JP2020500903A5 - - Google Patents
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- JP2020500903A5 JP2020500903A5 JP2019530645A JP2019530645A JP2020500903A5 JP 2020500903 A5 JP2020500903 A5 JP 2020500903A5 JP 2019530645 A JP2019530645 A JP 2019530645A JP 2019530645 A JP2019530645 A JP 2019530645A JP 2020500903 A5 JP2020500903 A5 JP 2020500903A5
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 26
- -1 CD86 Proteins 0.000 claims 17
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000004083 survival effect Effects 0.000 claims 8
- 108010083359 Antigen Receptors Proteins 0.000 claims 7
- 102000006306 Antigen Receptors Human genes 0.000 claims 7
- 101710164760 Chlorotoxin Proteins 0.000 claims 6
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- QPAKKWCQMHUHNI-GQIQPHNSSA-N chlorotoxin Chemical group C([C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]4CSSC[C@@H](C(N[C@@H](CCSC)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC4=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)=O)NC(=O)[C@@H](N)CCSC)C1=CC=C(O)C=C1 QPAKKWCQMHUHNI-GQIQPHNSSA-N 0.000 claims 6
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- 229920001184 polypeptide Polymers 0.000 claims 3
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- 101000585551 Equus caballus Pregnancy-associated glycoprotein Proteins 0.000 claims 2
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- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
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- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims 2
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- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims 2
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims 2
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 claims 2
- 101000692259 Homo sapiens Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Proteins 0.000 claims 2
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- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 2
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 2
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- 102100039904 Integrin alpha-D Human genes 0.000 claims 2
- 102100022339 Integrin alpha-L Human genes 0.000 claims 2
- 102100022338 Integrin alpha-M Human genes 0.000 claims 2
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- 108010041100 Integrin alpha6 Proteins 0.000 claims 2
- 108010030465 Integrin alpha6beta1 Proteins 0.000 claims 2
- 102100033016 Integrin beta-7 Human genes 0.000 claims 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 2
- 102000016397 Methyltransferase Human genes 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- 101100236305 Mus musculus Ly9 gene Proteins 0.000 claims 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 2
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- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 2
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims 2
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 2
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims 2
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 2
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims 2
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims 2
- 102100026066 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Human genes 0.000 claims 2
- 102100029216 SLAM family member 5 Human genes 0.000 claims 2
- 102100029198 SLAM family member 7 Human genes 0.000 claims 2
- 102100029214 SLAM family member 8 Human genes 0.000 claims 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 2
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 2
- 108010022394 Threonine synthase Proteins 0.000 claims 2
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 2
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
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- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 2
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims 2
- 230000031146 intracellular signal transduction Effects 0.000 claims 2
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- 125000006850 spacer group Chemical group 0.000 claims 2
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- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
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- 101710145634 Antigen 1 Proteins 0.000 claims 1
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- 108010056102 CD100 antigen Proteins 0.000 claims 1
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- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 1
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- 208000032612 Glial tumor Diseases 0.000 claims 1
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- 101710182312 High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 1
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
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- 101000900690 Homo sapiens GRB2-related adapter protein 2 Proteins 0.000 claims 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000985635 Homo sapiens Protein maestro Proteins 0.000 claims 1
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
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- 102000014128 RANK Ligand Human genes 0.000 claims 1
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- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
