JP3345401B2 - 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析 - Google Patents

複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Info

Publication number
JP3345401B2
JP3345401B2 JP2000566460A JP2000566460A JP3345401B2 JP 3345401 B2 JP3345401 B2 JP 3345401B2 JP 2000566460 A JP2000566460 A JP 2000566460A JP 2000566460 A JP2000566460 A JP 2000566460A JP 3345401 B2 JP3345401 B2 JP 3345401B2
Authority
JP
Japan
Prior art keywords
protein
affinity
reagent
group
tagged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000566460A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002523058A (ja
Inventor
ルドルフ ハンス アエバーソールド,
マイケル エイチ. ゲルブ,
スティーブン ピー. ジジ,
シー. ロナルド スコット,
フランティセック トゥレセック,
スコット エイ. ガーバー,
ビート リスト,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26793647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3345401(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Washington filed Critical University of Washington
Publication of JP2002523058A publication Critical patent/JP2002523058A/ja
Application granted granted Critical
Publication of JP3345401B2 publication Critical patent/JP3345401B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812Peptides or proteins is immobilized on, or in, an organic carrier
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/18Sulfur containing
    • Y10T436/182Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125Digestion or removing interfering materials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000566460A 1998-08-25 1999-08-25 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析 Expired - Lifetime JP3345401B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9778898P 1998-08-25 1998-08-25
US9911398P 1998-09-03 1998-09-03
US60/097,788 1998-09-03
US60/099,113 1998-09-03
PCT/US1999/019415 WO2000011208A1 (en) 1998-08-25 1999-08-25 Rapid quantitative analysis of proteins or protein function in complex mixtures

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2002208687A Division JP3793124B2 (ja) 1998-08-25 2002-07-17 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Publications (2)

Publication Number Publication Date
JP2002523058A JP2002523058A (ja) 2002-07-30
JP3345401B2 true JP3345401B2 (ja) 2002-11-18

Family

ID=26793647

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000566460A Expired - Lifetime JP3345401B2 (ja) 1998-08-25 1999-08-25 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
JP2002208687A Expired - Lifetime JP3793124B2 (ja) 1998-08-25 2002-07-17 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
JP2006043216A Expired - Lifetime JP4117320B2 (ja) 1998-08-25 2006-02-20 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002208687A Expired - Lifetime JP3793124B2 (ja) 1998-08-25 2002-07-17 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
JP2006043216A Expired - Lifetime JP4117320B2 (ja) 1998-08-25 2006-02-20 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析

Country Status (7)

Country Link
US (3) US6670194B1 (enExample)
EP (2) EP1105517B2 (enExample)
JP (3) JP3345401B2 (enExample)
AT (2) ATE536422T1 (enExample)
AU (1) AU755334C (enExample)
DE (1) DE69912444T3 (enExample)
WO (1) WO2000011208A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7180056B2 (en) 2004-06-04 2007-02-20 Hitachi, Ltd. Mass spectrometry and mass spectrometry system

