CN110636837B - 一种cyp17抑制剂的药物组合物及其制备方法 - Google Patents
一种cyp17抑制剂的药物组合物及其制备方法 Download PDFInfo
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- CN110636837B CN110636837B CN201880032789.5A CN201880032789A CN110636837B CN 110636837 B CN110636837 B CN 110636837B CN 201880032789 A CN201880032789 A CN 201880032789A CN 110636837 B CN110636837 B CN 110636837B
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- FAGMGMRSURYROS-UHFFFAOYSA-M trihexadecyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(CCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCC FAGMGMRSURYROS-UHFFFAOYSA-M 0.000 description 1
- HVLUSYMLLVVXGI-USGGBSEESA-M trimethyl-[(z)-octadec-9-enyl]azanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)C HVLUSYMLLVVXGI-USGGBSEESA-M 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
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- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
时间(min) | 参比制剂R(%) | 制剂A(%) | 制剂B(%) |
5 | 4.3 | 15.8 | 1.2 |
10 | 5.6 | 18.9 | 1.8 |
15 | 7.4 | 20.4 | 1.9 |
20 | 4.8 | 16.4 | 4.8 |
25 | 5.6 | 18.7 | 6 |
30 | 5.7 | 19.7 | 7.9 |
45 | 5.4 | 19.4 | 13.3 |
60 | 5.6 | 19.3 | 19.5 |
90 | 6.4 | 20.0 | 29.2 |
120 | 5.7 | 20.1 | 37.9 |
180 | 5.8 | 19.9 | 50.1 |
240 | 7.9 | 21 | 56.4 |
时间(min) | 制剂C(%) | 制剂D(%) | 制剂E(%) | 制剂F(%) |
5 | 15.4 | 1.2 | 0.6 | 43.8 |
10 | 18.8 | 1.3 | 0.7 | 48.8 |
15 | 21.0 | 1.2 | 0.6 | 53.0 |
20 | 76.9 | 32.9 | 37.5 | 58.9 |
25 | 68.4 | 33.9 | 33.8 | 50.7 |
30 | 70.0 | 41.6 | 39.5 | 51.0 |
45 | 64.8 | 52.0 | 44.1 | 54.0 |
60 | 59.9 | 53.1 | 39.7 | 38.7 |
90 | 24.9 | 43.0 | 31.5 | 10.2 |
120 | 30.1 | 50.1 | 22.7 | 9.9 |
180 | 13.0 | 14.3 | 8.3 | 18.1 |
时间(min) | 参比制剂(%) | 制剂J(%) |
5 | 5.2 | 67.7 |
10 | 14.4 | 82.3 |
15 | 27.3 | 89.5 |
20 | 42.9 | 90.8 |
25 | 48.3 | 92.8 |
30 | 62.7 | 96.2 |
45 | 77.4 | 95.5 |
60 | 82 | 94.3 |
90 | 87.9 | 96.2 |
120 | 90.7 | 95.5 |
180 | 92.2 | 96.4 |
时间(min) | SNAC(mg/ml) | 化合物A(ug/ml) |
5 | 6.89 | 22.41 |
15 | 13.40 | 33.84 |
30 | 15.31 | 33.64 |
45 | 15.64 | 23.55 |
60 | 15.49 | 17.36 |
90 | 15.72 | 16.34 |
120 | 15.52 | 13.36 |
Claims (39)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
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CN2017107508278 | 2017-08-28 | ||
CN201710750827 | 2017-08-28 | ||
CN2017107588253 | 2017-08-29 | ||
CN201710758825 | 2017-08-29 | ||
CN201810205415 | 2018-03-13 | ||
CN2018102054150 | 2018-03-13 | ||
PCT/CN2018/102492 WO2019042247A1 (zh) | 2017-08-28 | 2018-08-27 | 一种cyp17抑制剂的药物组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN110636837A CN110636837A (zh) | 2019-12-31 |
CN110636837B true CN110636837B (zh) | 2022-05-24 |
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CN201880032789.5A Active CN110636837B (zh) | 2017-08-28 | 2018-08-27 | 一种cyp17抑制剂的药物组合物及其制备方法 |
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Country | Link |
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CN111617257A (zh) * | 2019-02-28 | 2020-09-04 | 江苏恒瑞医药股份有限公司 | 一种阿比特龙或其衍生物药物组合物及其应用 |
CN111617258A (zh) * | 2019-02-28 | 2020-09-04 | 江苏恒瑞医药股份有限公司 | 一种制备阿比特龙或其衍生物药物组合物的方法及其应用 |
EP3941478A4 (en) * | 2019-03-18 | 2022-12-28 | Dispersol Technologies, LLC | ABIRATERONE AND CYCLIC OLIGOMER PHARMACEUTICAL FORMULATIONS AND METHODS OF FORMING AND ADMINISTRING SAME |
CN113384542B (zh) * | 2020-03-14 | 2024-03-29 | 鲁南制药集团股份有限公司 | 一种甾体cyp17抑制剂固体分散体的片剂及其制备方法 |
EP4122483A4 (en) * | 2020-03-18 | 2024-03-27 | Xizang Haisco Pharmaceutical Co Ltd | ORAL PHARMACEUTICAL COMPOSITION |
CN113750032A (zh) * | 2020-06-01 | 2021-12-07 | 成都海博为药业有限公司 | 一种口服的阿比特龙药物组合物及其制备方法及用途 |
CN114099499A (zh) * | 2020-08-26 | 2022-03-01 | 上海博志研新药物技术有限公司 | 依达拉奉口服持续释放组合物、制备方法及应用 |
US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
TW202333774A (zh) * | 2021-12-01 | 2023-09-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | Glp-1和gip受體雙重激動劑的醫藥組成物及其用途 |
CN115684514B (zh) * | 2022-11-24 | 2024-04-26 | 则正(济南)生物科技有限公司 | 评价仿制药和原研药生物利用度的方法及其应用 |
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