EA032943B1 - Способ получения терапевтических наночастиц (варианты) и терапевтическая наночастица (варианты) - Google Patents
Способ получения терапевтических наночастиц (варианты) и терапевтическая наночастица (варианты)Info
- Publication number
- EA032943B1 EA032943B1 EA201590583A EA201590583A EA032943B1 EA 032943 B1 EA032943 B1 EA 032943B1 EA 201590583 A EA201590583 A EA 201590583A EA 201590583 A EA201590583 A EA 201590583A EA 032943 B1 EA032943 B1 EA 032943B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- therapeutic
- preparing
- nanoparticles
- nanoparticle
- therapeutic nanoparticles
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к способу получения терапевтических наночастиц, где указанный способ включает объединение терапевтического средства с органической кислотой. Терапевтические наночастицы могут иметь, например, более высокую нагрузку лекарственного средства и/или обладают улучшенными свойствами в отношении высвобождения лекарственного средства.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261702037P | 2012-09-17 | 2012-09-17 | |
PCT/US2013/059936 WO2014043618A1 (en) | 2012-09-17 | 2013-09-16 | Process for preparing therapeutic nanoparticles |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201590583A1 EA201590583A1 (ru) | 2015-11-30 |
EA032943B1 true EA032943B1 (ru) | 2019-08-30 |
Family
ID=49274868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590583A EA032943B1 (ru) | 2012-09-17 | 2013-09-16 | Способ получения терапевтических наночастиц (варианты) и терапевтическая наночастица (варианты) |
Country Status (23)
Country | Link |
---|---|
US (1) | US9877923B2 (ru) |
EP (1) | EP2895156B1 (ru) |
JP (1) | JP6356678B2 (ru) |
KR (1) | KR20150056618A (ru) |
CN (1) | CN104812381B (ru) |
AU (1) | AU2013315118B2 (ru) |
BR (1) | BR112015005940A2 (ru) |
CA (1) | CA2885193C (ru) |
DK (1) | DK2895156T3 (ru) |
EA (1) | EA032943B1 (ru) |
ES (1) | ES2732377T3 (ru) |
HK (1) | HK1211470A1 (ru) |
HU (1) | HUE043998T2 (ru) |
IL (1) | IL237780A0 (ru) |
MX (1) | MX356097B (ru) |
MY (1) | MY179194A (ru) |
NZ (1) | NZ705812A (ru) |
PL (1) | PL2895156T3 (ru) |
PT (1) | PT2895156T (ru) |
SG (1) | SG11201502065UA (ru) |
SI (1) | SI2895156T1 (ru) |
TR (1) | TR201909389T4 (ru) |
WO (1) | WO2014043618A1 (ru) |
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HK1211470A1 (en) | 2016-05-27 |
EP2895156B1 (en) | 2019-05-08 |
EP2895156A1 (en) | 2015-07-22 |
BR112015005940A2 (pt) | 2017-07-04 |
TR201909389T4 (tr) | 2019-07-22 |
SI2895156T1 (sl) | 2019-08-30 |
MY179194A (en) | 2020-10-30 |
AU2013315118A1 (en) | 2015-04-02 |
CN104812381B (zh) | 2018-01-26 |
US9877923B2 (en) | 2018-01-30 |
IL237780A0 (en) | 2015-05-31 |
NZ705812A (en) | 2018-08-31 |
WO2014043618A1 (en) | 2014-03-20 |
MX2015003405A (es) | 2015-06-05 |
CN104812381A (zh) | 2015-07-29 |
AU2013315118B2 (en) | 2017-10-05 |
CA2885193C (en) | 2021-04-27 |
CA2885193A1 (en) | 2014-03-20 |
PL2895156T3 (pl) | 2019-09-30 |
ES2732377T3 (es) | 2019-11-22 |
US20140186452A1 (en) | 2014-07-03 |
HUE043998T2 (hu) | 2019-09-30 |
SG11201502065UA (en) | 2015-05-28 |
JP2015528510A (ja) | 2015-09-28 |
JP6356678B2 (ja) | 2018-07-11 |
DK2895156T3 (da) | 2019-07-15 |
PT2895156T (pt) | 2019-06-28 |
MX356097B (es) | 2018-05-14 |
EA201590583A1 (ru) | 2015-11-30 |
KR20150056618A (ko) | 2015-05-26 |
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