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
AU755334C (en) * 1998-08-25 2004-02-26 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
CA2361384A1 (en) * 1999-02-11 2000-08-17 Sun Ai Raillard High throughput mass spectrometry
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
CA2369868A1 (en) * 1999-04-15 2000-10-26 The University Of Virginia Patent Foundation Proteome mining
US6716636B1 (en) 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
EP1179175A2 (en) * 1999-05-14 2002-02-13 Karolinska Innovations AB Materials and methods relating to disease diagnosis
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US6783929B1 (en) 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
ATE340025T1 (de) * 2000-01-06 2006-10-15 Caliper Life Sciences Inc Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse
AU2001227280A1 (en) 2000-04-10 2001-10-23 The Scripps Research Institute Proteomic analysis using activity-based probe libraries
DE10021737C2 (de) * 2000-05-04 2002-10-17 Hermann Haller Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
ATE344456T1 (de) * 2000-05-05 2006-11-15 Purdue Research Foundation Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
AU2001269058A1 (en) * 2000-06-07 2001-12-17 Basf Aktiengesellschaft Method for the qualitative and quantitative analysis of complex mixtures of chemical compounds, using maldi-tof mass spectrometry
CA2411126A1 (en) 2000-06-09 2001-12-13 Mds Proteomics, Inc. Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing
AU2001266894B2 (en) 2000-06-12 2006-03-16 University Of Washington Selective labeling and isolation of phosphopeptides and applications to proteomeanalysis
US7567870B1 (en) 2000-07-31 2009-07-28 Institute For Systems Biology Multiparameter analysis for predictive medicine
EP1350106A2 (en) * 2000-08-11 2003-10-08 Agilix Corporation Ultra-sensitive detection systems
EP1332513A2 (en) * 2000-08-25 2003-08-06 Genencor International, Inc. Detecting polymers and polymer fragments
DE10043470B4 (de) * 2000-09-04 2006-01-19 Mpb Meltec Patent- Und Beteiligungsgesellschaft Mbh Verfahren zur Identifizierung von zellspezifischen Proteinen
WO2002029032A2 (en) * 2000-09-30 2002-04-11 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
SE0003566D0 (sv) * 2000-10-02 2000-10-02 Amersham Pharm Biotech Ab A method for the quantitative determination of one or more compounds
EP1325322A2 (en) * 2000-10-03 2003-07-09 Dionex Corporation Method and system for peak parking in liquid chromatography-mass spectrometer (lc-ms) analysis
US20040209251A1 (en) 2000-10-19 2004-10-21 Schneider Luke V Methods for determining protein and peptide terminal sequences
EP1330654B1 (en) 2000-10-23 2006-03-08 Genetics Institute, LLC Acid-labile isotope-coded extractant (alice) in mass spectometric analysis
AU4173202A (en) 2000-10-23 2002-06-18 Inst Genetics Llc Isotope-coded ionization-enhancing reagents (icier) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry
WO2002042427A2 (en) * 2000-10-25 2002-05-30 Surromed, Inc. Mass tags for quantitative analysis
SE0004094D0 (sv) * 2000-11-09 2000-11-09 Amersham Pharm Biotech Ab A method for the quantification of carbohudrates
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US6797523B2 (en) * 2000-11-30 2004-09-28 Affinium Pharmaceuticals, Inc. Methods for systematic identification of protein—protein interactions
US20020090652A1 (en) * 2000-12-22 2002-07-11 Fu Emil Wei-Ming Inverse labeling method for the rapid identification of marker/target proteins
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
WO2002055989A2 (en) * 2001-01-12 2002-07-18 The Regents Of The University Of California Stable isotope, site-specific mass tagging for protein identification
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US6969757B2 (en) 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
WO2002063271A2 (en) * 2001-02-05 2002-08-15 Activx Biosciences, Inc. Activity based probe analysis
US6818454B2 (en) 2001-02-16 2004-11-16 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
DE60237194D1 (de) 2001-03-02 2010-09-16 Activx Biosciences Inc Plattform für protein-profiling
WO2002077016A2 (en) * 2001-03-22 2002-10-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
EP1383920B1 (en) * 2001-04-03 2010-09-29 Thermo Finnigan Llc Methods and kits useful for the simplification of complex peptide mixtures
CN1463291A (zh) * 2001-04-19 2003-12-24 赛弗根生物系统股份有限公司 用质谱法和亲和标记物鉴定生物分子的特性
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
US7183116B2 (en) 2001-05-14 2007-02-27 The Institute For Systems Biology Methods for isolation and labeling of sample molecules
JP2005502030A (ja) * 2001-05-29 2005-01-20 リージェンツ オブ ザ ユニバーシティ オブ ミシガン タンパク質解析のシステムおよび方法
CA2349265A1 (en) * 2001-05-30 2002-11-30 Andrew Emili Protein expression profile database
CA2453725A1 (en) * 2001-07-13 2003-01-23 Syngenta Participations Ag System and method of determining proteomic differences
US6800449B1 (en) 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
AU2002322506A1 (en) * 2001-07-16 2003-03-03 President And Fellows Of Harvard College Non-affinity based isotope tagged peptides and methods for using the same
EP2053406A3 (en) 2001-07-16 2009-06-24 caprotec bioanalytics GmbH Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7343247B2 (en) 2001-07-30 2008-03-11 The Institute For Systems Biology Methods of classifying drug responsiveness using multiparameter analysis
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
AU2002341862C1 (en) * 2001-09-27 2009-01-29 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US6756586B2 (en) 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
DE10153631B4 (de) * 2001-10-31 2006-04-13 Lottspeich, Friedrich, Dr. Verfahren zum Vergleich zweier Proteinzustände
US7132295B2 (en) 2001-11-09 2006-11-07 Bayer Aktiengesellschaft Isotopically coded affinity markers 3
KR20040064275A (ko) 2001-11-09 2004-07-16 소스 프리시전 메디슨, 인코포레이티드 유전자 발현 프로파일을 이용한 질병의 동정, 모니터링,치료 및 생물학적 상태의 확인
CA2466356A1 (en) * 2001-11-09 2003-05-15 Bayer Healthcare Ag Isotopically coded affinity marker 2
DE10154744A1 (de) * 2001-11-09 2003-05-22 Bayer Ag Isotopencodierte Affinitätsmarker
WO2003042774A2 (en) * 2001-11-13 2003-05-22 Caprion Pharmaceuticals Inc. Mass intensity profiling system and uses thereof
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
DE10158860B4 (de) 2001-11-30 2007-04-05 Bruker Daltonik Gmbh Massenspektrometrische Proteingemischanalyse
EP1319954A1 (en) * 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
US7623969B2 (en) 2002-01-31 2009-11-24 The Institute For Systems Biology Gene discovery for the system assignment of gene function
EP1483399B1 (en) * 2002-02-12 2008-10-29 The Regents of the University of California Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products
CA2475011C (en) * 2002-02-14 2015-07-07 Ajinomoto Co., Inc. Method for analysis of compounds with amino group and analytical reagent therefor
DK1502102T3 (da) * 2002-03-11 2009-05-04 Caprotec Bioanalytics Gmbh Forbindelser og fremgangsmåder til analysering af proteomet
US7288382B2 (en) 2002-03-14 2007-10-30 The Board Of Trustees Od The Leland Stanford Junior University Methods for structural analysis of proteins
KR20040094856A (ko) * 2002-03-25 2004-11-10 데이진 가부시키가이샤 생체 시료내 보효소 a 류의 측정방법
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
US6989100B2 (en) * 2002-05-09 2006-01-24 Ppd Biomarker Discovery Sciences, Llc Methods for time-alignment of liquid chromatography-mass spectrometry data
AU2003261074A1 (en) * 2002-05-20 2003-12-02 Jason M. Hogan Protein identification from protein product ion spectra
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7052916B2 (en) * 2002-05-24 2006-05-30 Immunex Corporation Polypeptide analyses using stable isotope labeling
GB0212522D0 (en) * 2002-05-31 2002-07-10 Shimadzu Res Lab Europe Ltd Selective binding and analysis of macromolecules
EP1514107B1 (en) 2002-06-03 2013-05-15 The Institute for Systems Biology Methods for quantitative proteome analysis of glycoproteins
AU2003259029A1 (en) 2002-06-04 2003-12-19 The Institute For Systems Biology Methods for high throughput and quantitative proteome analysis
JP2005529335A (ja) * 2002-06-10 2005-09-29 フィネクサス, インク. 開放チャンネルを使って生体分子を固体相として抽出するシステムと方法
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
AU2003236369A1 (en) * 2002-06-28 2004-01-19 Shimadzu Corporation Sulfenyl compound, labeling reagent, and method of analyzing peptide
AU2003252593A1 (en) 2002-07-10 2004-02-02 Seikagaku Corporation Sulfotransferase inhibitors
CA2393726A1 (en) * 2002-07-16 2004-01-16 Steven J. Locke Quantitative proteomics via isotopically differentiated derivatization
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7409296B2 (en) * 2002-07-29 2008-08-05 Geneva Bioinformatics (Genebio), S.A. System and method for scoring peptide matches
AU2003256819B2 (en) * 2002-07-30 2009-11-12 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
US7501286B2 (en) 2002-08-14 2009-03-10 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US7473535B2 (en) 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
JP4395439B2 (ja) * 2002-09-12 2010-01-06 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー(ヴェーイーベー・ヴェーゼットウェー) 薬物標的の同定のための方法
EP1546359A4 (en) 2002-09-12 2007-05-09 Molecular Probes Inc JOB-SPECIFIC MARKING OF AFFINITY DAYS IN FUSION PROTEINS
WO2004036189A2 (en) 2002-10-18 2004-04-29 Promega Corporation Methods for separating molecules
US6944549B2 (en) * 2002-10-25 2005-09-13 Syngenta Participations Ag Method and apparatus for automated detection of peaks in spectroscopic data
EP2595173B1 (en) 2002-10-29 2016-09-14 Target Discovery, Inc. Method for increasing ionization efficiency in mass spectroscopy
US7846748B2 (en) 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
US7425451B2 (en) 2002-12-13 2008-09-16 Agilent Technologies, Inc. Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
US7109040B2 (en) * 2002-12-13 2006-09-19 Agilent Technologies, Inc. Modular isotope coding approach to proteomic analysis
US20060105343A1 (en) * 2003-01-09 2006-05-18 Children's Medical Center Corporation Methods for diagnosis and prognosis of cancer
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
EP1583972B1 (en) * 2003-01-16 2010-11-24 caprotec bioanalytics GmbH Methods for identifying drug non-target proteins
US20040219685A1 (en) 2003-01-30 2004-11-04 Applera Corporation Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents
WO2004079370A1 (en) * 2003-03-03 2004-09-16 Universiteit Leiden Analysis of the proteome of a living cell by labelling the proteins in the intact cell
TW200508606A (en) * 2003-03-07 2005-03-01 Nard Kenkyusho Kk Method of finding molecular weight of phosphoric acid monoester compound, and additive for mass spectrometric measurement
