JP2020078352A5 - - Google Patents
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- JP2020078352A5 JP2020078352A5 JP2020036624A JP2020036624A JP2020078352A5 JP 2020078352 A5 JP2020078352 A5 JP 2020078352A5 JP 2020036624 A JP2020036624 A JP 2020036624A JP 2020036624 A JP2020036624 A JP 2020036624A JP 2020078352 A5 JP2020078352 A5 JP 2020078352A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- polynucleotides
- amino acid
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000040430 polynucleotide Human genes 0.000 claims 47
- 108091033319 polynucleotide Proteins 0.000 claims 47
- 239000002157 polynucleotide Substances 0.000 claims 47
- 210000004027 cell Anatomy 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 108010054218 Factor VIII Proteins 0.000 claims 8
- 102000001690 Factor VIII Human genes 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 108010047303 von Willebrand Factor Proteins 0.000 claims 6
- 102100036537 von Willebrand factor Human genes 0.000 claims 6
- 229960001134 von willebrand factor Drugs 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 229960000301 factor viii Drugs 0.000 claims 3
- 102000004961 Furin Human genes 0.000 claims 2
- 108090001126 Furin Proteins 0.000 claims 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102000057593 human F8 Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 229960000900 human factor viii Drugs 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021163423A JP2022000471A (ja) | 2012-07-11 | 2021-10-04 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2023171467A JP7682968B2 (ja) | 2012-07-11 | 2023-10-02 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2025080421A JP2025134089A (ja) | 2012-07-11 | 2025-05-13 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261670401P | 2012-07-11 | 2012-07-11 | |
| US61/670,401 | 2012-07-11 | ||
| US201361759819P | 2013-02-01 | 2013-02-01 | |
| US61/759,819 | 2013-02-01 | ||
| US201361801544P | 2013-03-15 | 2013-03-15 | |
| US201361801504P | 2013-03-15 | 2013-03-15 | |
| US61/801,504 | 2013-03-15 | ||
| US61/801,544 | 2013-03-15 | ||
| US201361827158P | 2013-05-24 | 2013-05-24 | |
| US61/827,158 | 2013-05-24 | ||
| US201361840811P | 2013-06-28 | 2013-06-28 | |
| US61/840,811 | 2013-06-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018073823A Division JP2018102323A (ja) | 2012-07-11 | 2018-04-06 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021163423A Division JP2022000471A (ja) | 2012-07-11 | 2021-10-04 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020078352A JP2020078352A (ja) | 2020-05-28 |
| JP2020078352A5 true JP2020078352A5 (enExample) | 2020-07-09 |
| JP7022165B2 JP7022165B2 (ja) | 2022-02-17 |
Family
ID=49916682
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521785A Active JP6603128B2 (ja) | 2012-07-11 | 2013-07-10 | ＸＴＥＮおよびｖｏｎＷｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2018073823A Withdrawn JP2018102323A (ja) | 2012-07-11 | 2018-04-06 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2020036624A Active JP7022165B2 (ja) | 2012-07-11 | 2020-03-04 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2021163423A Withdrawn JP2022000471A (ja) | 2012-07-11 | 2021-10-04 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2023171467A Active JP7682968B2 (ja) | 2012-07-11 | 2023-10-02 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2025080421A Pending JP2025134089A (ja) | 2012-07-11 | 2025-05-13 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521785A Active JP6603128B2 (ja) | 2012-07-11 | 2013-07-10 | ＸＴＥＮおよびｖｏｎＷｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2018073823A Withdrawn JP2018102323A (ja) | 2012-07-11 | 2018-04-06 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021163423A Withdrawn JP2022000471A (ja) | 2012-07-11 | 2021-10-04 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2023171467A Active JP7682968B2 (ja) | 2012-07-11 | 2023-10-02 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
