BR112018000297A2 - polimorfo de macrociclo de diarila - Google Patents
polimorfo de macrociclo de diarilaInfo
- Publication number
- BR112018000297A2 BR112018000297A2 BR112018000297A BR112018000297A BR112018000297A2 BR 112018000297 A2 BR112018000297 A2 BR 112018000297A2 BR 112018000297 A BR112018000297 A BR 112018000297A BR 112018000297 A BR112018000297 A BR 112018000297A BR 112018000297 A2 BR112018000297 A2 BR 112018000297A2
- Authority
- BR
- Brazil
- Prior art keywords
- polymorph
- macrocycle
- diaryl
- diaryl macrocycle
- macrocycle polymorph
- Prior art date
Links
- -1 diaryl macrocycle Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188846P | 2015-07-06 | 2015-07-06 | |
| US201562218672P | 2015-09-15 | 2015-09-15 | |
| PCT/US2016/040972 WO2017007759A1 (en) | 2015-07-06 | 2016-07-05 | Diaryl macrocycle polymorph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018000297A2 true BR112018000297A2 (pt) | 2018-09-04 |
Family
ID=57685592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018000297A BR112018000297A2 (pt) | 2015-07-06 | 2016-07-05 | polimorfo de macrociclo de diarila |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10294242B2 (pt) |
| EP (1) | EP3319969B1 (pt) |
| JP (2) | JP6917974B2 (pt) |
| KR (1) | KR102623734B1 (pt) |
| CN (2) | CN108026108B (pt) |
| AU (1) | AU2016289454B2 (pt) |
| BR (1) | BR112018000297A2 (pt) |
| CA (1) | CA2990020C (pt) |
| HK (1) | HK1254492A1 (pt) |
| IL (2) | IL256443B (pt) |
| MX (2) | MX2017017081A (pt) |
| RU (1) | RU2765181C2 (pt) |
| WO (1) | WO2017007759A1 (pt) |
| ZA (1) | ZA201708436B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2735729T3 (es) | 2014-01-24 | 2019-12-20 | Turning Point Therapeutics Inc | Macrociclos de diarilo como moduladores de proteínas cinasas |
| US10316044B2 (en) | 2015-07-02 | 2019-06-11 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| BR112018001065A2 (pt) * | 2015-07-21 | 2018-09-11 | Tp Therapeutics, Inc. | macrociclos diarila quirais e usos dos mesmos |
| MX2019001125A (es) | 2016-07-28 | 2019-06-12 | Tp Therapeutics Inc | Inhibidores de cinasa macrociclica. |
| TWI808958B (zh) * | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN107586796B (zh) * | 2017-07-20 | 2021-08-06 | 暨明医药科技（苏州）有限公司 | (r)-2-(1-氨基乙基)-4-氟苯酚的合成方法 |
| BR112020001695A2 (pt) | 2017-07-28 | 2020-07-21 | Turning Point Therapeutics, Inc. | compostos macrocíclicos e usos dos mesmos |
| ES2929467T3 (es) | 2017-12-19 | 2022-11-29 | Turning Point Therapeutics Inc | Compuestos macrocíclicos para tratar enfermedades |
| CN113956269A (zh) * | 2018-04-16 | 2022-01-21 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的二(杂)芳基大环化合物 |
| CN113490664A (zh) | 2018-10-22 | 2021-10-08 | 埃斯克疗法股份有限公司 | Tyk2抑制剂和其用途 |
| EP3974434A4 (en) | 2019-05-21 | 2023-11-08 | Zhejiang Hisun Pharmaceutical Co., Ltd. | MACROLIDE DERIVATIVES, PRODUCTION PROCESS AND USE THEREOF |
| CA3143043A1 (en) * | 2019-06-19 | 2020-12-24 | Turning Point Therapeutics, Inc. | Polymorphs of a macrocyclic kinase inhibitor |
| CA3163095A1 (en) * | 2019-11-27 | 2021-06-03 | Turning Point Therapeutics, Inc. | Combination therapy involving diaryl macrocyclic compounds |
| CN114901286B (zh) * | 2019-11-27 | 2024-05-10 | 特普医药公司 | 涉及二芳基巨环化合物的组合疗法 |
| KR20230022151A (ko) * | 2020-03-02 | 2023-02-14 | 터닝 포인트 테라퓨틱스, 인크. | 거대고리 화합물의 치료 용도 |
| CN112174982A (zh) * | 2020-09-10 | 2021-01-05 | 上海希迈医药科技有限公司 | 一种洛普替尼晶型及其制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9403639D0 (en) * | 1994-02-25 | 1994-04-13 | Boots Co Plc | Therapeutic agents |
| WO2003011222A2 (en) * | 2001-07-27 | 2003-02-13 | Merck & Co., Inc. | Thrombin inhibitors |
| MX2011002470A (es) | 2008-09-08 | 2011-04-05 | Merck Patent Gmbh | Pirimidinas macrociclicas como inhibidores de aurora cinasa. |
| RS53350B (en) | 2008-09-22 | 2014-10-31 | Array Biopharma, Inc. | SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS |
| KR101634833B1 (ko) | 2008-10-22 | 2016-06-29 | 어레이 바이오파마 인크. | ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５ａ］ 피리미딘 화합물 |
| EP2348860B1 (en) | 2008-10-31 | 2015-05-27 | Genentech, Inc. | Pyrazolopyrimidine jak inhibitor compounds and methods |