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- 102000005497 Thymidylate Synthase Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims 1
- 229940045719 antineoplastic alkylating agent nitrosoureas Drugs 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
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- 229960004679 doxorubicin Drugs 0.000 claims 1
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- YAKWPXVTIGTRJH-UHFFFAOYSA-N fotemustine Chemical compound CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O YAKWPXVTIGTRJH-UHFFFAOYSA-N 0.000 claims 1
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- 208000005017 glioblastoma Diseases 0.000 claims 1
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- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 1
- 229960001924 melphalan Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 claims 1
- 108010043671 prostatic acid phosphatase Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
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- 239000000126 substance Substances 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023027231A JP2023078149A (ja) | 2016-12-09 | 2023-02-24 | キメラクロロトキシン受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662432404P | 2016-12-09 | 2016-12-09 | |
| US62/432,404 | 2016-12-09 | ||
| PCT/US2017/065488 WO2018107134A1 (en) | 2016-12-09 | 2017-12-09 | Chimeric chlorotoxin receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023027231A Division JP2023078149A (ja) | 2016-12-09 | 2023-02-24 | キメラクロロトキシン受容体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020500903A JP2020500903A (ja) | 2020-01-16 |
| JP2020500903A5 true JP2020500903A5 (enExample) | 2021-01-28 |
Family
ID=62491409
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530645A Pending JP2020500903A (ja) | 2016-12-09 | 2017-12-09 | キメラクロロトキシン受容体 |
| JP2023027231A Pending JP2023078149A (ja) | 2016-12-09 | 2023-02-24 | キメラクロロトキシン受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023027231A Pending JP2023078149A (ja) | 2016-12-09 | 2023-02-24 | キメラクロロトキシン受容体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11421005B2 (enExample) |
| EP (1) | EP3551657A4 (enExample) |
| JP (2) | JP2020500903A (enExample) |
| KR (2) | KR102618373B1 (enExample) |
| CN (1) | CN110352197B (enExample) |
| AU (1) | AU2017371329B2 (enExample) |
| CA (1) | CA3044393A1 (enExample) |
| IL (1) | IL266950B2 (enExample) |
| WO (1) | WO2018107134A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7186615B2 (ja) | 2015-09-03 | 2022-12-09 | ザ ユーエイビー リサーチ ファウンデーション | 遺伝子操作された薬物耐性ｔ細胞およびその使用方法 |
| AU2017371329B2 (en) | 2016-12-09 | 2024-11-21 | The Uab Research Foundation | Chimeric chlorotoxin receptors |
| CN115867581A (zh) * | 2020-03-25 | 2023-03-28 | 北京艺妙神州医药科技有限公司 | 含有保护肽的嵌合抗原受体及其用途 |
| US20220259768A1 (en) * | 2021-01-20 | 2022-08-18 | IN8bio, Inc. | Multivalent chlorotoxin chimeric antigen receptors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| TW200833840A (en) | 2006-10-25 | 2008-08-16 | Amgen Inc | Toxin peptide therapeutic agents |
| WO2009021136A1 (en) * | 2007-08-07 | 2009-02-12 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
| CA2735456C (en) * | 2008-08-26 | 2021-11-16 | City Of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| ES2633098T3 (es) | 2009-11-02 | 2017-09-19 | Children's Healthcare Of Atlanta, Inc. | Inmunoterapia resistente a fármaco para el tratamiento de un cáncer |
| HRP20171291T1 (hr) * | 2010-02-04 | 2017-10-20 | Morphotek, Inc. | Polipeptidi i konjugati klorotoksina i njihove uporabe |
| WO2014164554A1 (en) * | 2013-03-10 | 2014-10-09 | Baylor College Of Medicine | Chemotherapy-resistant immune cells |
| WO2015031645A1 (en) | 2013-08-28 | 2015-03-05 | Washington University | Monoclonal antibodies to human 14-3-3 epsilon and human 14-3-3 epsilon sv |
| GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| IL257678B2 (en) | 2015-08-25 | 2024-04-01 | Uab Res Found | Methods for stem cell transplantation |
| JP7186615B2 (ja) * | 2015-09-03 | 2022-12-09 | ザ ユーエイビー リサーチ ファウンデーション | 遺伝子操作された薬物耐性ｔ細胞およびその使用方法 |
| PT3362470T (pt) * | 2015-10-13 | 2021-12-10 | Hope City | Recetores de antigénios quiméricos que contêm um domínio de clorotoxina |
| AU2017371329B2 (en) | 2016-12-09 | 2024-11-21 | The Uab Research Foundation | Chimeric chlorotoxin receptors |
-
2017
- 2017-12-09 AU AU2017371329A patent/AU2017371329B2/en not_active Expired - Fee Related
- 2017-12-09 CN CN201780075849.7A patent/CN110352197B/zh not_active Expired - Fee Related
- 2017-12-09 US US16/467,467 patent/US11421005B2/en active Active
- 2017-12-09 IL IL266950A patent/IL266950B2/en unknown
- 2017-12-09 KR KR1020197016382A patent/KR102618373B1/ko active Active
- 2017-12-09 CA CA3044393A patent/CA3044393A1/en active Pending
- 2017-12-09 JP JP2019530645A patent/JP2020500903A/ja active Pending
- 2017-12-09 WO PCT/US2017/065488 patent/WO2018107134A1/en not_active Ceased
- 2017-12-09 KR KR1020237044314A patent/KR20240005979A/ko not_active Ceased
- 2017-12-09 EP EP17877604.3A patent/EP3551657A4/en active Pending
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2022
- 2022-07-14 US US17/864,935 patent/US20230037076A1/en active Pending
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2023
- 2023-02-24 JP JP2023027231A patent/JP2023078149A/ja active Pending