DE602004019541D1 - Cycloalkyläbü kondensierte indole - Google Patents

Cycloalkyläbü kondensierte indole

Info

Publication number
DE602004019541D1
DE602004019541D1 DE602004019541T DE602004019541T DE602004019541D1 DE 602004019541 D1 DE602004019541 D1 DE 602004019541D1 DE 602004019541 T DE602004019541 T DE 602004019541T DE 602004019541 T DE602004019541 T DE 602004019541T DE 602004019541 D1 DE602004019541 D1 DE 602004019541D1
Authority
DE
Germany
Prior art keywords
cycloalkyläbü
condensed indole
indole
condensed
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004019541T
Other languages
English (en)
Inventor
Sharon Davis Boggs
John G Catalano
Kristjan S Gudmundsson
Leah D Aurora Richardson
Paul Richard Sebahar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE602004019541D1 publication Critical patent/DE602004019541D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
DE602004019541T 2003-08-26 2004-06-07 Cycloalkyläbü kondensierte indole Active DE602004019541D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49784503P 2003-08-26 2003-08-26
PCT/US2004/017982 WO2005023245A1 (en) 2003-08-26 2004-06-07 Novel cycloalkyl’b! condensed indoles

Publications (1)

Publication Number Publication Date
DE602004019541D1 true DE602004019541D1 (de) 2009-04-02

Family

ID=34272613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004019541T Active DE602004019541D1 (de) 2003-08-26 2004-06-07 Cycloalkyläbü kondensierte indole

Country Status (7)

Country Link
US (1) US7622494B2 (de)
EP (1) EP1658068B1 (de)
JP (1) JP2007503434A (de)
AT (1) ATE422885T1 (de)
DE (1) DE602004019541D1 (de)
ES (1) ES2320663T3 (de)
WO (1) WO2005023245A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509057A (ja) * 2003-10-15 2007-04-12 カイロン コーポレイション ウイルス阻害のための組成物および方法
WO2006012310A2 (en) * 2004-06-25 2006-02-02 Genzyme Corporation Carbazole derivatives for treating polycystic kidney disease
WO2006121466A2 (en) * 2004-11-22 2006-11-16 Smithkline Beecham Corporation Hcv inhibitors
WO2013139929A1 (en) * 2012-03-22 2013-09-26 Ludwig-Maximilians-Universität München Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging
JP6653573B2 (ja) 2012-05-22 2020-02-26 トラスティーズ・オブ・ダートマウス・カレッジ シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法
EP2895462A1 (de) * 2012-09-13 2015-07-22 Baden-Württemberg Stiftung gGmbH Spezifische inhibitoren von protein p21 als therapeutika
WO2016196664A1 (en) * 2015-06-01 2016-12-08 Cedars-Sinai Medical Center Methods and use of compounds that bind to rela of nf-kb
US10882821B1 (en) 2017-09-26 2021-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes
US20220062233A1 (en) * 2018-12-18 2022-03-03 The Board Of Trustees Of The Leland Stanford Junior University Compounds for the Reduction of the Deleterious Activity of Extended Nucleotide Repeat Containing Genes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043741A1 (en) 1999-12-16 2001-06-21 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Cytotoxic n-unsubstituted indoles and cyclopent(b)indoles and method of making and using same
US20040009613A1 (en) 2001-02-16 2004-01-15 Ming-Ming Zhou Methods of identifying modulators of bromodomains
US20030139609A1 (en) 2001-09-10 2003-07-24 Skibo Edward B. Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles
JP2006508134A (ja) 2002-11-08 2006-03-09 グラクソ　グループ　リミテッド 医薬組成物
KR20060017545A (ko) 2003-06-10 2006-02-23 스미스클라인 비참 코포레이션 테트라하이드로카르바졸 유도체 및 이들의 약제학적 용도

Also Published As

Publication number Publication date
EP1658068A1 (de) 2006-05-24
ES2320663T3 (es) 2009-05-27
US20060281804A1 (en) 2006-12-14
US7622494B2 (en) 2009-11-24
WO2005023245A1 (en) 2005-03-17
ATE422885T1 (de) 2009-03-15
EP1658068B1 (de) 2009-02-18
JP2007503434A (ja) 2007-02-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition