JP4748912B2 - アルキルおよびアリールアラニンｐ２部分を含むｃ型肝炎ウイルスに対する大員環ｎｓ３−セリンプロテアーゼ阻害剤 - Google Patents

アルキルおよびアリールアラニンｐ２部分を含むｃ型肝炎ウイルスに対する大員環ｎｓ３−セリンプロテアーゼ阻害剤 Download PDF

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JP4748912B2
JP4748912B2 JP2001578418A JP2001578418A JP4748912B2 JP 4748912 B2 JP4748912 B2 JP 4748912B2 JP 2001578418 A JP2001578418 A JP 2001578418A JP 2001578418 A JP2001578418 A JP 2001578418A JP 4748912 B2 JP4748912 B2 JP 4748912B2
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mmol
compound
aryl
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JP2003531199A (ja
JP2003531199A5 (https=
Inventor
スリカント・ベンカトラマン
ケビン・エックス・チェン
アショック・アラサパン
エフ・ジョージ・ヌジョローグ
ビイヨール・エム・ギリジャバラバン
ティン−ヤウ・チャン
ブライアン・エイ・マッキトリック
アンドリュー・ジェイ・プロンゲイ
ビンセント・エス・マディソン
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2001578418A 2000-04-19 2001-04-17 アルキルおよびアリールアラニンｐ２部分を含むｃ型肝炎ウイルスに対する大員環ｎｓ３−セリンプロテアーゼ阻害剤 Expired - Fee Related JP4748912B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19820400P 2000-04-19 2000-04-19
US60/198,204 2000-04-19
PCT/US2001/012530 WO2001081325A2 (en) 2000-04-19 2001-04-17 Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties

Publications (3)

Publication Number Publication Date
JP2003531199A JP2003531199A (ja) 2003-10-21
JP2003531199A5 JP2003531199A5 (https=) 2008-02-28
JP4748912B2 true JP4748912B2 (ja) 2011-08-17

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JP2001578418A Expired - Fee Related JP4748912B2 (ja) 2000-04-19 2001-04-17 アルキルおよびアリールアラニンｐ２部分を含むｃ型肝炎ウイルスに対する大員環ｎｓ３−セリンプロテアーゼ阻害剤

Country Status (22)

Country Link
US (1) US6914122B2 (https=)
EP (1) EP1274724A2 (https=)
JP (1) JP4748912B2 (https=)
KR (1) KR20020097220A (https=)
CN (3) CN101580536A (https=)
AR (1) AR030558A1 (https=)
AU (1) AU2001253621A1 (https=)
BR (1) BR0110104A (https=)
CA (1) CA2406532A1 (https=)
CZ (1) CZ20023473A3 (https=)
HK (1) HK1048479A1 (https=)
HU (1) HUP0302957A2 (https=)
IL (1) IL151935A0 (https=)
MX (1) MXPA02010375A (https=)
NO (1) NO20025030L (https=)
NZ (1) NZ521456A (https=)
PE (1) PE20011288A1 (https=)
PL (1) PL358591A1 (https=)
RU (1) RU2002131163A (https=)
SK (1) SK14952002A3 (https=)
WO (1) WO2001081325A2 (https=)
ZA (1) ZA200208014B (https=)

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