ATE209032T1 - Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität - Google Patents

Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität

Info

Publication number
ATE209032T1
ATE209032T1 AT96111446T AT96111446T ATE209032T1 AT E209032 T1 ATE209032 T1 AT E209032T1 AT 96111446 T AT96111446 T AT 96111446T AT 96111446 T AT96111446 T AT 96111446T AT E209032 T1 ATE209032 T1 AT E209032T1
Authority
AT
Austria
Prior art keywords
porous microspheres
improved stability
reduced irritation
retinoid formulations
retinoid
Prior art date
Application number
AT96111446T
Other languages
English (en)
Inventor
Michael Froix
Sergio Nacht
Masha Pukshansky
Original Assignee
Enhanced Derm Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enhanced Derm Technologies Inc filed Critical Enhanced Derm Technologies Inc
Application granted granted Critical
Publication of ATE209032T1 publication Critical patent/ATE209032T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96111446T 1995-12-29 1996-07-16 Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität ATE209032T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/581,126 US5851538A (en) 1995-12-29 1995-12-29 Retinoid formulations in porous microspheres for reduced irritation and enhanced stability

Publications (1)

Publication Number Publication Date
ATE209032T1 true ATE209032T1 (de) 2001-12-15

Family

ID=24323987

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96111446T ATE209032T1 (de) 1995-12-29 1996-07-16 Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität

Country Status (11)