CA2521130C (en) 2003-04-01 2013-05-14 Activx Biosciences, Inc. Acyl-phosphate and phosphonate probes and methods of their synthesis and use in proteomic analysis
WO2004097372A2 (en) 2003-04-28 2004-11-11 The Regents Of The University Of California Element-coded affinity tags
US7267994B2 (en) 2003-04-28 2007-09-11 Regents Of The University Of California Element-coded affinity tags
GB0311961D0 (en) 2003-05-23 2003-06-25 Health Prot Agency Mass-based toxin assay and substrates therefor
EP1631553A4 (en) * 2003-06-06 2008-09-10 Harvard College PEPTIDES BASED ON CAPTURE AND RELEASE BASED ISOTOPES AND METHODS OF USING PEPTIDES
CA2529863A1 (en) * 2003-06-17 2004-12-23 Vib Vzw Peptide combos and their uses
GB0314209D0 (en) * 2003-06-19 2003-07-23 Amersham Biosciences Ab Novel MS reagents
WO2005007677A2 (en) 2003-07-10 2005-01-27 The Institute For Systems Biology Affinity capture of peptides by microarray and related methods
FR2857451B1 (fr) * 2003-07-11 2005-09-30 Commissariat Energie Atomique Procede et dispositif pour l'analyse de milieux reactionnels vivants
CA2535510C (en) * 2003-08-11 2013-10-15 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20050048499A1 (en) * 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
WO2005022156A1 (ja) * 2003-08-29 2005-03-10 Reverse Proteomics Research Institute Co., Ltd. タンパク質の固定化方法
US7485435B2 (en) * 2004-08-30 2009-02-03 Perkinelmer Las, Inc. Simultaneous detection of metabolic enzyme activity and metabolite levels
US20050074895A1 (en) * 2003-09-05 2005-04-07 Bio-Rad Laboratories, Inc. Alkyl-substituted vinyl pyridines for mass-coded tagging of proteins
US7081623B2 (en) 2003-09-05 2006-07-25 Lucent Technologies Inc. Wafer-based ion traps
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
US7145019B2 (en) * 2003-10-16 2006-12-05 Ambergen, Inc. Photocleavable isotope-coded affinity tags
US7348416B2 (en) * 2003-11-21 2008-03-25 Applera Corporation Selective capture and enrichment of proteins expressed on the cell surface
EP1686372A4 (en) * 2003-11-21 2009-04-01 Eisai R&D Man Co Ltd QUANTIFICATION METHOD USING AN ISOTOPE-MARKED INTERNAL CALIBRATION, ANALYSIS SYSTEM FOR EXECUTING THE QUANTIFICATION METHOD AND ASSOCIATED SEPARATION PROGRAM
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
WO2005069891A2 (en) * 2004-01-15 2005-08-04 Cedars-Sinai Medical Center System and method for expression proteomics based on isotope ratio modification
US20070087448A1 (en) * 2004-02-16 2007-04-19 Nelsestuen Gary L Biological profiles and methods of use
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
EP1731908B1 (en) * 2004-03-31 2010-09-01 Kazuo Shinya Method of biosubstance trapping, structural analysis or/and identification with use of a labeling substance
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP4861308B2 (ja) * 2004-04-07 2012-01-25 ジェネンテック, インコーポレイテッド 抗体結合体の質量分析
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
EP1766413A2 (en) * 2004-05-19 2007-03-28 Applera Corporation Expression quantification using mass spectrometry
DK1766412T3 (da) 2004-05-21 2009-05-25 Inst Systems Biology Sammensætninger og fremgangsmåder til kvantificering af serumglycoproteiner
US20080044857A1 (en) * 2004-05-25 2008-02-21 The Gov Of Usa As Represented By The Secretary Of Methods For Making And Using Mass Tag Standards For Quantitative Proteomics
WO2005116629A1 (ja) * 2004-05-26 2005-12-08 Ajinomoto Co., Inc. アミノ官能性化合物の分析方法及び装置
WO2006091214A2 (en) * 2004-06-18 2006-08-31 Molecular Probes, Inc. Fluorescent isotope tags and their method of use
CA2572754A1 (en) * 2004-07-12 2006-02-16 Applera Corporation Mass tags for quantitative analyses
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
US20060024757A1 (en) 2004-07-30 2006-02-02 Robert Hussa Detection of oncofetal fibronectin for selection of concepti
US7592139B2 (en) * 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
JP4563764B2 (ja) * 2004-10-01 2010-10-13 丸善製薬株式会社 ペプチドの定量方法
EP1814908A4 (en) * 2004-11-22 2009-07-01 Biosight Ltd Activated labeling reagents and method for their preparation and use
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
WO2006096704A2 (en) 2005-03-07 2006-09-14 Invitrogen Corporation Isotopically-labeled proteome standards
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
DE602005004902T2 (de) * 2005-06-02 2008-10-16 Entelechon Gmbh Künstliches Protein, Verfahren für absolute Quantifizierung der Proteine und seine Benutzung
JP2006337176A (ja) * 2005-06-02 2006-12-14 Eisai R & D Management Co Ltd 代謝物の定量方法
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
EP1754972A1 (en) 2005-08-17 2007-02-21 Agilent Technologies, Inc. Folded peptides containing metal binding pockets for protein tagging
JP5199101B2 (ja) * 2005-10-13 2013-05-15 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー 生体分子の検定を開発するための方法
US7998717B2 (en) 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
WO2007065273A1 (en) * 2005-12-08 2007-06-14 The University Of British Columbia Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith
US20070140967A1 (en) * 2005-12-19 2007-06-21 Wood Nichole L Agents and methods for analyzing protein interactions
US20070166810A1 (en) * 2005-12-23 2007-07-19 Perkinelmer Las, Inc. Methods and compositions for detecting enzymatic activity
US20070148721A1 (en) * 2005-12-28 2007-06-28 Agilent Technologies, Inc. Compositions, methods, systems, and kits for affinity purification
