JP2019533679A5 - - Google Patents

Download PDF

Info

Publication number
JP2019533679A5
JP2019533679A5 JP2019520794A JP2019520794A JP2019533679A5 JP 2019533679 A5 JP2019533679 A5 JP 2019533679A5 JP 2019520794 A JP2019520794 A JP 2019520794A JP 2019520794 A JP2019520794 A JP 2019520794A JP 2019533679 A5 JP2019533679 A5 JP 2019533679A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
etanercept
composition according
arginine
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019520794A
Other languages
English (en)
Japanese (ja)
Other versions
JP6884858B2 (ja
JP2019533679A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/057472 external-priority patent/WO2018075818A1/en
Publication of JP2019533679A publication Critical patent/JP2019533679A/ja
Publication of JP2019533679A5 publication Critical patent/JP2019533679A5/ja
Priority to JP2021080160A priority Critical patent/JP7402195B2/ja
Application granted granted Critical
Publication of JP6884858B2 publication Critical patent/JP6884858B2/ja
Priority to JP2023180119A priority patent/JP7754903B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019520794A 2016-10-21 2017-10-19 医薬製剤及びその製造方法 Active JP6884858B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021080160A JP7402195B2 (ja) 2016-10-21 2021-05-11 医薬製剤及びその製造方法
JP2023180119A JP7754903B2 (ja) 2016-10-21 2023-10-19 医薬製剤及びその製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662411458P 2016-10-21 2016-10-21
US62/411,458 2016-10-21
PCT/US2017/057472 WO2018075818A1 (en) 2016-10-21 2017-10-19 Pharmaceutical formulations and methods of making the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021080160A Division JP7402195B2 (ja) 2016-10-21 2021-05-11 医薬製剤及びその製造方法

Publications (3)

Publication Number Publication Date
JP2019533679A JP2019533679A (ja) 2019-11-21
JP2019533679A5 true JP2019533679A5 (enExample) 2020-12-10
JP6884858B2 JP6884858B2 (ja) 2021-06-09

Family

ID=61971152

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019520794A Active JP6884858B2 (ja) 2016-10-21 2017-10-19 医薬製剤及びその製造方法
JP2021080160A Active JP7402195B2 (ja) 2016-10-21 2021-05-11 医薬製剤及びその製造方法
JP2023180119A Active JP7754903B2 (ja) 2016-10-21 2023-10-19 医薬製剤及びその製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021080160A Active JP7402195B2 (ja) 2016-10-21 2021-05-11 医薬製剤及びその製造方法
JP2023180119A Active JP7754903B2 (ja) 2016-10-21 2023-10-19 医薬製剤及びその製造方法

Country Status (13)

Country Link
US (5) US20180110856A1 (enExample)
EP (1) EP3528787A4 (enExample)
JP (3) JP6884858B2 (enExample)
KR (2) KR102413592B1 (enExample)
CN (2) CN109982685B (enExample)
AU (1) AU2017345490B2 (enExample)
CA (1) CA3040899A1 (enExample)
CL (1) CL2019001053A1 (enExample)
EA (1) EA201990998A1 (enExample)
IL (1) IL266132B (enExample)
MX (1) MX2019004580A (enExample)
SG (1) SG11201903521XA (enExample)
WO (1) WO2018075818A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1909831A4 (en) 2005-06-14 2013-02-20 Amgen Inc SELF-BUFFING PROTEIN FORMULATIONS
AU2017345490B2 (en) 2016-10-21 2022-07-07 Amgen Inc. Pharmaceutical formulations and methods of making the same
MX2020005170A (es) 2017-11-17 2020-10-16 Amgen Inc Formulaciones de proteinas de fusion vegfr-fc.
SG11202112726SA (en) * 2019-07-09 2021-12-30 Unichem Lab Ltd Stable formulations of recombinant proteins
GB201911461D0 (en) * 2019-08-09 2019-09-25 Arecor Ltd Novel composition
WO2021183861A1 (en) 2020-03-12 2021-09-16 Amgen Inc. Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor
NZ792999A (en) * 2020-04-06 2025-08-29 Univ Leland Stanford Junior Antibody formulation
EP4007164A4 (en) 2020-05-12 2022-11-23 NEC Corporation DISTORTION COMPENSATION DEVICE AND DISTORTION COMPENSATION METHOD

