JP2020513839A5 - - Google Patents

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JP2020513839A5
JP2020513839A5 JP2019558994A JP2019558994A JP2020513839A5 JP 2020513839 A5 JP2020513839 A5 JP 2020513839A5 JP 2019558994 A JP2019558994 A JP 2019558994A JP 2019558994 A JP2019558994 A JP 2019558994A JP 2020513839 A5 JP2020513839 A5 JP 2020513839A5
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cells
seq
optionally
acid sequence
amino acid
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JP2019558994A
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JP7303749B2 (ja
JP2020513839A (ja
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Priority claimed from PCT/US2018/013551 external-priority patent/WO2018132695A1/en
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JP2019558994A 2017-01-13 2018-01-12 Tim-1を標的とするキメラ抗原受容体 Active JP7303749B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762445976P 2017-01-13 2017-01-13
US62/445,976 2017-01-13
PCT/US2018/013551 WO2018132695A1 (en) 2017-01-13 2018-01-12 Chimeric antigen receptors targeting tim-1

Publications (3)

Publication Number Publication Date
JP2020513839A JP2020513839A (ja) 2020-05-21
JP2020513839A5 true JP2020513839A5 (enExample) 2021-02-25
JP7303749B2 JP7303749B2 (ja) 2023-07-05

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JP2019558994A Active JP7303749B2 (ja) 2017-01-13 2018-01-12 Tim-1を標的とするキメラ抗原受容体