Country Link
US (1) US5851538A (de)
EP (1) EP0781551B1 (de)
JP (1) JP2960022B2 (de)
KR (1) KR100262117B1 (de)
AT (1) ATE209032T1 (de)
AU (1) AU697584B2 (de)
CA (1) CA2184433C (de)
DE (1) DE69617181T2 (de)
DK (1) DK0781551T3 (de)
ES (1) ES2168414T3 (de)
PT (1) PT781551E (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2774907B1 (fr) * 1998-02-19 2000-05-12 Luc Dewandre Nouvelle formulation topique a base de retinaldehyde
US6683069B1 (en) 1998-04-02 2004-01-27 Regents Of The University Of Michigan Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin
TWI234455B (en) * 1998-04-02 2005-06-21 Univ Michigan Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin
US6228894B1 (en) 1998-04-17 2001-05-08 Enhanced Derm Technologies, Inc. Softgel-compatible composition containing retinol
US5891470A (en) * 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol
BR9803936A (pt) 1998-09-08 2000-04-04 Cosmeticos Natural Ind Com Processo e composição para aumentar a ação de vitamina a na atividade celular de um indivìduo e uso de vitamina c.
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US7758888B2 (en) 2000-04-21 2010-07-20 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
CA2406008C (en) 2000-04-21 2011-03-15 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
AU2001257534A1 (en) * 2000-05-05 2001-11-20 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing hydroquinone and retinol
US6896890B2 (en) * 2000-05-05 2005-05-24 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing free and entrapped hydroquinone and retinol
US6896905B2 (en) 2001-02-15 2005-05-24 Rohm And Haas Company Porous particles, their aqueous dispersions, and method of preparation
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
EP1304161B1 (de) * 2001-10-19 2007-02-28 Pacific Corporation Thermotropische, flüssigkristalline, polymerische Mikrokapseln, ihr Herstellungsverfahren sowie kosmetische Zubereitungen
US6524606B1 (en) 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20030232091A1 (en) * 2002-06-17 2003-12-18 Adi Shefer Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
WO2004037305A1 (en) * 2002-10-21 2004-05-06 Allegiance Corporation Coating composition for skin-contacting surface of elastomeric articles and articles containing the same
CN100462070C (zh) * 2003-06-30 2009-02-18 于美丽 一种维甲酸控释纳米微球及其制备方法
US20050002996A1 (en) * 2003-07-02 2005-01-06 Milan Sojka Sustained release compositions and controlled delivery method
WO2005055987A1 (en) * 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER
WO2005055986A1 (en) * 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research Taste masked pharmaceutical composition comprising ph sensitive polymer
AU2004325469B2 (en) * 2004-12-10 2009-02-05 Council Of Scientific And Industrial Research Pharmaceutical composition for improving palatability of drugs and process for preparation thereof
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
JP2009221164A (ja) 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
ES2784554T3 (es) 2004-12-22 2020-09-28 Nitto Denko Corp Portador de fármacos y kit de portador de fármacos para inhibir la fibrosis
WO2007015243A2 (en) * 2005-08-02 2007-02-08 Sol-Gel Technologies Ltd. Metal oxide coating of water insoluble ingredients
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
JP5342834B2 (ja) * 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
US20080020023A1 (en) 2006-07-20 2008-01-24 Shiping Wang Nonaqueous coating composition for elastomeric articles and articles containing the same
MXPA06008988A (es) * 2006-08-08 2008-02-07 Fernando Ahumada Ayala Preparaciones topicas antiacne que contienen retinoide (tazaroteno o adapaleno), antibiotico (fosfato de clindamicina) y/o queratolitico (peroxido de bonzoilo en microesponjas).
MX2009008250A (es) 2007-02-01 2009-08-27 Sol Gel Technologies Ltd Composiciones para aplicacion topica que comprenden un peroxido y retinoide.
FR2921257B1 (fr) * 2007-09-21 2009-11-06 Exsymol Sa Utilisation topique de derives thiazolidines contre les consequences du stress oxydatif de la peau
US20090155371A1 (en) * 2007-12-17 2009-06-18 Sojka Milan F Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same
US8632816B2 (en) 2007-12-17 2014-01-21 Elc Management, Llc Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same
CA2713041A1 (en) * 2008-02-01 2009-08-13 Amcol International Corporation Improved skin brightening compositions
US20100040696A1 (en) * 2008-08-12 2010-02-18 Ilse Sente Composite Particles Having An Antioxidant-Based Protective System, And Topical Compositions Comprising The Same
MX2011002709A (es) * 2008-09-12 2011-04-21 Amcol International Corp Composiciones topicas retinoides de bajo ph.
US20120014888A1 (en) * 2009-01-29 2012-01-19 Amcol International Corporation Matte Skin Finish Compositions
KR101080186B1 (ko) * 2010-06-21 2011-11-07 주식회사 필라이트솔루션 개량형 ｌｅｄ 조명등
JP5950428B2 (ja) 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
PL2729220T3 (pl) 2011-12-20 2016-05-31 Oriflame Res And Development Ltd Związki o aktywnościach przeciwstarzeniowych
WO2013124820A1 (en) 2012-02-21 2013-08-29 Ranbaxy Laboratories Limited Composition comprising a retinoid and benzoyl peroxide
FR2991180B1 (fr) 2012-06-01 2014-06-13 Galderma Res & Dev Compositions topiques de type emulsion sans emulsionnant a base de particules stabilisantes.
US9084778B2 (en) 2012-06-01 2015-07-21 Galderma Research & Development Topical compositions containing a retinoid of the oil-in-water emulsion type
FR2991176B1 (fr) 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide solubilise, de type gel hydroglycolique
FR2991177B1 (fr) 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide, de type emulsion huile dans eau sans emulsionnant
US9687465B2 (en) 2012-11-27 2017-06-27 Sol-Gel Technologies Ltd. Compositions for the treatment of rosacea
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
AU2014233420A1 (en) * 2013-03-15 2015-11-12 Laboratory Skin Care, Inc. Fine dry particulate retinoid active agent compositions and topical formulations including the same
US9976142B2 (en) 2014-04-02 2018-05-22 Nitto Denko Corporation Targeting molecule and a use thereof
WO2015155810A1 (en) 2014-04-07 2015-10-15 Nitto Denko Corporation Novel polymer-based hydrotropes for hydrophobic drug delivery
KR101950693B1 (ko) * 2014-07-24 2019-02-21 주식회사 엘지생활건강 레티놀 또는 레티놀 유도체를 함유하는 마이크로니들
CN106146734B (zh) * 2015-03-31 2018-07-20 中国石油化工股份有限公司 一种偶联剂及其应用以及丁苯无规共聚物及其制备方法
WO2017029665A1 (en) 2015-08-20 2017-02-23 Sol-Gel Technologies Ltd. Compositions for topical application comprising benzoyl peroxide and adapalene
WO2017180440A1 (en) 2016-04-11 2017-10-19 Amcol International Corporation Delivery system based on a natural microparticle for use in personal care and other topical applications
WO2017184868A1 (en) 2016-04-20 2017-10-26 Duke University Compositions, systems and methods for encapsulation and delivery of a substance
WO2019068288A1 (de) 2017-10-04 2019-04-11 Berlimed International Research Gmbh Wirkstoff und wirkstoffmatrix enthaltendes produkt zur transdermalen wirkstoffabgabe sowie dessen herstellung und verwendung sowie die wirkstoffmatrix, ihre herstellung und verwendung
EP3892257A4 (de) * 2018-12-04 2022-12-14 LG Household & Health Care Ltd. Gehaltreiche retinoidkapsel mit verzögerter freisetzung und zusammensetzung zur verminderung von falten damit
WO2022192672A1 (en) * 2021-03-11 2022-09-15 Peace Out Inc. Anhydrous skin care composition comprising retinol and/or bakuchiol
EP4322910A1 (de) * 2021-04-16 2024-02-21 DSM IP Assets B.V. Retinolformulierung (i)
CN117202889A (zh) * 2021-04-16 2023-12-08 帝斯曼知识产权资产管理有限公司 视黄醇制剂（ii）

