ES2168414T3 - Formulaciones de retinoides en microesferas porosas de irritacion reducida y estabilidad aumentada. - Google Patents

Formulaciones de retinoides en microesferas porosas de irritacion reducida y estabilidad aumentada.

Info

Publication number
ES2168414T3
ES2168414T3 ES96111446T ES96111446T ES2168414T3 ES 2168414 T3 ES2168414 T3 ES 2168414T3 ES 96111446 T ES96111446 T ES 96111446T ES 96111446 T ES96111446 T ES 96111446T ES 2168414 T3 ES2168414 T3 ES 2168414T3
Authority
ES
Spain
Prior art keywords
retinoids
formulations
porous microspheres
increased stability
reduced irritation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96111446T
Other languages
English (en)
Inventor
Michael Froix
Sergio Nacht
Masha Pukshansky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catalent Pharma Solutions LLC
Original Assignee
Catalent Pharma Solutions LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalent Pharma Solutions LLC filed Critical Catalent Pharma Solutions LLC
Application granted granted Critical
Publication of ES2168414T3 publication Critical patent/ES2168414T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE FORMULAN RETINOIDES PARA LA APLICACION CUTANEA TOPICA COMO IMPREGNANTES EN MICROESFERAS POROSAS. DE ESTA FORMA FORMULADOS, LOS RETINOIDES MUESTRAN UN SORPRENDENTEMENTE ALTO NIVEL DE ESTABILIDAD Y BAJO GRADO DE IRRITACION CUTANEO.
ES96111446T 1995-12-29 1996-07-16 Formulaciones de retinoides en microesferas porosas de irritacion reducida y estabilidad aumentada. Expired - Lifetime ES2168414T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/581,126 US5851538A (en) 1995-12-29 1995-12-29 Retinoid formulations in porous microspheres for reduced irritation and enhanced stability

Publications (1)

Publication Number Publication Date
ES2168414T3 true ES2168414T3 (es) 2002-06-16

Family

ID=24323987

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96111446T Expired - Lifetime ES2168414T3 (es) 1995-12-29 1996-07-16 Formulaciones de retinoides en microesferas porosas de irritacion reducida y estabilidad aumentada.

Country Status (11)

Country Link
US (1) US5851538A (es)
EP (1) EP0781551B1 (es)
JP (1) JP2960022B2 (es)
KR (1) KR100262117B1 (es)
AT (1) ATE209032T1 (es)
AU (1) AU697584B2 (es)
CA (1) CA2184433C (es)
DE (1) DE69617181T2 (es)
DK (1) DK0781551T3 (es)
ES (1) ES2168414T3 (es)
PT (1) PT781551E (es)

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US7758888B2 (en) 2000-04-21 2010-07-20 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
US6896890B2 (en) * 2000-05-05 2005-05-24 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing free and entrapped hydroquinone and retinol
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JP4121537B2 (ja) 2004-12-22 2008-07-23 日東電工株式会社 線維化抑制のための薬物担体および薬物担体キット
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JP5342834B2 (ja) * 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
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KR101080186B1 (ko) * 2010-06-21 2011-11-07 주식회사 필라이트솔루션 개량형 ｌｅｄ 조명등
JP5950428B2 (ja) 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
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FR2991177B1 (fr) 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide, de type emulsion huile dans eau sans emulsionnant
FR2991180B1 (fr) * 2012-06-01 2014-06-13 Galderma Res & Dev Compositions topiques de type emulsion sans emulsionnant a base de particules stabilisantes.
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KR101950693B1 (ko) * 2014-07-24 2019-02-21 주식회사 엘지생활건강 레티놀 또는 레티놀 유도체를 함유하는 마이크로니들
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JP6526322B2 (ja) 2015-08-20 2019-06-05 ソル − ゲル テクノロジーズ リミテッド 過酸化ベンゾイルおよびアダパレンを含む局所投与用組成物
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CN113164368B (zh) * 2018-12-04 2023-06-13 株式会社Lg生活健康 高含量和缓释型类维生素a胶囊以及包含其的皱纹改善用组合物
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Also Published As

Publication number Publication date
KR970032851A (ko) 1997-07-22
AU5831096A (en) 1997-07-03
KR100262117B1 (ko) 2000-07-15
EP0781551B1 (en) 2001-11-21
EP0781551A1 (en) 1997-07-02
DE69617181D1 (de) 2002-01-03
CA2184433A1 (en) 1997-06-30
JP2960022B2 (ja) 1999-10-06
AU697584B2 (en) 1998-10-08
CA2184433C (en) 2000-01-18
DK0781551T3 (da) 2002-05-21
DE69617181T2 (de) 2002-06-06
US5851538A (en) 1998-12-22
PT781551E (pt) 2002-04-29
JPH09183722A (ja) 1997-07-15
ATE209032T1 (de) 2001-12-15

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