TWI908382B - 噻吩并吡咯化合物 - Google Patents
噻吩并吡咯化合物Info
- Publication number
- TWI908382B TWI908382B TW113138376A TW113138376A TWI908382B TW I908382 B TWI908382 B TW I908382B TW 113138376 A TW113138376 A TW 113138376A TW 113138376 A TW113138376 A TW 113138376A TW I908382 B TWI908382 B TW I908382B
- Authority
- TW
- Taiwan
- Prior art keywords
- groups
- group
- membered
- compounds
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163176109P | 2021-04-16 | 2021-04-16 | |
| US63/176,109 | 2021-04-16 | ||
| US202163216418P | 2021-06-29 | 2021-06-29 | |
| US63/216,418 | 2021-06-29 | ||
| US202263305610P | 2022-02-01 | 2022-02-01 | |
| US63/305,610 | 2022-02-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202519532A TW202519532A (zh) | 2025-05-16 |
| TWI908382B true TWI908382B (zh) | 2025-12-11 |
Family
ID=81580723
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW113138376A TWI908382B (zh) | 2021-04-16 | 2022-04-15 | 噻吩并吡咯化合物 |
| TW111114449A TWI861488B (zh) | 2021-04-16 | 2022-04-15 | 噻吩并吡咯化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111114449A TWI861488B (zh) | 2021-04-16 | 2022-04-15 | 噻吩并吡咯化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11661431B2 (enExample) |
| EP (1) | EP4323369A1 (enExample) |
| JP (1) | JP2024513945A (enExample) |
| KR (1) | KR20230171469A (enExample) |
| AU (1) | AU2022257039B2 (enExample) |
| BR (1) | BR112023021107A2 (enExample) |
| CA (1) | CA3214808A1 (enExample) |
| CL (2) | CL2023002998A1 (enExample) |
| CO (1) | CO2023013397A2 (enExample) |
| CR (1) | CR20230478A (enExample) |
| DO (1) | DOP2023000219A (enExample) |
| IL (1) | IL307203A (enExample) |
| MX (1) | MX2023012110A (enExample) |
| PE (1) | PE20240919A1 (enExample) |
| TW (2) | TWI908382B (enExample) |
| WO (1) | WO2022221642A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202440078A (zh) | 2021-09-10 | 2024-10-16 | 美商基利科學股份有限公司 | 噻吩并吡咯化合物 |
| WO2023247670A1 (en) * | 2022-06-24 | 2023-12-28 | F. Hoffmann-La Roche Ag | New heterocyclic-carbonyl-cyclic compounds as magl inhibitors |
| EP4619005A2 (en) * | 2022-11-18 | 2025-09-24 | The United States Government As Represented By The Department Of Veterans Affairs | Methods for treating rheumatoid arthritis using a syndecan-1 inhibitor or a syntenin-1 inhibitor |
| WO2024182811A1 (en) * | 2023-03-02 | 2024-09-06 | University Of South Florida | Compositions and methods for treating uterine leiomyomas |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
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| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| GB9718833D0 (en) | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
| US6329412B1 (en) | 1997-11-04 | 2001-12-11 | Pfizer Inc | Bisamidine compounds as antiproliferative agents |
| US7825154B2 (en) | 2005-08-12 | 2010-11-02 | The United States Of America As Represented By The Secretary Of The Army | Small molecule inhibitors of botulinum neurotoxins |
| RU2385865C2 (ru) | 2005-08-15 | 2010-04-10 | Айрм Ллк | Соединения и композиции в качестве миметиков тро |
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| WO2022022489A1 (zh) | 2020-07-27 | 2022-02-03 | 江苏恒瑞医药股份有限公司 | 吲哚稠环类衍生物、其制备方法及其在医药上的应用 |
| CN114075219B (zh) | 2020-08-14 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 喹啉稠环类衍生物、其制备方法及其在医药上的应用 |
| CN114075212B (zh) | 2020-08-14 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 稠合三环类衍生物、其制备方法及其在医药上的应用 |
| EP4200015B1 (en) | 2020-08-19 | 2026-04-29 | Bristol-Myers Squibb Company | Substituted heteroaryl compounds useful as inhibitors of tlr9 |
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| EP4267559A1 (en) | 2020-12-22 | 2023-11-01 | Gilead Sciences, Inc. | Substituted indole compounds |
-
2022
- 2022-04-15 US US17/721,636 patent/US11661431B2/en active Active
- 2022-04-15 IL IL307203A patent/IL307203A/en unknown
- 2022-04-15 EP EP22721581.1A patent/EP4323369A1/en active Pending
- 2022-04-15 KR KR1020237039381A patent/KR20230171469A/ko active Pending
- 2022-04-15 WO PCT/US2022/024984 patent/WO2022221642A1/en not_active Ceased
- 2022-04-15 CR CR20230478A patent/CR20230478A/es unknown
- 2022-04-15 JP JP2023562311A patent/JP2024513945A/ja active Pending
- 2022-04-15 TW TW113138376A patent/TWI908382B/zh active
- 2022-04-15 TW TW111114449A patent/TWI861488B/zh active
- 2022-04-15 MX MX2023012110A patent/MX2023012110A/es unknown
- 2022-04-15 PE PE2023002819A patent/PE20240919A1/es unknown
- 2022-04-15 BR BR112023021107A patent/BR112023021107A2/pt unknown
- 2022-04-15 CA CA3214808A patent/CA3214808A1/en active Pending
- 2022-04-15 AU AU2022257039A patent/AU2022257039B2/en active Active
-
2023
- 2023-03-08 US US18/180,438 patent/US20230365594A1/en not_active Abandoned
- 2023-10-06 CL CL2023002998A patent/CL2023002998A1/es unknown
- 2023-10-09 DO DO2023000219A patent/DOP2023000219A/es unknown
- 2023-10-09 CO CONC2023/0013397A patent/CO2023013397A2/es unknown
-
2024
- 2024-04-24 CL CL2024001266A patent/CL2024001266A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20240919A1 (es) | 2024-04-30 |
| TW202519532A (zh) | 2025-05-16 |
| WO2022221642A1 (en) | 2022-10-20 |
| CA3214808A1 (en) | 2022-10-20 |
| TWI861488B (zh) | 2024-11-11 |
| CL2024001266A1 (es) | 2024-11-08 |
| CL2023002998A1 (es) | 2024-04-26 |
| BR112023021107A2 (pt) | 2023-12-12 |
| IL307203A (en) | 2023-11-01 |
| AU2022257039B2 (en) | 2026-06-18 |
| AU2022257039A1 (en) | 2023-10-05 |
| CR20230478A (es) | 2023-11-30 |
| JP2024513945A (ja) | 2024-03-27 |
| EP4323369A1 (en) | 2024-02-21 |
| MX2023012110A (es) | 2023-10-24 |
| TW202302598A (zh) | 2023-01-16 |
| US11661431B2 (en) | 2023-05-30 |
| KR20230171469A (ko) | 2023-12-20 |
| CO2023013397A2 (es) | 2023-10-30 |
| US20230365594A1 (en) | 2023-11-16 |
| DOP2023000219A (es) | 2023-11-15 |
| US20220389034A1 (en) | 2022-12-08 |
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