AU1952497A - Novel antibody-cytokine fusion protein, and methods of making and using the same - Google Patents

Novel antibody-cytokine fusion protein, and methods of making and using the same

Info

Publication number
AU1952497A
AU1952497A AU19524/97A AU1952497A AU1952497A AU 1952497 A AU1952497 A AU 1952497A AU 19524/97 A AU19524/97 A AU 19524/97A AU 1952497 A AU1952497 A AU 1952497A AU 1952497 A AU1952497 A AU 1952497A
Authority
AU
Australia
Prior art keywords
making
methods
same
fusion protein
novel antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU19524/97A
Inventor
Eric T. Harvill
Sherie L. Morrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
ERIC T HARVILL
SHERIE L MORRISON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ERIC T HARVILL, SHERIE L MORRISON filed Critical ERIC T HARVILL
Publication of AU1952497A publication Critical patent/AU1952497A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
AU19524/97A 1996-02-13 1997-02-11 Novel antibody-cytokine fusion protein, and methods of making and using the same Abandoned AU1952497A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US011569 1993-02-01
US1156996P 1996-02-13 1996-02-13
PCT/US1997/001420 WO1997030089A1 (en) 1996-02-13 1997-02-11 Novel antibody-cytokine fusion protein, and methods of making and using the same

Publications (1)

Publication Number Publication Date
AU1952497A true AU1952497A (en) 1997-09-02

Family

ID=21750974

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19524/97A Abandoned AU1952497A (en) 1996-02-13 1997-02-11 Novel antibody-cytokine fusion protein, and methods of making and using the same

Country Status (2)

Country Link
AU (1) AU1952497A (en)
WO (1) WO1997030089A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1442750B1 (en) * 1997-11-20 2012-08-01 Vical Incorporated Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor
ATE243045T1 (en) 1997-11-20 2003-07-15 Vical Inc TREATMENT OF CANCER BY USING CYTOKINE-EXPRESSING POLYNUCLEOTIDES AND COMPOSITIONS THEREOF
US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
US7736652B2 (en) * 2002-03-21 2010-06-15 The Regents Of The University Of California Antibody fusion proteins: effective adjuvants of protein vaccination
US20050069521A1 (en) * 2003-08-28 2005-03-31 Emd Lexigen Research Center Corp. Enhancing the circulating half-life of interleukin-2 proteins
CA2553883C (en) 2004-01-22 2013-04-02 Merck Patent Gesellschaft Mit Beschraenkter Haftung Anti-cancer antibodies with reduced complement fixation
EP1966245B1 (en) 2005-12-30 2011-05-18 Merck Patent GmbH Anti-cd19 antibodies with reduced immunogenicity
CN101351475B (en) 2005-12-30 2013-05-15 默克专利有限公司 Interleukin-12p40 variants with improved stability
CA2759333A1 (en) 2009-04-22 2010-10-28 Merck Patent Gmbh Antibody fusion proteins with modified fcrn binding sites
US8617557B2 (en) 2010-03-12 2013-12-31 The Regents Of The University Of California Antibody fusion with IL-12 proteins with disrupted heparin-binding activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229272A (en) * 1989-04-25 1993-07-20 Igen, Inc. Catalytic antibody components
US5314995A (en) * 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
EP0521985B1 (en) * 1990-03-20 1997-09-24 The Trustees Of Columbia University In The City Of New York Chimeric antibodies with receptor binding ligands in place of their constant region
US5349053A (en) * 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
WO1995009917A1 (en) * 1993-10-07 1995-04-13 The Regents Of The University Of California Genetically engineered bispecific tetravalent antibodies

Also Published As

Publication number Publication date
WO1997030089A1 (en) 1997-08-21

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