AR089641A1 - COMPUESTOS BICICLICOS Y SUS USOS COMO INHIBIDORES DUALES DE c-SRC/JAK - Google Patents

COMPUESTOS BICICLICOS Y SUS USOS COMO INHIBIDORES DUALES DE c-SRC/JAK

Info

Publication number
AR089641A1
AR089641A1 ARP110100492A ARP110100492A AR089641A1 AR 089641 A1 AR089641 A1 AR 089641A1 AR P110100492 A ARP110100492 A AR P110100492A AR P110100492 A ARP110100492 A AR P110100492A AR 089641 A1 AR089641 A1 AR 089641A1
Authority
AR
Argentina
Prior art keywords
substituted
alkyl
heteroaryl
inhibitors
aryl
Prior art date
Application number
ARP110100492A
Other languages
English (en)
Inventor
Mallister Andres
Murone Maximilien
Sengupta Saumitra
Jayaram Shetty Shankar
Original Assignee
Debiopharm Sa
Aurigene Discovery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa, Aurigene Discovery Tech Ltd filed Critical Debiopharm Sa
Publication of AR089641A1 publication Critical patent/AR089641A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos bicíclicos aromáticos sustituidos que contienen anillos de pirimidina y piridina así como también sales aceptables para uso farmacéuticos de los mismos. Estos compuestos son útiles como inhibidores de la tirosina quinasa, con preferencia inhibidores de la familia SRC de las quinasas (SKF), en particular como inhibidores de las SFK/JAK quinasas e incluso, con preferencia, como inhibidores duales de las c-SRC/JAK quinasas, inhibiendo así la activación de STAT3 y, por lo tanto, el crecimiento anormal de los tipos celulares particulares. Estos compuestos son útiles para el tratamiento o inhibición de ciertas enfermedades que son el resultado de la desregulación de STAT3. Reivindicación 1: Un compuesto de la fórmula (1) donde R¹ es H, arilo, arilo sustituido, alquilo, alquilo sustituido, heteroarilo, heteroarilo sustituido, heterociclilo, heterociclilo sustituido, heterociclilalquilo o heterociclilalquilo sustituido; X es CH₂ o C=O; R² es H, alquilo C₁₋₆, halógeno, CF₃, u O-alquilo C₁₋₆; Y es -NHCO-, -CONH-, -NHSO₂, -NH-, -NCH₃-CO-, -NHCH₂-, O, -NHCONH- o -NHCOCH₂; R³ es alquilo, alquilo sustituido, arilo, o arilo sustituido, heteroarilo, heteroarilo sustituido, cicloalquilo, cicloalquilo sustituido o heterocicloalquilo; o una sal aceptable para uso farmacéutico del mismo.
ARP110100492A 2010-02-17 2011-02-17 COMPUESTOS BICICLICOS Y SUS USOS COMO INHIBIDORES DUALES DE c-SRC/JAK AR089641A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN415CH2010 2010-02-17

Publications (1)

Publication Number Publication Date
AR089641A1 true AR089641A1 (es) 2014-09-10

Family

ID=43903941

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100492A AR089641A1 (es) 2010-02-17 2011-02-17 COMPUESTOS BICICLICOS Y SUS USOS COMO INHIBIDORES DUALES DE c-SRC/JAK

Country Status (28)

Country Link
US (2) US8440679B2 (es)
EP (1) EP2536722B1 (es)
JP (1) JP2013519725A (es)
KR (1) KR20120130294A (es)
CN (1) CN102858770A (es)
AR (1) AR089641A1 (es)
AU (1) AU2011216895B2 (es)
BR (1) BR112012020639A2 (es)
CA (1) CA2789655A1 (es)
CU (1) CU20120118A7 (es)
CY (1) CY1115420T1 (es)
DK (1) DK2536722T3 (es)
EA (1) EA201290757A1 (es)
ES (1) ES2470190T3 (es)
HK (1) HK1178897A1 (es)
HR (1) HRP20140437T1 (es)
IL (1) IL221487A (es)
MX (1) MX2012009482A (es)
NZ (1) NZ602271A (es)
PL (1) PL2536722T3 (es)
PT (1) PT2536722E (es)
RS (1) RS53458B (es)
SA (1) SA111320200B1 (es)
SG (1) SG183329A1 (es)
SI (1) SI2536722T1 (es)
SM (1) SMT201400090B (es)
TW (1) TW201130838A (es)
WO (1) WO2011101806A1 (es)

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CN102858770A (zh) 2013-01-02
EA201290757A1 (ru) 2013-04-30
MX2012009482A (es) 2012-11-29
TW201130838A (en) 2011-09-16
RS53458B (en) 2014-12-31
US20130012518A1 (en) 2013-01-10
CY1115420T1 (el) 2017-01-04
SA111320200B1 (ar) 2014-02-16
CA2789655A1 (en) 2011-08-25
WO2011101806A1 (en) 2011-08-25
SMT201400090B (it) 2014-09-08
US8962637B2 (en) 2015-02-24
AU2011216895B2 (en) 2015-11-05
EP2536722B1 (en) 2014-04-16
SI2536722T1 (sl) 2014-10-30
EP2536722A1 (en) 2012-12-26
SG183329A1 (en) 2012-09-27
PL2536722T3 (pl) 2014-11-28
AU2011216895A1 (en) 2012-09-27
HRP20140437T1 (hr) 2014-08-29
KR20120130294A (ko) 2012-11-30
PT2536722E (pt) 2014-05-26
HK1178897A1 (en) 2013-09-19
US8440679B2 (en) 2013-05-14
US20130143895A1 (en) 2013-06-06
NZ602271A (en) 2013-09-27
IL221487A (en) 2014-11-30
DK2536722T3 (da) 2014-05-26
ES2470190T3 (es) 2014-06-23
JP2013519725A (ja) 2013-05-30
BR112012020639A2 (pt) 2017-08-08
CU20120118A7 (es) 2012-10-15

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