JP2019516352A5 - - Google Patents
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- JP2019516352A5 JP2019516352A5 JP2018551409A JP2018551409A JP2019516352A5 JP 2019516352 A5 JP2019516352 A5 JP 2019516352A5 JP 2018551409 A JP2018551409 A JP 2018551409A JP 2018551409 A JP2018551409 A JP 2018551409A JP 2019516352 A5 JP2019516352 A5 JP 2019516352A5
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 25
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
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- -1 OX-40 Proteins 0.000 claims 14
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- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 13
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 12
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022035975A JP7561155B2 (ja) | 2016-04-01 | 2022-03-09 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
| JP2024070373A JP2024105337A (ja) | 2016-04-01 | 2024-04-24 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317219P | 2016-04-01 | 2016-04-01 | |
| US62/317,219 | 2016-04-01 | ||
| PCT/US2017/025613 WO2017173410A1 (en) | 2016-04-01 | 2017-03-31 | Chimeric receptors to flt3 and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022035975A Division JP7561155B2 (ja) | 2016-04-01 | 2022-03-09 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019516352A JP2019516352A (ja) | 2019-06-20 |
| JP2019516352A5 true JP2019516352A5 (enExample) | 2020-05-07 |
Family
ID=58530714
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551409A Pending JP2019516352A (ja) | 2016-04-01 | 2017-03-31 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
| JP2022035975A Active JP7561155B2 (ja) | 2016-04-01 | 2022-03-09 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
| JP2024070373A Pending JP2024105337A (ja) | 2016-04-01 | 2024-04-24 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022035975A Active JP7561155B2 (ja) | 2016-04-01 | 2022-03-09 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
| JP2024070373A Pending JP2024105337A (ja) | 2016-04-01 | 2024-04-24 | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20190183931A1 (enExample) |
| EP (1) | EP3436479A1 (enExample) |
| JP (3) | JP2019516352A (enExample) |
| KR (2) | KR102694879B1 (enExample) |
| CN (1) | CN109641956A (enExample) |
| AR (2) | AR109626A1 (enExample) |
| AU (3) | AU2017240801A1 (enExample) |
| BR (1) | BR112018070187A8 (enExample) |
| CA (1) | CA3019655A1 (enExample) |
| CL (1) | CL2018002792A1 (enExample) |
| CO (1) | CO2018011804A2 (enExample) |
| CR (2) | CR20240116A (enExample) |
| EA (1) | EA201892193A1 (enExample) |
| IL (2) | IL262061B2 (enExample) |
| MA (1) | MA44507A (enExample) |
| MX (1) | MX2023013729A (enExample) |
| MY (2) | MY210545A (enExample) |
| NZ (1) | NZ746925A (enExample) |
| PE (2) | PE20190201A1 (enExample) |
| PH (1) | PH12018502118B1 (enExample) |
| SA (1) | SA518400154B1 (enExample) |
| SG (2) | SG11201808622SA (enExample) |
| TN (1) | TN2018000337A1 (enExample) |
| TW (2) | TW202313669A (enExample) |
| UA (1) | UA128326C2 (enExample) |
| WO (1) | WO2017173410A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| EP3092049A1 (en) | 2014-01-08 | 2016-11-16 | Flodesign Sonics Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3013407A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| EP3436004B1 (en) | 2016-04-01 | 2024-12-11 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SG11201808411RA (en) * | 2016-04-01 | 2018-10-30 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
| KR20210089262A (ko) | 2016-04-01 | 2021-07-15 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
| CN117903307A (zh) | 2016-04-01 | 2024-04-19 | 凯德药业股份有限公司 | Bcma结合分子及其使用方法 |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CA3045902A1 (en) | 2016-12-21 | 2018-06-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for flt3 and uses thereof |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EA039702B1 (ru) | 2017-05-22 | 2022-03-01 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| EA201992782A1 (ru) | 2017-05-22 | 2020-03-24 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| PE20241587A1 (es) * | 2017-06-02 | 2024-08-01 | Pfizer | Receptores de antigenos quimericos que se dirigen a flt3 |
| WO2019028316A1 (en) | 2017-08-03 | 2019-02-07 | Amgen Inc. | INTERLEUKIN-21 MUTÉINS AND METHODS OF TREATMENT |
| AR112797A1 (es) | 2017-09-08 | 2019-12-11 | Amgen Inc | Inhibidores de kras g12c y métodos para utilizarlos |
| ES2941740T3 (es) | 2018-01-12 | 2023-05-25 | Amgen Inc | Anticuerpos anti-PD-1 y métodos de tratamiento |
