JP2015517464A5 - - Google Patents

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JP2015517464A5
JP2015517464A5 JP2015510319A JP2015510319A JP2015517464A5 JP 2015517464 A5 JP2015517464 A5 JP 2015517464A5 JP 2015510319 A JP2015510319 A JP 2015510319A JP 2015510319 A JP2015510319 A JP 2015510319A JP 2015517464 A5 JP2015517464 A5 JP 2015517464A5
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JP
Japan
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days
recombinant
protein
falciparum
formulation
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JP2015510319A
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Japanese (ja)
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JP6238967B2 (ja
JP2015517464A (ja
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Priority claimed from US13/844,261 external-priority patent/US9169304B2/en
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JP2015510319A 2012-05-01 2013-04-22 組み換え熱帯熱マラリア原虫スポロゾイト周囲タンパク質を精製するプロセス Active JP6238967B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261641105P 2012-05-01 2012-05-01
US61/641,105 2012-05-01
US13/844,261 2013-03-15
US13/844,261 US9169304B2 (en) 2012-05-01 2013-03-15 Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
PCT/US2013/037656 WO2013165732A1 (en) 2012-05-01 2013-04-22 Process for purifying recombinant plasmodium falciparum circumsporozoite protein

Publications (3)

Publication Number Publication Date
JP2015517464A JP2015517464A (ja) 2015-06-22
JP2015517464A5 true JP2015517464A5 (enExample) 2016-06-16
JP6238967B2 JP6238967B2 (ja) 2017-11-29

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JP2015510319A Active JP6238967B2 (ja) 2012-05-01 2013-04-22 組み換え熱帯熱マラリア原虫スポロゾイト周囲タンパク質を精製するプロセス

Country Status (16)

Country Link
US (2) US9169304B2 (enExample)
EP (1) EP2844666B1 (enExample)
JP (1) JP6238967B2 (enExample)
KR (1) KR102087461B1 (enExample)
CN (1) CN104379596B (enExample)
AR (1) AR090900A1 (enExample)
AU (1) AU2013256757B2 (enExample)
BR (1) BR112014027019B1 (enExample)
CA (1) CA2870198C (enExample)
MX (1) MX352093B (enExample)
MY (1) MY166380A (enExample)
NZ (1) NZ630121A (enExample)
SG (1) SG11201407108TA (enExample)
TW (1) TWI630213B (enExample)
WO (1) WO2013165732A1 (enExample)
ZA (1) ZA201407420B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
WO2015105551A1 (en) * 2014-01-09 2015-07-16 Kentucky Bioprocessing, Inc. Method of purifying monoclonal antibodies
US10632156B2 (en) 2014-03-28 2020-04-28 Atterx Biotherapeutics, Inc. Preparation of small colony variants of therapeutic bacteria
CN113444183B (zh) 2014-12-01 2025-06-17 佩利肯科技控股公司 用于肽生产的融合伴侣
CN109966319B (zh) * 2017-12-22 2022-11-22 四川好医生攀西药业有限责任公司 一种康复新液的原料及其制备方法和应用
CN108559721A (zh) * 2018-05-15 2018-09-21 北京师范大学 一种净化空气的复合微生物菌剂及其应用
EP4171630A1 (en) * 2020-06-29 2023-05-03 Path Pre-erythrocytic malaria vaccines

