ES2078258T3 - Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas. - Google Patents

Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.

Info

Publication number
ES2078258T3
ES2078258T3 ES90107892T ES90107892T ES2078258T3 ES 2078258 T3 ES2078258 T3 ES 2078258T3 ES 90107892 T ES90107892 T ES 90107892T ES 90107892 T ES90107892 T ES 90107892T ES 2078258 T3 ES2078258 T3 ES 2078258T3
Authority
ES
Spain
Prior art keywords
mutants
vaccines
pertussic
antipertussic
development
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90107892T
Other languages
English (en)
Inventor
Mariagrazia Pizza
Antonello Covacci
Rino Rappuoli
Luciano Nencioni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sclavo SpA
Original Assignee
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26327122&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2078258(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT8920341A external-priority patent/IT1230139B/it
Priority claimed from IT01928690A external-priority patent/IT1238007B/it
Application filed by Sclavo SpA filed Critical Sclavo SpA
Application granted granted Critical
Publication of ES2078258T3 publication Critical patent/ES2078258T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ESTOS MUTANTES (PT) SON INMUNOLOGICAMENTE ACTIVAS, TIENEN UNA TOXICIDAD REDUCIDA O NO, Y ESTAN CARACTERIZADOS EN QUE AL MENOS UNO DE LOS RESIDUOS AMINOACIDOS GLU129, ASP11, TRP26, ARG9, FE50, ASP1, ARG13, TYR130, GLY86, LLE88, TIR44, THR53 Y GLY80 DE SUBUNIDADES DE AMINOACIDO ES SUPRIMIDO Y SUSTITUIDO POR UN RESIDUO AMINOACIDO DIFERENTE. LAS CADENAS BORDETELLA CAPACES DE PROVEER Y SEGREGAR DICHAS MUTANTES PT Y EL SIGNIFICADO Y METODOS PARA OBTENERLAS SON TAMBIEN DESCRITAS. LAS CADENAS BORDETELLA Y LOS MUTANTES PRODUCIDOS SON PARTICULARMENTE APROPIADOS PARA LA PREPARACION DE VACUNAS CELULARES Y VACUNAS ANTIPERTUSIS ACELULARES.
ES90107892T 1989-04-28 1990-04-25 Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas. Expired - Lifetime ES2078258T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8920341A IT1230139B (it) 1989-04-28 1989-04-28 Ceppi di bordetella utili come vaccini antipertosse
IT01928690A IT1238007B (it) 1990-02-07 1990-02-07 Mutanti della tossina della pertosse, ceppi di bordetella capaci di produrre detti mutanti e loro impiego per lo sviluppo di vaccini antipertosse

Publications (1)

Publication Number Publication Date
ES2078258T3 true ES2078258T3 (es) 1995-12-16

Family

ID=26327122

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90107892T Expired - Lifetime ES2078258T3 (es) 1989-04-28 1990-04-25 Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.

Country Status (10)

Country Link
US (2) US7427404B1 (es)
EP (1) EP0396964B1 (es)
JP (2) JP2655583B2 (es)
AT (1) ATE127347T1 (es)
CA (1) CA2015677C (es)
DE (1) DE69022106T2 (es)
DK (1) DK0396964T3 (es)
ES (1) ES2078258T3 (es)
GR (1) GR3018285T3 (es)
HK (1) HK17096A (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
ES2078258T3 (es) * 1989-04-28 1995-12-16 Sclavo Spa Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
DE4113385A1 (de) * 1991-04-24 1992-10-29 Biotechnolog Forschung Gmbh Hybridtransposon mit pt-operon, plasmide und bakterienstaemme dafuer
GB9115332D0 (en) * 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
GB9513371D0 (en) 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
AU7788194A (en) 1993-10-05 1995-05-01 Medeva Holdings B.V. Vaccine compositions
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
FR2754543B1 (fr) * 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
GB9622660D0 (en) 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
AU2001271495A1 (en) * 2000-06-26 2002-01-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services A high yield pertussis vaccine production strain and method for making same
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
BRPI0402630B8 (pt) * 2004-07-05 2021-05-25 Fund Butantan processo de obtenção de vacina pertussis celular menos reatogênica
US9096908B2 (en) * 2009-04-24 2015-08-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Selective detection of Bordetella species
US20100317593A1 (en) * 2009-06-12 2010-12-16 Astrazeneca Ab 2,3-dihydro-1h-indene compounds
CA2793978C (en) 2010-03-30 2021-08-03 Pfenex Inc. High level expression of recombinant toxin proteins
CN104024400B (zh) * 2011-12-21 2018-02-16 亚洲生物网有限公司 经修饰的百日咳博德特氏菌菌株
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
EP3620172A1 (en) 2012-10-12 2020-03-11 GlaxoSmithKline Biologicals SA Non-cross-linked acellular pertussis antigens for use in combination vaccines
ES2597832T3 (es) 2013-03-08 2017-01-23 Janssen Vaccines & Prevention B.V. Vacuna acelular contra la tosferina
CA2919773A1 (en) 2013-08-05 2015-02-12 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
EP3283102A4 (en) 2015-04-16 2018-10-03 Inventprise, LLC. Bordetella pertussis immunogenic vaccine compositions
MX2021005303A (es) 2018-11-06 2021-07-07 Glaxosmithkline Biologicals Sa Composiciones inmunogenicas.
EP3799884A1 (en) 2019-10-01 2021-04-07 GlaxoSmithKline Biologicals S.A. Immunogenic compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
IT1223334B (it) * 1987-11-02 1990-09-19 Sclavo Spa Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
US6713072B1 (en) * 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
US5221618A (en) 1987-11-24 1993-06-22 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
IT1223529B (it) * 1987-12-18 1990-09-19 Sclavo Spa Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
US5000952A (en) * 1988-08-02 1991-03-19 The Board Of Trustees Of The Leland Stanford, Jr. University Polypeptide pertussis toxin vaccine
ES2078258T3 (es) * 1989-04-28 1995-12-16 Sclavo Spa Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.

Also Published As

Publication number Publication date
EP0396964B1 (en) 1995-09-06
US7666436B1 (en) 2010-02-23
JPH03169825A (ja) 1991-07-23
ATE127347T1 (de) 1995-09-15
US7427404B1 (en) 2008-09-23
DE69022106T2 (de) 1996-02-15
JP2655583B2 (ja) 1997-09-24
CA2015677A1 (en) 1990-10-28
DE69022106D1 (de) 1995-10-12
HK17096A (en) 1996-02-09
EP0396964A1 (en) 1990-11-14
JP2852025B2 (ja) 1999-01-27
GR3018285T3 (en) 1996-03-31
DK0396964T3 (da) 1995-10-30
CA2015677C (en) 2005-06-21
JPH09163978A (ja) 1997-06-24

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