JP2018527014A5 - - Google Patents
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- JP2018527014A5 JP2018527014A5 JP2018515108A JP2018515108A JP2018527014A5 JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5 JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5
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- JP
- Japan
- Prior art keywords
- acid sequence
- cell
- hiv
- nucleic acid
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 58
- 150000007523 nucleic acids Chemical group 0.000 claims description 58
- 230000011664 signaling Effects 0.000 claims description 44
- 210000004027 cell Anatomy 0.000 claims description 41
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 28
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 26
- 230000000139 costimulatory effect Effects 0.000 claims description 26
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 241000124008 Mammalia Species 0.000 claims description 16
- 230000009870 specific binding Effects 0.000 claims description 14
- 108700010039 chimeric receptor Proteins 0.000 claims description 11
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 10
- -1 OX9 Proteins 0.000 claims description 10
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 8
- 230000027455 binding Effects 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 101710145634 Antigen 1 Proteins 0.000 claims description 6
- 102100024263 CD160 antigen Human genes 0.000 claims description 6
- 102100027207 CD27 antigen Human genes 0.000 claims description 6
- 101150013553 CD40 gene Proteins 0.000 claims description 6
- 102100035793 CD83 antigen Human genes 0.000 claims description 6
- 208000031886 HIV Infections Diseases 0.000 claims description 6
- 208000037357 HIV infectious disease Diseases 0.000 claims description 6
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims description 6
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 6
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 6
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 6
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims description 6
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims description 6
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 6
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims description 6
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 6
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 6
- 102100032818 Integrin alpha-4 Human genes 0.000 claims description 6
- 102100032816 Integrin alpha-6 Human genes 0.000 claims description 6
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims description 6
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 6
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 6
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- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 6
- 108091008874 T cell receptors Proteins 0.000 claims description 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 6
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 6
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims description 6
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 6
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 6
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 6
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 6
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 6
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 6
- 230000003834 intracellular effect Effects 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 6
- 210000004698 lymphocyte Anatomy 0.000 claims description 6
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 4
- 102100038077 CD226 antigen Human genes 0.000 claims description 4
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 claims description 4
- 102000003886 Glycoproteins Human genes 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 4
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims description 4
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims description 4
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims description 4
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- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 4
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims description 4
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims description 4
- 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 claims description 4
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims description 4
- 102100025323 Integrin alpha-1 Human genes 0.000 claims description 4
- 102100039904 Integrin alpha-D Human genes 0.000 claims description 4
- 102100022341 Integrin alpha-E Human genes 0.000 claims description 4
- 102100022338 Integrin alpha-M Human genes 0.000 claims description 4
- 102100022297 Integrin alpha-X Human genes 0.000 claims description 4
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 4
- 102100025390 Integrin beta-2 Human genes 0.000 claims description 4
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims description 4
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims description 4
- 102000014128 RANK Ligand Human genes 0.000 claims description 4
- 108010025832 RANK Ligand Proteins 0.000 claims description 4
- 102100027744 Semaphorin-4D Human genes 0.000 claims description 4
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims description 4
- 102100027010 Toll-like receptor 1 Human genes 0.000 claims description 4
- 108010060889 Toll-like receptor 1 Proteins 0.000 claims description 4
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 4
- 238000011225 antiretroviral therapy Methods 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 2
- 108010056102 CD100 antigen Proteins 0.000 claims description 2
- 108010017009 CD11b Antigen Proteins 0.000 claims description 2
- 108010062802 CD66 antigens Proteins 0.000 claims description 2
- 102100027217 CD82 antigen Human genes 0.000 claims description 2
- 101710139831 CD82 antigen Proteins 0.000 claims description 2
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims description 2
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims description 2
- 101000585551 Equus caballus Pregnancy-associated glycoprotein Proteins 0.000 claims description 2
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims description 2
- 102100022086 GRB2-related adapter protein 2 Human genes 0.000 claims description 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 2
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims description 2
- 101000900690 Homo sapiens GRB2-related adapter protein 2 Proteins 0.000 claims description 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 2
- 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 claims description 2
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims description 2
- 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 claims description 2
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims description 2
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims description 2
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims description 2
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims description 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 2
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims description 2
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims description 2
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 claims description 2
- 101000692259 Homo sapiens Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Proteins 0.000 claims description 2
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims description 2
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims description 2
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 2
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims description 2
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims description 2
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims description 2
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims description 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 2
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 claims description 2
- 101000669406 Homo sapiens Toll-like receptor 6 Proteins 0.000 claims description 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims description 2
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims description 2
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims description 2
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102100022339 Integrin alpha-L Human genes 0.000 claims description 2
- 108010041100 Integrin alpha6 Proteins 0.000 claims description 2
- 108010030465 Integrin alpha6beta1 Proteins 0.000 claims description 2
- 102100033016 Integrin beta-7 Human genes 0.000 claims description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 2
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims description 2
- 241000713666 Lentivirus Species 0.000 claims description 2
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims description 2
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims description 2
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 claims description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
- 101100236305 Mus musculus Ly9 gene Proteins 0.000 claims description 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 2
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims description 2
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims description 2
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims description 2
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims description 2
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims description 2
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims description 2
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims description 2
- 102100026066 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Human genes 0.000 claims description 2
- 102100029216 SLAM family member 5 Human genes 0.000 claims description 2
- 102100029198 SLAM family member 7 Human genes 0.000 claims description 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 2
- 230000024932 T cell mediated immunity Effects 0.000 claims description 2
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 2
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims description 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims description 2
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims description 2
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims description 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 2
- 102100039357 Toll-like receptor 5 Human genes 0.000 claims description 2
- 102100039387 Toll-like receptor 6 Human genes 0.000 claims description 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims description 2
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims description 2
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims description 2
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 2
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims description 2
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims description 2
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004520 electroporation Methods 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000001890 transfection Methods 0.000 claims description 2
- 241001430294 unidentified retrovirus Species 0.000 claims description 2
- 210000002845 virion Anatomy 0.000 claims description 2
- 108700028369 Alleles Proteins 0.000 claims 3
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 3
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 101150017501 CCR5 gene Proteins 0.000 claims 1
- 101100055418 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) AMF1 gene Proteins 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222132P | 2015-09-22 | 2015-09-22 | |
| US62/222,132 | 2015-09-22 | ||
| US201562253790P | 2015-11-11 | 2015-11-11 | |
| US62/253,790 | 2015-11-11 | ||
| PCT/US2016/053097 WO2017053556A1 (en) | 2015-09-22 | 2016-09-22 | Method of redirecting t cells to treat hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527014A JP2018527014A (ja) | 2018-09-20 |
