DE69022106D1 - Pertussistoxin-Mutanten, dieselbe produzierende Bordetella-Stämme und ihre Verwendung als Vakzin gegen Pertussis. - Google Patents

Pertussistoxin-Mutanten, dieselbe produzierende Bordetella-Stämme und ihre Verwendung als Vakzin gegen Pertussis.

Info

Publication number
DE69022106D1
DE69022106D1 DE69022106T DE69022106T DE69022106D1 DE 69022106 D1 DE69022106 D1 DE 69022106D1 DE 69022106 T DE69022106 T DE 69022106T DE 69022106 T DE69022106 T DE 69022106T DE 69022106 D1 DE69022106 D1 DE 69022106D1
Authority
DE
Germany
Prior art keywords
pertussis
mutants
bordetella strains
vaccine against
pertussis toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69022106T
Other languages
English (en)
Other versions
DE69022106T2 (de
Inventor
Mariagrazia Pizza
Antonello Covacci
Rino Rappuoli
Luciano Nencioni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sclavo SpA
Original Assignee
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26327122&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69022106(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT8920341A external-priority patent/IT1230139B/it
Priority claimed from IT01928690A external-priority patent/IT1238007B/it
Application filed by Sclavo SpA filed Critical Sclavo SpA
Application granted granted Critical
Publication of DE69022106D1 publication Critical patent/DE69022106D1/de
Publication of DE69022106T2 publication Critical patent/DE69022106T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69022106T 1989-04-28 1990-04-25 Pertussistoxin-Mutanten, dieselbe produzierende Bordetella-Stämme und ihre Verwendung als Vakzin gegen Pertussis. Expired - Lifetime DE69022106T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8920341A IT1230139B (it) 1989-04-28 1989-04-28 Ceppi di bordetella utili come vaccini antipertosse
IT01928690A IT1238007B (it) 1990-02-07 1990-02-07 Mutanti della tossina della pertosse, ceppi di bordetella capaci di produrre detti mutanti e loro impiego per lo sviluppo di vaccini antipertosse

Publications (2)

Publication Number Publication Date
DE69022106D1 true DE69022106D1 (de) 1995-10-12
DE69022106T2 DE69022106T2 (de) 1996-02-15

Family

ID=26327122

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69022106T Expired - Lifetime DE69022106T2 (de) 1989-04-28 1990-04-25 Pertussistoxin-Mutanten, dieselbe produzierende Bordetella-Stämme und ihre Verwendung als Vakzin gegen Pertussis.

Country Status (10)

Country Link
US (2) US7427404B1 (de)
EP (1) EP0396964B1 (de)
JP (2) JP2655583B2 (de)
AT (1) ATE127347T1 (de)
CA (1) CA2015677C (de)
DE (1) DE69022106T2 (de)
DK (1) DK0396964T3 (de)
ES (1) ES2078258T3 (de)
GR (1) GR3018285T3 (de)
HK (1) HK17096A (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
ES2078258T3 (es) * 1989-04-28 1995-12-16 Sclavo Spa Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
DE4113385A1 (de) * 1991-04-24 1992-10-29 Biotechnolog Forschung Gmbh Hybridtransposon mit pt-operon, plasmide und bakterienstaemme dafuer
GB9115332D0 (en) * 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
GB9513371D0 (en) 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
AU7788194A (en) 1993-10-05 1995-05-01 Medeva Holdings B.V. Vaccine compositions
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
FR2754543B1 (fr) * 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
GB9622660D0 (en) 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
AU2001271495A1 (en) * 2000-06-26 2002-01-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services A high yield pertussis vaccine production strain and method for making same
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
BRPI0402630B8 (pt) * 2004-07-05 2021-05-25 Fund Butantan processo de obtenção de vacina pertussis celular menos reatogênica
US9096908B2 (en) * 2009-04-24 2015-08-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Selective detection of Bordetella species
US20100317593A1 (en) * 2009-06-12 2010-12-16 Astrazeneca Ab 2,3-dihydro-1h-indene compounds
CA2793978C (en) 2010-03-30 2021-08-03 Pfenex Inc. High level expression of recombinant toxin proteins
CN104024400B (zh) * 2011-12-21 2018-02-16 亚洲生物网有限公司 经修饰的百日咳博德特氏菌菌株
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
EP3620172A1 (de) 2012-10-12 2020-03-11 GlaxoSmithKline Biologicals SA Unvernetzte azelluläre pertussis-antigene zur verwendung in kombinationsimpfstoffen
ES2597832T3 (es) 2013-03-08 2017-01-23 Janssen Vaccines & Prevention B.V. Vacuna acelular contra la tosferina
CA2919773A1 (en) 2013-08-05 2015-02-12 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
EP3283102A4 (de) 2015-04-16 2018-10-03 Inventprise, LLC. Immunogene impfstoffzusammensetzungen gegen bordetella pertussis
MX2021005303A (es) 2018-11-06 2021-07-07 Glaxosmithkline Biologicals Sa Composiciones inmunogenicas.
EP3799884A1 (de) 2019-10-01 2021-04-07 GlaxoSmithKline Biologicals S.A. Immunogene zusammensetzungen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
IT1223334B (it) * 1987-11-02 1990-09-19 Sclavo Spa Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
US6713072B1 (en) * 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
US5221618A (en) 1987-11-24 1993-06-22 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
IT1223529B (it) * 1987-12-18 1990-09-19 Sclavo Spa Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
US5000952A (en) * 1988-08-02 1991-03-19 The Board Of Trustees Of The Leland Stanford, Jr. University Polypeptide pertussis toxin vaccine
ES2078258T3 (es) * 1989-04-28 1995-12-16 Sclavo Spa Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.

Also Published As

Publication number Publication date
EP0396964B1 (de) 1995-09-06
US7666436B1 (en) 2010-02-23
JPH03169825A (ja) 1991-07-23
ATE127347T1 (de) 1995-09-15
US7427404B1 (en) 2008-09-23
DE69022106T2 (de) 1996-02-15
JP2655583B2 (ja) 1997-09-24
ES2078258T3 (es) 1995-12-16
CA2015677A1 (en) 1990-10-28
HK17096A (en) 1996-02-09
EP0396964A1 (de) 1990-11-14
JP2852025B2 (ja) 1999-01-27
GR3018285T3 (en) 1996-03-31
DK0396964T3 (da) 1995-10-30
CA2015677C (en) 2005-06-21
JPH09163978A (ja) 1997-06-24

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Legal Events

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