| SG11202010454PA (en) * | 2018-03-23 | 2020-11-27 | Gavish Galilee Bio Appl Ltd | Genetically reprogrammed tregs expressing membrane-bound il-10 |
| CA3095920A1 (en) * | 2018-04-10 | 2019-10-17 | Amgen Inc. | Chimeric receptors to dll3 and methods of use thereof |
| MX2020010808A (es) * | 2018-04-13 | 2021-03-02 | Sangamo Therapeutics France | Receptor de antigeno quimerico especifico para el receptor de interleucina-23. |
| SG11202104352XA (en) | 2018-12-18 | 2021-05-28 | Boehringer Ingelheim Io Canada Inc | Flt3 agonist antibodies and uses thereof |
| CA3136618A1 (en) * | 2019-04-10 | 2020-10-15 | Elevatebio Technologies, Inc. | Flt3-specific chimeric antigen receptors and methods of using the same |
| EP3962527A4 (en) | 2019-04-30 | 2023-11-01 | Senti Biosciences, Inc. | CHIMERIC RECEPTORS AND METHODS OF USE THEREOF |
| JP2023506501A (ja) * | 2019-12-16 | 2023-02-16 | ワシントン・ユニバーシティ | キメラ抗原受容体樹状細胞（ｃａｒ－ｄｃ）ならびにこれを作製および使用する方法 |
| CA3175392A1 (en) * | 2020-04-17 | 2021-10-21 | Michael A. Caligiuri | Flt3-targeted chimeric antigen receptor modified cells for treatment of flt3-positive malignancies |
| CN111808821B (zh) * | 2020-06-24 | 2022-06-14 | 南方医科大学珠江医院 | Flt3-nkg2d双靶点car-t的构建与制备 |
| WO2022140388A1 (en) | 2020-12-21 | 2022-06-30 | Allogene Therapeutics, Inc. | Protease-activating cd45-gate car |
| IL303847A (en) * | 2021-01-28 | 2023-08-01 | Allogene Therapeutics Inc | Methods for transferring immune cells |
| JP2024505075A (ja) | 2021-01-29 | 2024-02-02 | アロジーン セラピューティクス，インコーポレイテッド | 同種細胞産物のＴ細胞認識を軽減するための、ＴＡＰ２、ＮＬＲＣ５、β２ｍ、ＴＲＡＣ、ＲＦＸ５、ＲＦＸＡＰ及びＲＦＸＡＮＫのうち１つ以上のノックダウン又はノックアウト |
| CN116410315A (zh) * | 2021-12-31 | 2023-07-11 | 博生吉医药科技(苏州)有限公司 | 一种新型靶向人flt3的嵌合抗原受体修饰的t细胞的构建及应用 |
| AU2023312973A1 (en) | 2022-07-29 | 2025-01-09 | Allogene Therapeutics, Inc. | Engineered cells with reduced gene expression to mitigate immune cell recognition |
| WO2025096560A1 (en) | 2023-10-30 | 2025-05-08 | Allogene Therapeutics, Inc. | Engineered cells |
| CN120157768A (zh) * | 2023-12-15 | 2025-06-17 | 博生吉安科细胞技术有限公司 | 一种识别flt3-car分子的单克隆抗体及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US5834266A (en) | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
| US5830462A (en) | 1993-02-12 | 1998-11-03 | President & Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US20030036654A1 (en) | 1994-08-18 | 2003-02-20 | Holt Dennis A. | Synthetic multimerizing agents |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| EP1257632B1 (en) | 2000-02-24 | 2007-09-12 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7446190B2 (en) * | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| JP5373396B2 (ja) * | 2005-08-26 | 2013-12-18 | ロシュ グリクアート アクチェンゲゼルシャフト | 改変された細胞シグナル活性有する改変抗原結合分子 |
| US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| ES2573642T3 (es) * | 2009-12-23 | 2016-06-09 | Synimmune Gmbh | Anticuerpos anti-FLT3 y métodos de usar los mismos |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| AU2012209103B2 (en) | 2011-01-26 | 2015-12-03 | Takeda Pharmaceutical Company Limited | Methods and compositions for the synthesis of multimerizing agents |
| ES2841983T3 (es) | 2011-03-23 | 2021-07-12 | Hutchinson Fred Cancer Res | Método y composiciones para inmunoterapia celular |
| WO2013142034A1 (en) * | 2012-03-23 | 2013-09-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| AU2014216130B2 (en) | 2013-02-15 | 2017-11-16 | The Regents Of The University Of California | Chimeric antigen receptor and methods of use thereof |
| EP2968502B1 (en) | 2013-03-14 | 2020-08-26 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
| JP6543626B2 (ja) | 2013-07-29 | 2019-07-10 | ブルーバード バイオ， インコーポレイテッド | 多部分シグナル伝達タンパク質およびその使用 |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| AU2015218396A1 (en) | 2014-02-14 | 2016-08-11 | Bellicum Pharmaceuticals, Inc. | Methods for activating T cells using an inducible chimeric polypeptide |
| EP3593812A3 (en) * | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| EP3174901B1 (en) * | 2014-07-31 | 2019-06-26 | Amgen Research (Munich) GmbH | Optimized cross-species specific bispecific single chain antibody constructs |
| RU2749922C2 (ru) * | 2014-09-19 | 2021-06-21 | Сити Оф Хоуп | Т-КЛЕТКИ С КОСТИМУЛИРУЮЩИМ ХИМЕРНЫМ АНТИГЕННЫМ РЕЦЕПТОРОМ, НАЦЕЛЕННЫЕ НА IL13Rα2 |
| TWI829617B (zh) * | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| SG11201808411RA (en) * | 2016-04-01 | 2018-10-30 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
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