| JP2025080421A Pending JP2025134089A (ja) | 2012-07-11 | 2025-05-13 | ＸＴＥＮおよびｖｏｎ Ｗｉｌｌｅｂｒａｎｄ因子タンパク質を有する第ＶＩＩＩ因子の複合体、および、その使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US10138291B2 (enExample) |
| EP (3) | EP3674410A1 (enExample) |
| JP (6) | JP6603128B2 (enExample) |
| KR (2) | KR102403545B1 (enExample) |
| CN (2) | CN104661674A (enExample) |
| AR (1) | AR091735A1 (enExample) |
| AU (4) | AU2013290173B2 (enExample) |
| BR (1) | BR112015000267B1 (enExample) |
| CA (1) | CA2878679A1 (enExample) |
| CL (1) | CL2015000060A1 (enExample) |
| CO (1) | CO7170123A2 (enExample) |
| CY (1) | CY1122729T1 (enExample) |
| DK (1) | DK2882450T3 (enExample) |
| EA (2) | EA029685B1 (enExample) |
| ES (1) | ES2770501T3 (enExample) |
| HR (1) | HRP20200007T1 (enExample) |
| HU (1) | HUE047088T2 (enExample) |
| IL (1) | IL236412B (enExample) |
| LT (1) | LT2882450T (enExample) |
| MX (1) | MX381011B (enExample) |
| NZ (1) | NZ703366A (enExample) |
| PH (1) | PH12015500039B1 (enExample) |
| PL (1) | PL2882450T3 (enExample) |
| PT (1) | PT2882450T (enExample) |
| RS (1) | RS59876B1 (enExample) |
| SG (3) | SG11201500045RA (enExample) |
| SI (1) | SI2882450T1 (enExample) |
| TW (1) | TWI667258B (enExample) |
| UA (1) | UA116632C2 (enExample) |
| WO (1) | WO2014011819A2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010091122A1 (en) * | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
| BR112012004094A2 (pt) | 2009-08-24 | 2016-03-08 | Amunix Operating Inc | composições de fator vii de coagulação e métodos para fazer e usar as mesmas |
| EA035323B1 (ru) * | 2012-01-12 | 2020-05-28 | Биовератив Терапьютикс Инк. | Полипептиды химерного фактора viii и их применение |
| HRP20221531T1 (hr) | 2012-02-15 | 2023-02-17 | Bioverativ Therapeutics Inc. | Pripravci faktora viii i postupci dobivanja i korištenja istih |
| LT2822577T (lt) | 2012-02-15 | 2019-03-25 | Bioverativ Therapeutics Inc. | Rekombinantiniai faktoriaus viii baltymai |
| WO2014008480A2 (en) | 2012-07-06 | 2014-01-09 | Biogen Idec Ma Inc. | Cell line expressing single chain factor viii polypeptides and uses thereof |
| US10138291B2 (en) * | 2012-07-11 | 2018-11-27 | Bioverativ Therapeutics Inc. | Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof |
| LT2956477T (lt) | 2013-02-15 | 2021-02-10 | Bioverativ Therapeutics Inc. | Optimizuotas faktoriaus viii genas |
| EA037906B1 (ru) | 2013-03-15 | 2021-06-04 | Биовератив Терапьютикс Инк. | Препараты полипептида фактора ix |
| DK2796145T3 (da) | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
| WO2014210558A1 (en) * | 2013-06-28 | 2014-12-31 | Biogen Idec Ma Inc. | Thrombin cleavable linker with xten and its uses thereof |
| EP3043813B1 (en) * | 2013-08-08 | 2021-01-13 | Bioverativ Therapeutics Inc. | Purification of chimeric fviii molecules |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| DK3091997T5 (da) * | 2014-01-10 | 2024-10-14 | Bioverativ Therapeutics Inc | Kimære faktor viii-proteiner og anvendelser deraf |
| EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
| AU2016231328B2 (en) * | 2015-03-06 | 2018-07-05 | CSL Behring Lengnau AG | Compounds for improving the half-life of von Willebrand factor |
| SG11201708755WA (en) * | 2015-05-22 | 2017-12-28 | Csl Behring Recombinant Facility Ag | Truncated von willebrand factor polypeptides for treating hemophilia |
| MX2018001497A (es) | 2015-08-03 | 2018-05-15 | Bioverativ Therapeutics Inc | Proteinas de fusion de factor ix y metodos para producirlas y usarlas. |
| JP2018529760A (ja) | 2015-08-12 | 2018-10-11 | セル マシン，インコーポレイテッド | 長半減期凝固複合体と関連する方法及び組成物 |
| IL319047A (en) * | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| SG11201805497QA (en) | 2016-01-07 | 2018-07-30 | Csl Behring Recombinant Facility Ag | Mutated truncated von willebrand factor |
| PL3411478T3 (pl) | 2016-02-01 | 2022-10-03 | Bioverativ Therapeutics Inc. | Geny zoptymalizowanego czynnika VIII |
| EP3458085B1 (en) | 2016-05-20 | 2022-12-07 | Octapharma AG | Glycosylated vwf fusion proteins with improved pharmacokinetics |
