DK0725653T3 - Vaccinepræparater - Google Patents
VaccinepræparaterInfo
- Publication number
- DK0725653T3 DK0725653T3 DK94928455T DK94928455T DK0725653T3 DK 0725653 T3 DK0725653 T3 DK 0725653T3 DK 94928455 T DK94928455 T DK 94928455T DK 94928455 T DK94928455 T DK 94928455T DK 0725653 T3 DK0725653 T3 DK 0725653T3
- Authority
- DK
- Denmark
- Prior art keywords
- double mutant
- antigen
- substituted
- manufacture
- amino acid
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 231100000252 nontoxic Toxicity 0.000 abstract 3
- 230000003000 nontoxic effect Effects 0.000 abstract 3
- 108010081690 Pertussis Toxin Proteins 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 241000588832 Bordetella pertussis Species 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939320454A GB9320454D0 (en) | 1993-10-05 | 1993-10-05 | Vaccine compositions |
| GB939324743A GB9324743D0 (en) | 1993-12-02 | 1993-12-02 | Adjuvant compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0725653T3 true DK0725653T3 (da) | 2004-10-11 |
Family
ID=26303633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94928455T DK0725653T3 (da) | 1993-10-05 | 1994-10-04 | Vaccinepræparater |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7169399B2 (da) |
| EP (1) | EP0725653B2 (da) |
| AT (1) | ATE275970T1 (da) |
| AU (1) | AU7788194A (da) |
| DE (1) | DE69434000T3 (da) |
| DK (1) | DK0725653T3 (da) |
| WO (1) | WO1995009649A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9513371D0 (en) | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| ATE275970T1 (de) | 1993-10-05 | 2004-10-15 | Celltech Pharmaceuticals Ltd | Impfstoffzusammensetzungen |
| GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| US20030072774A1 (en) * | 1994-06-10 | 2003-04-17 | Diane M. Gajewczyk | Proteinaceous adjuvants |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US7115730B1 (en) | 1999-04-27 | 2006-10-03 | Chiron Srl | Immunogenic detoxified mutant E. coli LT-A-toxin |
| AU2002366267B2 (en) * | 2001-11-19 | 2007-05-10 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| EP1790358A1 (en) | 2005-11-23 | 2007-05-30 | Université de Reims Champagne-Ardennes | Protein constructs designed for targeting and lysis of cells |
| KR20130072201A (ko) | 2010-03-30 | 2013-07-01 | 피페넥스 인크. | 재조합 독소 단백질의 고수준 발현 |
| JP5966018B2 (ja) * | 2011-12-21 | 2016-08-10 | バイオネット−エイジア，カンパニー・リミテッド | 改変ボルデテラ・パータシス株 |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| WO2016011155A1 (en) * | 2014-07-15 | 2016-01-21 | Kapre Subhash V | Genetically detoxified pertussis that maintains intrinsic adjuvant activity |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8727489D0 (en) * | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| JPH03500606A (ja) | 1988-05-05 | 1991-02-14 | アプライド マイクロバイオロジー，インコーポレイテッド | プロテアーゼ欠損グラム陽性菌類及び組換え体産生用宿主有機体としての用途 |
| AP8900132A0 (en) * | 1988-07-22 | 1991-01-14 | Smithkline Biolog | Bordetella pertussis vaccine |
| ES2078258T3 (es) | 1989-04-28 | 1995-12-16 | Sclavo Spa | Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas. |
| US5601826A (en) * | 1989-06-30 | 1997-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide which produces protective immunity against tetanus |
| DK0425082T3 (da) | 1989-09-04 | 1995-07-03 | Evans Medical Ltd | Vacciner |
| JPH03135923A (ja) * | 1989-10-20 | 1991-06-10 | Chemo Sero Therapeut Res Inst | 百日咳毒素ｂオリゴマーの構成サブユニットを含有する経鼻接種ワクチン |
| IT1248735B (it) | 1990-06-21 | 1995-01-26 | Sclavo Spa | Vaccini acellulari contro la pertosse |
| EP0484621A3 (en) | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
| CA2083553A1 (en) | 1991-11-25 | 1993-05-26 | Kuniharu Seki | Immunogen composition |
| IT1253009B (it) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
| ATE275970T1 (de) | 1993-10-05 | 2004-10-15 | Celltech Pharmaceuticals Ltd | Impfstoffzusammensetzungen |
| GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| US20030072774A1 (en) * | 1994-06-10 | 2003-04-17 | Diane M. Gajewczyk | Proteinaceous adjuvants |
| US6019982A (en) | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
| DE69937571T2 (de) | 1998-09-30 | 2008-09-04 | The Government Of The United States Of America As Represented By The Uniformed Services University Of The Health Sciences | Mutiertes cholera holotoxin als hilfsmittel |
-
1994
- 1994-10-04 AT AT94928455T patent/ATE275970T1/de not_active IP Right Cessation
- 1994-10-04 DE DE69434000T patent/DE69434000T3/de not_active Expired - Fee Related
- 1994-10-04 DK DK94928455T patent/DK0725653T3/da active
- 1994-10-04 AU AU77881/94A patent/AU7788194A/en not_active Abandoned
- 1994-10-04 WO PCT/GB1994/002152 patent/WO1995009649A1/en active IP Right Grant
- 1994-10-04 EP EP94928455A patent/EP0725653B2/en not_active Expired - Lifetime
-
2001
- 2001-02-02 US US09/775,909 patent/US7169399B2/en not_active Expired - Fee Related
-
2007
- 2007-01-09 US US11/651,346 patent/US20100255033A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995009649A1 (en) | 1995-04-13 |
| EP0725653B1 (en) | 2004-09-15 |
| DE69434000T3 (de) | 2008-11-06 |
| DE69434000T2 (de) | 2005-01-27 |
| EP0725653B2 (en) | 2008-04-02 |
| AU7788194A (en) | 1995-05-01 |
| ATE275970T1 (de) | 2004-10-15 |
| US20010018056A1 (en) | 2001-08-30 |
| DE69434000D1 (de) | 2004-10-21 |
| EP0725653A1 (en) | 1996-08-14 |
| US20100255033A1 (en) | 2010-10-07 |
| US7169399B2 (en) | 2007-01-30 |
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