JP3734266B2 - 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法 - Google Patents

糸球体腎炎および他の炎症性疾患の治療のための組成物および方法 Download PDF

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JP3734266B2
JP3734266B2 JP52852395A JP52852395A JP3734266B2 JP 3734266 B2 JP3734266 B2 JP 3734266B2 JP 52852395 A JP52852395 A JP 52852395A JP 52852395 A JP52852395 A JP 52852395A JP 3734266 B2 JP3734266 B2 JP 3734266B2
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antibody
human
complement
seq
antibodies
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JPH10500289A (ja
Inventor
エバンス、マーク・ジェイ
マティス、ルイス
ミューラー、アイリーン・エリオット
ニュー、スティーブン・エイチ
ローリンズ、スコット
ローサー、ラッセル・ピー
スプリングホーン、ジェレミー・ピー
スクウィント、ステファン・ピー
トーマス、トーマス・シー
ワン、イー
ウィルキンズ、ジェイムズ・エイ
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アレクシオン ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Magnetic Record Carriers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP52852395A 1994-05-02 1995-05-01 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法 Expired - Lifetime JP3734266B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/236,208 US6074642A (en) 1994-05-02 1994-05-02 Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US08/236,208 1994-05-02
PCT/US1995/005688 WO1995029697A1 (en) 1994-05-02 1995-05-01 Methods and compositions for the treatment of glomerulonephritis and other inflammatory diseases

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2005012176A Division JP4294596B2 (ja) 1994-05-02 2005-01-19 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2005198116A Division JP2006020633A (ja) 1994-05-02 2005-07-06 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法

Publications (2)

Publication Number Publication Date
JPH10500289A JPH10500289A (ja) 1998-01-13
JP3734266B2 true JP3734266B2 (ja) 2006-01-11

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ID=22888581

Family Applications (5)

Application Number Title Priority Date Filing Date
JP52852395A Expired - Lifetime JP3734266B2 (ja) 1994-05-02 1995-05-01 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2005012176A Expired - Lifetime JP4294596B2 (ja) 1994-05-02 2005-01-19 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2005198116A Pending JP2006020633A (ja) 1994-05-02 2005-07-06 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2009001080A Expired - Lifetime JP5047996B2 (ja) 1994-05-02 2009-01-06 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2011248008A Withdrawn JP2012095650A (ja) 1994-05-02 2011-11-11 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2005012176A Expired - Lifetime JP4294596B2 (ja) 1994-05-02 2005-01-19 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2005198116A Pending JP2006020633A (ja) 1994-05-02 2005-07-06 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2009001080A Expired - Lifetime JP5047996B2 (ja) 1994-05-02 2009-01-06 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法
JP2011248008A Withdrawn JP2012095650A (ja) 1994-05-02 2011-11-11 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法

Country Status (15)

Country Link
US (2) US6074642A (enExample)
EP (5) EP0758904B1 (enExample)
JP (5) JP3734266B2 (enExample)
KR (2) KR100381128B1 (enExample)
AT (1) ATE448791T1 (enExample)
AU (1) AU2474795A (enExample)
BR (1) BR9507594B8 (enExample)
CA (2) CA2690298A1 (enExample)
DE (2) DE69536017D1 (enExample)
DK (1) DK0758904T3 (enExample)
ES (1) ES2336051T3 (enExample)
FR (1) FR10C0016I2 (enExample)
NL (1) NL300433I2 (enExample)
PT (1) PT758904E (enExample)
WO (1) WO1995029697A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241628B2 (en) 2008-08-05 2012-08-14 Novartis Ag Compositions and methods for antibodies targeting complement protein C5
US9051365B2 (en) 2011-12-21 2015-06-09 Novartis Ag Antibodies that bind factor P

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* Cited by examiner, † Cited by third party
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US6395888B1 (en) * 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
DE69534701T2 (de) * 1994-09-23 2006-10-19 Alexion Pharmaceuticals, Inc., Cheshire Verfahren zur behandlung von entzündlichen gelenkerkrankungen
JP4437192B2 (ja) 1998-02-20 2010-03-24 タノックス インコーポレイテッド 補体活性化阻害剤
US7112327B2 (en) 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
US6956107B2 (en) 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
DE19913707A1 (de) * 1999-03-26 2000-10-05 Privates Inst Bioserv Gmbh Immunadsorber zur Sepsistherapie
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JP4764590B2 (ja) 2000-04-29 2011-09-07 ユニバーシティー オブ アイオワ リサーチ ファウンデーション 黄班変性関連疾患の診断および治療
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