JP2022040287A5 - - Google Patents
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- JP2022040287A5 JP2022040287A5 JP2022005510A JP2022005510A JP2022040287A5 JP 2022040287 A5 JP2022040287 A5 JP 2022040287A5 JP 2022005510 A JP2022005510 A JP 2022005510A JP 2022005510 A JP2022005510 A JP 2022005510A JP 2022040287 A5 JP2022040287 A5 JP 2022040287A5
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- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 26
- 238000000034 method Methods 0.000 claims 21
- 210000001744 T-lymphocyte Anatomy 0.000 claims 16
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 102100020873 Interleukin-2 Human genes 0.000 claims 6
- 108010002350 Interleukin-2 Proteins 0.000 claims 6
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 5
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 4
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 4
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 4
- 238000010361 transduction Methods 0.000 claims 4
- 230000026683 transduction Effects 0.000 claims 4
- 238000005406 washing Methods 0.000 claims 4
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 3
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000004062 sedimentation Methods 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 238000002617 apheresis Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000011748 cell maturation Effects 0.000 claims 1
- 102000046157 human CSF2 Human genes 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024067465A JP2024086948A (ja) | 2014-04-25 | 2024-04-18 | 養子細胞療法薬を製造するための改善された方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461984558P | 2014-04-25 | 2014-04-25 | |
| US61/984,558 | 2014-04-25 | ||
| JP2019199637A JP7012056B2 (ja) | 2014-04-25 | 2019-11-01 | 養子細胞療法薬を製造するための改善された方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019199637A Division JP7012056B2 (ja) | 2014-04-25 | 2019-11-01 | 養子細胞療法薬を製造するための改善された方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024067465A Division JP2024086948A (ja) | 2014-04-25 | 2024-04-18 | 養子細胞療法薬を製造するための改善された方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022040287A JP2022040287A (ja) | 2022-03-10 |
| JP2022040287A5 true JP2022040287A5 (enExample) | 2022-03-30 |
| JP7536808B2 JP7536808B2 (ja) | 2024-08-20 |
Family
ID=54333268
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564075A Active JP6817069B2 (ja) | 2014-04-25 | 2015-04-24 | 養子細胞療法薬を製造するための改善された方法 |
| JP2018041688A Withdrawn JP2018087254A (ja) | 2014-04-25 | 2018-03-08 | 養子細胞療法薬を製造するための改善された方法 |
| JP2019199637A Active JP7012056B2 (ja) | 2014-04-25 | 2019-11-01 | 養子細胞療法薬を製造するための改善された方法 |
| JP2022005510A Active JP7536808B2 (ja) | 2014-04-25 | 2022-01-18 | 養子細胞療法薬を製造するための改善された方法 |
| JP2024067465A Withdrawn JP2024086948A (ja) | 2014-04-25 | 2024-04-18 | 養子細胞療法薬を製造するための改善された方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564075A Active JP6817069B2 (ja) | 2014-04-25 | 2015-04-24 | 養子細胞療法薬を製造するための改善された方法 |
| JP2018041688A Withdrawn JP2018087254A (ja) | 2014-04-25 | 2018-03-08 | 養子細胞療法薬を製造するための改善された方法 |
| JP2019199637A Active JP7012056B2 (ja) | 2014-04-25 | 2019-11-01 | 養子細胞療法薬を製造するための改善された方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024067465A Withdrawn JP2024086948A (ja) | 2014-04-25 | 2024-04-18 | 養子細胞療法薬を製造するための改善された方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US12291722B2 (enExample) |
| EP (2) | EP3738597A1 (enExample) |
| JP (5) | JP6817069B2 (enExample) |
| KR (3) | KR20160141865A (enExample) |
| CN (2) | CN106456670B (enExample) |
| AU (2) | AU2015249376C1 (enExample) |
| BR (1) | BR112016024957A2 (enExample) |
| CA (1) | CA2946552A1 (enExample) |
| CY (1) | CY1123142T1 (enExample) |
| DK (1) | DK3134095T3 (enExample) |
| ES (1) | ES2800906T3 (enExample) |
| HR (1) | HRP20200978T1 (enExample) |
| HU (1) | HUE049514T2 (enExample) |
| IL (2) | IL248349B (enExample) |
| LT (1) | LT3134095T (enExample) |
| MX (2) | MX370018B (enExample) |
| NZ (1) | NZ725201A (enExample) |
| PL (1) | PL3134095T3 (enExample) |
| PT (1) | PT3134095T (enExample) |
| RS (1) | RS60544B1 (enExample) |
| RU (1) | RU2741899C2 (enExample) |
| SG (2) | SG10201808258SA (enExample) |
| SI (1) | SI3134095T1 (enExample) |
| SM (1) | SMT202000355T1 (enExample) |
| WO (1) | WO2015164745A1 (enExample) |
| ZA (2) | ZA201607175B (enExample) |
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| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
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| US11400115B2 (en) | 2014-04-23 | 2022-08-02 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
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