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2837168A1 (de) 1978-08-25 1980-03-06 Blutspendedienst Dt Rote Kreuz Verfahren zur herstellung einer fuer die intravenoese anwendung geeigneten immunglobulinloesung
US4362661A (en) 1979-08-09 1982-12-07 Teijin Limited Immunoglobulin composition having a high monomer content, and process for production thereof
CA1153695A (en) 1979-08-30 1983-09-13 Syoji Ono S-sulfonated immunoglobulin composition having a high monomer content and a process for production thereof
US4374763A (en) 1979-09-17 1983-02-22 Morishita Pharmaceutical Co., Ltd. Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof
US4396608A (en) 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
US5702699A (en) 1982-09-23 1997-12-30 Cetus Corporation Process for the recovery of lipophilic proteins
US4681713A (en) 1984-03-15 1987-07-21 Toyo Boseki Kabushiki Kaisha Method of making a hollow fiber membrane for dialysis
US4597966A (en) 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
US6673347B1 (en) 1986-04-30 2004-01-06 Gryphon Therapeutics Polypeptide and protein derivatives and process for their preparation
GB8628104D0 (en) 1986-11-25 1986-12-31 Connaught Lab Pasteurization of immunoglobin solutions
DE3640513A1 (de) 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
JP2547556B2 (ja) 1987-02-06 1996-10-23 株式会社 ミドリ十字 ｒ−グロブリンの液状製剤
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
US5395760A (en) 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
DE10399023I2 (de) 1989-09-12 2006-11-23 Ahp Mfg B V TFN-bindende Proteine
DE3939346A1 (de) 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
US5177194A (en) 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
US5945098A (en) 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
GB9017002D0 (en) 1990-08-02 1990-09-19 Health Lab Service Board Improved method for the purification of erwina l-asparaginase
JP3179538B2 (ja) 1990-12-11 2001-06-25 ノバルティス アクチエンゲゼルシャフト 安定なヒトカルシトニンの水性溶液
US5110910A (en) 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
US5256571A (en) 1991-05-01 1993-10-26 Cytyc Corporation Cell preservative solution
AU3095892A (en) 1991-12-20 1993-07-28 Protein Design Labs, Inc. Human type antibody reactive with GPIIb/IIIa
US6004555A (en) 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US5298410A (en) 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5484892A (en) 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
DE4344824C1 (de) 1993-12-28 1995-08-31 Immuno Ag Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung
GB9401448D0 (en) 1994-01-26 1994-03-23 Ciba Geigy Ag Stable dry powders
US5580856A (en) 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
ATE306930T1 (de) 1994-08-12 2005-11-15 Immunomedics Inc Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
DE69721548T2 (de) 1996-02-09 2004-04-01 Abbott Laboratories(Bermuda)Ltd. HUMANE ANTIKÖRPER WELCHE AN HUMANEN TNFalpha BINDEN
TWI240627B (en) 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
GB9610992D0 (en) 1996-05-24 1996-07-31 Glaxo Group Ltd Concentrated antibody preparation
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
KR20000067911A (ko) 1996-07-18 2000-11-25 씨에스엘 리미티드 면역글로불린 용액의 저온살균방법
TW491855B (en) 1996-08-07 2002-06-21 Csl Ltd Purification of immunoglobulins
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
JP3679406B2 (ja) 1998-05-20 2005-08-03 協和醗酵工業株式会社 遺伝子組換え抗体
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
ES2421736T3 (es) 1998-06-09 2013-09-05 Csl Behring Ag Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos
US6610206B1 (en) 1998-10-20 2003-08-26 Advanced Renal Technologies Buffered compositions for dialysis
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US7294481B1 (en) 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
CA2362126C (en) 1999-02-03 2017-01-17 Amgen Inc. B7rp-1 polypeptides
CA2369451C (en) 1999-04-08 2009-09-22 Genentech, Inc. Composition based on oppositely-charged polypeptides
PL203797B1 (pl) 1999-04-09 2009-11-30 Ortho Mcneil Pharm Inc Kompozycje farmaceutyczne erytropoetyny
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
WO2000062790A2 (en) 1999-04-19 2000-10-26 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
US20010021380A1 (en) 1999-04-19 2001-09-13 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
CN100389821C (zh) 1999-10-04 2008-05-28 希龙公司 稳定化的含多肽的液体药物组合物
IL149890A0 (en) 1999-12-14 2002-11-10 Genentech Inc Tnt-alpha antagonist and lfa-1 antagonist for treating lfa-1 or tnf-alpha mediated
CA2394536A1 (en) 1999-12-16 2001-06-21 Amgen Inc. Tnfr/opg-like molecules and uses thereof
EP1261364A1 (en) 2000-02-10 2002-12-04 Wyeth Method of treating or inhibiting cellular injury or cell death
PT1255558E (pt) 2000-02-16 2006-11-30 Genentech Inc Anticorpos anti-april e células hibridoma
WO2002008417A1 (fr) 2000-07-25 2002-01-31 Takeda Chemical Industries, Ltd. Procede de production d'une proteine de recombinaison
US20040038878A1 (en) 2000-08-04 2004-02-26 Masahiko Tanikawa Injectable protein formulations
WO2002013860A1 (en) 2000-08-11 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing preparations
IL155002A0 (en) 2000-10-12 2003-10-31 Genentech Inc Reduced-viscosity concentrated protein formulations
BR0116686A (pt) 2000-12-14 2003-12-30 Fujisawa Pharmaceutical Co Anticorpos anti-cd28 silenciados e uso dos mesmos
US6693173B2 (en) 2000-12-26 2004-02-17 Alpha Therapeutic Corporation Method to remove citrate and aluminum from proteins
AR032028A1 (es) 2001-01-05 2003-10-22 Pfizer Anticuerpos contra el receptor del factor de crecimiento similar a insulina
ES2184594B1 (es) 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
CZ20032208A3 (cs) 2001-02-23 2004-01-14 Immunex Corporation Zvýšený výtěžek aktivních proteinů
GB0113179D0 (en) 2001-05-31 2001-07-25 Novartis Ag Organic compounds
WO2003001563A1 (en) 2001-06-25 2003-01-03 Koninklijke Philips Electronics N.V. High-pressure gas discharge lamp and method of manufacturing the same
ES2706902T3 (es) 2001-06-26 2019-04-01 Amgen Inc Anticuerpos para OPGL
IL160358A0 (en) 2001-08-23 2004-07-25 Genmab As Human antibodies specific for interleukin 15 (il-15)
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
AU2002305767B2 (en) 2001-09-20 2008-04-10 Cornell Research Foundation, Inc. Methods and compositions for treating and preventing skin disorders using binding agents specific for PSMA
US20030138417A1 (en) 2001-11-08 2003-07-24 Kaisheva Elizabet A. Stable liquid pharmaceutical formulation of IgG antibodies
AU2002359495A1 (en) 2001-11-30 2003-06-17 Centocor, Inc. Anti-tnf antibodies, compositions, methods and uses
WO2003059935A2 (en) 2001-12-21 2003-07-24 Immunex Corporation Methods for purifying protein
WO2003068259A1 (fr) 2002-02-14 2003-08-21 Chugai Seiyaku Kabushiki Kaisha Produits pharmaceutiques en solution contenant des anticorps
CN1646161A (zh) 2002-02-21 2005-07-27 杜克大学 自身免疫疾病的药剂和治疗方法
US20030180287A1 (en) * 2002-02-27 2003-09-25 Immunex Corporation Polypeptide formulation
WO2003083066A2 (en) 2002-03-27 2003-10-09 Immunex Corporation Methods for increasing polypeptide production
US7718776B2 (en) 2002-04-05 2010-05-18 Amgen Inc. Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors
DE10218570B4 (de) 2002-04-26 2007-10-18 Lohmann Gmbh & Co Kg Acrylatcopolymere und daraus erhältliche Haftklebemassen zum Verkleben von niederenergetischen Oberflächen sowie ihre Verwendung
JP4319979B2 (ja) 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
US20030206898A1 (en) 2002-04-26 2003-11-06 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
CN1671741A (zh) 2002-06-21 2005-09-21 拜奥根Idec公司 浓缩抗体的缓冲剂制剂及其使用方法
CN101745112A (zh) 2002-07-19 2010-06-23 艾博特生物技术有限公司 TNFα相关疾病的治疗
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
WO2004042012A2 (en) 2002-11-01 2004-05-21 Bayer Healthcare Llc Process for concentration of macromolecules
US20040086532A1 (en) 2002-11-05 2004-05-06 Allergan, Inc., Botulinum toxin formulations for oral administration
EP2272864A3 (en) 2002-12-20 2011-02-16 Amgen Inc. Binding agents which inhibit myostatin
EP1603948A1 (en) 2003-03-14 2005-12-14 Pharmacia Corporation Antibodies to igf-i receptor for the treatment of cancers
DK1610820T4 (da) 2003-04-04 2013-11-04 Genentech Inc Høj-koncentration antistof- og proteinformuleringer
JP4850709B2 (ja) 2003-05-14 2012-01-11 ダニスコ・ユーエス・インコーポレーテッド 反復配列タンパク質ポリマーを使用する、活性剤の制御放出
US7354578B2 (en) 2003-06-06 2008-04-08 Regeneron Pharmaceuticals, Inc. Method of tumor regression with VEGF inhibitors
DK1639011T3 (da) 2003-06-30 2009-02-16 Domantis Ltd Pegylerede enkelt-domæne antistoffer (dAb)
WO2005047331A2 (en) 2003-11-07 2005-05-26 Immunex Corporation Antibodies that bind interleukin-4 receptor
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
EP1713502A1 (de) 2004-02-12 2006-10-25 MERCK PATENT GmbH Hochkonzentrierte, flüssige formulierungen von anti-egfr-antikörpern
WO2005095454A1 (en) 2004-03-25 2005-10-13 Diadexus, Inc. Lng105 antibody composition and methods of use, and use of lng105 to assess lung cancer risk
MXPA06012992A (es) 2004-05-12 2007-02-12 Baxter Int Microesferas que comprenden proteina y que muestran inyectabilidad en altas concentraciones de este agente.
WO2006003999A1 (ja) 2004-07-05 2006-01-12 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute ヒト抗ヒトb7rp-1抗体およびその抗体フラグメント
JP5015774B2 (ja) * 2004-07-29 2012-08-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ジフルオロ置換複素環化合物および液晶媒体における構成要素としてのその使用
TW200621282A (en) 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
US7300773B2 (en) 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
WO2006024497A1 (en) 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
WO2006064373A2 (en) 2004-12-16 2006-06-22 Genzyme Polyclonals S.A.S. Methods of purifying immunologlobulins
JP4498939B2 (ja) 2005-02-01 2010-07-07 東京応化工業株式会社 ポジ型レジスト組成物およびレジストパターン形成方法
US8597709B2 (en) 2005-04-12 2013-12-03 Inovobiologic Inc. Dietary supplement and methods of use
EP1909831A4 (en) 2005-06-14 2013-02-20 Amgen Inc SELF-BUFFING PROTEIN FORMULATIONS
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US20070049732A1 (en) 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
CA2630606A1 (en) 2005-09-21 2007-03-29 Burcon Nutrascience (Mb) Corp. Preparation of canola protein isolate involving isoelectric precipitation
US8067350B2 (en) 2005-12-15 2011-11-29 Kimberly-Clark Worldwide, Inc. Color changing cleansing composition
US20070202051A1 (en) 2006-02-10 2007-08-30 Pari Gmbh Aerosols for sinunasal drug delivery
AU2007240732B2 (en) 2006-04-21 2013-07-04 Amgen, Inc. Buffering agents for biopharmaceutical formulations
GEP20125628B (en) 2006-04-21 2012-09-10 Novartis Ag Pharmaceutical compositions containing antagonist anti-cd40 antibody
US20080161242A1 (en) 2006-09-15 2008-07-03 Randolph Theodore W High pressure treatment of proteins for reduced immunogenicity
KR20090101893A (ko) 2006-10-27 2009-09-29 애보트 바이오테크놀로지 리미티드 결정형 항-ｈＴＮＦ알파 항체
JP5577098B2 (ja) 2006-12-21 2014-08-20 アムジエン・インコーポレーテツド ポリペプチドを含有する安定な緩衝化された製剤
TWI661833B (zh) * 2007-11-30 2019-06-11 百慕達商艾伯維生物技術有限責任公司 蛋白質調配物及製造其之方法
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
