HK1178897A1 - Bicyclic compounds and their uses as dual c-src / jak inhibitors - Google Patents

Bicyclic compounds and their uses as dual c-src / jak inhibitors

Info

Publication number
HK1178897A1
HK1178897A1 HK13105802.2A HK13105802A HK1178897A1 HK 1178897 A1 HK1178897 A1 HK 1178897A1 HK 13105802 A HK13105802 A HK 13105802A HK 1178897 A1 HK1178897 A1 HK 1178897A1
Authority
HK
Hong Kong
Prior art keywords
src
dual
jak inhibitors
bicyclic compounds
bicyclic
Prior art date
Application number
HK13105802.2A
Other languages
English (en)
Inventor
Allister Andres Mc
Maximilien Murone
Saumitra Sengupta
Shankar Jayaram Shetty
Original Assignee
Debiopharm Sa
Aurigene Discovery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa, Aurigene Discovery Tech Ltd filed Critical Debiopharm Sa
Publication of HK1178897A1 publication Critical patent/HK1178897A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK13105802.2A 2010-02-17 2013-05-16 Bicyclic compounds and their uses as dual c-src / jak inhibitors HK1178897A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN415CH2010 2010-02-17
PCT/IB2011/050669 WO2011101806A1 (en) 2010-02-17 2011-02-17 Bicyclic compounds and their uses as dual c-src / jak inhibitors

Publications (1)

Publication Number Publication Date
HK1178897A1 true HK1178897A1 (en) 2013-09-19

Family

ID=43903941

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13105802.2A HK1178897A1 (en) 2010-02-17 2013-05-16 Bicyclic compounds and their uses as dual c-src / jak inhibitors

Country Status (28)

Country Link
US (2) US8440679B2 (es)
EP (1) EP2536722B1 (es)
JP (1) JP2013519725A (es)
KR (1) KR20120130294A (es)
CN (1) CN102858770A (es)
AR (1) AR089641A1 (es)
AU (1) AU2011216895B2 (es)
BR (1) BR112012020639A2 (es)
CA (1) CA2789655A1 (es)
CU (1) CU20120118A7 (es)
CY (1) CY1115420T1 (es)
DK (1) DK2536722T3 (es)
EA (1) EA201290757A1 (es)
ES (1) ES2470190T3 (es)
HK (1) HK1178897A1 (es)
HR (1) HRP20140437T1 (es)
IL (1) IL221487A (es)
MX (1) MX2012009482A (es)
NZ (1) NZ602271A (es)
PL (1) PL2536722T3 (es)
PT (1) PT2536722E (es)
RS (1) RS53458B (es)
SA (1) SA111320200B1 (es)
SG (1) SG183329A1 (es)
SI (1) SI2536722T1 (es)
SM (1) SMT201400090B (es)
TW (1) TW201130838A (es)
WO (1) WO2011101806A1 (es)

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Also Published As

Publication number Publication date
SI2536722T1 (sl) 2014-10-30
CU20120118A7 (es) 2012-10-15
DK2536722T3 (da) 2014-05-26
ES2470190T3 (es) 2014-06-23
NZ602271A (en) 2013-09-27
US8962637B2 (en) 2015-02-24
AU2011216895B2 (en) 2015-11-05
HRP20140437T1 (hr) 2014-08-29
KR20120130294A (ko) 2012-11-30
EA201290757A1 (ru) 2013-04-30
WO2011101806A1 (en) 2011-08-25
US8440679B2 (en) 2013-05-14
SA111320200B1 (ar) 2014-02-16
MX2012009482A (es) 2012-11-29
CA2789655A1 (en) 2011-08-25
BR112012020639A2 (pt) 2017-08-08
SMT201400090B (it) 2014-09-08
EP2536722B1 (en) 2014-04-16
AU2011216895A1 (en) 2012-09-27
CN102858770A (zh) 2013-01-02
RS53458B (en) 2014-12-31
PT2536722E (pt) 2014-05-26
US20130143895A1 (en) 2013-06-06
US20130012518A1 (en) 2013-01-10
AR089641A1 (es) 2014-09-10
JP2013519725A (ja) 2013-05-30
SG183329A1 (en) 2012-09-27
EP2536722A1 (en) 2012-12-26
IL221487A (en) 2014-11-30
CY1115420T1 (el) 2017-01-04
TW201130838A (en) 2011-09-16
PL2536722T3 (pl) 2014-11-28

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Effective date: 20180217