DE602004019541D1 - Cycloalkyläbü kondensierte indole - Google Patents

Cycloalkyläbü kondensierte indole

Info

Publication number
DE602004019541D1
DE602004019541D1 DE602004019541T DE602004019541T DE602004019541D1 DE 602004019541 D1 DE602004019541 D1 DE 602004019541D1 DE 602004019541 T DE602004019541 T DE 602004019541T DE 602004019541 T DE602004019541 T DE 602004019541T DE 602004019541 D1 DE602004019541 D1 DE 602004019541D1
Authority
DE
Germany
Prior art keywords
cycloalkyläbü
condensed indole
indole
condensed
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004019541T
Other languages
English (en)
Inventor
Sharon Davis Boggs
John G Catalano
Kristjan S Gudmundsson
Leah D Aurora Richardson
Paul Richard Sebahar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE602004019541D1 publication Critical patent/DE602004019541D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004019541T 2003-08-26 2004-06-07 Cycloalkyläbü kondensierte indole Expired - Lifetime DE602004019541D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49784503P 2003-08-26 2003-08-26
PCT/US2004/017982 WO2005023245A1 (en) 2003-08-26 2004-06-07 Novel cycloalkyl’b! condensed indoles

Publications (1)

Publication Number Publication Date
DE602004019541D1 true DE602004019541D1 (de) 2009-04-02

Family

ID=34272613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004019541T Expired - Lifetime DE602004019541D1 (de) 2003-08-26 2004-06-07 Cycloalkyläbü kondensierte indole

Country Status (7)

Country Link
US (1) US7622494B2 (de)
EP (1) EP1658068B1 (de)
JP (1) JP2007503434A (de)
AT (1) ATE422885T1 (de)
DE (1) DE602004019541D1 (de)
ES (1) ES2320663T3 (de)
WO (1) WO2005023245A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070276009A1 (en) * 2003-10-15 2007-11-29 Zhi-Jie Ni Compositions and Methods for Viral Inhibition
WO2006012310A2 (en) * 2004-06-25 2006-02-02 Genzyme Corporation Carbazole derivatives for treating polycystic kidney disease
EP1817026A2 (de) * 2004-11-22 2007-08-15 SmithKline Beecham Corporation Hcv-hemmer
WO2013139929A1 (en) * 2012-03-22 2013-09-26 Ludwig-Maximilians-Universität München Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging
JP6653573B2 (ja) 2012-05-22 2020-02-26 トラスティーズ・オブ・ダートマウス・カレッジ シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法
EP2895462A1 (de) * 2012-09-13 2015-07-22 Baden-Württemberg Stiftung gGmbH Spezifische inhibitoren von protein p21 als therapeutika
EP3303286B1 (de) * 2015-06-01 2023-10-04 Cedars-Sinai Medical Center An rela von nf-kb anbindende verbindungen zur verwendung bei der behandlung von krebs
US10882821B1 (en) 2017-09-26 2021-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes
CN114173780A (zh) * 2018-12-18 2022-03-11 小利兰·斯坦福大学托管委员会 用于降低含有延伸的核苷酸重复序列的基因的有害活性的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043741A1 (en) 1999-12-16 2001-06-21 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Cytotoxic n-unsubstituted indoles and cyclopent(b)indoles and method of making and using same
US20040009613A1 (en) 2001-02-16 2004-01-15 Ming-Ming Zhou Methods of identifying modulators of bromodomains
US20030139609A1 (en) 2001-09-10 2003-07-24 Skibo Edward B. Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles
ES2286471T3 (es) 2002-11-08 2007-12-01 Glaxo Group Limited Composiciones farmaceuticas antivirales.
ES2314446T3 (es) 2003-06-10 2009-03-16 Smithkline Beecham Corporation Derivados de tetrahidrocarbazol y su uso farmaceutico.

Also Published As

Publication number Publication date
WO2005023245A1 (en) 2005-03-17
ATE422885T1 (de) 2009-03-15
EP1658068B1 (de) 2009-02-18
US20060281804A1 (en) 2006-12-14
EP1658068A1 (de) 2006-05-24
ES2320663T3 (es) 2009-05-27
JP2007503434A (ja) 2007-02-22
US7622494B2 (en) 2009-11-24

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Legal Events

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