| EP2918588B1 (en) | 2010-05-20 | 2017-05-03 | Array Biopharma, Inc. | Macrocyclic compounds as TRK kinase inhibitors |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| EP2508607A1 (en) | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
| WO2013001310A1 (en) | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| AU2012299223A1 (en) * | 2011-08-19 | 2014-02-27 | Merck Sharp & Dohme Corp. | Process and intermediates for preparing macrolactams |
| JP6046728B2 (ja) | 2011-09-30 | 2016-12-21 | オンコデザイン エス．ア． | 大環状ｆｌｔ３キナーゼ阻害剤 |
| CN104169286B (zh) | 2012-03-06 | 2016-06-08 | 辉瑞大药厂 | 用于治疗增殖性疾病的大环衍生物 |
| MX347917B (es) | 2012-03-09 | 2017-05-17 | Lexicon Pharmaceuticals Inc | Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso. |
| EP2834243B1 (en) | 2012-03-09 | 2018-04-25 | Lexicon Pharmaceuticals, Inc. | PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE |
| GB201205669D0 (en) | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
| US10497029B2 (en) * | 2013-10-21 | 2019-12-03 | Disney Enterprises, Inc. | Systems and methods for facilitating brand integration within online content and promoting that online content |
| ES2735729T3 (es) * | 2014-01-24 | 2019-12-20 | Turning Point Therapeutics Inc | Macrociclos de diarilo como moduladores de proteínas cinasas |
| US10316044B2 (en) * | 2015-07-02 | 2019-06-11 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| BR112018001065A2 (pt) * | 2015-07-21 | 2018-09-11 | Tp Therapeutics, Inc. | macrociclos diarila quirais e usos dos mesmos |
-
2016
- 2016-07-05 BR BR112018000297A patent/BR112018000297A2/pt not_active Application Discontinuation
- 2016-07-05 WO PCT/US2016/040972 patent/WO2017007759A1/en active Application Filing
- 2016-07-05 RU RU2018104269A patent/RU2765181C2/ru active
- 2016-07-05 EP EP16821872.5A patent/EP3319969B1/en active Active
- 2016-07-05 US US15/741,893 patent/US10294242B2/en active Active
- 2016-07-05 KR KR1020187002778A patent/KR102623734B1/ko active IP Right Grant
- 2016-07-05 JP JP2018500582A patent/JP6917974B2/ja active Active
- 2016-07-05 AU AU2016289454A patent/AU2016289454B2/en active Active
- 2016-07-05 MX MX2017017081A patent/MX2017017081A/es unknown
- 2016-07-05 CA CA2990020A patent/CA2990020C/en active Active
- 2016-07-05 CN CN201680051405.5A patent/CN108026108B/zh active Active
- 2016-07-05 CN CN202110623105.2A patent/CN113354653A/zh active Pending
-
2017
- 2017-12-12 ZA ZA2017/08436A patent/ZA201708436B/en unknown
- 2017-12-20 IL IL256443A patent/IL256443B/en active IP Right Grant
- 2017-12-20 MX MX2021008145A patent/MX2021008145A/es unknown
-
2018
- 2018-10-25 HK HK18113701.3A patent/HK1254492A1/zh unknown
-
2019
- 2019-04-08 US US16/378,095 patent/US20190233437A1/en not_active Abandoned
-
2020
- 2020-10-15 US US17/071,569 patent/US20210094974A1/en not_active Abandoned
-
2021
- 2021-04-16 JP JP2021069649A patent/JP7212713B2/ja active Active
- 2021-05-13 IL IL283184A patent/IL283184B2/en unknown
-
2022
- 2022-09-19 US US17/933,434 patent/US20230295184A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018529633A (ja) | 2018-10-11 |
| HK1254492A1 (zh) | 2019-07-19 |
| EP3319969B1 (en) | 2024-04-03 |
| MX2021008145A (es) | 2021-08-11 |
| ZA201708436B (en) | 2021-03-31 |
| EP3319969A4 (en) | 2019-07-03 |
| IL283184A (en) | 2021-06-30 |
| JP2021119151A (ja) | 2021-08-12 |
| IL256443B (en) | 2021-05-31 |
| JP7212713B2 (ja) | 2023-01-25 |
| AU2016289454B2 (en) | 2020-07-09 |
| WO2017007759A1 (en) | 2017-01-12 |
| CA2990020C (en) | 2024-02-27 |
| EP3319969A1 (en) | 2018-05-16 |
| IL256443A (en) | 2018-02-28 |
| RU2018104269A3 (pt) | 2019-12-17 |
| CN108026108A (zh) | 2018-05-11 |
| US10294242B2 (en) | 2019-05-21 |
| RU2765181C2 (ru) | 2022-01-26 |
| CN113354653A (zh) | 2021-09-07 |
| JP6917974B2 (ja) | 2021-08-11 |
| KR20180026480A (ko) | 2018-03-12 |
| MX2017017081A (es) | 2018-08-16 |
| CN108026108B (zh) | 2021-06-22 |
| RU2018104269A (ru) | 2019-08-06 |
| IL283184B2 (en) | 2023-06-01 |
| US20190233437A1 (en) | 2019-08-01 |
| US20230295184A1 (en) | 2023-09-21 |
| AU2016289454A1 (en) | 2018-01-04 |
| US20210094974A1 (en) | 2021-04-01 |
| US20180194777A1 (en) | 2018-07-12 |
| CA2990020A1 (en) | 2017-01-12 |
| KR102623734B1 (ko) | 2024-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: TURNING POINT THERAPEUTICS, INC. (US) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |