JP2018527014A5 - - Google Patents
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- JP2018527014A5 JP2018527014A5 JP2018515108A JP2018515108A JP2018527014A5 JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5 JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5
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- JP
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- Prior art keywords
- acid sequence
- cell
- hiv
- nucleic acid
- domain
- Prior art date
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- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 58
- 150000007523 nucleic acids Chemical group 0.000 claims description 58
- 230000011664 signaling Effects 0.000 claims description 44
- 210000004027 cell Anatomy 0.000 claims description 41
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 28
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 26
- 230000000139 costimulatory effect Effects 0.000 claims description 26
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 241000124008 Mammalia Species 0.000 claims description 16
- 230000009870 specific binding Effects 0.000 claims description 14
- 108700010039 chimeric receptor Proteins 0.000 claims description 11
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 10
- -1 OX9 Proteins 0.000 claims description 10
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 8
- 230000027455 binding Effects 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 101710145634 Antigen 1 Proteins 0.000 claims description 6
- 102100024263 CD160 antigen Human genes 0.000 claims description 6
- 102100027207 CD27 antigen Human genes 0.000 claims description 6
- 101150013553 CD40 gene Proteins 0.000 claims description 6
- 102100035793 CD83 antigen Human genes 0.000 claims description 6
- 208000031886 HIV Infections Diseases 0.000 claims description 6
- 208000037357 HIV infectious disease Diseases 0.000 claims description 6
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims description 6
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 6
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 6
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 6
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims description 6
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims description 6
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 6
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims description 6
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 6
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 6
- 102100032818 Integrin alpha-4 Human genes 0.000 claims description 6
- 102100032816 Integrin alpha-6 Human genes 0.000 claims description 6
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims description 6
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 6
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 6
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- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 6
- 108091008874 T cell receptors Proteins 0.000 claims description 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 6
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 6
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims description 6
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 6
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 6
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 6
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 6
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 6
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 6
- 230000003834 intracellular effect Effects 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 6
- 210000004698 lymphocyte Anatomy 0.000 claims description 6
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 4
- 102100038077 CD226 antigen Human genes 0.000 claims description 4
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 claims description 4
- 102000003886 Glycoproteins Human genes 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 4
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims description 4
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims description 4
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims description 4
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- 101001035237 Homo sapiens Integrin alpha-D Proteins 0.000 claims description 4
- 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 claims description 4
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 4
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims description 4
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims description 4
- 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 claims description 4
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims description 4
- 102100025323 Integrin alpha-1 Human genes 0.000 claims description 4
- 102100039904 Integrin alpha-D Human genes 0.000 claims description 4
- 102100022341 Integrin alpha-E Human genes 0.000 claims description 4
- 102100022338 Integrin alpha-M Human genes 0.000 claims description 4
- 102100022297 Integrin alpha-X Human genes 0.000 claims description 4
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 4
- 102100025390 Integrin beta-2 Human genes 0.000 claims description 4
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims description 4
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims description 4
- 102000014128 RANK Ligand Human genes 0.000 claims description 4
- 108010025832 RANK Ligand Proteins 0.000 claims description 4
- 102100027744 Semaphorin-4D Human genes 0.000 claims description 4
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims description 4
- 102100027010 Toll-like receptor 1 Human genes 0.000 claims description 4
- 108010060889 Toll-like receptor 1 Proteins 0.000 claims description 4
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 4
- 238000011225 antiretroviral therapy Methods 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 2
- 108010056102 CD100 antigen Proteins 0.000 claims description 2
- 108010017009 CD11b Antigen Proteins 0.000 claims description 2
- 108010062802 CD66 antigens Proteins 0.000 claims description 2