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906108A (en) * 1973-10-12 1975-09-16 Johnson & Johnson Stabilized tretinoin cream emulsion
US4247547A (en) * 1979-03-19 1981-01-27 Johnson & Johnson Tretinoin in a gel vehicle for acne treatment
US4603146A (en) * 1984-05-16 1986-07-29 Kligman Albert M Methods for retarding the effects of aging of the skin
US4877805A (en) * 1985-07-26 1989-10-31 Kligman Albert M Methods for treatment of sundamaged human skin with retinoids
US4826828A (en) * 1985-04-22 1989-05-02 Avon Products, Inc. Composition and method for reducing wrinkles
US5145675A (en) * 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
US5089269A (en) * 1987-11-07 1992-02-18 Shiseido Company Ltd. Cosmetic containing fine soft microcapsules
ZA892859B (en) * 1988-04-22 1989-12-27 Advanced Polymer Systems Inc Porous particles in preparations involving immiscible phases
DE68917429T2 (de) * 1988-11-16 1995-02-23 Advanced Polymer Systems Inc Kationische Präparate zur topischen Anwendung.
US5156843A (en) * 1989-03-20 1992-10-20 Advanced Polymer Systems, Inc. Fabric impregnated with functional substances for controlled release
US5073365A (en) * 1989-06-01 1991-12-17 Advanced Polymer Systems Clinical and personal care articles enhanced by lubricants and adjuvants
DK0494996T3 (da) * 1989-10-03 1996-03-18 Advanced Polymer Systems Inc Eroderbare makroporøse hydrogelpartikler og fremstilling heraf
JP3014780B2 (ja) * 1990-01-29 2000-02-28 ジヨンソン・アンド・ジヨンソン・コンシユーマー・プロダクツ・インコーポレーテツド スキンケア組成物
FR2666015B1 (fr) * 1990-08-23 1994-11-10 Oreal Composition cosmetique et/ou dermopharmaceutique contenant de l'acide retinouique ou ses derives, destinee au traitement des cheveux ou du cuir chevelu.
KR100250700B1 (ko) * 1991-06-27 2000-07-01 차알스 제이. 메츠 안정화된 레티노이드 함유 피부 보호용 조성물
WO1994001074A1 (en) * 1992-07-13 1994-01-20 Shiseido Company, Ltd. Composition for dermatologic preparation
GR1002207B (en) * 1992-08-06 1996-03-27 Johnson & Johnson Consumer Skin care compositions containing imidazoles.

Also Published As

Publication number Publication date
JP2960022B2 (ja) 1999-10-06
EP0781551A1 (de) 1997-07-02
AU697584B2 (en) 1998-10-08
JPH09183722A (ja) 1997-07-15
CA2184433C (en) 2000-01-18
KR970032851A (ko) 1997-07-22
DK0781551T3 (da) 2002-05-21
PT781551E (pt) 2002-04-29
CA2184433A1 (en) 1997-06-30
DE69617181T2 (de) 2002-06-06
US5851538A (en) 1998-12-22
AU5831096A (en) 1997-07-03
ES2168414T3 (es) 2002-06-16
KR100262117B1 (ko) 2000-07-15
DE69617181D1 (de) 2002-01-03
EP0781551B1 (de) 2001-11-21

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UEP Publication of translation of european patent specification