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2145092B (en) 1983-01-28 1988-04-07 Univ New York Protective peptide antigen
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
CH660375A5 (it) 1983-02-08 1987-04-15 Sclavo Spa Procedimento per la produzione di proteine correlate alla tossina difterica.
US4755465A (en) 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
US5281532A (en) 1983-07-27 1994-01-25 Mycogen Corporation Pseudomas hosts transformed with bacillus endotoxin genes
US4830962A (en) 1984-02-09 1989-05-16 Cetus Corporation Recombinant diphtheria toxin fragments
ZA855232B (en) 1984-07-23 1986-02-26 Univ New York Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein
ZA856655B (en) 1984-09-12 1986-04-30 Univ New York Cross-reactive and protective epitopes of circumsporozoite proteins
US5178861A (en) 1984-09-12 1993-01-12 New York University Cross-reactive and protective epitopes of circumsporozoite proteins
US4695462A (en) 1985-06-28 1987-09-22 Mycogen Corporation Cellular encapsulation of biological pesticides
US4695455A (en) 1985-01-22 1987-09-22 Mycogen Corporation Cellular encapsulation of pesticides produced by expression of heterologous genes
US4709017A (en) 1985-06-07 1987-11-24 President And Fellows Of Harvard College Modified toxic vaccines
GB8517071D0 (en) 1985-07-05 1985-08-14 Hoffmann La Roche Gram-positive expression control sequence
ATE118784T1 (de) 1985-07-12 1995-03-15 Univ New York Mit dem plasmodium-vivax-circumsporozoit-protein übereinstimmendes immunogenes peptidantigen.
CA1340373C (en) 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
EP0252588A3 (en) 1986-05-12 1989-07-12 Smithkline Beecham Corporation Process for the isolation and purification of p. falciparum cs protein expressed in recombinant e. coli, and its use as a vaccine
US4892827A (en) 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
WO1988005817A1 (en) 1987-01-30 1988-08-11 Smith Kline - Rit S.A. Expression of the p. falciparum circumsporozoite protein by yeast
WO1989001976A1 (en) 1987-09-04 1989-03-09 Amgen Inc. Recombinant dna-derived bordetella toxin subunit analogs
US5792458A (en) 1987-10-05 1998-08-11 The United States Of America As Represented By The Department Of Health And Human Services Mutant diphtheria toxin conjugates
GB8727489D0 (en) 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
US5128130A (en) 1988-01-22 1992-07-07 Mycogen Corporation Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens
AU625713B2 (en) 1988-02-19 1992-07-16 Microgenesys, Inc. Method for producing recombinant protein derived from the circumsporozoite gene of plasmodium falciparum
US5055294A (en) 1988-03-03 1991-10-08 Mycogen Corporation Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens
GB8812214D0 (en) 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5028425A (en) 1988-07-07 1991-07-02 The United States Of America As Represented By The Department Of Health And Human Services Synthetic vaccine against P. falciparum malaria
ATE151110T1 (de) * 1988-09-02 1997-04-15 Protein Eng Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US6043057A (en) 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
US6048728A (en) * 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
KR910700352A (ko) 1988-12-21 1991-03-14 스미스클라인 바이올로지칼즈(s.a.) 곤충 세포내에서 플라스모듐 서컴스포로 조이트 단백질의 발현
AU5027890A (en) 1989-02-10 1990-09-05 Genesit Oy A method for producing pertussis toxin subunits
US7232671B2 (en) 1989-02-15 2007-06-19 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
NZ233255A (en) 1989-04-11 1993-02-25 Chiron Corp Plasmodium cs protein analogues lacking one or more of the repeat epitopes, and containing at least one nonrepeat flanking epitope
EP0396964B1 (en) 1989-04-28 1995-09-06 SCLAVO S.p.A. Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines
GB8914122D0 (en) 1989-06-20 1989-08-09 Wellcome Found Polypeptide expression
US5169760A (en) 1989-07-27 1992-12-08 Mycogen Corporation Method, vectors, and host cells for the control of expression of heterologous genes from lac operated promoters
ATE93271T1 (de) 1989-11-28 1993-09-15 Wellcome Found Vakzine.
ATE363532T1 (de) 1991-03-01 2007-06-15 Dyax Corp Verfahren zur herstellung bindender miniproteine
WO1992017204A1 (en) 1991-04-01 1992-10-15 The United States Of America, Represented By The Secretary, United States Department Of Commerce Circumsporozoite protein of plasmodium reichenowi and vaccine for human malaria
US5935580A (en) 1992-04-21 1999-08-10 Institut Pasteur Recombinant mutants for inducing specific immune responses
PT761231E (pt) 1992-06-25 2000-06-30 Smithkline Beecham Biolog Composicao de vacina contendo adjuvantes
EP0616034B1 (en) 1993-03-05 2004-10-20 Wyeth Holdings Corporation Plasmid for production of CRM protein and diphtheria toxin
DK0725653T3 (da) 1993-10-05 2004-10-11 Celltech Pharmaceuticals Ltd Vaccinepræparater
GB9406492D0 (en) 1994-03-31 1994-05-25 Isis Innovation Malaria peptides
US20040214157A1 (en) 1994-06-29 2004-10-28 Simon C. Burton Chromatographic resins and methods for using same
US5652348A (en) 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
CN1165539A (zh) 1994-09-29 1997-11-19 味之素株式会社 肽及蛋白质的修饰
US5932714A (en) 1995-02-23 1999-08-03 Connaught Laboratories Limited Expression of gene products from genetically manipulated strains of Bordetella