| JP2018527014A5 true JP2018527014A5 (enExample) | 2019-10-31 |
| JP6991131B2 JP6991131B2 (ja) | 2022-02-03 |
Family
ID=58387210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515108A Active JP6991131B2 (ja) | 2015-09-22 | 2016-09-22 | Ｈｉｖ感染症を処置するためにｔ細胞を再度方向付ける方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10738099B2 (enExample) |
| EP (1) | EP3353197A4 (enExample) |
| JP (1) | JP6991131B2 (enExample) |
| KR (1) | KR20180050413A (enExample) |
| CN (1) | CN108779161A (enExample) |
| AU (1) | AU2016326500A1 (enExample) |
| BR (1) | BR112018005741A2 (enExample) |
| CA (1) | CA2999496A1 (enExample) |
| CL (1) | CL2018000750A1 (enExample) |
| EA (1) | EA201890782A1 (enExample) |
| IL (1) | IL258191A (enExample) |
| MA (1) | MA42951A (enExample) |
| MX (1) | MX2018003463A (enExample) |
| PH (1) | PH12018500609A1 (enExample) |
| WO (1) | WO2017053556A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
| CN108779161A (zh) * | 2015-09-22 | 2018-11-09 | 宾夕法尼亚大学董事会 | 重定向t细胞以治疗hiv感染的方法 |
| AU2016347058B2 (en) | 2015-10-25 | 2023-11-09 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of HIV infection |
| EP3413926A4 (en) | 2016-02-08 | 2019-10-09 | American Gene Technologies International, Inc. | HIV VACCINATION AND IMMUNOTHERAPY |
| EP4257193B1 (en) | 2016-04-13 | 2025-12-31 | Sanofi | TRISPECIFIC AND/OR TRIVALENT LINKING PROTEINS |
| JP7195929B2 (ja) | 2016-04-13 | 2022-12-26 | サノフイ | 三重特異性および／または三価結合タンパク質 |
| AU2017292582C1 (en) | 2016-07-08 | 2021-11-11 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| WO2018208606A1 (en) * | 2017-05-08 | 2018-11-15 | The Regents Of The University Of California | Protective chimeric antigen receptor stem cell gene therapy for viral infection |
| CN110662553A (zh) * | 2017-05-17 | 2020-01-07 | 迅雷生物科技有限公司 | 转基因巨噬细胞、嵌合抗原受体和相关方法 |
| US10415017B2 (en) | 2017-05-17 | 2019-09-17 | Thunder Biotech, Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
| US12496338B2 (en) | 2017-10-23 | 2025-12-16 | City Of Hope | CAR for treatment of HIV infection |
| CN108059675B (zh) * | 2017-12-12 | 2021-09-10 | 武汉波睿达生物科技有限公司 | 重组pg9-car分子的构建及其在清除hiv-1感染细胞中的应用 |
| TWI841576B (zh) | 2018-07-13 | 2024-05-11 | 大陸商南京傳奇生物科技有限公司 | 用於治療傳染病之共受體系統 |
| EP3917946A4 (en) * | 2019-01-28 | 2022-10-26 | Xyphos Biosciences Inc. | MODIFIED NKG2D NON-NATURAL LIGANDS THAT DELIVER SELECTIVELY BOUND HETEROLOGOUS MOLECULES TO NON-NATURAL NKG2D RECEPTORS ON CAR CELLS |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN110358793A (zh) * | 2019-05-30 | 2019-10-22 | 南京艾德免疫治疗研究院有限公司 | 一种用于car-t制备的慢病毒载体制备方法 |
| WO2020247837A1 (en) * | 2019-06-07 | 2020-12-10 | The Trustees Of The University Of Pennsylvania | Dual car expressing t cells individually linked to cd28 and 4-1bb |
| CN110343175B (zh) * | 2019-06-26 | 2021-02-26 | 深圳市再生之城生物医药技术有限公司 | 抑制HIV-1病毒感染的scFv序列及其应用 |
| CA3170630A1 (en) * | 2020-03-03 | 2021-09-10 | American Gene Technologies International Inc. | On demand expression of exogenous factors in lymphocytes to treat hiv |
| EP4458952A4 (en) * | 2021-12-31 | 2025-10-08 | Beijing Solobio Genetechnology Co Ltd | Chimeric Antigen Receptor T Cells Targeting HIV-Infected Cells |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5851828A (en) | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| WO1993006216A1 (en) * | 1991-09-26 | 1993-04-01 | Oklahoma Medical Research Foundation | Fusion proteins targeted to lysosomes, for the treatment of aids |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| PT781095E (pt) * | 1994-08-02 | 2003-06-30 | Gen Hospital Corp | Celulas contendo receptores chamariz cd4 e moleculas e metodos com elas relacionados |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9708384B2 (en) * | 2011-09-22 | 2017-07-18 | The Trustees Of The University Of Pennsylvania | Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens |
| AU2013221672B2 (en) | 2012-02-13 | 2017-11-09 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| IN2014DN11156A (enExample) | 2012-07-13 | 2015-10-02 | Univ Pennsylvania | |
| US9573988B2 (en) | 2013-02-20 | 2017-02-21 | Novartis Ag | Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| JP6516740B2 (ja) | 2013-08-02 | 2019-05-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 幹細胞及びキメラ抗原受容体を介した抗腫瘍性ｔ細胞免疫の改変 |
| US10144770B2 (en) | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| WO2015077789A2 (en) * | 2013-11-25 | 2015-05-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control hiv infection |
| AU2015218396A1 (en) * | 2014-02-14 | 2016-08-11 | Bellicum Pharmaceuticals, Inc. | Methods for activating T cells using an inducible chimeric polypeptide |
| US10301370B2 (en) * | 2014-05-02 | 2019-05-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor T cells |
| CN108779161A (zh) * | 2015-09-22 | 2018-11-09 | 宾夕法尼亚大学董事会 | 重定向t细胞以治疗hiv感染的方法 |
-
2016
- 2016-09-22 CN CN201680066602.4A patent/CN108779161A/zh active Pending
- 2016-09-22 CA CA2999496A patent/CA2999496A1/en active Pending
- 2016-09-22 EP EP16849585.1A patent/EP3353197A4/en active Pending
- 2016-09-22 BR BR112018005741A patent/BR112018005741A2/pt not_active Application Discontinuation
- 2016-09-22 KR KR1020187011293A patent/KR20180050413A/ko not_active Withdrawn
- 2016-09-22 MA MA042951A patent/MA42951A/fr unknown
- 2016-09-22 US US15/761,563 patent/US10738099B2/en active Active
- 2016-09-22 MX MX2018003463A patent/MX2018003463A/es unknown
- 2016-09-22 AU AU2016326500A patent/AU2016326500A1/en not_active Abandoned
- 2016-09-22 JP JP2018515108A patent/JP6991131B2/ja active Active
- 2016-09-22 WO PCT/US2016/053097 patent/WO2017053556A1/en not_active Ceased
- 2016-09-22 EA EA201890782A patent/EA201890782A1/ru unknown
-
2018
- 2018-03-18 IL IL258191A patent/IL258191A/en unknown
- 2018-03-21 CL CL2018000750A patent/CL2018000750A1/es unknown
- 2018-03-21 PH PH12018500609A patent/PH12018500609A1/en unknown
-
2020
- 2020-08-07 US US16/988,415 patent/US12122820B2/en active Active
-
2024
- 2024-09-13 US US18/885,127 patent/US20250084147A1/en active Pending
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