AU2016326500A1 - Method of redirecting T cells to treat HIV infection - Google Patents
Method of redirecting T cells to treat HIV infection Download PDFInfo
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- AU2016326500A1 AU2016326500A1 AU2016326500A AU2016326500A AU2016326500A1 AU 2016326500 A1 AU2016326500 A1 AU 2016326500A1 AU 2016326500 A AU2016326500 A AU 2016326500A AU 2016326500 A AU2016326500 A AU 2016326500A AU 2016326500 A1 AU2016326500 A1 AU 2016326500A1
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
| WO2017053556A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
| NZ781602A (en) | 2015-10-25 | 2025-07-25 | Sanofi Sa | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| EP3443006B1 (en) | 2016-04-13 | 2023-08-02 | Sanofi | Trispecific and/or trivalent binding proteins |
| EP4257193B1 (en) | 2016-04-13 | 2025-12-31 | Sanofi | TRISPECIFIC AND/OR TRIVALENT LINKING PROTEINS |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| US20200061117A1 (en) * | 2017-05-08 | 2020-02-27 | The Regents Of The University Of California | Protective Chimeric Antigen Receptor Stem Cell Gene Therapy for Viral Infection |
| CN110662553A (zh) * | 2017-05-17 | 2020-01-07 | 迅雷生物科技有限公司 | 转基因巨噬细胞、嵌合抗原受体和相关方法 |
| US10415017B2 (en) | 2017-05-17 | 2019-09-17 | Thunder Biotech, Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
| WO2019084018A1 (en) * | 2017-10-23 | 2019-05-02 | City Of Hope | CAR FOR THE TREATMENT OF HIV INFECTION |
| CN108059675B (zh) * | 2017-12-12 | 2021-09-10 | 武汉波睿达生物科技有限公司 | 重组pg9-car分子的构建及其在清除hiv-1感染细胞中的应用 |
| WO2020011247A1 (en) | 2018-07-13 | 2020-01-16 | Nanjing Legend Biotech Co., Ltd. | Co-receptor systems for treating infectious diseases |
| JP7641223B2 (ja) * | 2019-01-28 | 2025-03-06 | サイフォス、バイオサイエンシズ、インコーポレイテッド | Ｃａｒ細胞上の非天然ｎｋｇ２ｄ受容体に、結合した異種分子を選択的に送達する改変非天然ｎｋｇ２ｄリガンド |
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| CN110358793A (zh) * | 2019-05-30 | 2019-10-22 | 南京艾德免疫治疗研究院有限公司 | 一种用于car-t制备的慢病毒载体制备方法 |
| AU2020286471B2 (en) * | 2019-06-07 | 2025-07-31 | The Trustees Of The University Of Pennsylvania | Dual CAR expressing T cells individually linked to CD28 and 4-1BB |
| CN110343175B (zh) * | 2019-06-26 | 2021-02-26 | 深圳市再生之城生物医药技术有限公司 | 抑制HIV-1病毒感染的scFv序列及其应用 |
| IL296096A (en) * | 2020-03-03 | 2022-11-01 | American Gene Tech Int Inc | On demand expression of exogenous factors in lymphocytes to treat hiv |
| US20250057884A1 (en) * | 2021-12-31 | 2025-02-20 | Beijing Solobio Genetechnology Co. , Ltd. | Chimeric Antigen Receptor-T Cells Targeting HIV-Infected Cells |
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| EP3584256A1 (en) | 2012-07-13 | 2019-12-25 | The Trustees Of The University Of Pennsylvania | Methods of assessing the suitability of transduced t cells for administration |
| EP3744736A1 (en) | 2013-02-20 | 2020-12-02 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP3027755B1 (en) | 2013-08-02 | 2019-10-09 | The Regents of The University of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| US10246505B2 (en) * | 2013-11-25 | 2019-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control HIV infection |
| CA2937750A1 (en) | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
| CN107074929B (zh) * | 2014-05-02 | 2021-09-03 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
| WO2017053556A1 (en) * | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
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| US20250084147A1 (en) | 2025-03-13 |
| CN108779161A (zh) | 2018-11-09 |
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