DK1706428T3 - Anti-cancer-antistoffer med reduceret komplementfiksering - Google Patents
Anti-cancer-antistoffer med reduceret komplementfikseringInfo
- Publication number
- DK1706428T3 DK1706428T3 DK05701002T DK05701002T DK1706428T3 DK 1706428 T3 DK1706428 T3 DK 1706428T3 DK 05701002 T DK05701002 T DK 05701002T DK 05701002 T DK05701002 T DK 05701002T DK 1706428 T3 DK1706428 T3 DK 1706428T3
- Authority
- DK
- Denmark
- Prior art keywords
- complement fixation
- cancer antibodies
- reduced complement
- cell
- modified antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53834804P | 2004-01-22 | 2004-01-22 | |
| PCT/EP2005/000428 WO2005070967A2 (en) | 2004-01-22 | 2005-01-18 | Anti-cancer antibodies with reduced complement fixation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1706428T3 true DK1706428T3 (da) | 2009-11-30 |
Family
ID=34807180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05701002T DK1706428T3 (da) | 2004-01-22 | 2005-01-18 | Anti-cancer-antistoffer med reduceret komplementfiksering |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US7432357B2 (da) |
| EP (1) | EP1706428B1 (da) |
| JP (1) | JP4987484B2 (da) |
| AT (1) | ATE443724T1 (da) |
| AU (1) | AU2005206277B2 (da) |
| CA (1) | CA2553883C (da) |
| DE (1) | DE602005016773D1 (da) |
| DK (1) | DK1706428T3 (da) |
| ES (1) | ES2330860T3 (da) |
| PL (1) | PL1706428T3 (da) |
| PT (1) | PT1706428E (da) |
| WO (1) | WO2005070967A2 (da) |
Families Citing this family (59)
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| DE60239454D1 (de) | 2001-05-03 | 2011-04-28 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
| ES2326964T3 (es) * | 2001-10-25 | 2009-10-22 | Genentech, Inc. | Composiciones de glicoproteina. |
| ES2381025T3 (es) | 2001-12-04 | 2012-05-22 | Merck Patent Gmbh | Inmunocitocinas con selectividad modulada |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
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| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| ES2561048T3 (es) | 2004-07-23 | 2016-02-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| RU2437893C2 (ru) * | 2004-12-09 | 2011-12-27 | Мерк Патент Гмбх | Варианты il-7 со сниженной иммуногенностью |
| KR20160137665A (ko) | 2005-11-23 | 2016-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
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| JP2009521912A (ja) | 2005-12-30 | 2009-06-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 低減された免疫原性を有する抗ｃｄ１９抗体 |
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| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| AU2008211007B2 (en) | 2007-02-01 | 2013-09-19 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for treating or preventing breast cancer |
| TW202021980A (zh) | 2007-02-02 | 2020-06-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| CA3039330C (en) | 2007-02-09 | 2021-11-09 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for promoting bone growth in cancer patients |
| CN107412734A (zh) | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| JP5922928B2 (ja) | 2008-08-14 | 2016-05-24 | アクセルロン ファーマ， インコーポレイテッド | 赤血球レベルを高めるためのｇｄｆトラップの使用 |
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| PT2691417T (pt) | 2011-03-29 | 2018-10-31 | Roche Glycart Ag | Variantes de fc de anticorpos |
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| EP2861251A1 (en) | 2012-06-18 | 2015-04-22 | Apeiron Biologics AG | Method for treating a gd2 positive cancer |
