PE20240919A1 - Compuestos de tienopirrol - Google Patents
Compuestos de tienopirrolInfo
- Publication number
- PE20240919A1 PE20240919A1 PE2023002819A PE2023002819A PE20240919A1 PE 20240919 A1 PE20240919 A1 PE 20240919A1 PE 2023002819 A PE2023002819 A PE 2023002819A PE 2023002819 A PE2023002819 A PE 2023002819A PE 20240919 A1 PE20240919 A1 PE 20240919A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- fused bicyclic
- membered fused
- monocyclic
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 230000004968 inflammatory condition Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 108010060825 Toll-Like Receptor 7 Proteins 0.000 abstract 1
- 108010060752 Toll-Like Receptor 8 Proteins 0.000 abstract 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 abstract 1
- 102100033110 Toll-like receptor 8 Human genes 0.000 abstract 1
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Referido a compuestos de tienopirrol de Formula I, o una sal farmaceuticamente aceptable de este, en donde R1 es heterociclilo biciclico fusionado de 8-10 miembros o heteroarilo biciclico fusionado de 8-10 miembros, en donde el heterociclilo biciclico fusionado de 8-10 miembros y el heteroarilo biciclico fusionado de 8-10 miembros estan cada uno sustituidos opcionalmente de manera independiente con grupos 1-4 Ra; R2 es H, alquilo C1-6, o cicloalquilo C3-7 monociclico, en donde el alquilo C1-6 y el cicloalquilo monociclico C3-7estan cada uno sustituidos opcionalmente de manera independiente con 1-4 grupos independientemente seleccionados del halogeno y alcoxi C1-6; R3 es H, halogeno, -CN, alquilo C1-6, cicloalquilo monociclico C 3-7 o heterociclilo monociclico de 4-7 miembros; Z es alquilo C1-6, alquenilo C2-6, -C(O)R13, -C(O)NR6R7 -S(O)2R6, entre otros. Estos compuestos inhiben la actividad del receptor 7 y/u 8 tipo toll. Tambien se refiere a una composicion farmaceutica que comprende dicho compuesto, metodos para prepararlos, y su uso para tratar una condicion inflamatoria, tales como enfermedad autoinmunitaria y/o condicion inflamatoria, que incluye el lupus eritematoso sistemico y lupus eritematoso cutaneo, entre otros.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163176109P | 2021-04-16 | 2021-04-16 | |
| US202163216418P | 2021-06-29 | 2021-06-29 | |
| US202263305610P | 2022-02-01 | 2022-02-01 | |
| PCT/US2022/024984 WO2022221642A1 (en) | 2021-04-16 | 2022-04-15 | Thienopyrrole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240919A1 true PE20240919A1 (es) | 2024-04-30 |
Family
ID=81580723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023002819A PE20240919A1 (es) | 2021-04-16 | 2022-04-15 | Compuestos de tienopirrol |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11661431B2 (es) |
| EP (1) | EP4323369A1 (es) |
| JP (1) | JP2024513945A (es) |
| KR (1) | KR20230171469A (es) |
| AU (1) | AU2022257039A1 (es) |
| BR (1) | BR112023021107A2 (es) |
| CA (1) | CA3214808A1 (es) |
| CL (1) | CL2023002998A1 (es) |
| CO (1) | CO2023013397A2 (es) |
| CR (1) | CR20230478A (es) |
| DO (1) | DOP2023000219A (es) |
| IL (1) | IL307203A (es) |
| MX (1) | MX2023012110A (es) |
| PE (1) | PE20240919A1 (es) |
| TW (1) | TW202302598A (es) |
| WO (1) | WO2022221642A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202327574A (zh) * | 2021-09-10 | 2023-07-16 | 美商基利科學股份有限公司 | 噻吩并吡咯化合物 |
| WO2023247670A1 (en) * | 2022-06-24 | 2023-12-28 | F. Hoffmann-La Roche Ag | New heterocyclic-carbonyl-cyclic compounds as magl inhibitors |
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2022
- 2022-04-15 IL IL307203A patent/IL307203A/en unknown
- 2022-04-15 CA CA3214808A patent/CA3214808A1/en active Pending
- 2022-04-15 MX MX2023012110A patent/MX2023012110A/es unknown
- 2022-04-15 PE PE2023002819A patent/PE20240919A1/es unknown
- 2022-04-15 TW TW111114449A patent/TW202302598A/zh unknown
- 2022-04-15 BR BR112023021107A patent/BR112023021107A2/pt unknown
- 2022-04-15 WO PCT/US2022/024984 patent/WO2022221642A1/en active Application Filing
- 2022-04-15 KR KR1020237039381A patent/KR20230171469A/ko unknown
- 2022-04-15 JP JP2023562311A patent/JP2024513945A/ja active Pending
- 2022-04-15 CR CR20230478A patent/CR20230478A/es unknown
- 2022-04-15 EP EP22721581.1A patent/EP4323369A1/en active Pending
- 2022-04-15 US US17/721,636 patent/US11661431B2/en active Active
- 2022-04-15 AU AU2022257039A patent/AU2022257039A1/en active Pending
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2023
- 2023-03-08 US US18/180,438 patent/US20230365594A1/en active Pending
- 2023-10-06 CL CL2023002998A patent/CL2023002998A1/es unknown
- 2023-10-09 CO CONC2023/0013397A patent/CO2023013397A2/es unknown
- 2023-10-09 DO DO2023000219A patent/DOP2023000219A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR20230478A (es) | 2023-11-30 |
| AU2022257039A1 (en) | 2023-10-05 |
| KR20230171469A (ko) | 2023-12-20 |
| TW202302598A (zh) | 2023-01-16 |
| US11661431B2 (en) | 2023-05-30 |
| WO2022221642A1 (en) | 2022-10-20 |
| EP4323369A1 (en) | 2024-02-21 |
| CL2023002998A1 (es) | 2024-04-26 |
| MX2023012110A (es) | 2023-10-24 |
| CA3214808A1 (en) | 2022-10-20 |
| CO2023013397A2 (es) | 2023-10-30 |
| JP2024513945A (ja) | 2024-03-27 |
| BR112023021107A2 (pt) | 2023-12-12 |
| US20230365594A1 (en) | 2023-11-16 |
| US20220389034A1 (en) | 2022-12-08 |
| DOP2023000219A (es) | 2023-11-15 |
| IL307203A (en) | 2023-11-01 |
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