CN110352197B - 嵌合氯毒素受体 - Google Patents

嵌合氯毒素受体 Download PDF

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Publication number
CN110352197B
CN110352197B CN201780075849.7A CN201780075849A CN110352197B CN 110352197 B CN110352197 B CN 110352197B CN 201780075849 A CN201780075849 A CN 201780075849A CN 110352197 B CN110352197 B CN 110352197B
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ctx
cell
cells
car
domain
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CN110352197A (zh
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L.S.小兰布
A.迪斯塔西
Y.G.吉勒斯皮
L.佩瑞博瓦
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UAB Research Foundation
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CN201780075849.7A 2016-12-09 2017-12-09 嵌合氯毒素受体 Expired - Fee Related CN110352197B (zh)

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US201662432404P 2016-12-09 2016-12-09
US62/432404 2016-12-09
PCT/US2017/065488 WO2018107134A1 (en) 2016-12-09 2017-12-09 Chimeric chlorotoxin receptors

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Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
KR20180086183A (ko) 2015-09-03 2018-07-30 더 유에이비 리서치 파운데이션 유전자 조작 약물 내성 t 세포 및 이것의 사용 방법
CN110352197B (zh) 2016-12-09 2024-02-02 Uab研究基金会 嵌合氯毒素受体
CN115335407B (zh) * 2020-03-25 2024-08-27 北京艺妙神州医药科技有限公司 结合cd19的嵌合抗原受体及其用途
KR20230134134A (ko) * 2021-01-20 2023-09-20 인8바이오 인코포레이티드 다가 클로로톡신 키메라 항원 수용체

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108368159A (zh) * 2015-10-13 2018-08-03 希望之城公司 含有氯毒素域的嵌合抗原受体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US7910102B2 (en) 2006-10-25 2011-03-22 Amgen Inc. Methods of using conjugated toxin peptide therapeutic agents
US20110091380A1 (en) * 2007-08-07 2011-04-21 Transmolecular, Inc. Chlorotoxins as drug carriers
WO2010025177A1 (en) * 2008-08-26 2010-03-04 City Of Hope Method and compositions for enhanced anti-tumor effector functioning of t cells
ES2882916T3 (es) 2009-11-02 2021-12-03 Univ Emory Inmunoterapia resistente a medicamentos para tratamiento de un cáncer
CN106995493B (zh) * 2010-02-04 2021-09-24 卫材公司 氯毒素多肽和结合物及其应用
US20160024175A1 (en) * 2013-03-10 2016-01-28 Baylor College Of Medicine Chemotherapy-resistant immune cells
WO2015031645A1 (en) 2013-08-28 2015-03-05 Washington University Monoclonal antibodies to human 14-3-3 epsilon and human 14-3-3 epsilon sv
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
JP7105188B2 (ja) 2015-08-25 2022-07-22 ザ・ユー・エイ・ビー・リサーチ・フアンデーシヨン 幹細胞移植方法
KR20180086183A (ko) * 2015-09-03 2018-07-30 더 유에이비 리서치 파운데이션 유전자 조작 약물 내성 t 세포 및 이것의 사용 방법
CN110352197B (zh) 2016-12-09 2024-02-02 Uab研究基金会 嵌合氯毒素受体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108368159A (zh) * 2015-10-13 2018-08-03 希望之城公司 含有氯毒素域的嵌合抗原受体

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Abstract B128: Chimeric antigen receptor transduced gamma delta T lymphocytes provide enhanced tumor specificity;Jonathan Fisher et al.;Cancer Immunol Res;摘要 *
Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma CellMotility via Receptor-Mediated Endocytosis;Tomonari Kasai et al.;《Journal of Drug Delivery》;20121231;摘要 *
Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma CellMotility via Receptor-Mediated Endocytosis;Tomonari Kasai et al.;Journal of Drug Delivery;摘要 *
Chlorotoxin-Fc Fusion Inhibits Release of MMP-2 from Pancreatic Cancer Cells;Samah El-Ghlban et al.;《BioMed Research International》;20141231;全文 *
Dynamics of Circulating γδT Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma;Benjamin H. Beck et al.;PLOS ONE;第2页第2段 *
Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates;Yongjun Cheng et al.;《Am J Nucl Med Mol Imaging》;20141231;全文 *
Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma;Richard A. Morgan et al.;《HUMAN GENE THERAPY》;20121031;全文 *
Recruitment of Immune Effector Cells against Glioblastoma-Multiforme by a MHC-Chlorotoxin Chimeric Protein;O. Cohen-Inbar;《17th BIENNIAL CANADIAN NEURO-ONCOLOGY MEETING》;20160611;全文 *

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US11421005B2 (en) 2022-08-23
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