MX2010008696A (es) * 2008-02-07 2010-08-30 Amgen Inc Composiciones de proteina estabilizadas.
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
MX2010012691A (es) 2008-05-20 2011-03-30 Avant Medical Corp Star Sistema auto-inyector.
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
MX2011003013A (es) * 2008-09-19 2011-04-11 Pfizer Formulacion liquida estable de anticuerpos.
EP3011953A1 (en) * 2008-10-29 2016-04-27 Ablynx N.V. Stabilised formulations of single domain antigen binding molecules
CA2754528A1 (en) 2009-03-06 2010-09-10 Genetech, Inc. Antibody formulation
US20110070227A1 (en) 2009-09-18 2011-03-24 Anna-Marie Novotney-Barry Treatment of Autoimmune and Inflammatory Diseases
MX344727B (es) 2010-11-11 2017-01-05 Abbvie Biotechnology Ltd Formulaciones liquidas de anticuerpos anti-tnf-alfa de alta concentracion mejoradas.
US9173999B2 (en) 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
CA2833748C (en) 2011-04-20 2019-07-16 Amgen Inc. Autoinjector apparatus
US9453067B2 (en) * 2011-04-20 2016-09-27 Sandoz Ag Stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc
UY34105A (es) 2011-06-03 2012-07-31 Lg Life Sciences Ltd Formulación líquida estable de etanercept
WO2013006454A1 (en) 2011-07-01 2013-01-10 Biogen Idec Ma Inc. Arginine - free tnfr : fc- fusion polypeptide compositions and methods of use
BR112014009031A2 (pt) * 2011-10-18 2017-05-09 Coherus Biosciences Inc formulações de etanercept estabilizadas com íons de metais
EP2863951A1 (en) 2012-06-12 2015-04-29 Boehringer Ingelheim International GmbH Pharmaceutical formulation for a therapeutic antibody
BR112015000078A2 (pt) 2012-07-05 2017-10-03 Unitract Syringe Pty Ltd Injetor automático
MX2015000337A (es) 2012-07-09 2015-09-25 Coherus Biosciences Inc Formulaciones de etanercept que exhiben reduccion notable en particulas subvisibles.
LT2895188T (lt) * 2012-09-11 2018-04-10 Coherus Biosciences, Inc. Aukšto grynumo ir geros išeigos teisingos struktūros etanerceptas
PL2919801T3 (pl) * 2012-10-26 2021-01-25 Lupin Atlantis Holdings, Sa Stabilna kompozycja farmaceutyczna białka fuzyjnego TNFR:FC etanerceptu
US9649383B2 (en) 2012-11-19 2017-05-16 Merck Sharp & Dohme Corp. Liquid formulations for TNFR:Fc fusion proteins
JP6026002B2 (ja) * 2012-11-27 2016-11-16 アルテオジェン インコーポレイテッド タンパク質とＦｃドメインを融合した融合タンパク質の安定化用組成物
AR094458A1 (es) 2012-12-06 2015-08-05 Iams Co Alimento con formas perceptibles para mascotas
CN105007896B (zh) 2012-12-28 2019-04-09 雅培心血管系统公司 包含抗体的治疗组合物
US10492990B2 (en) 2013-03-15 2019-12-03 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
JP6336564B2 (ja) 2013-03-15 2018-06-06 アムゲン・インコーポレーテッド 薬物カセット、自動注入器、および自動注入器システム
JP2016518386A (ja) 2013-05-02 2016-06-23 マブキシェンス エス．アー． ＴＮＦＲ：Ｆｃ融合ポリペプチドの代替配合物
EP3892288A1 (en) 2013-10-24 2021-10-13 Astrazeneca AB Stable, aqueous antibody formulations
US9700595B2 (en) 2013-11-29 2017-07-11 Ares Trading Sa Liquid formulation of a fusion protein comprising TNFR and Fc region
ES2733298T3 (es) 2014-07-18 2019-11-28 Sandoz Ag Cuantificación de TNFR2:Fc plegado erróneamente
EP3185933B1 (en) 2014-08-28 2020-08-19 UNL Holdings LLC Sensor systems for drug delivery devices
MX384301B (es) 2014-08-28 2025-03-14 Unitract Syringe Pty Ltd Sensores de piel para dispositivos de administración de fármacos.
AU2015371381A1 (en) * 2014-12-22 2017-07-20 Ares Trading S.A. Liquid pharmaceutical composition
WO2016149139A1 (en) 2015-03-13 2016-09-22 Samsung Bioepis Co., Ltd. Anti-tnf-alpha polypeptide composition and use thereof
US9763976B1 (en) 2016-08-02 2017-09-19 Zo Skin Health, Inc. Composition and method for treating skin conditions
AU2017345490B2 (en) 2016-10-21 2022-07-07 Amgen Inc. Pharmaceutical formulations and methods of making the same

