JP2018527014A5 - - Google Patents
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- Publication number
- JP2018527014A5 JP2018527014A5 JP2018515108A JP2018515108A JP2018527014A5 JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5 JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018515108 A JP2018515108 A JP 2018515108A JP 2018527014 A5 JP2018527014 A5 JP 2018527014A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- cell
- hiv
- nucleic acid
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222132P | 2015-09-22 | 2015-09-22 | |
| US62/222,132 | 2015-09-22 | ||
| US201562253790P | 2015-11-11 | 2015-11-11 | |
| US62/253,790 | 2015-11-11 | ||
| PCT/US2016/053097 WO2017053556A1 (en) | 2015-09-22 | 2016-09-22 | Method of redirecting t cells to treat hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527014A JP2018527014A (ja) | 2018-09-20 |
| JP2018527014A5 true JP2018527014A5 (enExample) | 2019-10-31 |
| JP6991131B2 JP6991131B2 (ja) | 2022-02-03 |
Family
ID=58387210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515108A Active JP6991131B2 (ja) | 2015-09-22 | 2016-09-22 | Ｈｉｖ感染症を処置するためにｔ細胞を再度方向付ける方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10738099B2 (enExample) |
| EP (1) | EP3353197A4 (enExample) |
| JP (1) | JP6991131B2 (enExample) |
| KR (1) | KR20180050413A (enExample) |
| CN (1) | CN108779161A (enExample) |
| AU (1) | AU2016326500A1 (enExample) |
| BR (1) | BR112018005741A2 (enExample) |
| CA (1) | CA2999496A1 (enExample) |
| CL (1) | CL2018000750A1 (enExample) |
| EA (1) | EA201890782A1 (enExample) |
| IL (1) | IL258191A (enExample) |
| MA (1) | MA42951A (enExample) |
| MX (1) | MX2018003463A (enExample) |
| PH (1) | PH12018500609A1 (enExample) |
| WO (1) | WO2017053556A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
| WO2017053556A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
| MX2018005048A (es) | 2015-10-25 | 2018-09-06 | Sanofi Sa | Proteinas de union triespecificas y/o trivalantes para la prevencion o el tratamiento de la infeccion por vih. |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| SI3443006T1 (sl) | 2016-04-13 | 2024-01-31 | Sanofi | Trispecifični in/ali trivalentni vezni proteini |
| BR112018070998A2 (pt) | 2016-04-13 | 2019-02-26 | Sanofi | proteínas de ligação triespecíficas e/ou trivalentes |
| WO2018009246A1 (en) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| US20200061117A1 (en) * | 2017-05-08 | 2020-02-27 | The Regents Of The University Of California | Protective Chimeric Antigen Receptor Stem Cell Gene Therapy for Viral Infection |
| US10415017B2 (en) | 2017-05-17 | 2019-09-17 | Thunder Biotech, Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
| AU2017414703B2 (en) * | 2017-05-17 | 2025-02-06 | Thunder Biotech Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
| WO2019084018A1 (en) * | 2017-10-23 | 2019-05-02 | City Of Hope | CAR FOR THE TREATMENT OF HIV INFECTION |
| CN108059675B (zh) * | 2017-12-12 | 2021-09-10 | 武汉波睿达生物科技有限公司 | 重组pg9-car分子的构建及其在清除hiv-1感染细胞中的应用 |
| US20210275589A1 (en) * | 2018-07-13 | 2021-09-09 | Nanjing Legend Biotech Co. Ltd. | Co-receptor systems for treating infectious diseases |
| CN113710689B (zh) * | 2019-01-28 | 2025-05-06 | 修普霍斯生物科学有限公司 | 选择性地将附着的异源分子递送至car细胞上的非天然nkg2d受体的修饰的非天然nkg2d配体 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN110358793A (zh) * | 2019-05-30 | 2019-10-22 | 南京艾德免疫治疗研究院有限公司 | 一种用于car-t制备的慢病毒载体制备方法 |
| WO2020247837A1 (en) * | 2019-06-07 | 2020-12-10 | The Trustees Of The University Of Pennsylvania | Dual car expressing t cells individually linked to cd28 and 4-1bb |
| CN110343175B (zh) * | 2019-06-26 | 2021-02-26 | 深圳市再生之城生物医药技术有限公司 | 抑制HIV-1病毒感染的scFv序列及其应用 |
| WO2021178571A1 (en) * | 2020-03-03 | 2021-09-10 | American Gene Technologies International Inc. | On demand expression of exogenous factors in lymphocytes to treat hiv |
| KR20240128090A (ko) * | 2021-12-31 | 2024-08-23 | 베이징 솔로바이오 진테크놀로지 컴퍼니 리미티드 | Hiv 감염 세포를 표적으로 하는 키메라 항원 수용체 t 세포 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5851828A (en) | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| WO1993006216A1 (en) * | 1991-09-26 | 1993-04-01 | Oklahoma Medical Research Foundation | Fusion proteins targeted to lysosomes, for the treatment of aids |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| DK0781095T3 (da) * | 1994-08-02 | 2003-06-23 | Gen Hospital Corp | Celler der bærer CD4 lokkeduereceptorer og beslægtede molekyler og fremgangsmåder |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9708384B2 (en) * | 2011-09-22 | 2017-07-18 | The Trustees Of The University Of Pennsylvania | Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| CN112375846A (zh) | 2012-07-13 | 2021-02-19 | 宾夕法尼亚大学董事会 | 评估用于施用的转导t细胞的适用性的方法 |
| ES2814962T3 (es) * | 2013-02-20 | 2021-03-29 | Novartis Ag | Fijación eficaz como objetivo de la leucemia humana primaria utilizando células T modificadas con receptor de antígeno quimérico anti-CD123 |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| WO2015017755A1 (en) | 2013-08-02 | 2015-02-05 | The Regents Of The University Of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| WO2015077789A2 (en) * | 2013-11-25 | 2015-05-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control hiv infection |
| JP6772063B2 (ja) * | 2014-02-14 | 2020-10-21 | ベリカム ファーマシューティカルズ， インコーポレイテッド | 誘導可能なキメラポリペプチドを使用して細胞を活性化するための方法 |
| DK3166968T3 (da) * | 2014-05-02 | 2021-12-06 | Univ Pennsylvania | Sammensætninger og fremgangsmåder til kimæriske autoantistofreceptor-T-celler |
| WO2017053556A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
-
2016
- 2016-09-22 WO PCT/US2016/053097 patent/WO2017053556A1/en not_active Ceased
- 2016-09-22 MA MA042951A patent/MA42951A/fr unknown
- 2016-09-22 MX MX2018003463A patent/MX2018003463A/es unknown
- 2016-09-22 JP JP2018515108A patent/JP6991131B2/ja active Active
- 2016-09-22 CA CA2999496A patent/CA2999496A1/en active Pending
- 2016-09-22 EP EP16849585.1A patent/EP3353197A4/en active Pending
- 2016-09-22 KR KR1020187011293A patent/KR20180050413A/ko not_active Withdrawn
- 2016-09-22 BR BR112018005741A patent/BR112018005741A2/pt not_active Application Discontinuation
- 2016-09-22 AU AU2016326500A patent/AU2016326500A1/en not_active Abandoned
- 2016-09-22 US US15/761,563 patent/US10738099B2/en active Active
- 2016-09-22 CN CN201680066602.4A patent/CN108779161A/zh active Pending
- 2016-09-22 EA EA201890782A patent/EA201890782A1/ru unknown
-
2018
- 2018-03-18 IL IL258191A patent/IL258191A/en unknown
- 2018-03-21 CL CL2018000750A patent/CL2018000750A1/es unknown
- 2018-03-21 PH PH12018500609A patent/PH12018500609A1/en unknown
-
2020
- 2020-08-07 US US16/988,415 patent/US12122820B2/en active Active
-
2024
- 2024-09-13 US US18/885,127 patent/US20250084147A1/en active Pending
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