaltende zusammensetzung mit anhaltender freisetzung
JP5569398B2 (ja) 2008-02-29 2014-08-13 フェッローサン メディカル ディバイス エー/エス 止血および/または創傷治癒を促進するための装置
JP5351183B2 (ja) * 2009-02-05 2013-11-27 ニチバン株式会社 照射架橋水溶性高分子粒子及び照射架橋ゼラチン粒子の製造方法
EP2428215B1 (de) * 2009-05-07 2017-10-18 FUJIFILM Corporation Rekombinante Gelatine zur Verwendung in der Behandlung von ischämischen und Herzerkrankungen und anderen
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
AU2010262058B2 (en) 2009-06-16 2013-08-29 Baxter Healthcare S.A. Hemostatic sponge
WO2011010399A1 (ja) * 2009-07-24 2011-01-27 千寿製薬株式会社 角膜内皮細胞増殖促進剤
WO2011052089A1 (ja) * 2009-11-02 2011-05-05 ニチバン株式会社 電離性放射線で架橋したヒドロゲルから成る生体内薬剤徐放用担体材料及びその製造方法
CN102597230A (zh) * 2009-11-13 2012-07-18 株式会社日立高新技术 含有粒子的细胞聚集体
JP2013514093A (ja) 2009-12-16 2013-04-25 バクスター・インターナショナル・インコーポレイテッド 止血スポンジ
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
WO2011151386A1 (en) 2010-06-01 2011-12-08 Baxter International Inc. Process for making dry and stable hemostatic compositions
ES2682302T3 (es) 2010-06-01 2018-09-19 Baxter International Inc Proceso para la producción de composiciones hemostáticas secas y estables
MX344402B (es) 2010-06-01 2016-12-14 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
MX356185B (es) 2011-10-11 2018-05-17 Baxter Int Composiciones hemostaticas.
EP2766058B1 (de) 2011-10-11 2022-11-23 Baxter International Inc. Hämostatische zusammensetzungen
CN103889447B (zh) 2011-10-27 2015-11-25 巴克斯特国际公司 止血组合物
RU2657955C2 (ru) 2012-03-06 2018-06-18 Ферросан Медикал Дивайсиз А/С Контейнер под давлением, содержащий гемостатическую пасту
CA2874290C (en) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Dry haemostatic composition
US9347037B2 (en) * 2013-02-11 2016-05-24 Evan Masataka Masutani Methods and apparatus for building complex 3D scaffolds and biomimetic scaffolds built therefrom
JP6339062B2 (ja) * 2013-02-15 2018-06-06 国立大学法人高知大学 ハイドロゲルを担体として過酸化水素を徐放する腫瘍内局注用の放射線/化学療法増感剤
WO2014202760A2 (en) 2013-06-21 2014-12-24 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3079731B1 (de) 2013-12-11 2018-08-08 Ferrosan Medical Devices A/S Trockenzusammensetzung mit extrusionsverstärker
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
RU2705905C2 (ru) 2014-12-24 2019-11-12 Ферросан Медикал Дивайсиз А/С Шприц для удерживания и смешивания первого и второго веществ
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
CN108495709B (zh) * 2016-01-25 2021-09-03 三得利控股株式会社 含有功能性物质的胶囊及其制造方法
CN109069654A (zh) * 2016-03-28 2018-12-21 富士胶片株式会社 制剂、制剂用部件及它们的制造方法
CN112368028A (zh) 2018-05-09 2021-02-12 弗罗桑医疗设备公司 用于制备止血组合物的方法
JP2023015416A (ja) * 2019-12-27 2023-02-01 Eaファーマ株式会社 瘻孔治療用材料

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923969A (en) * 1973-06-12 1975-12-02 Battelle Institut E V Carrier system for a drug with sustained release
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
MX163953B (es) * 1984-03-27 1992-07-03 Univ New Jersey Med Procedimiento para preparar una matriz biodegradable a base de colageno
JPH0759522B2 (ja) * 1985-12-27 1995-06-28 住友製薬株式会社 徐放性製剤の製造法
JP2587219B2 (ja) * 1986-06-10 1997-03-05 エーザイ株式会社 溶解遅延性のゼラチン製剤組成物
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
US5164410A (en) * 1988-01-09 1992-11-17 Takeda Chemical Industries, Ltd. Fumagillol derivatives and pharmaceutical compositions thereof
JPH01282394A (ja) 1988-05-10 1989-11-14 Toshiba Corp 電動機の張力制御装置
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
JPH0249734A (ja) * 1988-08-12 1990-02-20 Wakunaga Pharmaceut Co Ltd 新規組成物
US5202311A (en) * 1988-08-19 1993-04-13 Children's Medical Center Corporation Stabilized fgf composition
US5298243A (en) * 1988-10-20 1994-03-29 Denki Kagaku Kogyo Kabushiki Kaisha Colony stimulating factor-gelatin conjugate
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
CA2020654A1 (en) * 1989-07-07 1991-01-08 Yohko Akiyama Stabilized fgf composition and production thereof
GB9014871D0 (en) * 1990-07-05 1990-08-22 Erba Carlo Spa Drug delivery system for administering growth factor
JP3135138B2 (ja) * 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
JPH05132426A (ja) * 1991-02-15 1993-05-28 Takeda Chem Ind Ltd 骨組織の形成促進剤
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5656598A (en) * 1994-03-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Use of fibroblast growth factors to stimulate bone growth
WO1995024211A1 (en) * 1994-03-08 1995-09-14 Osteosa, Inc. Use of fibroblast growth factors to stimulate bone growth

Also Published As

Publication number Publication date
WO1994027630A1 (fr) 1994-12-08
US6831058B1 (en) 2004-12-14
EP0702959B1 (de) 2001-08-08
EP0702959A1 (de) 1996-03-27
DE69427908T2 (de) 2001-11-22
DE69427908D1 (de) 2001-09-13
EP0702959A4 (de) 1996-11-27
JP3639593B2 (ja) 2005-04-20

Similar Documents

Publication Publication Date Title
ATE203913T1 (de) Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
DE69414626D1 (de) Helle Haarpflegezusammensetzung
ES2168414T3 (es) Formulaciones de retinoides en microesferas porosas de irritacion reducida y estabilidad aumentada.
CA2047154A1 (en) Hair dye composition and its application method
DE19775083I2 (de) 7-Piperazinyl-oder 7-Morpholino-4-oxo-chinolin-3-carbonsaeurederivate ihre Herstellung und ihre Verwendung als antimikrobielle Mittel
PT871476E (pt) Composicao seca de factor sanguineo compreendendo trealose
ES2164691T3 (es) Formulacion de insulina.
DE3590594T1 (de)
FI905003A0 (fi) Glykosaminoglykan modifierat protein.
MX9304710A (es) Composicion farmaceutica y/o cosmetica y su uso.
CA2006386A1 (en) Absorbent material
DE3889980D1 (de) Reaktivfarbstoffe, deren Herstellung und Verwendung.
DE68905705D1 (de) Sphaerische phosphoraggregate, ihre herstellung und verwendung in roentgenstrahlschirmen.
PT86153A (de) Optisch aktive gyrasehemmer ihre herstellung und verwendung als antibiotika
NO902104D0 (no) Kosmetisk blanding.
ITRM920384A1 (it) Procedimento per la produzione di leuco coloranti allo zolfo e prodotto ottenuto.
DE3872337D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
DE3862766D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
DE68912083T2 (de) Substituierte Karbonsäuren, ihre Herstellung und Verwendung.
DE3771548D1 (de) Verwendung von carbonsaeure in fuer topische anwendung vorgesehenen pharmazeutischen zubereitungen.
DK181089D0 (da) 1-dimethylcarbamoyl-3-substituerede-5-substituerede-1h-1,2,4-triazoler
DE68905586T2 (de) Benzamidderivate sowie diese enthaltende Pflanzenwachstumsregulatoren.
DE58906370D1 (de) Reaktivfarbstoffe, deren Herstellung und Verwendung.
DE3865033D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
FR2630457B1 (fr) Utilisation de l'acide para-amino-salicylique pour la stabilisation de l'activite enzymatique de la peroxydase en solution, agent stabilisant et solution stabilisee en comportant application

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties