JP2024513945A5 - - Google Patents

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Publication number
JP2024513945A5
JP2024513945A5 JP2023562311A JP2023562311A JP2024513945A5 JP 2024513945 A5 JP2024513945 A5 JP 2024513945A5 JP 2023562311 A JP2023562311 A JP 2023562311A JP 2023562311 A JP2023562311 A JP 2023562311A JP 2024513945 A5 JP2024513945 A5 JP 2024513945A5
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JP
Japan
Prior art keywords
monocyclic
membered
groups
alkyl
bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023562311A
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English (en)
Japanese (ja)
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JP2024513945A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/024984 external-priority patent/WO2022221642A1/en
Publication of JP2024513945A publication Critical patent/JP2024513945A/ja
Publication of JP2024513945A5 publication Critical patent/JP2024513945A5/ja
Pending legal-status Critical Current

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JP2023562311A 2021-04-16 2022-04-15 チオノピロール化合物 Pending JP2024513945A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163176109P 2021-04-16 2021-04-16
US63/176,109 2021-04-16
US202163216418P 2021-06-29 2021-06-29
US63/216,418 2021-06-29
US202263305610P 2022-02-01 2022-02-01
US63/305,610 2022-02-01
PCT/US2022/024984 WO2022221642A1 (en) 2021-04-16 2022-04-15 Thienopyrrole compounds

Publications (2)

Publication Number Publication Date
JP2024513945A JP2024513945A (ja) 2024-03-27
JP2024513945A5 true JP2024513945A5 (enExample) 2025-04-21

Family

ID=81580723

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023562311A Pending JP2024513945A (ja) 2021-04-16 2022-04-15 チオノピロール化合物

Country Status (16)

Country Link
US (2) US11661431B2 (enExample)
EP (1) EP4323369A1 (enExample)
JP (1) JP2024513945A (enExample)
KR (1) KR20230171469A (enExample)
AU (1) AU2022257039B2 (enExample)
BR (1) BR112023021107A2 (enExample)
CA (1) CA3214808A1 (enExample)
CL (2) CL2023002998A1 (enExample)
CO (1) CO2023013397A2 (enExample)
CR (1) CR20230478A (enExample)
DO (1) DOP2023000219A (enExample)
IL (1) IL307203A (enExample)
MX (1) MX2023012110A (enExample)
PE (1) PE20240919A1 (enExample)
TW (2) TWI908382B (enExample)
WO (1) WO2022221642A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202440078A (zh) 2021-09-10 2024-10-16 美商基利科學股份有限公司 噻吩并吡咯化合物
WO2023247670A1 (en) * 2022-06-24 2023-12-28 F. Hoffmann-La Roche Ag New heterocyclic-carbonyl-cyclic compounds as magl inhibitors
EP4619005A2 (en) * 2022-11-18 2025-09-24 The United States Government As Represented By The Department Of Veterans Affairs Methods for treating rheumatoid arthritis using a syndecan-1 inhibitor or a syntenin-1 inhibitor
WO2024182811A1 (en) * 2023-03-02 2024-09-06 University Of South Florida Compositions and methods for treating uterine leiomyomas
WO2025024265A1 (en) 2023-07-21 2025-01-30 Bristol-Myers Squibb Company Methods of assessing citrullination and activity of pad4 modulators
WO2026020127A2 (en) 2024-07-19 2026-01-22 Bristol-Myers Squibb Company Methods of assessing citrullination and activity of pad2 modulators

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US5364620A (en) 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US4902514A (en) 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
GB9718833D0 (en) 1997-09-04 1997-11-12 Merck Sharp & Dohme Therapeutic agents
US6329412B1 (en) 1997-11-04 2001-12-11 Pfizer Inc Bisamidine compounds as antiproliferative agents
US7825154B2 (en) 2005-08-12 2010-11-02 The United States Of America As Represented By The Secretary Of The Army Small molecule inhibitors of botulinum neurotoxins
RU2385865C2 (ru) 2005-08-15 2010-04-10 Айрм Ллк Соединения и композиции в качестве миметиков тро
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
EP2044083A1 (en) 2006-07-14 2009-04-08 Genelabs Technologies, Inc. Antiviral agents
CN101583598B (zh) 2007-01-15 2012-09-12 参天制药株式会社 具有IκB激酶β抑制活性的新型吲哚衍生物
HUE029188T2 (en) 2007-03-12 2017-03-28 Ym Biosciences Australia Pty Phenylamino-pyrimidine compounds and their use
WO2008152471A1 (en) 2007-06-12 2008-12-18 Coley Pharmaceutical Group, Inc. Quinazoline derivative useful as toll-like receptor antagonist
US8354400B2 (en) 2008-09-26 2013-01-15 Eisai R&D Co., Ltd. Benzoxazole compounds and methods of use
WO2011050245A1 (en) 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
AU2012262021B2 (en) 2011-06-01 2016-07-28 Janus Biotherapeutics, Inc. Novel immune system modulators
BR112013030894A2 (pt) 2011-06-01 2016-08-16 Janus Biotherapeutics Inc moduladores do sistema imune
WO2013052263A2 (en) 2011-09-16 2013-04-11 Microbiotix, Inc. Antifungal compounds
CA2850932A1 (en) 2011-10-04 2013-04-11 Janus Biotherapeutics, Inc. Novel imidazole quinoline-based immune system modulators
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
KR101452579B1 (ko) 2012-08-17 2014-10-21 주식회사 두산 신규 화합물 및 이를 포함하는 유기 전계 발광 소자
ES2670550T3 (es) 2013-10-14 2018-05-30 Eisai R&D Management Co., Ltd. Derivados de quinolina selectivamente sustituidos
KR101823488B1 (ko) 2013-10-14 2018-01-30 에자이 알앤드디 매니지먼트 가부시키가이샤 선택적으로 치환된 퀴놀린 화합물
US20170275287A1 (en) 2014-08-22 2017-09-28 Janus Biotherapeutics, Inc. Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof
LT3277677T (lt) 2015-03-30 2021-05-25 Mission Therapeutics Limited 1-ciano-pirolidino junginiai kaip usp30 inhibitoriai
WO2017075694A1 (en) 2015-11-04 2017-05-11 Simon Fraser University Antibiotic compounds, pharmaceutical formulations thereof and methods and uses therefor
MX2021006804A (es) 2015-12-17 2023-01-13 Merck Patent Gmbh Antagonistas policiclicos del receptor 7/8 tipo toll (tlr7/8) y uso de los mismos en el tratamiento de trastornos inmunitarios.
KR102706837B1 (ko) 2016-04-15 2024-09-19 캔써 리서치 테크놀로지 리미티드 Ret 키나아제 억제제로서의 헤테로사이클릭 화합물
TWI746545B (zh) 2016-04-26 2021-11-21 日商大日本住友製藥股份有限公司 經取代嘌呤衍生物
US10071079B2 (en) 2016-06-29 2018-09-11 Bristol-Myers Squibb Company [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
CN109715617B (zh) 2016-07-30 2022-04-19 百时美施贵宝公司 作为tlr7、tlr8或tlr9抑制剂的二甲氧基苯基取代的吲哚化合物
AU2017311047B2 (en) 2016-08-08 2021-07-22 Merck Patent Gmbh TLR7/8 antagonists and uses thereof
ES2902504T3 (es) 2016-09-09 2022-03-28 Bristol Myers Squibb Co Compuestos de indol sustituidos con piridilo
EP4059934B1 (en) 2016-09-09 2026-07-29 Novartis AG Compounds and compositions as inhibitors of endosomal toll-like receptors
WO2019018354A1 (en) 2017-07-18 2019-01-24 Merck Patent Gmbh ANTAGONISTS OF TLR7 / 8 AND USES THEREOF
CN110997670B (zh) 2017-08-04 2022-11-01 百时美施贵宝公司 [1,2,4]三唑并[4,3-a]吡啶基取代的吲哚化合物
EP3661926B1 (en) 2017-08-04 2022-02-23 Bristol-Myers Squibb Company Substituted indole compounds useful as inhibitors of tlr7/8/9
JP2021035910A (ja) 2017-11-01 2021-03-04 大日本住友製薬株式会社 置換プリン化合物
AU2018364807B2 (en) 2017-11-08 2022-05-19 Council Of Scientific & Industrial Research Purine based compounds as toll-like receptor 9 antagonist
CN111448190B (zh) 2017-11-14 2023-09-26 百时美施贵宝公司 取代的吲哚化合物
US12030878B2 (en) 2017-12-15 2024-07-09 Bristol-Myers Squibb Company Substituted indole ether compounds
MX2020006168A (es) 2017-12-18 2020-08-13 Bristol Myers Squibb Co Compuestos de 4-azaindol.
EP3728253B1 (en) 2017-12-19 2024-03-27 Bristol-Myers Squibb Company 6-azaindole compounds
EA202091474A1 (ru) 2017-12-19 2020-11-18 Бристол-Маерс Сквибб Компани Замещенные индольные соединения, применимые в качестве ингибиторов tlr
WO2019126081A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Amide substituted indole compounds useful as tlr inhibitors
JP2021506862A (ja) 2017-12-19 2021-02-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Tlr7/8アンタゴニストおよびそれらの使用
JP7287967B2 (ja) 2017-12-20 2023-06-06 ブリストル-マイヤーズ スクイブ カンパニー Tlr阻害剤として有効なアミノインドール化合物
KR102730859B1 (ko) 2017-12-20 2024-11-15 브리스톨-마이어스 스큅 컴퍼니 아릴 및 헤테로아릴 치환된 인돌 화합물
EA202091530A1 (ru) 2017-12-20 2020-09-14 Бристол-Маерс Сквибб Компани Диазаиндольные соединения
JP2021507889A (ja) 2017-12-22 2021-02-25 ノバルティス アーゲー ピラゾロピペリジン誘導体の新規な使用
CN110194770B (zh) * 2018-02-26 2022-08-09 药捷安康(南京)科技股份有限公司 肽酰精氨酸脱亚胺酶抑制剂及其用途
WO2019220390A1 (en) 2018-05-18 2019-11-21 Novartis Ag Crystalline forms of a tlr7/tlr8 inhibitor
SG11202100818RA (en) 2018-07-31 2021-02-25 Merck Patent Gmbh Tlr7/8 antagonists and uses thereof
ES2963696T3 (es) 2018-10-24 2024-04-01 Bristol Myers Squibb Co Compuestos diméricos de indol sustituidos
US12172995B2 (en) 2018-10-24 2024-12-24 Bristol-Myers Squibb Company Substituted indole and indazole compounds
US20220213099A1 (en) 2019-05-07 2022-07-07 Bristol-Myers Squibb Company Prodrug compounds
KR102904576B1 (ko) 2019-05-09 2025-12-24 브리스톨-마이어스 스큅 컴퍼니 치환된 벤즈이미다졸론 화합물
EP3972636A4 (en) 2019-05-23 2023-08-02 The University Of Montana VACCINE ADJUVANTS BASED ON TLR RECEPTOR LIGANDS
TW202115083A (zh) * 2019-09-27 2021-04-16 大陸商南京藥捷安康生物科技有限公司 肽醯精胺酸脫亞胺酶抑制劑及其用途
WO2021067326A1 (en) * 2019-10-01 2021-04-08 Bristol-Myers Squibb Company Substituted bicyclic heteroaryl compounds
CN114829350B (zh) 2019-10-04 2024-05-28 百时美施贵宝公司 经取代的咔唑化合物
JP7652772B2 (ja) 2019-11-01 2025-03-27 ブリストル-マイヤーズ スクイブ カンパニー 置換ピラゾール化合物
US20240024308A1 (en) 2020-05-14 2024-01-25 Merck Healthcare Kgaa Tlr7/8 antagonists for the treatment of coronavirus infections
JP7751597B2 (ja) 2020-06-11 2025-10-08 ブリストル-マイヤーズ スクイブ カンパニー 皮膚エリテマトーデスを治療するためにプレドニゾロンまたはヒドロキシクロロキンと組み合わせるtlr7阻害剤
KR20230027212A (ko) 2020-06-22 2023-02-27 브리스톨-마이어스 스큅 컴퍼니 류마티스 관절염의 치료 방법
WO2022022489A1 (zh) 2020-07-27 2022-02-03 江苏恒瑞医药股份有限公司 吲哚稠环类衍生物、其制备方法及其在医药上的应用
CN114075219B (zh) 2020-08-14 2023-11-14 江苏恒瑞医药股份有限公司 喹啉稠环类衍生物、其制备方法及其在医药上的应用
CN114075212B (zh) 2020-08-14 2023-05-12 江苏恒瑞医药股份有限公司 稠合三环类衍生物、其制备方法及其在医药上的应用
EP4200015B1 (en) 2020-08-19 2026-04-29 Bristol-Myers Squibb Company Substituted heteroaryl compounds useful as inhibitors of tlr9
EP4253387A4 (en) 2020-11-26 2024-05-15 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Fused tricyclic compound, preparation method therefor and application thereof in medicine
EP4267560A1 (en) 2020-12-22 2023-11-01 Gilead Sciences, Inc. 6-substituted indole compounds
EP4267559A1 (en) 2020-12-22 2023-11-01 Gilead Sciences, Inc. Substituted indole compounds

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