JP4628545B2 - 逆熱ゲル化特性を有する生分解性低分子量トリブロックポリエステルポリエチレングリコールコポリマー - Google Patents

逆熱ゲル化特性を有する生分解性低分子量トリブロックポリエステルポリエチレングリコールコポリマー Download PDF

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JP4628545B2
JP4628545B2 JP2000572276A JP2000572276A JP4628545B2 JP 4628545 B2 JP4628545 B2 JP 4628545B2 JP 2000572276 A JP2000572276 A JP 2000572276A JP 2000572276 A JP2000572276 A JP 2000572276A JP 4628545 B2 JP4628545 B2 JP 4628545B2
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drug
polymer
biodegradable
composition
triblock copolymer
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JP2002525404A (ja
JP2002525404A5 (OSRAM
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ラシ,ラメシュ・シー
ゼントナー,ゲイレン・エム
チョン,バイオングムーン
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プロセリックス・ソルト・レイク・シティ,インコーポレーテッド
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91Polymers modified by chemical after-treatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups
    • C08G63/664Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP2000572276A 1998-10-01 1999-09-30 逆熱ゲル化特性を有する生分解性低分子量トリブロックポリエステルポリエチレングリコールコポリマー Expired - Fee Related JP4628545B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/164,865 1998-10-01
US09/164,865 US6117949A (en) 1998-10-01 1998-10-01 Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US09/396,589 1999-09-15
US09/396,589 US6201072B1 (en) 1997-10-03 1999-09-15 Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
PCT/US1999/022755 WO2000018821A1 (en) 1998-10-01 1999-09-30 Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties

Publications (3)

Publication Number Publication Date
JP2002525404A JP2002525404A (ja) 2002-08-13
JP2002525404A5 JP2002525404A5 (OSRAM) 2007-11-29
JP4628545B2 true JP4628545B2 (ja) 2011-02-09

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JP2000572276A Expired - Fee Related JP4628545B2 (ja) 1998-10-01 1999-09-30 逆熱ゲル化特性を有する生分解性低分子量トリブロックポリエステルポリエチレングリコールコポリマー

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US (1) US6201072B1 (OSRAM)
EP (1) EP1141079B1 (OSRAM)
JP (1) JP4628545B2 (OSRAM)
KR (1) KR100558025B1 (OSRAM)
CN (1) CN1161396C (OSRAM)
AT (1) ATE378365T1 (OSRAM)
AU (1) AU758475B2 (OSRAM)
BR (1) BR9914258B1 (OSRAM)
CA (1) CA2345659C (OSRAM)
CY (1) CY1107888T1 (OSRAM)
DK (1) DK1141079T3 (OSRAM)
ES (1) ES2301250T3 (OSRAM)
IL (1) IL142313A0 (OSRAM)
NO (1) NO332941B1 (OSRAM)
NZ (1) NZ510832A (OSRAM)
PL (1) PL205127B1 (OSRAM)
RU (1) RU2232779C2 (OSRAM)
TR (1) TR200100900T2 (OSRAM)
WO (1) WO2000018821A1 (OSRAM)

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RU2232779C2 (ru) 2004-07-20
NZ510832A (en) 2002-10-25
IL142313A0 (en) 2002-03-10
KR20010083880A (ko) 2001-09-03
ES2301250T3 (es) 2008-06-16
AU758475B2 (en) 2003-03-20
EP1141079A1 (en) 2001-10-10
NO20011639D0 (no) 2001-03-30
TR200100900T2 (tr) 2001-10-22
EP1141079A4 (en) 2004-03-24

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