JP5356231B2 - 化合物の非経口送達のための処方物およびその使用 - Google Patents

化合物の非経口送達のための処方物およびその使用 Download PDF

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JP5356231B2
JP5356231B2 JP2009522896A JP2009522896A JP5356231B2 JP 5356231 B2 JP5356231 B2 JP 5356231B2 JP 2009522896 A JP2009522896 A JP 2009522896A JP 2009522896 A JP2009522896 A JP 2009522896A JP 5356231 B2 JP5356231 B2 JP 5356231B2
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methylnaltrexone
formulation
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formulations
concentration
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JP2009545603A (ja
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サイド・エム・シャー
クリスチャン・オフスラガー
マーディ・ビー・フォーツィ
バジナ・ナタリーア
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ワイス・エルエルシー
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/08—Solutions
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P25/36—Opioid-abuse
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    • A61P35/00—Antineoplastic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
JP2009522896A 2006-08-04 2007-08-03 化合物の非経口送達のための処方物およびその使用 Active JP5356231B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83557406P 2006-08-04 2006-08-04
US60/835,574 2006-08-04
PCT/US2007/017430 WO2008019115A2 (en) 2006-08-04 2007-08-03 Formulations for parenteral delivery of compounds and uses thereof

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JP2009545603A JP2009545603A (ja) 2009-12-24
JP2009545603A5 JP2009545603A5 (https=) 2010-09-24
JP5356231B2 true JP5356231B2 (ja) 2013-12-04

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US (7) US20080070975A1 (https=)
EP (1) EP2046388B1 (https=)
JP (1) JP5356231B2 (https=)
KR (1) KR20090040248A (https=)
CN (2) CN102846613A (https=)
AR (1) AR063471A1 (https=)
AU (1) AU2007281984B8 (https=)
BR (1) BRPI0708965B8 (https=)
CA (1) CA2646901C (https=)
EC (1) ECSP088752A (https=)
ES (1) ES2655863T3 (https=)
GT (1) GT200800185A (https=)
HN (1) HN2008001464A (https=)
IL (2) IL194182A (https=)
MX (1) MX2008011993A (https=)
NO (1) NO343701B1 (https=)
NZ (1) NZ597260A (https=)
PE (1) PE20080741A1 (https=)
PH (1) PH12013500801A1 (https=)
PL (1) PL2046388T3 (https=)
RU (1) RU2539387C2 (https=)
SG (1) SG174030A1 (https=)
TW (1) TWI489984B (https=)
WO (1) WO2008019115A2 (https=)
ZA (1) ZA200808203B (https=)

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