Similar Documents

Publication Publication Date Title
JP2019533679A5 (enExample)
JP2021120393A5 (enExample)
JP2019536761A5 (enExample)
JP2022174082A5 (enExample)
JP2019504086A5 (enExample)
JP2018523682A5 (enExample)
JP2016531901A5 (enExample)
JP2010513522A5 (enExample)
MX2014015799A (es) Composiciones farmaceuticas que comprenden rifaximina y aminoacidos, metodo de preparacion y uso de las mismas.
RU2015119603A (ru) Стабильная фармацевтическая композиция на основе слитого белка tnfr:fc
JP2017516848A5 (enExample)
JP2009538287A5 (ja) 低粘度グリコサミノグリカンで構成される組成物及び該組成物の間質性膀胱炎の治療での使用
ES2689150T3 (es) Métodos para la prevención de agregación de componentes víricos
JP2021502951A5 (enExample)
WO2017162103A1 (zh) 一种注射用阿扎胞苷的制备方法
KR101784951B1 (ko) 바이러스의 성장을 유도하기 위한 조성물, 방법 및 용도
PT92305B (pt) Metodo para solubilizacao e naturacao da somatotropina
JP2020510619A5 (enExample)
JP5922609B2 (ja) ２−アミノ−３−（４−ブロモベンゾイル）フェニル酢酸含有水性組成物
CN105919931A (zh) 一种稳定的盐酸法舒地尔注射液及其制备方法
JP2011510667A5 (enExample)
JP2017502947A5 (enExample)
US6387695B1 (en) DNA pharmaceutical formulations comprising citrate or triethanolamine and combinations thereof
CN100591324C (zh) 羧甲基壳聚糖季铵盐作为吸湿保湿剂的应用
JP2010047482A (ja) エダラボン注射液