| HUE056217T2 (hu) | 2012-07-13 | 2022-02-28 | Roche Glycart Ag | Bispecifikus anti-VEGF/anti-ANG-2 antitestek és ezek alkalmazása szemészeti érbetegségek kezelésében |
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| KR102207859B1 (ko) * | 2013-03-15 | 2021-01-27 | 메모리얼 슬로안 케터링 캔서 센터 | 고 친화도 항-gd2 항체 |
| CN106414494B (zh) * | 2013-11-12 | 2020-09-18 | Ogd2药物 | 具有促凋亡活性的人IgG1衍生的抗体 |
| DK3071220T3 (da) | 2013-11-21 | 2020-02-10 | Apeiron Biologics Ag | Præparater til at behandle en gd2-positiv cancer |
| US9840566B2 (en) | 2013-11-21 | 2017-12-12 | Apeiron Biologics Ag | Preparations and methods for treating a GD2 positive cancer |
| BR122023023170A2 (pt) | 2014-06-13 | 2024-02-20 | Acceleron Pharma Inc. | Uso de um antagonista de actrii no tratamento ou prevenção de úlcera cutânea associada com beta-talassemia |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| MD4801C1 (ro) | 2014-12-03 | 2022-10-31 | Celgene Corporation | Antagonişti ai activin-ActRII şi utilizarea lor pentru tratamentul sindroamelor mielodisplazice |
| WO2016130918A1 (en) * | 2015-02-12 | 2016-08-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating neuroblastoma |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2018152530A1 (en) * | 2017-02-20 | 2018-08-23 | Adimab, Llc | Proteins binding gd2, nkg2d and cd16 |
| RU2663104C1 (ru) * | 2017-07-13 | 2018-08-01 | Общество с ограниченной ответственностью "Реал Таргет" | Получение пегилированных фрагментов gd2-специфичных антител, индуцирующих прямую клеточную гибель gd2-позитивных опухолевых клеток, и их применение в терапии gd2-позитивных опухолей |
| CN108948211B (zh) * | 2018-07-24 | 2021-08-20 | 北京美康基免生物科技有限公司 | 一种基于靶向gd2的嵌合抗原受体及其应用 |
| EP3883610A4 (en) | 2018-11-20 | 2022-11-02 | Cornell University | MACROCYCLIC COMPLEXES OF RADIONUCLIDES AND THEIR USE IN CANCER RADIATION THERAPY |
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-
2005
- 2005-01-18 WO PCT/EP2005/000428 patent/WO2005070967A2/en active Application Filing
- 2005-01-18 JP JP2006550009A patent/JP4987484B2/ja active Active
- 2005-01-18 DK DK05701002T patent/DK1706428T3/da active
- 2005-01-18 DE DE602005016773T patent/DE602005016773D1/de active Active
- 2005-01-18 CA CA2553883A patent/CA2553883C/en active Active
- 2005-01-18 ES ES05701002T patent/ES2330860T3/es active Active
- 2005-01-18 AT AT05701002T patent/ATE443724T1/de active
- 2005-01-18 EP EP05701002A patent/EP1706428B1/en active Active
- 2005-01-18 AU AU2005206277A patent/AU2005206277B2/en active Active
- 2005-01-18 PL PL05701002T patent/PL1706428T3/pl unknown
- 2005-01-18 PT PT05701002T patent/PT1706428E/pt unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2005070967A2 (en) | 2005-08-04 |
| WO2005070967A3 (en) | 2005-12-01 |
| EP1706428B1 (en) | 2009-09-23 |
| PT1706428E (pt) | 2009-12-29 |
| US9617349B2 (en) | 2017-04-11 |
| US7432357B2 (en) | 2008-10-07 |
| US8835606B2 (en) | 2014-09-16 |
| US20150065691A1 (en) | 2015-03-05 |
| CA2553883A1 (en) | 2005-08-04 |
| CA2553883C (en) | 2013-04-02 |
| DE602005016773D1 (de) | 2009-11-05 |
| ATE443724T1 (de) | 2009-10-15 |
| US20190031769A1 (en) | 2019-01-31 |
| JP4987484B2 (ja) | 2012-07-25 |
| AU2005206277A1 (en) | 2005-08-04 |
| EP1706428A2 (en) | 2006-10-04 |
| US10633452B2 (en) | 2020-04-28 |
| JP2007537719A (ja) | 2007-12-27 |
| US10017579B2 (en) | 2018-07-10 |
| AU2005206277B2 (en) | 2011-06-23 |
| ES2330860T3 (es) | 2009-12-16 |
| PL1706428T3 (pl) | 2010-02-26 |
| US20050202021A1 (en) | 2005-09-15 |
| US20090148441A1 (en) | 2009-06-11 |
| US20170210817A1 (en) | 2017-07-27 |
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