MX2009005463A - Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros. - Google Patents
Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros.Info
- Publication number
- MX2009005463A MX2009005463A MX2009005463A MX2009005463A MX2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A
- Authority
- MX
- Mexico
- Prior art keywords
- epoxy
- stereoisomers
- isolating
- processes
- synthesizing quaternary
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen métodos para la síntesis de 4,5-epoxi-morfinanos usando dimetil formamida y resolución de los productos diaestereoméricos por medio de HPLC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86710306P | 2006-11-22 | 2006-11-22 | |
PCT/US2007/085085 WO2008064150A1 (en) | 2006-11-22 | 2007-11-19 | Processes for synthesizing quaternary 4,5-epoxy-morphinan analogs and isolating their n-stereoisomers |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005463A true MX2009005463A (es) | 2009-08-28 |
Family
ID=39430057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005463A MX2009005463A (es) | 2006-11-22 | 2007-11-19 | Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20080161570A1 (es) |
EP (1) | EP2097418A1 (es) |
JP (1) | JP2010510318A (es) |
CN (1) | CN101636400A (es) |
AU (1) | AU2007323718A1 (es) |
BR (1) | BRPI0719593A2 (es) |
CA (1) | CA2670386A1 (es) |
MX (1) | MX2009005463A (es) |
WO (1) | WO2008064150A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2368554B1 (en) | 2003-04-08 | 2014-12-24 | Progenics Pharmaceuticals, Inc. | Pharmaceutical formulations containing methylnaltrexone |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
TW200815451A (en) | 2006-08-04 | 2008-04-01 | Wyeth Corp | 6-carboxy-normorphinan derivatives, synthesis and uses thereof |
PE20130480A1 (es) | 2007-03-29 | 2013-05-08 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
MX2009010515A (es) | 2007-03-29 | 2009-10-19 | Wyeth Corp | Antagonistas del receptor opioide periferico y usos de los mismos. |
EP3263571B2 (en) | 2007-03-29 | 2023-08-23 | Progenics Pharmaceuticals, Inc. | Crystal form of (r)-n-methylnaltrexone bromide and uses thereof |
CA2713568C (en) | 2008-02-06 | 2016-09-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
WO2010096788A1 (en) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinanium quaternary salts and processes for their production |
WO2010096790A1 (en) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinananium n-oxides and processes for their production |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
US8563724B2 (en) * | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
EP2753622B1 (en) | 2011-09-08 | 2016-01-20 | Mallinckrodt LLC | Production of alkaloids without the isolation of intermediates |
CN105753876A (zh) * | 2014-12-15 | 2016-07-13 | 北大方正集团有限公司 | 一种Delta-7溴甲纳曲酮的制备方法 |
CN105753875A (zh) * | 2014-12-15 | 2016-07-13 | 北大方正集团有限公司 | 一种乙酰化Delta-7甲基纳曲酮甲酸盐及其制备方法 |
CN105777767A (zh) * | 2014-12-15 | 2016-07-20 | 北大方正集团有限公司 | 一种乙酰化Delta-7溴甲纳曲酮及其制备方法 |
CN105777766B (zh) * | 2014-12-15 | 2017-11-24 | 北大方正集团有限公司 | Delta‑7溴甲纳曲酮的制备方法 |
CN105753874A (zh) * | 2014-12-15 | 2016-07-13 | 北大方正集团有限公司 | 一种Delta-7甲基纳曲酮甲酸盐及其制备方法 |
CN107033155B (zh) * | 2016-02-04 | 2019-04-26 | 国药集团国瑞药业有限公司 | 一种吗啡酮类化合物的立体选择性还原方法 |
CN111323529B (zh) * | 2020-04-23 | 2023-08-25 | 广东华南药业集团有限公司 | 一种液相色谱法分离测定右美沙芬与左美沙芬的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
DE10229842A1 (de) * | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
EP1562953B1 (en) * | 2002-11-08 | 2009-09-30 | Mallinckrodt Inc. | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
-
2007
- 2007-11-19 BR BRPI0719593-1A patent/BRPI0719593A2/pt not_active Application Discontinuation
- 2007-11-19 US US11/942,292 patent/US20080161570A1/en not_active Abandoned
- 2007-11-19 WO PCT/US2007/085085 patent/WO2008064150A1/en active Application Filing
- 2007-11-19 EP EP07864581A patent/EP2097418A1/en not_active Withdrawn
- 2007-11-19 CN CN200780050175A patent/CN101636400A/zh active Pending
- 2007-11-19 JP JP2009538469A patent/JP2010510318A/ja active Pending
- 2007-11-19 CA CA002670386A patent/CA2670386A1/en not_active Abandoned
- 2007-11-19 AU AU2007323718A patent/AU2007323718A1/en not_active Abandoned
- 2007-11-19 MX MX2009005463A patent/MX2009005463A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2010510318A (ja) | 2010-04-02 |
CA2670386A1 (en) | 2008-05-29 |
AU2007323718A1 (en) | 2008-05-29 |
US20080161570A1 (en) | 2008-07-03 |
WO2008064150A1 (en) | 2008-05-29 |
EP2097418A1 (en) | 2009-09-09 |
BRPI0719593A2 (pt) | 2013-12-17 |
CN101636400A (zh) | 2010-01-27 |
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