- 102100027217 CD82 antigen Human genes 0.000 claims description 2
- 101710139831 CD82 antigen Proteins 0.000 claims description 2
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims description 2
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims description 2
- 101000585551 Equus caballus Pregnancy-associated glycoprotein Proteins 0.000 claims description 2
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims description 2
- 102100022086 GRB2-related adapter protein 2 Human genes 0.000 claims description 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 2
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims description 2
- 101000900690 Homo sapiens GRB2-related adapter protein 2 Proteins 0.000 claims description 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 2
- 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 claims description 2
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims description 2
- 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 claims description 2
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims description 2
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims description 2
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims description 2
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims description 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 2
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims description 2
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims description 2
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 claims description 2
- 101000692259 Homo sapiens Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Proteins 0.000 claims description 2
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims description 2
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims description 2
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 2
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims description 2
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims description 2
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims description 2
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims description 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 2
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 claims description 2
- 101000669406 Homo sapiens Toll-like receptor 6 Proteins 0.000 claims description 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims description 2
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims description 2
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims description 2
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102100022339 Integrin alpha-L Human genes 0.000 claims description 2
- 108010041100 Integrin alpha6 Proteins 0.000 claims description 2
- 108010030465 Integrin alpha6beta1 Proteins 0.000 claims description 2
- 102100033016 Integrin beta-7 Human genes 0.000 claims description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 2
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims description 2
- 241000713666 Lentivirus Species 0.000 claims description 2
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims description 2
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims description 2
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 claims description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
- 101100236305 Mus musculus Ly9 gene Proteins 0.000 claims description 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 2
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims description 2
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims description 2
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims description 2
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims description 2
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims description 2
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims description 2
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims description 2
- 102100026066 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Human genes 0.000 claims description 2
- 102100029216 SLAM family member 5 Human genes 0.000 claims description 2
- 102100029198 SLAM family member 7 Human genes 0.000 claims description 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 2
- 230000024932 T cell mediated immunity Effects 0.000 claims description 2
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 2
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims description 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims description 2
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims description 2
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims description 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 2
- 102100039357 Toll-like receptor 5 Human genes 0.000 claims description 2
- 102100039387 Toll-like receptor 6 Human genes 0.000 claims description 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims description 2
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims description 2
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims description 2
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 2
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims description 2
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims description 2
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004520 electroporation Methods 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000001890 transfection Methods 0.000 claims description 2
- 241001430294 unidentified retrovirus Species 0.000 claims description 2
- 210000002845 virion Anatomy 0.000 claims description 2
- 108700028369 Alleles Proteins 0.000 claims 3
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 3
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 101150017501 CCR5 gene Proteins 0.000 claims 1
- 101100055418 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) AMF1 gene Proteins 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222132P | 2015-09-22 | 2015-09-22 | |
| US62/222,132 | 2015-09-22 | ||
| US201562253790P | 2015-11-11 | 2015-11-11 | |
| US62/253,790 | 2015-11-11 | ||
| PCT/US2016/053097 WO2017053556A1 (en) | 2015-09-22 | 2016-09-22 | Method of redirecting t cells to treat hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527014A JP2018527014A (ja) | 2018-09-20 |
| JP2018527014A5 true JP2018527014A5 (enExample) | 2019-10-31 |
| JP6991131B2 JP6991131B2 (ja) | 2022-02-03 |
Family
ID=58387210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515108A Active JP6991131B2 (ja) | 2015-09-22 | 2016-09-22 | Ｈｉｖ感染症を処置するためにｔ細胞を再度方向付ける方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10738099B2 (enExample) |
| EP (1) | EP3353197A4 (enExample) |
| JP (1) | JP6991131B2 (enExample) |
| KR (1) | KR20180050413A (enExample) |
| CN (1) | CN108779161A (enExample) |
| AU (1) | AU2016326500A1 (enExample) |
| BR (1) | BR112018005741A2 (enExample) |
| CA (1) | CA2999496A1 (enExample) |
| CL (1) | CL2018000750A1 (enExample) |
| EA (1) | EA201890782A1 (enExample) |
| IL (1) | IL258191A (enExample) |
| MA (1) | MA42951A (enExample) |
| MX (1) | MX2018003463A (enExample) |
| PH (1) | PH12018500609A1 (enExample) |
| WO (1) | WO2017053556A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
| CA2999496A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
| CN116675776A (zh) | 2015-10-25 | 2023-09-01 | 赛诺菲 | 用于预防或治疗hiv感染的三特异性和/或三价结合蛋白 |
| WO2017139065A1 (en) | 2016-02-08 | 2017-08-17 | American Gene Technologies International Inc. | Hiv vaccination and immunotherapy |
| CN109476732B (zh) | 2016-04-13 | 2024-03-22 | 赛诺菲 | 三特异性和/或三价结合蛋白 |
| MY192090A (en) | 2016-04-13 | 2022-07-26 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
| EP3481418A4 (en) | 2016-07-08 | 2020-03-11 | American Gene Technologies International Inc. | PRE-IMMUNIZATION AND IMMUNOTHERAPY OF HIV |
| US20200061117A1 (en) * | 2017-05-08 | 2020-02-27 | The Regents Of The University Of California | Protective Chimeric Antigen Receptor Stem Cell Gene Therapy for Viral Infection |
| US10415017B2 (en) | 2017-05-17 | 2019-09-17 | Thunder Biotech, Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
| EP3624834A1 (en) * | 2017-05-17 | 2020-03-25 | Thunder Biotech Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
| WO2019084018A1 (en) * | 2017-10-23 | 2019-05-02 | City Of Hope | CAR FOR THE TREATMENT OF HIV INFECTION |
| CN108059675B (zh) * | 2017-12-12 | 2021-09-10 | 武汉波睿达生物科技有限公司 | 重组pg9-car分子的构建及其在清除hiv-1感染细胞中的应用 |
| US20210275589A1 (en) | 2018-07-13 | 2021-09-09 | Nanjing Legend Biotech Co. Ltd. | Co-receptor systems for treating infectious diseases |
| MX2021009020A (es) * | 2019-01-28 | 2021-09-28 | Xyphos Biosciences Inc | Ligandos nkg2d no naturales modificados que entregan selectivamente moleculas heterologas unidas a receptores nkg2d no naturales en celulas car. |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN110358793A (zh) * | 2019-05-30 | 2019-10-22 | 南京艾德免疫治疗研究院有限公司 | 一种用于car-t制备的慢病毒载体制备方法 |
| WO2020247837A1 (en) * | 2019-06-07 | 2020-12-10 | The Trustees Of The University Of Pennsylvania | Dual car expressing t cells individually linked to cd28 and 4-1bb |
| CN110343175B (zh) * | 2019-06-26 | 2021-02-26 | 深圳市再生之城生物医药技术有限公司 | 抑制HIV-1病毒感染的scFv序列及其应用 |
| JP2023516685A (ja) * | 2020-03-03 | 2023-04-20 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖを処置するためのリンパ球における外因性因子のオンデマンド発現 |
| JP2025501273A (ja) * | 2021-12-31 | 2025-01-17 | 北京三▲諾▼佳邑生物技▲術▼有限▲責▼任公司 | Ｈｉｖ感染細胞を標的とするキメラ抗原受容体ｔ細胞 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| US5851828A (en) * | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| AU2752892A (en) * | 1991-09-26 | 1993-04-27 | Oklahoma Medical Research Foundation | Fusion proteins targeted to lysosomes, for the treatment of aids |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| ES2191058T3 (es) * | 1994-08-02 | 2003-09-01 | Gen Hospital Corp | Celulas portadoras de receptores simulados de cd4, y moleculas y metodos relacionados. |
| AU1086501A (en) | 1999-10-15 | 2001-04-30 | Carnegie Institution Of Washington | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9708384B2 (en) * | 2011-09-22 | 2017-07-18 | The Trustees Of The University Of Pennsylvania | Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens |
| WO2013123061A1 (en) | 2012-02-13 | 2013-08-22 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| IN2014DN11156A (enExample) * | 2012-07-13 | 2015-10-02 | Univ Pennsylvania | |
| WO2014130635A1 (en) * | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| TWI654206B (zh) * | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| JP6516740B2 (ja) | 2013-08-02 | 2019-05-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 幹細胞及びキメラ抗原受容体を介した抗腫瘍性ｔ細胞免疫の改変 |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| AU2014352638B2 (en) * | 2013-11-25 | 2018-08-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control HIV infection |
| CN111849912B (zh) * | 2014-02-14 | 2024-03-15 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
| CN107074929B (zh) * | 2014-05-02 | 2021-09-03 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
| CA2999496A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
-
2016
- 2016-09-22 CA CA2999496A patent/CA2999496A1/en active Pending
- 2016-09-22 MA MA042951A patent/MA42951A/fr unknown
- 2016-09-22 US US15/761,563 patent/US10738099B2/en active Active
- 2016-09-22 MX MX2018003463A patent/MX2018003463A/es unknown
- 2016-09-22 KR KR1020187011293A patent/KR20180050413A/ko not_active Withdrawn
- 2016-09-22 EP EP16849585.1A patent/EP3353197A4/en active Pending
- 2016-09-22 EA EA201890782A patent/EA201890782A1/ru unknown
- 2016-09-22 AU AU2016326500A patent/AU2016326500A1/en not_active Abandoned
- 2016-09-22 CN CN201680066602.4A patent/CN108779161A/zh active Pending
- 2016-09-22 BR BR112018005741A patent/BR112018005741A2/pt not_active Application Discontinuation
- 2016-09-22 WO PCT/US2016/053097 patent/WO2017053556A1/en not_active Ceased
- 2016-09-22 JP JP2018515108A patent/JP6991131B2/ja active Active
-
2018
- 2018-03-18 IL IL258191A patent/IL258191A/en unknown
- 2018-03-21 CL CL2018000750A patent/CL2018000750A1/es unknown
- 2018-03-21 PH PH12018500609A patent/PH12018500609A1/en unknown
-
2020
- 2020-08-07 US US16/988,415 patent/US12122820B2/en active Active
-
2024
- 2024-09-13 US US18/885,127 patent/US20250084147A1/en active Pending
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