| JP6877469B2 (ja) * | 2016-06-24 | 2021-05-26 | モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ | Ｆｖｉｉｉおよびｖｗｆ因子を含むキメラタンパク質、ならびにそれらの使用 |
| CN107759694B (zh) | 2016-08-19 | 2023-01-13 | 安源医药科技（上海）有限公司 | 双特异性抗体及其制备方法与用途 |
| CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| AU2017358865A1 (en) | 2016-11-11 | 2019-05-09 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| TW201828975A (zh) | 2016-11-11 | 2018-08-16 | 瑞士商Ｃｓｌ貝林重組技能公司 | 用於治療血友病之截短型類血友病因子（ｖｏｎ Ｗｉｌｌｅｂｒａｎｄ ｆａｃｔｏｒ）多肽類 |
| WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| BR112019011198A2 (pt) | 2016-12-02 | 2019-12-17 | Bioverativ Therapeutics Inc | métodos de indução de tolerância imune a fatores de coagulação |
| EA201991768A1 (ru) | 2017-01-31 | 2020-01-22 | Байоверетив Терапьютикс Инк. | Слитые белки на основе фактора ix и способы их получения и пути применения |
| GB201707139D0 (en) * | 2017-05-04 | 2017-06-21 | Imp Innovations Ltd | Polypeptides |
| JP7374883B2 (ja) | 2017-08-09 | 2023-11-07 | バイオベラティブ セラピューティクス インコーポレイテッド | 核酸分子およびその使用 |
| WO2019126576A1 (en) | 2017-12-21 | 2019-06-27 | Amunix Pharmaceuticals, Inc. | Release segments and binding compositions comprising same |
| RS66972B1 (sr) * | 2018-05-18 | 2025-07-31 | Bioverativ Therapeutics Inc | Metode lečenja hemofilije a |
| CN119955796A (zh) | 2018-08-09 | 2025-05-09 | 比奥维拉迪维治疗股份有限公司 | 核酸分子及其用于非病毒基因疗法的用途 |
| IL280880B2 (en) | 2018-08-27 | 2025-04-01 | Regeneron Pharma | Using Raman Spectroscopy in Downstream Purification |
| MX2021005757A (es) | 2018-11-15 | 2021-08-11 | Quantum Si Inc | Metodos y composiciones para la secuenciacion de proteinas. |
| BR112021010047A2 (pt) | 2018-12-06 | 2021-08-24 | Bioverativ Therapeutics Inc. | Uso de vetores lentivirais expressando o fator ix |
| US10654911B1 (en) | 2019-04-02 | 2020-05-19 | Beijing Neoletix Biological Technology Co., Ltd. | Vector co-expressing truncated von Willebrand factor and factor VIII |
| CN114007637A (zh) * | 2019-06-19 | 2022-02-01 | 比奥维拉迪维治疗股份有限公司 | 用于治疗血友病和低骨矿物质密度的重组因子viii-fc |
| CN112175088B (zh) * | 2019-07-02 | 2023-03-28 | 江苏晟斯生物制药有限公司 | 改进的fix融合蛋白、缀合物及其应用 |
| WO2021043127A1 (zh) * | 2019-09-02 | 2021-03-11 | 甘李药业股份有限公司 | 嵌合蛋白 |
| CN115279896A (zh) | 2019-09-30 | 2022-11-01 | 比奥维拉迪维治疗股份有限公司 | 慢病毒载体配制品 |
| CA3157605A1 (en) | 2019-11-13 | 2021-05-20 | Volker Schellenberger | Barcoded xten polypeptides and compositions thereof, and methods for making and using the same |
| CN116925237A (zh) | 2019-12-31 | 2023-10-24 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
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| JP2023527764A (ja) * | 2020-05-20 | 2023-06-30 | クアンタム－エスアイ インコーポレイテッド | タンパク質シーケンスのための方法及び組成物 |
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| JP2023545684A (ja) | 2020-09-30 | 2023-10-31 | ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド | ポリペプチドコンジュゲートおよび使用の方法 |
| CA3220564A1 (en) | 2021-06-23 | 2022-12-29 | Bioverativ Therapeutics Inc. | Formulations of factor viii chimeric proteins and uses thereof |
| CN113862301A (zh) * | 2021-08-25 | 2021-12-31 | 上海交通大学医学院附属瑞金医院 | 一种vwf前肽表达载体及其制备方法和应用 |
| CA3252113A1 (en) | 2022-03-30 | 2023-10-05 | Beijing Ql Biopharmaceutical Co Ltd | Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use |
| CN121013866A (zh) | 2023-02-10 | 2025-11-25 | 阿穆尼克斯制药公司 | 靶向前列腺特异性膜抗原（psma）的组合物及其制备和使用方法 |
| WO2024200652A1 (en) | 2023-03-31 | 2024-10-03 | Octapharma Ag | Fviii-vwf fusion proteins with improved pharmacokinetics |
| AU2024258990A1 (en) | 2023-04-17 | 2025-10-23 | Amunix Pharmaceuticals, Inc. | Compositions targeting epidermal growth factor receptor and methods for making and using the same |
| WO2025122957A1 (en) | 2023-12-08 | 2025-06-12 | Amunix Pharmaceuticals, Inc. | Protease activatable cytokines and methods for making and using the same |
| WO2025181343A1 (en) | 2024-02-29 | 2025-09-04 | Octapharma Ag | Cystine knot domain fusion protein dimers |
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