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US (2) US11541076B2 (enExample)
EP (1) EP3568416A4 (enExample)
JP (1) JP7303749B2 (enExample)
CN (1) CN110494451B (enExample)
WO (1) WO2018132695A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3035080A1 (en) 2016-09-27 2018-04-05 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
JP7286658B2 (ja) 2017-09-26 2023-06-05 セロ・セラピューティクス・インコーポレイテッド キメラエンガルフメント受容体分子および使用方法
AU2019243154A1 (en) 2018-03-28 2020-10-01 Cero Therapeutics, Inc. Cellular immunotherapy compositions and uses thereof
EP3774906A1 (en) 2018-03-28 2021-02-17 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
WO2019222579A1 (en) * 2018-05-17 2019-11-21 St. Jude Children's Research Hospital, Inc. Chimeric antigen receptors with myd88 and cd40 costimulatory domains
CN110615842B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含共刺激受体的嵌合抗原受体及应用
IL280329B2 (en) * 2018-08-02 2024-09-01 Kite Pharma Inc Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof
AU2019327913A1 (en) * 2018-08-29 2021-03-18 Nanjing Legend Biotech Co., Ltd. Anti-mesothelin chimeric antigen receptor (CAR) constructs and uses thereof
EP3902838A4 (en) 2018-12-26 2022-12-21 Nanjing Legend Biotech Co., Ltd. Cd30-binding moieties, chimeric antigen receptors, and uses thereof
CA3139319A1 (en) * 2019-05-07 2020-11-12 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of polypeptides and chimeric antigen receptors via hinge domains
JP2022541320A (ja) * 2019-07-24 2022-09-22 エウレカ セラピューティクス インコーポレイテッド キメラ抗原受容体t細胞及びその使用
CN112079934B (zh) * 2019-12-17 2021-01-29 合源生物科技(天津)有限公司 一种靶向cd19的嵌合抗原受体及其用途
WO2021130535A2 (en) * 2019-12-28 2021-07-01 Shanghai Cell Therapy Group Company Co., Ltd. Cell expressing immune modulatory molecules and system for expressing immune modulatory molecules
JP2023514232A (ja) * 2020-02-14 2023-04-05 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Cd2活性化を伴うキメラ抗原受容体
GB202004371D0 (en) * 2020-03-26 2020-05-13 Glaxosmithkline Ip Dev Ltd CAR constructs
CR20220540A (es) * 2020-03-31 2022-12-07 Chugai Pharmaceutical Co Ltd Moléculas de union al antígeno multiespecíficas dirigidas a claudina-6 y sus usos
US12264190B2 (en) * 2020-04-24 2025-04-01 Astrazeneca Ab Compositions and methods of treating cancer with chimeric antigen receptors
CN115884781A (zh) * 2020-06-09 2023-03-31 杭州领知医药科技有限公司 用于增强免疫应答的组合物和方法
CN112063588A (zh) * 2020-08-13 2020-12-11 南京北恒生物科技有限公司 工程化免疫细胞及其用途
JP2023546067A (ja) * 2020-10-13 2023-11-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア mRNA治療剤のためのT細胞のインビボ標的化
CN114149505B (zh) * 2021-01-12 2022-11-04 北京门罗生物科技有限公司 治疗b细胞相关疾病的免疫细胞、制备方法及其应用
CN114807044B (zh) * 2021-04-30 2023-09-08 四川大学华西医院 一种具有高nkt细胞比例的car-cik细胞制备方法及应用
WO2022248602A1 (en) * 2021-05-25 2022-12-01 Institut Curie Myeloid cells overexpressing bcl2
CN115521917A (zh) * 2021-06-25 2022-12-27 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CN113583122B (zh) * 2021-07-29 2023-08-29 武汉华美生物工程有限公司 抗人sema4d抗体及其制备方法和应用
CN115322257B (zh) * 2021-08-16 2023-05-30 上海优替济生生物医药有限公司 Bcma靶向抗体、嵌合抗原受体及其应用
CN116426483B (zh) * 2021-12-30 2024-02-23 南京紫珑生物科技有限公司 Cd258蛋白在免疫治疗中的应用
CN115974976B (zh) * 2022-11-23 2024-06-04 华中科技大学 拮抗多肽及用于制备抗急性肾损伤药物的应用
US20250092362A1 (en) * 2023-09-15 2025-03-20 Terumo Bct, Inc. System And Methods For Producing Chimeric Antigen Receptor Cells
CN119409822B (zh) * 2024-11-01 2026-02-17 中国科学技术大学 抗体或其抗原结合片段及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ530457A (en) * 2001-06-01 2007-12-21 Biogen Idec Inc Molecules and methods for inhibiting shedding of KIM-1
US20050014687A1 (en) 2002-03-19 2005-01-20 Anderson David W. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
ES2557769T3 (es) 2003-03-19 2016-01-28 Amgen Fremont Inc. Anticuerpos contra el antígeno del dominio de inmunoglobulina de células T y el dominio 1 de mucina (TIM-1) y usos de los mismos
CA2569509C (en) * 2004-06-03 2014-08-12 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
EP1957115B8 (en) * 2005-11-10 2014-03-05 Celldex Therapeutics, Inc. Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
US9845362B2 (en) 2010-10-08 2017-12-19 The University Of North Carolina At Charlotte Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2013078089A1 (en) * 2011-11-22 2013-05-30 Biogen Idec Ma Inc. Anti-tim-1 antibodies and uses thereof
KR102264290B1 (ko) 2012-08-20 2021-06-10 프레드 헛친슨 켄서 리서치 센터 세포 면역요법을 위한 방법 및 조성물
US10836998B2 (en) 2014-02-14 2020-11-17 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
JP2017513818A (ja) * 2014-03-15 2017-06-01 ノバルティス アーゲー キメラ抗原受容体を使用する癌の処置
EP2939690A1 (en) * 2014-04-29 2015-11-04 Medizinische Hochschule Hannover Vaccine
WO2016062898A1 (en) * 2014-10-24 2016-04-28 Bcrt Holding Bv T cell-based immunotherapeutics
WO2016115482A1 (en) * 2015-01-16 2016-07-21 Novartis Pharma Ag Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor
US11161907B2 (en) * 2015-02-02 2021-11-02 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
WO2016168595A1 (en) 2015-04-17 2016-10-20 Barrett David Maxwell Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells

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