WO2007078229A1 (en) * 2006-01-05 2007-07-12 Ge Healthcare Bio-Sciences Ab Kit and method for mass labelling
WO2008048345A2 (en) * 2006-02-14 2008-04-24 Perkinelmer Las, Inc. Detection systems for mass labels
WO2008076139A1 (en) 2006-03-10 2008-06-26 Tethys Bioscience, Inc. Multiplex protein fractionation
EP1999270A4 (en) * 2006-03-13 2010-04-28 Perkinelmer Las Inc SUBSTRATES AND INTERNAL STANDARDS FOR MASS SPECTROSCOPY DETECTION
US20090215098A1 (en) * 2006-04-28 2009-08-27 Ucl Business Plc. Quantification of enzyme activity by mass spectrometry
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
WO2008094205A2 (en) * 2006-08-04 2008-08-07 The Board Of Trustees Of The Leland Stanford Junior University A mild chemically cleavable linker system
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
EP1916526A1 (en) * 2006-10-26 2008-04-30 Koninklijke Philips Electronics N.V. Method for diagnostic and therapeutic target discovery by combining isotopic and isobaric labels
EP1921081A1 (en) * 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Use of arylboronic acids in protein labelling
SI2436696T1 (sl) 2007-01-05 2017-10-30 University Of Zurich Anti-beta-amiloidno protitelo in načini njegove uporabe
KR100805777B1 (ko) * 2007-02-22 2008-02-21 한국기초과학지원연구원 질량 스펙트럼 데이터 및 1차원 젤에서의 밴드 위치분석을 포함하는 단백질 수식화 분석 시스템 및 이를이용한 단백질 수식화 분석 방법
CA2690612C (en) 2007-05-14 2016-07-05 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
JP5003274B2 (ja) * 2007-05-16 2012-08-15 株式会社日立製作所 質量分析システムおよび質量分析方法
WO2008150488A1 (en) * 2007-06-01 2008-12-11 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
JP5593221B2 (ja) 2007-06-15 2014-09-17 ヒストロックス,インコーポレイテッド. 顕微鏡機器を標準化するための方法およびシステム
JP4883540B2 (ja) * 2007-06-21 2012-02-22 国立大学法人福井大学 同位体化合物を標識として使用するタンパク質の分析方法
EP2015076A1 (en) * 2007-07-11 2009-01-14 Koninklijke Philips Electronics N.V. Protein labelling with tags comprising isotope-coded sub-tags and isobaric sub-tags
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
WO2009026252A1 (en) * 2007-08-17 2009-02-26 University Of Washington Methods for assaying alpha-l-iduronidase enzymatic activity
US7978258B2 (en) 2007-08-31 2011-07-12 Historx, Inc. Automatic exposure time selection for imaging tissue
JP4921302B2 (ja) * 2007-09-26 2012-04-25 株式会社日立ハイテクノロジーズ 質量分析システム
US8604692B2 (en) 2007-11-06 2013-12-10 Translational Therapeutics, Inc. Mass spectrometry assay for eIF4E and eIF4E regulon activity
WO2009061904A2 (en) * 2007-11-06 2009-05-14 Translational Therapeutics, Inc. MASS SPECTROMETRY ASSAY FOR eIF4E AND eIF4E REGULON ACTIVITY
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
BRPI0906090A2 (pt) * 2008-03-13 2016-05-03 Perkinelmar Las Inc substrato para análise de uma enzima, molécula e método para detectar atividade enzimática .
EP2108957A1 (en) * 2008-04-07 2009-10-14 Koninklijke Philips Electronics N.V. Compounds and methods for the labelling and affinity-selection of proteins
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
CA2725599A1 (en) 2008-05-30 2009-12-03 The University Of British Columbia Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
US20110151494A1 (en) 2008-06-30 2011-06-23 H. Lee Moffit Cancer & Research Institute Methods and materials for monitoring myeloma using quantitative mass spectrometry
US9240043B2 (en) 2008-09-16 2016-01-19 Novartis Ag Reproducible quantification of biomarker expression
US20100081924A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081915A1 (en) * 2008-09-29 2010-04-01 Searete Llc, Alimited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081927A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081928A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological Facilitation systems and methods
US20100081916A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware. Histological facilitation systems and methods
US20100081926A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US8673267B2 (en) 2009-03-02 2014-03-18 Massachusetts Institute Of Technology Methods and products for in vivo enzyme profiling
US8227251B2 (en) * 2009-04-14 2012-07-24 Institute For Systems Biology Mass spectrum-based identification and quantitation of proteins and peptides
WO2010133173A1 (en) * 2009-05-21 2010-11-25 Rongxiu Li Process for differential polypeptides detection and uses thereof
GB0916881D0 (en) 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
EP2309262A1 (en) 2009-10-06 2011-04-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for quantifying biomolecules
WO2011075530A1 (en) * 2009-12-15 2011-06-23 Dh Technologies Development Pte. Ltd. Analysis of amino acids and amine-containing compounds using tagging reagents and lc-ms workflow
AU2010340358B2 (en) 2009-12-21 2014-07-24 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
WO2011087869A1 (en) * 2009-12-22 2011-07-21 Expression Pathology, Inc. Secreted protein acidic and rich in cysteine (sparc) protein srm/mrm assay
DK2517011T3 (en) * 2009-12-22 2015-11-23 Expression Pathology Inc SRM / MRM analysis for the receptor protein for the insulin-like growth factor 1 (IGF-1R)
US9453845B2 (en) 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
DE102011017084B4 (de) 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
WO2012003478A2 (en) 2010-07-02 2012-01-05 Ventana Medical Systems, Inc. Detecting targets using mass tags and mass spectrometry
WO2012021733A2 (en) 2010-08-12 2012-02-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
US8742333B2 (en) 2010-09-17 2014-06-03 Wisconsin Alumni Research Foundation Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer
CN103547679A (zh) * 2010-11-24 2014-01-29 Dh科技发展私人贸易有限公司 葡萄糖-6-磷酸脱氢酶的高产量、灵敏检测
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
ES2881535T3 (es) 2011-03-15 2021-11-29 Massachusetts Inst Technology Detección multiplexada con indicadores codificados con isótopos
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
US9659146B2 (en) 2011-05-02 2017-05-23 Tyler Stuart Bray Method for quantitative analysis of complex proteomic data
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
WO2013036885A1 (en) 2011-09-08 2013-03-14 The Regents Of The University Of California Metabolic flux measurement, imaging and microscopy
EP2802670B1 (en) 2011-11-08 2019-12-25 University of Washington Lysosomal enzyme assay methods and compositions
EP2788772B1 (en) 2011-12-07 2018-02-14 GlaxoSmithKline LLC Methods for determining total body skeletal muscle mass
DE102013212179A1 (de) * 2012-07-31 2014-02-06 Agilent Technologies, Inc. Derivatisierung von PNGase F-freigesetzter Glykane auf einem HPLC-Chip
RU2015126651A (ru) 2012-12-10 2017-01-16 Фред Хатчинсон Кэнсер Рисёрч Сентер Способы скрининга
EP4414372A3 (en) 2013-03-15 2024-10-02 Perkinelmer Health Sciences Inc. Compounds and methods relating to testing for lysosomal storage disorders
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
WO2014190234A1 (en) 2013-05-23 2014-11-27 Iphenotype Llc Method and system for maintaining or improving wellness
JP6847660B2 (ja) 2013-06-07 2021-03-24 マサチューセッツ インスティテュート オブ テクノロジー リガンドをコードする合成バイオマーカーのアフィニティベースの検出
CN109813914A (zh) * 2013-06-07 2019-05-28 皮尔斯生物科技有限公司 通过质谱分析用复用内标物对蛋白质和蛋白质修饰的绝对定量
JP6482577B2 (ja) * 2014-12-29 2019-03-13 株式会社日立ハイテクノロジーズ 分析方法、及び分析装置
EP3289107B1 (en) 2015-05-01 2024-12-11 The University of British Columbia Biomarkers for the detection of acute rejection in heart transplantation
WO2017040976A1 (en) * 2015-09-02 2017-03-09 Erkki Ruoslahti Compounds and compositions for targeting brain injuries and methods of use thereof
CN105384785B (zh) * 2015-11-24 2018-06-19 中国人民解放军第二军医大学 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用
AU2016380362B2 (en) * 2015-12-31 2021-07-01 University Of Notre Dame Du Lac ESI-MS via an electrokinetically pumped interface
EP3405783B1 (en) 2016-01-22 2022-03-09 Purdue Research Foundation Charged mass labeling system
CN105911101B (zh) * 2016-04-08 2018-09-11 中南大学 一种简单灵敏的膜性能检测方法
WO2017177115A1 (en) 2016-04-08 2017-10-12 Massachusetts Institute Of Technology Methods to specifically profile protease activity at lymph nodes
WO2017193070A1 (en) 2016-05-05 2017-11-09 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
JPWO2018003652A1 (ja) * 2016-06-29 2019-05-16 株式会社日立ハイテクノロジーズ 酵素反応及び質量分析方法に用いる化合物
US11339434B2 (en) * 2016-07-29 2022-05-24 The Regents Of The University Of California Methods for determining gene functions
DE102017103600A1 (de) * 2017-02-22 2018-08-23 Eberhard Karls Universität Tübingen Medizinische Fakultät Radioaktiv markiertes beta-Galactosidase Substrat für PET Bildgebung der Seneszenz
US11519905B2 (en) 2017-04-07 2022-12-06 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
WO2018213331A1 (en) * 2017-05-16 2018-11-22 Lankenau Institute For Medical Research Compositions comprising ligands to rhob protein and the uses thereof
CN107325154B (zh) * 2017-06-23 2020-11-20 广东华肽生物科技有限公司 一种具有改善记忆功效的多肽及其分离制备方法和用途
CN108169397B (zh) * 2017-11-30 2019-11-15 中国农业科学院北京畜牧兽医研究所 一种相对定量分析肉鸡谷胱甘肽s转移酶gsta2的方法
EP3739328A4 (en) * 2018-01-09 2021-10-20 Shimadzu Corporation PROCESS FOR IDENTIFYING PROTEINS
WO2019173332A1 (en) 2018-03-05 2019-09-12 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
US10656059B2 (en) 2018-03-07 2020-05-19 Alcala Pharmaceutical, Inc. Method for qualitative and quantitative multiplexing of drug analytes from biological samples
RU2678090C1 (ru) * 2018-05-28 2019-01-23 Федеральное государственное бюджетное научное учреждение "Федеральный научный центр пищевых систем им. В.М. Горбатова" РАН Способ подтверждения аутентичности вареных колбасных изделий
US12173349B2 (en) 2018-09-25 2024-12-24 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
US11835522B2 (en) 2019-01-17 2023-12-05 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
WO2020154541A1 (en) * 2019-01-24 2020-07-30 The Board Of Trustees Of The Leland Stanford Junior University Compact hydroxamate-based affinity tags for artificially tagging biological macromolecules
CN110280229B (zh) * 2019-06-28 2022-03-11 东南大学 喋呤类化合物选择性分离富集材料制备与应用方法
CN115769056A (zh) * 2020-06-09 2023-03-07 里珍纳龙药品有限公司 用于定量抗体的高通量和基于质谱的方法
EP4229074A1 (en) 2020-10-16 2023-08-23 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Anti-tumor immunity induces the presentation of aberrant peptides
CN116829922A (zh) * 2020-12-17 2023-09-29 豪夫迈·罗氏有限公司 用于质谱法的基于蒸发的样品制备工作流程
CN113156002A (zh) * 2021-04-01 2021-07-23 河北利德检测技术有限公司 一种葡萄糖酸钙中5种有关物质的检测方法
WO2023080788A1 (en) 2021-11-05 2023-05-11 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Tryptophan depletion induces production and presentation of tryptophan to phenylalanine substitutions
WO2024238393A1 (en) * 2023-05-10 2024-11-21 Northwestern University Proteoform imaging and characterization mass spectrometry

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614368A (en) 1990-02-09 1997-03-25 Molecular Devices Corporation Chromophoric reagents for incorporation of biotin or other haptens into macromolecules
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798795A (en) 1987-02-17 1989-01-17 Hoechst Celanese Corporation Biotinylating agents
WO1990004786A1 (en) * 1988-10-17 1990-05-03 Molecular Devices Corporation Hapten derivatized capture membrane and diagnostic assays using such membrane
US5438017A (en) * 1989-05-01 1995-08-01 The University Of Colorado Foundation, Inc. Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency
CA1340966C (en) 1989-05-19 2000-04-18 Thomas R. Covey Method of protein analysis
US5534440A (en) 1991-02-22 1996-07-09 Biomedical Research Centre Limited Compounds and methods for sequencing amino acids
US5240859A (en) 1991-02-22 1993-08-31 B.R. Centre Limited Methods for amino acid sequencing of a polypeptide
DE4310142A1 (de) 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung
US5496934A (en) 1993-04-14 1996-03-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acids encoding a cellulose binding domain
US5491071A (en) * 1993-08-03 1996-02-13 Abbott Laboratories Reagents and methods for the detection and quantification of testosterone in fluid samples
US5854084A (en) 1996-07-12 1998-12-29 Biotraces, Inc. Enhanced chromatography using multiphoton detection
US5527711A (en) 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
DE4343479A1 (de) * 1993-12-21 1995-06-22 Boehringer Mannheim Gmbh Acylierte Proteinaggregate und deren Verwendung zur Entstörung von Immunoassays
JP3027770B2 (ja) * 1994-03-05 2000-04-04 ロシュ ダイアグノスティックス ゲーエムベーハー イムノアッセイで使用するための干渉除去剤
US6017693A (en) 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5534132A (en) 1995-05-04 1996-07-09 Vreeke; Mark Electrode and method for the detection of an affinity reaction
US5686310A (en) 1995-06-06 1997-11-11 University Of Virginia Patent Foundation Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
US5965457A (en) 1995-06-06 1999-10-12 Magnani; John L. Methods of screening for a candidate compound able to bind to CD34+ cells
WO1996040662A2 (en) 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
CA2223261C (en) 1995-06-07 2010-05-11 Immunomedics, Inc. Improved delivery of diagnostic and therapeutic agents to a target site
US5958703A (en) 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
JP2001524808A (ja) 1996-12-10 2001-12-04 ジーントレイス・システムズ・インコーポレイテッド 放出可能な不揮発性の質量標識分子
WO1998032876A1 (en) 1997-01-23 1998-07-30 Brax Group Limited Characterising polypeptides
NZ502088A (en) 1997-07-11 2002-05-31 Brax Group Ltd Characterising nucleic acids using mass spectroscopy
EP0994968A1 (en) 1997-07-11 2000-04-26 Brax Group Limited Characterising nucleic acid
AU755334C (en) * 1998-08-25 2004-02-26 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
AU2001266894B2 (en) 2000-06-12 2006-03-16 University Of Washington Selective labeling and isolation of phosphopeptides and applications to proteomeanalysis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5614368A (en) 1990-02-09 1997-03-25 Molecular Devices Corporation Chromophoric reagents for incorporation of biotin or other haptens into macromolecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nature Biotech.,Vol.17,No.10,P.994−999(Oct.1999)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7180056B2 (en) 2004-06-04 2007-02-20 Hitachi, Ltd. Mass spectrometry and mass spectrometry system

Also Published As

Publication number Publication date
US20020076739A1 (en) 2002-06-20
US6670194B1 (en) 2003-12-30
EP1329513A1 (en) 2003-07-23
JP3793124B2 (ja) 2006-07-05
AU755334C (en) 2004-02-26
ATE536422T1 (de) 2011-12-15
EP1105517A4 (en) 2001-09-19
JP2006184290A (ja) 2006-07-13
EP1105517A1 (en) 2001-06-13
EP1105517B2 (en) 2009-09-30
US7544518B2 (en) 2009-06-09
WO2000011208A1 (en) 2000-03-02
EP1105517B1 (en) 2003-10-29
US6852544B2 (en) 2005-02-08
ATE253126T1 (de) 2003-11-15
AU5691399A (en) 2000-03-14
AU755334B2 (en) 2002-12-12
DE69912444D1 (de) 2003-12-04
US20050233399A1 (en) 2005-10-20
US20030087322A9 (en) 2003-05-08
EP1329513B1 (en) 2011-12-07
JP4117320B2 (ja) 2008-07-16
JP2003107066A (ja) 2003-04-09
DE69912444T2 (de) 2004-07-22
JP2002523058A (ja) 2002-07-30
DE69912444T3 (de) 2010-05-06

Similar Documents

Publication Publication Date Title
JP3345401B2 (ja) 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析
US7052915B2 (en) Selective labeling and isolation of phosphopeptides and applications to proteome analysis
EP1311858B1 (en) Affinity selected signature peptides for protein identification and quantification
AU2003249692B2 (en) Methods for quantitative proteome analysis of glycoproteins
EP1456632B1 (en) Methods for isolating and labeling sample molecules
US7449170B2 (en) Materials and methods for controlling isotope effects during fractionation of analytes
WO2008056290A9 (en) Use of arylboronic acids in protein labelling

Legal Events

Date Code Title Description
TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20020815

R150 Certificate of patent or registration of utility model

Ref document number: 3345401

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080830

Year of fee payment: 6

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090830

Year of fee payment: 7

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100830

Year of fee payment: 8

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110830

Year of fee payment: 9

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110830

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120830

Year of fee payment: 10

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120830

Year of fee payment: 10

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130830

Year of fee payment: 11

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term