AU2017371329B2 - Chimeric chlorotoxin receptors - Google Patents

Chimeric chlorotoxin receptors Download PDF

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Publication number
AU2017371329B2
AU2017371329B2 AU2017371329A AU2017371329A AU2017371329B2 AU 2017371329 B2 AU2017371329 B2 AU 2017371329B2 AU 2017371329 A AU2017371329 A AU 2017371329A AU 2017371329 A AU2017371329 A AU 2017371329A AU 2017371329 B2 AU2017371329 B2 AU 2017371329B2
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Australia
Prior art keywords
cell
ctx
car
cells
cancer
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Expired - Fee Related
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AU2017371329A
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AU2017371329A1 (en
Inventor
Antonio DI STASI
Yancey G. Gillespie
Lawrence S. Lamb Jr.
Larisa PEREBOEVA
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UAB Research Foundation
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UAB Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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AU2017371329A 2016-12-09 2017-12-09 Chimeric chlorotoxin receptors Expired - Fee Related AU2017371329B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662432404P 2016-12-09 2016-12-09
US62/432,404 2016-12-09
PCT/US2017/065488 WO2018107134A1 (en) 2016-12-09 2017-12-09 Chimeric chlorotoxin receptors

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AU2017371329A1 AU2017371329A1 (en) 2019-06-06
AU2017371329B2 true AU2017371329B2 (en) 2024-11-21

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US (2) US11421005B2 (enExample)
EP (1) EP3551657A4 (enExample)
JP (2) JP2020500903A (enExample)
KR (2) KR102618373B1 (enExample)
CN (1) CN110352197B (enExample)
AU (1) AU2017371329B2 (enExample)
CA (1) CA3044393A1 (enExample)
IL (1) IL266950B2 (enExample)
WO (1) WO2018107134A1 (enExample)

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EP3551657A4 (en) 2020-07-15
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US11421005B2 (en) 2022-08-23
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