CU20120118A7 - Compuestos bicíclicos y sus usos como inhibidores duales de c-src/jak - Google Patents
Compuestos bicíclicos y sus usos como inhibidores duales de c-src/jakInfo
- Publication number
- CU20120118A7 CU20120118A7 CU2012000118A CU20120118A CU20120118A7 CU 20120118 A7 CU20120118 A7 CU 20120118A7 CU 2012000118 A CU2012000118 A CU 2012000118A CU 20120118 A CU20120118 A CU 20120118A CU 20120118 A7 CU20120118 A7 CU 20120118A7
- Authority
- CU
- Cuba
- Prior art keywords
- src
- inhibitors
- jak
- present
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a compuestos bicíclicos aromáticos sustituidos que contienen anillos de pirimidina y piridina así como también sales aceptables para uso farmacéuticos de los mismos.Los compuestos de la presente invención son útiles como inhibidores de la tirosina quinasa, con preferencia inhibidores de la familia SRC de las quinasas( SFK), en particular como inhibidores múltiples de la SFK/JAK quinasas e incluso, con preferencia, como inhibidores duales de las c- SRC/JAK quinasas, inhibiendo así la activación de STAT3 y, por lo tanto, el crecimiento anormal de los tipos celulares particulares.Notablemente, los compuestos de la presente invención son útiles para el tratamiento o inhibición de ciertas enfermedades que son el resultado de la desregulación de STAT3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN415CH2010 | 2010-02-17 | ||
PCT/IB2011/050669 WO2011101806A1 (en) | 2010-02-17 | 2011-02-17 | Bicyclic compounds and their uses as dual c-src / jak inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20120118A7 true CU20120118A7 (es) | 2012-10-15 |
Family
ID=43903941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2012000118A CU20120118A7 (es) | 2010-02-17 | 2012-08-15 | Compuestos bicíclicos y sus usos como inhibidores duales de c-src/jak |
Country Status (28)
Country | Link |
---|---|
US (2) | US8440679B2 (es) |
EP (1) | EP2536722B1 (es) |
JP (1) | JP2013519725A (es) |
KR (1) | KR20120130294A (es) |
CN (1) | CN102858770A (es) |
AR (1) | AR089641A1 (es) |
AU (1) | AU2011216895B2 (es) |
BR (1) | BR112012020639A2 (es) |
CA (1) | CA2789655A1 (es) |
CU (1) | CU20120118A7 (es) |
CY (1) | CY1115420T1 (es) |
DK (1) | DK2536722T3 (es) |
EA (1) | EA201290757A1 (es) |
ES (1) | ES2470190T3 (es) |
HK (1) | HK1178897A1 (es) |
HR (1) | HRP20140437T1 (es) |
IL (1) | IL221487A (es) |
MX (1) | MX2012009482A (es) |
NZ (1) | NZ602271A (es) |
PL (1) | PL2536722T3 (es) |
PT (1) | PT2536722E (es) |
RS (1) | RS53458B (es) |
SA (1) | SA111320200B1 (es) |
SG (1) | SG183329A1 (es) |
SI (1) | SI2536722T1 (es) |
SM (1) | SMT201400090B (es) |
TW (1) | TW201130838A (es) |
WO (1) | WO2011101806A1 (es) |
Families Citing this family (67)
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MY159449A (en) | 2005-12-13 | 2017-01-13 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
TR201903488T4 (tr) | 2007-06-13 | 2019-04-22 | Incyte Holdings Corp | Janus kinaz inhibitörü (r)-3-(4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-siklopentilpropannitril tuzlarının kullanımı. |
AR076920A1 (es) | 2009-05-22 | 2011-07-20 | Incyte Corp | 3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)octano-o heptano--nitrilo como inhibidores de jak |
SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
PT3050882T (pt) | 2010-03-10 | 2018-04-16 | Incyte Holdings Corp | Derivados de piperidin-4-ilazetidina como inibidores de jak1 |
EP2574168B9 (en) | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
AU2011329734B2 (en) | 2010-11-19 | 2015-05-28 | Incyte Holdings Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
ES2560611T3 (es) | 2011-06-20 | 2016-02-22 | Incyte Holdings Corporation | Derivados de fenil de azetidinilo, carboxamida de piridilo o pirazinilo como inhibidores de JAK |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
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WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
BR112015010663B1 (pt) | 2012-11-15 | 2022-12-06 | Incyte Holdings Corporation | Formas de dosagem oral de liberação sustentada, e uso de ruxolitinib ou de sal farmaceuticamente aceitável do mesmo |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
EP2951590A1 (en) | 2013-02-04 | 2015-12-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for assaying jak2 activity in red blood cells and uses thereof |
UA121532C2 (uk) | 2013-03-06 | 2020-06-10 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки при отриманні інгібітора jak |
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2011
- 2011-02-16 SA SA111320200A patent/SA111320200B1/ar unknown
- 2011-02-17 PT PT117094847T patent/PT2536722E/pt unknown
- 2011-02-17 EP EP11709484.7A patent/EP2536722B1/en not_active Not-in-force
- 2011-02-17 EA EA201290757A patent/EA201290757A1/ru unknown
- 2011-02-17 PL PL11709484T patent/PL2536722T3/pl unknown
- 2011-02-17 SG SG2012060489A patent/SG183329A1/en unknown
- 2011-02-17 DK DK11709484.7T patent/DK2536722T3/da active
- 2011-02-17 US US13/578,656 patent/US8440679B2/en not_active Expired - Fee Related
- 2011-02-17 JP JP2012553436A patent/JP2013519725A/ja not_active Ceased
- 2011-02-17 RS RS20140277A patent/RS53458B/en unknown
- 2011-02-17 NZ NZ602271A patent/NZ602271A/xx not_active IP Right Cessation
- 2011-02-17 CN CN2011800165418A patent/CN102858770A/zh active Pending
- 2011-02-17 ES ES11709484.7T patent/ES2470190T3/es active Active
- 2011-02-17 MX MX2012009482A patent/MX2012009482A/es active IP Right Grant
- 2011-02-17 KR KR1020127023889A patent/KR20120130294A/ko not_active Application Discontinuation
- 2011-02-17 AR ARP110100492A patent/AR089641A1/es unknown
- 2011-02-17 TW TW100105192A patent/TW201130838A/zh unknown
- 2011-02-17 SI SI201130155T patent/SI2536722T1/sl unknown
- 2011-02-17 WO PCT/IB2011/050669 patent/WO2011101806A1/en active Application Filing
- 2011-02-17 AU AU2011216895A patent/AU2011216895B2/en not_active Expired - Fee Related
- 2011-02-17 CA CA2789655A patent/CA2789655A1/en not_active Abandoned
- 2011-02-17 BR BR112012020639A patent/BR112012020639A2/pt not_active IP Right Cessation
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2012
- 2012-08-15 IL IL221487A patent/IL221487A/en not_active IP Right Cessation
- 2012-08-15 CU CU2012000118A patent/CU20120118A7/es unknown
-
2013
- 2013-01-14 US US13/741,019 patent/US8962637B2/en not_active Expired - Fee Related
- 2013-05-16 HK HK13105802.2A patent/HK1178897A1/xx not_active IP Right Cessation
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2014
- 2014-05-15 HR HRP20140437AT patent/HRP20140437T1/hr unknown
- 2014-06-03 CY CY20141100393T patent/CY1115420T1/el unknown
- 2014-07-10 SM SM201400090T patent/SMT201400090B/xx unknown
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HK1178897A1 (en) | 2013-09-19 |
SA111320200B1 (ar) | 2014-02-16 |
US8440679B2 (en) | 2013-05-14 |
AU2011216895A1 (en) | 2012-09-27 |
WO2011101806A1 (en) | 2011-08-25 |
BR112012020639A2 (pt) | 2017-08-08 |
RS53458B (en) | 2014-12-31 |
SMT201400090B (it) | 2014-09-08 |
SI2536722T1 (sl) | 2014-10-30 |
CY1115420T1 (el) | 2017-01-04 |
DK2536722T3 (da) | 2014-05-26 |
US20130012518A1 (en) | 2013-01-10 |
AR089641A1 (es) | 2014-09-10 |
US8962637B2 (en) | 2015-02-24 |
PL2536722T3 (pl) | 2014-11-28 |
PT2536722E (pt) | 2014-05-26 |
IL221487A (en) | 2014-11-30 |
CN102858770A (zh) | 2013-01-02 |
CA2789655A1 (en) | 2011-08-25 |
EP2536722A1 (en) | 2012-12-26 |
NZ602271A (en) | 2013-09-27 |
KR20120130294A (ko) | 2012-11-30 |
MX2012009482A (es) | 2012-11-29 |
EA201290757A1 (ru) | 2013-04-30 |
HRP20140437T1 (hr) | 2014-08-29 |
EP2536722B1 (en) | 2014-04-16 |
ES2470190T3 (es) | 2014-06-23 |
TW201130838A (en) | 2011-09-16 |
AU2011216895B2 (en) | 2015-11-05 |
JP2013519725A (ja) | 2013-05-30 |
US20130143895A1 (en) | 2013-06-06 |
SG183329A1 (en) | 2012-09-27 |
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