JP5261187B2 - アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用 - Google Patents

アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用 Download PDF

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JP5261187B2
JP5261187B2 JP2008542460A JP2008542460A JP5261187B2 JP 5261187 B2 JP5261187 B2 JP 5261187B2 JP 2008542460 A JP2008542460 A JP 2008542460A JP 2008542460 A JP2008542460 A JP 2008542460A JP 5261187 B2 JP5261187 B2 JP 5261187B2
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polypeptide
actriia
bone
activin
composition
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JP2009517051A5 (enExample
JP2009517051A (ja
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ジョン クノップフ，
ジャスビル セーラ，
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アクセルロン ファーマ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
JP2008542460A 2005-11-23 2006-11-22 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用 Active JP5261187B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US73946205P 2005-11-23 2005-11-23
US60/739,462 2005-11-23
US78332206P 2006-03-17 2006-03-17
US60/783,322 2006-03-17
US84485506P 2006-09-15 2006-09-15
US60/844,855 2006-09-15
PCT/US2006/045322 WO2007062188A2 (en) 2005-11-23 2006-11-22 Activin-actriia antagonists and uses for promoting bone growth

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009269343A Division JP2010094129A (ja) 2005-11-23 2009-11-26 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2012080382A Division JP5785129B2 (ja) 2005-11-23 2012-03-30 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用

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JP2009517051A JP2009517051A (ja) 2009-04-30
JP2009517051A5 JP2009517051A5 (enExample) 2010-01-21
JP5261187B2 true JP5261187B2 (ja) 2013-08-14

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JP2008542460A Active JP5261187B2 (ja) 2005-11-23 2006-11-22 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2009269343A Withdrawn JP2010094129A (ja) 2005-11-23 2009-11-26 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2012080382A Active JP5785129B2 (ja) 2005-11-23 2012-03-30 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2013101251A Withdrawn JP2013153765A (ja) 2005-11-23 2013-05-13 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2015215654A Withdrawn JP2016026212A (ja) 2005-11-23 2015-11-02 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2015215653A Active JP6195885B2 (ja) 2005-11-23 2015-11-02 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2017195841A Withdrawn JP2018000205A (ja) 2005-11-23 2017-10-06 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2019115565A Withdrawn JP2019156848A (ja) 2005-11-23 2019-06-21 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2021104040A Withdrawn JP2021151266A (ja) 2005-11-23 2021-06-23 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用

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JP2009269343A Withdrawn JP2010094129A (ja) 2005-11-23 2009-11-26 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2012080382A Active JP5785129B2 (ja) 2005-11-23 2012-03-30 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2013101251A Withdrawn JP2013153765A (ja) 2005-11-23 2013-05-13 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2015215654A Withdrawn JP2016026212A (ja) 2005-11-23 2015-11-02 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2015215653A Active JP6195885B2 (ja) 2005-11-23 2015-11-02 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2017195841A Withdrawn JP2018000205A (ja) 2005-11-23 2017-10-06 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2019115565A Withdrawn JP2019156848A (ja) 2005-11-23 2019-06-21 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用
JP2021104040A Withdrawn JP2021151266A (ja) 2005-11-23 2021-06-23 アクチビン−ＡｃｔＲＩＩａアンタゴニストおよび骨成長を促進するための使用

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US (9) US7612041B2 (enExample)
EP (5) EP3811965A1 (enExample)
JP (9) JP5261187B2 (enExample)
KR (8) KR20190006086A (enExample)
CN (4) CN104844713B (enExample)
AU (1) AU2006318449B2 (enExample)
BR (1) BRPI0618947B1 (enExample)
CA (2) CA2631013C (enExample)
CR (1) CR10008A (enExample)
DK (1) DK1973559T3 (enExample)
EA (4) EA201692543A1 (enExample)
EC (1) ECSP088463A (enExample)
ES (3) ES2401805T3 (enExample)
HR (1) HRP20080377B1 (enExample)
IL (5) IL191596A (enExample)
IN (1) IN2015DN02553A (enExample)
ME (1) ME00380B (enExample)
MX (1) MX2008006626A (enExample)
NZ (1) NZ568369A (enExample)
PL (1) PL1973559T3 (enExample)
PT (1) PT1973559E (enExample)
RS (1) RS58231B1 (enExample)
SG (1) SG10201509620SA (enExample)
WO (1) WO2007062188A2 (enExample)

Cited By (1)

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JP5922928B2 (ja) 2008-08-14 2016-05-24 アクセルロン ファーマ， インコーポレイテッド 赤血球レベルを高めるためのｇｄｆトラップの使用
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