SE9600590D0 (sv) 1996-02-19 1996-02-19 Pharmacia Biotech Ab Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris
GB9616351D0 (en) 1996-08-02 1996-09-11 Smithkline Beecham Biolog Vaccine composition
EP2298900A1 (en) 1996-09-17 2011-03-23 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for treating intracellular diseases
US7393630B2 (en) 1997-12-16 2008-07-01 Novartis Vaccines And Diagnostics, Inc. Use of microparticles combined with submicron oil-in-water emulsions
JP2002537310A (ja) 1999-02-18 2002-11-05 エールエムエフ・ディクタジェーヌ・ソシエテ・アノニム マラリアワクチン
GB9904582D0 (en) 1999-02-26 1999-04-21 Nycomed Imaging As Process
US6942866B2 (en) * 2000-08-16 2005-09-13 Apovia, Inc. Malaria immunogen and vaccine
AUPR011700A0 (en) 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
AU2001293074A1 (en) 2000-09-25 2002-04-08 Walter Reed Army Institute Of Research Human liver cell line
US7781186B2 (en) 2000-09-25 2010-08-24 The United States Of America As Represented By The Secretary Of The Army Screening methods using normal human liver cell line
US7363166B2 (en) * 2001-03-30 2008-04-22 Council Of Scientific & Industrial Research Computational method for the identification of candidate proteins useful as anti-infectives
SE0104353D0 (sv) 2001-12-19 2001-12-19 Amersham Biosciences Ab Separation method
AU2003299527A1 (en) 2002-06-17 2004-06-07 Jimmy D. Ballard Mutant of clostridium difficile toxin b and methods of use
US20040067880A1 (en) 2002-10-04 2004-04-08 Kuo Macus Tien Prodrug therapy of liver diseases using receptor-mediated delivery of malarial circumsporozoite protein as a carrier
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
NZ539509A (en) 2002-10-23 2008-05-30 Glaxosmithkline Biolog Sa Priming vaccine comprising a polynucleotide encoding at least one first malarial antigen and a boosting vaccine comprising at least one polypeptide comprising at least one second malarial antigen having at least one epitope in common with the first malarial antigen of the priming vaccine
AU2003298361B2 (en) 2002-12-17 2009-05-14 Crucell Holland B.V. Recombinant viral-based malaria vaccines
US7670631B2 (en) 2003-03-12 2010-03-02 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists
US8399217B2 (en) 2003-03-14 2013-03-19 Brookhaven Science Associates, Llc High density growth of T7 expression strains with auto-induction option
MXPA06005634A (es) 2003-11-19 2006-08-23 Dow Global Technologies Inc Sistemas mejorados de expresion de proteinas.
PL2336153T3 (pl) 2003-11-21 2016-08-31 Pfenex Inc Udoskonalone systemy ekspresji z układem wydzielania SEC
WO2005063805A1 (en) 2003-12-23 2005-07-14 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies against the amino terminus region of circumsporozoite protein prevent the onset of malaria infection
KR101183720B1 (ko) 2004-01-16 2012-09-17 다우 글로벌 테크놀로지스 엘엘씨 슈도모나스 플루오레센스에서의 포유류 단백질의 발현
AU2005269527B2 (en) 2004-07-26 2011-12-01 Pfenex Inc. Process for improved protein expression by strain engineering
JP2008510465A (ja) 2004-08-20 2008-04-10 ケイエムティー ヒパテック インコーポレイテッド キメラヒト肝臓を有するマラリア動物モデル
GB0420634D0 (en) 2004-09-16 2004-10-20 Glaxosmithkline Biolog Sa Vaccines
CA2593643C (en) 2005-01-18 2016-03-22 Walter Reed Army Institute Of Research A plasmodium vivax hybrid circumsporozoite protein and vaccine
EP1754717A1 (en) 2005-08-19 2007-02-21 Université de Lausanne Antigenic peptides and their use
BRPI0616602A2 (pt) 2005-09-30 2011-06-28 Seattle Biomedical Res Inst polipeptìdeo isolado, composição imunogênica, molécula de ácido nucleico isolada, e, uso de uma composição imunogênica
US7749519B2 (en) 2005-12-09 2010-07-06 Kim Lee Sim Unique DNA and polypeptide sequences based on the circumsporozoite protein of Plasmodium vivax
AU2007254993A1 (en) 2006-05-30 2007-12-13 Dow Global Technologies Llc Codon optimization method
KR101491867B1 (ko) 2007-01-31 2015-02-10 피페넥스 인크. 증가된 발현을 위한 박테리아 리더 서열
EP2615172A1 (en) 2007-04-27 2013-07-17 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
MX2010001752A (es) 2007-08-13 2010-03-10 Glaxosmithkline Biolog Sa Vacunas.
WO2009114202A2 (en) 2008-03-14 2009-09-17 The United States Of America As Represented By The Secretary Of The Navy Vaccine and immunization method using plasmodium antigen 2
WO2010008764A1 (en) 2008-06-23 2010-01-21 Dow Global Technologies Inc. Pseudomonas fluorescens strains for production of extracellular recombinant protein
CA2739568C (en) 2008-10-31 2015-12-01 Shujun Sun Purification of acidic proteins using ceramic hydroxyapatite chromatography
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
CA2791361C (en) 2010-03-04 2018-06-12 Pfenex Inc. Method for producing soluble recombinant interferon protein without denaturing
AU2011238711B2 (en) 2010-03-30 2015-06-18 Pelican Technology Holdings, Inc. High level expression of recombinant toxin proteins
JP2013525484A (ja) 2010-05-03 2013-06-20 ジェネンテック， インコーポレイテッド タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法
EP2385107B1 (en) * 2010-05-03 2016-08-24 Institut Pasteur Lentiviral vector based immunological compounds against malaria
US9115205B2 (en) * 2010-10-18 2015-08-25 The United States Of America, As Represented By The Secretary Of The Army Plasmodium falciparum circumsporozoite vaccine gene optimization for soluble protein expression
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein

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